Pancreatic neoplasm

This early-phase trial tested a combination of two chemotherapy drugs (gemcitabine and carboplatin) plus lenalidomide, a drug that blocks blood vessel growth in tumors, in 18 adults with advanced solid tumors, especially urothelial (bladder) cancer. The main goal was to find the …

This early-phase study tests a new drug called AB680, combined with immunotherapy (zimberelimab) and two chemotherapy drugs (nab-paclitaxel and gemcitabine), in people with advanced pancreatic cancer that has spread. The main goals are to check safety and find the right dose. Abo…

This pilot study tested a wearable device that delivers low-intensity electric fields (TTFields) together with immunotherapy (atezolizumab) and two chemotherapy drugs (gemcitabine and nab-paclitaxel) in 84 people with metastatic pancreatic cancer who had not received prior treatm…

This phase II trial tests whether giving chemotherapy and proton beam radiation before surgery can help people with borderline-resectable pancreatic cancer. The goal is to shrink the tumor enough so that surgeons can remove it completely, with no cancer cells left at the edges. P…

This study tests whether giving higher doses of radiation, guided by MRI, can help people with pancreatic cancer that cannot be removed by surgery. Participants must have already had several months of chemotherapy without the cancer spreading. The goal is to see if this approach …

This study tested whether adding a Chinese herbal formula (QingyiHuaji) to standard chemotherapy helps people with stage IV pancreatic cancer live longer. About 305 adults with advanced pancreatic cancer were randomly assigned to receive either the herbal formula plus chemo or a …

This phase II trial tests whether combining niraparib and dostarlimab can control metastatic pancreatic cancer in people who carry BRCA1/2 or PALB2 gene mutations. Niraparib blocks enzymes that cancer cells need to grow, while dostarlimab helps the immune system attack the tumor.…

This trial tests whether adding a Braun anastomosis, an extra connection between two parts of the small intestine, during standard pancreatic surgery helps prevent delayed gastric emptying. Delayed gastric emptying is a common complication where the stomach is slow to empty food,…

This early-phase trial tests a combination of two immunotherapy drugs (nivolumab and ipilimumab), a vaccine targeting TGFβ-15, and targeted radiation for pancreatic cancer that has not responded to standard treatments. The goal is to see if this mix can safely boost the immune sy…

This trial tests an experimental drug called SNS-101, which targets a protein called VISTA that may help tumors evade the immune system. Researchers give SNS-101 alone or with another immunotherapy, cemiplimab, to adults with advanced solid tumors that have not responded to stand…

This study tested two different treatment plans for people with a specific type of pancreatic cancer that is on the edge of being removable by surgery. 130 patients received either chemotherapy alone or chemotherapy plus radiation before surgery. The goal was to see which approac…

This study tests a 3-week course of radiation (using photons or protons) combined with chemotherapy for people with pancreatic cancer that hasn't spread. The goal is to see if this shorter treatment is safe and effective, either before surgery or as the main therapy. Researchers …

This study tested an experimental drug called CBX-12 in 69 adults with advanced solid tumors (like ovarian, lung, breast, or colon cancer) that had stopped responding to standard therapies. The main goals were to check the drug's safety, find the best dose, and see if it could sh…

This trial investigates an experimental oral drug, LY3143921 hydrate, which blocks a protein called Cdc7 that cancer cells need to divide. It is being tested in adults with advanced solid tumours, including colorectal, ovarian, lung, and pancreatic cancers, that have not responde…

This phase 2 trial is testing whether adding hydroxychloroquine to standard radiation and chemotherapy before surgery can better control pancreatic cancer. About 50 people with resectable pancreatic cancer will receive either proton or photon radiation along with capecitabine and…

This trial is testing whether adding an experimental antibody called XB2001 to a standard chemotherapy regimen can help people with advanced pancreatic cancer. The study has two parts: first, it finds the safest dose of XB2001, then it compares the antibody plus chemo against a p…

This trial is testing whether adding high-dose vitamin C (ascorbic acid) to a standard three-drug chemotherapy cocktail can safely and effectively control metastatic pancreatic cancer in people who have not yet received any treatment. The study enrolls adults with stage IV pancre…

This early-phase trial tests two drugs together in 15 people with advanced pancreatic cancer. One drug, calaspargase pegol-mknl, lowers a nutrient that cancer cells need to grow. The other, cobimetinib, blocks a protein that helps cancer cells survive. The goal is to find a safe …

This phase II trial tests whether adding high-dose vitamin C (ascorbate) to standard chemotherapy (gemcitabine and nab-paclitaxel) can help people with metastatic pancreatic cancer live longer. About 40 participants are randomly assigned to receive either standard chemo alone or …

This study monitors the safety and effectiveness of the drug olaparib (Lynparza) in people with ovarian, breast, prostate, or pancreatic cancer who are prescribed it as part of routine care in South Korea. Researchers will track side effects and how long the cancer stays under co…

This study tested a new drug called brigimadlin (BI 907828) in 99 adults with advanced cancers of the bile duct, pancreas, lung, or bladder that have a specific genetic change (MDM2 amplification). Participants took the drug as a tablet once every 3 weeks. The goal was to see if …

This trial tests whether using a radiofrequency device to cut the pancreas during distal pancreatectomy reduces the chance of a pancreatic fistula (a leak of digestive fluids) compared to the standard stapler method. About 112 adults having this surgery for benign or malignant tu…

This study tests whether endoscopic ultrasound-guided gallbladder drainage can be safely performed using conscious sedation given by the endoscopist, instead of deep sedation or general anesthesia. The trial enrolls elderly, high-risk patients with acute cholecystitis who are not…

This trial investigates a type of immunotherapy called CAR-T cells that are designed to recognize and attack cancer cells carrying a protein called CEA. The study includes adults with advanced gastric, colon, rectal, esophageal, or pancreatic cancer who have not responded to at l…

This study tests whether adding the drug surufatinib to standard chemotherapy can help shrink pancreatic tumors enough to allow successful surgery. It involves 29 adults with locally advanced or borderline resectable pancreatic cancer. The main goal is to see how many tumors can …

This study tests a treatment plan for people with advanced pancreatic cancer that has spread to a major artery. Participants receive chemotherapy and radiation before surgery, then more chemo after. The goal is to see if this approach is safe and helps patients live longer. The t…

This study tests a new drug called pegilodecakin, a lab-made version of a natural immune protein (interleukin-10), in people with advanced solid tumors such as melanoma, lung, breast, prostate, ovarian, kidney, colorectal, and pancreatic cancers. The drug is given as a daily shot…

This early-stage trial tests a new type of cell therapy called CEA-targeted CAR-T for people with advanced colorectal, esophageal, stomach, or pancreatic cancers that have stopped responding to standard treatments. The therapy involves taking a patient's own immune cells, enginee…

This early-phase study tests whether adding losartan (a blood pressure medicine) to a shorter, higher-dose radiation treatment can help people with pancreatic cancer that is hard to remove surgically. The main goal is to check for side effects and find the safest dose. About 22 a…

This trial investigates whether adding antroquinonol (Hocena) to standard chemotherapy (nab-paclitaxel and gemcitabine) can safely treat people with metastatic pancreatic cancer that has not yet been treated. The study has two phases: first, finding the best dose, and second, che…

This early-phase trial tested an experimental drug called KVA12123, given alone or with the immunotherapy Keytruda, in 40 adults with advanced solid tumors (like lung, breast, or colon cancer) that had stopped responding to standard treatments. The main goals were to check safety…

This Phase II trial tested a combination of chemotherapy drugs (FOLFIRINOX) plus the blood pressure drug losartan, followed by proton radiation, in 50 people with locally advanced pancreatic cancer. The goal was to see if this approach could shrink tumors enough to allow complete…

This trial tested a new treatment called EGFR BATs for people with advanced pancreatic cancer. The treatment uses a patient's own immune cells, armed with a special antibody, to target cancer cells. The study included 22 participants who had already received chemotherapy. The goa…

This early-phase trial tested a new type of vaccine made from a patient's own immune cells (dendritic cells) that are engineered to target a protein called WT1 found in many cancers. Ten people with advanced esophageal, pancreatic, ovarian, or liver cancer received six vaccines o…

This early-phase trial tested two drugs together—pembrolizumab (Keytruda) and XL888—in 47 people with advanced gastrointestinal cancers like colorectal and pancreatic cancer that had spread or could not be removed. The main goal was to find the safest dose and check for side effe…

This phase 2 trial tested whether adding the drug veliparib to standard chemotherapy (FOLFIRI) helps people with metastatic pancreatic cancer live longer. 123 patients whose cancer had returned after initial treatment were randomly assigned to get FOLFIRI alone or FOLFIRI plus ve…

This study looked at whether using epidural anesthesia (a numbing shot in the back) during pancreatic cancer surgery helps people live longer and stay cancer-free longer. About 540 adults having surgery for pancreatic cancer took part. The goal was to see if this type of pain con…

This study looked at 708 patients with a rare, low-grade pancreatic tumor called solid pseudopapillary neoplasm. Researchers compared a less invasive surgery that saves healthy pancreas tissue to a more extensive surgery that removes more of the organ. They also examined whether …

This study tested whether adding two experimental drugs (TTX-030 and budigalimab) to standard chemotherapy could help people with metastatic pancreatic cancer live longer without their disease getting worse. 194 adults who had not yet received treatment for their advanced cancer …

This study tested a combination of three drugs (nivolumab, BMS-813160, and GVAX) in 22 people with locally advanced pancreatic cancer who had already received chemotherapy and radiation. The goal was to see if the treatment was safe and could help the immune system better attack …

This study tested a combination of three chemotherapy drugs (paclitaxel protein bound, gemcitabine, and cisplatin) in 34 people with metastatic pancreatic cancer that had not been treated before. If the cancer got worse, a fourth drug (paricalcitol) was added. The goal was to see…

This early-stage study tested a custom-made yeast vaccine designed to train the immune system to recognize and attack leftover cancer cells. Five adults with various cancers (like colorectal, breast, or lung) who had completed initial treatment received the vaccine. The goal was …

This phase 1 trial tested a personalized vaccine made from each patient's unique cancer mutations (neoantigens) combined with an immune booster (poly-ICLC) in 33 people with pancreatic cancer. The vaccine was given after standard chemotherapy, either before or after surgery. The …

This study tested a combination of two drugs, lenvatinib and pembrolizumab, in 611 people with advanced cancers like breast, ovarian, stomach, colorectal, brain, bile duct, or pancreatic cancer that had stopped responding to standard treatments. The goal was to see if the combo c…

This study tested a combination of four drugs (tadalafil, pembrolizumab, ipilimumab, and CRS-207) in 17 people with advanced pancreatic cancer that had worsened after at least one round of chemotherapy. The goal was to see if the combination was safe and could shrink tumors. The …

This early-phase study tested a combination of three drugs (gemcitabine, capecitabine, and erlotinib) in 30 people with advanced pancreatic cancer that had already been treated. The main goal was to find the safest dose and understand side effects. This is not a cure, but aims to…

This early-phase trial tested a new type of radiation called carbon ion therapy for people with locally advanced pancreatic cancer that cannot be removed by surgery. Fourteen participants received increasing doses of carbon ion radiation along with chemotherapy. The main goal was…

This early-phase trial tested two drugs—binimetinib and hydroxychloroquine—in 34 people with a specific type of advanced pancreatic cancer (KRAS-mutant) that had spread. The goal was to find the safest dose of hydroxychloroquine when used with binimetinib, and to see if the combi…

This study tested an experimental immunotherapy called indoximod added to standard chemotherapy (gemcitabine and nab-paclitaxel) in 157 people with metastatic pancreatic cancer. The goal was to find a safe dose and see if the combination helps people live longer. The trial has co…

This study tested a new way to reconnect the pancreas to the intestine during Whipple surgery for certain cancers. The new method uses a stent and wraps the connection with omentum (fatty tissue) to try to prevent leaks. 48 patients were split into two groups to compare the new t…

This early-phase trial tested an experimental oral drug called IOA-289 combined with standard chemotherapy (gemcitabine and nab-paclitaxel) in 16 people with metastatic pancreatic cancer. The main goal was to check safety and find the right dose. Researchers also looked at how th…

This study tested a combination of two oral chemotherapy drugs, vemurafenib and sorafenib, in 10 people with advanced pancreatic cancer that has a specific genetic change called a KRAS mutation. All participants had already tried at least two standard treatments without success. …

This study looked at 60 people with advanced pancreatic body or tail cancer that couldn't be removed by surgery. It compared a targeted treatment called splenic artery infusion chemotherapy (SAIC), which delivers chemo directly to the tumor's blood supply, with standard chemo giv…

This study tested a drug called niraparib in 32 people with advanced pancreatic cancer that has certain gene changes (like BRCA). The goal was to see if the drug could slow down or stop the cancer from growing. While not a cure, it offers a targeted treatment option for patients …

This phase 2 trial tested a combination of chemotherapy drugs given directly into the liver artery for people with pancreatic cancer that had spread only to the liver and stopped responding to standard treatment. The 40 participants received a mix of oxaliplatin, irinotecan lipos…

This study tested a new cancer drug called ERAS-007, given by mouth, together with other targeted therapies in 101 people with advanced colorectal or pancreatic cancers that have certain gene changes. The main goals were to check safety, find the best dose, and see how the drugs …

This early-stage study tested a new drug called cabotamig in 33 adults with advanced cancers of the digestive system (like colon, pancreas, or liver) that had stopped responding to standard treatments. The goal was to see if the drug is safe and how it affects the body and tumors…

This phase II trial tested a combination of a pancreatic cancer vaccine (GVAX), an immunotherapy drug (pembrolizumab), and focused radiation (SBRT) in 58 patients with locally advanced pancreatic cancer. The goal was to see if this approach could delay the spread of the cancer to…

This study tested a combination of two drugs—NT-I7 (efineptakin alfa) and pembrolizumab (Keytruda)—in 215 people with advanced solid tumors that had stopped responding to treatment. The goal was to check safety, find the right dose, and see if the combo could shrink tumors. The t…

This study tested a special type of radiation called carbon ion therapy for people with pancreatic cancer that cannot be removed by surgery. The goal was to see if this treatment works better than standard radiation at controlling the cancer and helping people live longer. Twenty…

This study tested a combination of chemotherapy drugs given both before and after surgery for people with early-stage pancreatic cancer. The goal was to shrink the tumor before surgery and kill any remaining cancer cells afterward. 46 participants were enrolled to see if this app…

This completed Phase 2 trial tested whether combining an immunotherapy drug (durvalumab) with an epigenetic drug (tazemetostat) can control advanced solid tumors like pancreatic, colorectal, and soft-tissue sarcoma. The study enrolled 164 adults and measured how well the combo sh…

This trial tested a new approach for people with advanced gastrointestinal cancers that had stopped responding to standard treatments. Doctors removed immune cells from patients' tumors, used CRISPR gene editing to disable a gene called CISH, and then infused the modified cells b…

This study tested a modified cold virus called LOAd703 in 51 people with pancreatic cancer. The virus is designed to infect and kill cancer cells while also boosting the immune system. It was given alongside standard chemotherapy, and in some cases an immunotherapy drug, to see i…

This early-phase trial tested whether adding the drug anakinra to standard chemotherapy is safe for people with metastatic pancreatic cancer. Thirteen adults with advanced disease received the combination. The main goal was to check for side effects, not to see if it works.

This study tested a drug called romiplostim in 165 adults with gastrointestinal, pancreatic, or colorectal cancer who were receiving chemotherapy. The goal was to see if romiplostim could prevent low platelet counts (thrombocytopenia) that often force doctors to delay or reduce c…

This completed phase 2 trial tested whether adding an anti-PD-1 immunotherapy drug to standard chemotherapy (modified-FOLFIRINOX) helps patients with locally advanced or borderline resectable pancreatic cancer. The study enrolled 392 participants and compared the combination agai…

This early-stage study tested whether combining a procedure that uses electrical pulses to destroy tumors (IRE) with an immunotherapy drug (pembrolizumab) is safe for people with locally advanced pancreatic cancer that cannot be removed by surgery. Only 2 participants were enroll…

This study tested whether adding two immunotherapy drugs (pembrolizumab and defactinib) to standard chemotherapy before and after surgery could help the body fight pancreatic cancer better. It involved 28 people with early-stage, removable pancreatic cancer. The goal was to see i…

This early-phase study tests two experimental drugs, BI 765049 and ezabenlimab, in adults with advanced solid tumors like colorectal, lung, and pancreatic cancer. The main goal is to find the highest safe dose of BI 765049 alone and in combination with ezabenlimab. Participants r…

This early-phase trial tested a new drug called SNB-101 in 21 people with advanced solid tumors (like colorectal, breast, and lung cancers) that had stopped responding to standard treatments. SNB-101 is a nanoparticle version of SN-38, the active part of a common chemotherapy dru…

This study tested a combination of two drugs, pembrolizumab (an immunotherapy) and azacitidine (a drug that affects gene activity), in people with advanced pancreatic cancer that had worsened after initial treatment. The goal was to see if this combination could help control the …

This phase II trial tested whether adding paricalcitol (a vitamin D drug) and hydroxychloroquine (an autophagy inhibitor) to standard chemotherapy could help shrink tumors in 10 people with advanced or metastatic pancreatic cancer. The goal was to see if the combination improved …

This study compared miniinvasive (robotic or laparoscopic) Whipple surgery to the traditional open approach in 320 patients with pancreatic, bile duct, or ampulla of Vater cancers. The goal was to see which method leads to fewer complications like pancreatic leaks, bleeding, or i…

This early-phase trial tested a new drug called CUE-102 in 42 adults with certain advanced cancers (colorectal, gastric, pancreatic, or ovarian) that had returned or spread despite prior treatments. The drug is designed to help the immune system attack cancer cells that carry a s…

This study looked at the safety of LYNPARZA (olaparib) when used as a maintenance treatment after platinum-based chemotherapy in 130 patients with BRCA-mutated pancreatic cancer that could not be surgically removed. Researchers tracked side effects like bone marrow problems, lung…

This phase II trial tested two chemotherapy combinations as first-line treatment for people with advanced or metastatic pancreatic cancer. One group received a newer regimen called SLOG, while the other got a standard combo called mFOLFIRINOX. The study aimed to see which worked …

This study compared robotic-assisted pancreatic surgery to the standard open approach for people with pancreatic and related tumors. Researchers wanted to see if robotic surgery could help patients recover faster after the operation. A total of 268 patients took part across multi…

This early-phase trial tested a new way to treat advanced cancers that have spread. It combined a special type of radiation with two immunotherapy drugs (MEDI4736 and tremelimumab) to see if the combination is safe and tolerable. The study included 53 adults with advanced melanom…

This small pilot study tested whether adding a vitamin D-like drug called paricalcitol to standard chemotherapy could help people with advanced pancreatic cancer that had stopped responding. 27 patients received chemotherapy first, then paricalcitol was added if their disease sta…

This phase 2 trial tested two drugs, cabozantinib and pembrolizumab, in 21 people with metastatic pancreatic cancer that had worsened after standard treatment. The goal was to see if the combination could slow cancer growth. The study is complete, and results may help guide futur…

This study tested a new combination of drugs (ABT-888 plus chemotherapy) in 64 people with pancreatic cancer that had spread. The goal was to see if adding ABT-888, which blocks cancer cells from fixing DNA damage, could make chemotherapy work better and shrink tumors. The study …

This pilot study tested a highly targeted form of radiation called stereotactic body radiation therapy (SBRT) in 36 patients with pancreatic cancer that could not be removed by surgery or had come back after other treatments. The main goal was to see how safe the treatment was by…

This study tested a smartphone app to help young adult cancer survivors (ages 18-39) lose weight. The app tracked diet and activity as part of a behavioral weight loss program. The goal was to see if this approach was practical and well-liked by participants. The study involved 6…

This study tested a new experimental therapy using special immune cells (T cells) trained to attack proteins found on pancreatic cancer cells. The trial included 37 patients whose cancer had returned or not responded to standard treatment, or who chose not to have chemotherapy. T…

This early-phase study tested whether adding high-dose vitamin C (ascorbate) to standard chemotherapy and radiation is safe for people with pancreatic cancer. Sixteen adults with pancreatic cancer took part. The main goal was to see how many serious side effects occurred, with a …

This study looked at nearly 1,000 adults having pancreatic surgery to see which antibiotic, cefoxitin or piperacillin-tazobactam, works better at preventing wound infections within 30 days after the operation. Participants received one of the two antibiotics before surgery. The g…

This study tested an experimental drug called BMS-813160, given together with chemotherapy or the immunotherapy nivolumab (Opdivo), in 332 people with advanced colorectal or pancreatic cancer. The main goals were to check safety, side effects, and how the body processes the drug,…

This study tested a new treatment plan for people with advanced pancreatic cancer that has spread. It combined chemotherapy with drugs that change how genes work and boost the immune system. The goal was to see if this approach is safe and can help control the disease. 75 patient…

This study tested two types of endoscopes used in ERCP, a procedure to treat bile duct and pancreas problems. One scope had a single-use plastic cover on its tip, while the other was a standard reusable scope. Researchers compared how well each worked and how often complications …

This completed phase I trial tested whether higher doses of a precise type of radiation called stereotactic body radiotherapy (SBRT) are safe for people with pancreatic cancer. Thirty patients with inoperable or locally advanced pancreatic cancer received five targeted radiation …

This study follows people with a significantly elevated risk of pancreatic cancer—due to inherited gene mutations or strong family history—who choose to undergo early detection testing. Participants receive endoscopic ultrasound (EUS) and MRI scans on an alternating schedule ever…

This trial evaluates a new biopsy needle (Micro-Tech FNB) used during endoscopic ultrasound to collect tissue samples from suspected pancreatic tumors. The goal is to see if this needle provides accurate diagnoses and yields enough high-quality tissue for genetic sequencing, whic…

This trial is evaluating whether a specialized ultrasound technique, called shear wave elastography, can accurately identify pancreatic cancer. The study will include 130 adults with a solid pancreatic mass of unknown cause. By measuring tissue stiffness, the technique may help d…

This study tests a special SPECT imaging agent that seeks out a protein called LRRC15, found on many aggressive cancers like pancreatic, breast, lung, and brain tumors. The goal is to see if this scan can help doctors diagnose and stage these cancers more accurately. Healthy volu…

This study tested whether a PET scan using a tracer called 18F-FAZA can measure low oxygen levels (hypoxia) in pancreatic cancer. Hypoxia can affect how the cancer grows and responds to treatment. 48 adults with pancreatic cancer received the scan, and researchers also collected …

This study looked at whether a special ultrasound done before surgery can find small cancer spots that have spread from the main pancreatic tumor. Doctors used an endoscopic ultrasound to check lymph nodes near and far from the tumor. The goal was to see if this method could impr…

This study looked at 477 adults with pancreatic cysts to find better ways to tell which cysts are harmless and which might become cancer. Researchers combined medical images, patient history, and fluid from the cysts to create a more accurate prediction model. The goal is to help…

This early-phase study tested a new imaging agent called NMK89 in 10 people with pancreatic cancer. NMK89 is designed to attach to a protein (MUC5AC) found on these cancer cells and show up on PET scans. The main goal was to check if it is safe and how well it helps doctors see t…

This study tested whether omeprazole, a common heartburn medication, could prevent nerve damage caused by oxaliplatin chemotherapy in 46 adults with colorectal or pancreatic cancer. Participants took omeprazole before and during chemotherapy cycles. The goal was to see if it redu…

This study tested whether a device that gently stimulates the vagus nerve through the ear could reduce delayed stomach emptying after a major pancreatic surgery (pancreaticoduodenectomy). 84 patients were randomly assigned to receive the stimulation during surgery or not. The goa…

This study tests whether a conversation game called 'Hello' can help people with cancer and their loved ones discuss advance care planning—decisions about future medical care. Participants will play either the Hello game or a similar conversation game, complete questionnaires, an…

This early-stage study tests whether a single dose of psilocybin, the active ingredient in magic mushrooms, can reduce depression and anxiety in people with advanced pancreatic, biliary, or other gastrointestinal cancers. The study enrolls 24 adults aged 19-85 with stage IV or in…

This trial tests whether an ultrasound-guided injection of alcohol and a numbing agent around the celiac ganglia can relieve pain in people newly diagnosed with inoperable pancreatic cancer. Participants receive either the nerve block or a sham procedure, alongside standard pain …

This study tests whether a low dose of oral ketamine can safely help with anxiety in people with pancreatic cancer. Twenty participants will receive both ketamine and a placebo at different times to compare effects. The main goal is to see if such a study is even possible, not to…

This study tests a program called STRONG that gives pancreatic cancer patients extra support from a dietician and a Fitbit to track their food intake. The goal is to see if patients find the program helpful and easy to stick with while they are on chemotherapy. About 80 adults wi…

This study tested a home monitoring system for people with advanced pancreatic cancer receiving a strong chemotherapy called mFOLFIRINOX. The system tracked symptoms, activity, sleep, and weight using connected devices and an online platform. The goal was to see if early alerts c…

This study tested whether a remote nutrition coaching program is practical and well-liked by people with pancreatic cancer who are undergoing chemotherapy. Forty participants were asked to complete online food questionnaires and attend coaching sessions over 12 weeks. The goal wa…

This study tested an investigational drug called ponsegromab in 187 adults with lung, pancreatic, or colorectal cancer who also had cachexia—a condition causing severe weight loss, loss of appetite, and fatigue. The goal was to see if ponsegromab could help patients gain weight a…

This study tested a procedure called endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) to treat pain in 19 people with advanced pancreatic cancer that could not be removed by surgery. The goal was to see if zapping the celiac ganglion—a bundle of nerves—could reduce …

This study tested a program that provides nutrition and supportive care remotely to adults with pancreatic cancer who are receiving chemotherapy. The goal was to see if the program was easy to use and if patients were satisfied with it. 50 participants were enrolled to track how …

This pilot study tested a 12-week digital health coaching program for people with pancreatic cancer and their caregivers. The program included coaching sessions by phone, text, or email to help manage symptoms. The study aimed to see if the program was easy to use and if particip…

This phase 2 trial looked at whether adding acupuncture and acupressure to oral cryotherapy (sucking on ice chips) can reduce nerve pain caused by oxaliplatin chemotherapy in people with gastrointestinal cancers. 78 patients were split into two groups: one got cryotherapy alone, …

This study looked at whether having a palliative care team work alongside surgeons improves quality of life for patients with gastrointestinal cancers like pancreatic or liver cancer. About 379 patients and their family members took part. The main goal was to see if this team app…

This study looked at whether giving an additional anesthetic nerve block after pancreatic surgery helps patients use fewer opioid painkillers. 136 adults having open pancreatic surgery for cancer were randomly assigned to receive either one nerve block or a repeat block. The main…

This study tested a drug called telotristat ethyl in 23 people with advanced pancreatic cancer who had lost at least 10% of their body weight. The goal was to see if the drug could help them stabilize or gain weight by reducing bowel movements. Maintaining weight may help patient…

This study looked at placing a small metal tube (stent) into the portal vein of 63 cancer patients whose vein was blocked by a tumor. The goal was to relieve serious symptoms like fluid buildup in the belly or bleeding in the gut. The procedure was done through a needle in the li…

Researchers at a large hospital in Seoul reviewed records from nearly 33,000 adults who had curative-intent surgery for one of seven cancers in the abdomen or pelvis: pancreatic, gastric, rectal, cervical, endometrial, kidney, or prostate. They grouped patients by whether they re…

This study is testing whether a special type of ultrasound, called endoscopic ultrasound elastography, can predict the texture of the pancreas and the risk of a pancreatic fistula after a major surgery called pancreaticoduodenectomy. The study will enroll 100 adults scheduled for…

This study looked at whether a special website or coaching phone calls could help more people with a personal or family history of certain cancers get genetic testing. Over 800 participants were randomly assigned to one of these two methods or to standard care. The goal was to se…

This study investigates low-oxygen (hypoxic) areas within pancreatic tumors by giving patients a special marker before surgery. The marker highlights oxygen-deprived regions in the removed tumor tissue. Researchers will then analyze how these hypoxic zones relate to patient survi…

This study creates a registry of adults with pancreatic exocrine insufficiency (PEI), a condition where the pancreas does not produce enough enzymes to digest food properly. Researchers at eight specialist centers across Europe will track how doctors prescribe pancreatic enzyme r…

This study looked at 58 patients scheduled for pancreatic surgery due to suspected cancer. Researchers collected blood samples before and after surgery to measure immune function and inflammation. They then tracked complications like low blood pressure and infections. The goal wa…

This study looked at a thin layer inside blood vessels called the glycocalyx in 78 adults having major abdominal surgery. Researchers used a special camera to measure changes in this layer during and after surgery. The goal was to see if tracking glycocalyx thickness could help d…

This study looked at whether an AI computer program could suggest cancer treatments that match what experts recommend. Researchers reviewed medical records of 30 people with stomach, colon, or pancreatic cancer. They entered key details into the AI and compared its suggestions to…

This study followed 159 people with metastatic colorectal, pancreatic, biliary, or esophageal cancers who were starting a new line of therapy. Researchers collected blood samples (tumor markers and liquid biopsies) and patient-reported quality-of-life data to see if these could p…

This study followed 99 people who had both an operable pancreatic tumor and diabetes for one year after surgery. Researchers tracked their fatigue, blood sugar control, diabetes self-care, and quality of life to understand how these factors change over time. The goal was to learn…

This study aimed to find biological markers (biomarkers) in pancreatic tumor cells and blood that could help predict how well a patient might respond to treatment. Researchers analyzed genetic and protein information from tumor samples collected via ultrasound-guided biopsy, as w…

This study looked at over 2,000 older adults (80+) with pancreatic cancer that hadn't spread, all in good general health. Researchers compared those who had surgery to remove the tumor with those who didn't, using data from a German cancer registry. The goal was to see if surgery…

This study looked at whether giving a short, strong dose of radiation right before surgery is possible for people with pancreatic cancer. Ten patients took part to see if the approach was safe and could help surgeons remove the tumor completely. The main goal was to check for com…

This study tested whether it is safe and possible to collect a blood sample from the portal vein (a major liver blood vessel) during a routine endoscopic ultrasound in 23 people with pancreatic cancer. The goal was to find and count circulating tumor cells (cancer cells in the bl…

This completed study tested whether a new biomarker called 'mass response' can predict how well a cancer therapy will work. Researchers collected tumor cells from 72 patients with various cancers through fluid drainage or biopsies. The goal was to see if this biomarker could guid…

This study looks at whether the drug T-DXd works better than standard treatments for people with several types of HER2-positive solid tumors. Researchers will compare data from previous T-DXd trials with real-world medical records of patients who received standard care. The goal …

This study tested whether squirting vinegar into the small intestine during an endoscopy can help collect pancreatic juice for cancer testing. 75 people with suspected pancreatic cancer took part. The goal was to see if this method works and find the best amount of vinegar and co…

This study tested a newer biopsy method called fine-needle biopsy (FNB) for diagnosing pancreatic masses. Researchers wanted to see if FNB could provide better tissue samples than the standard fine-needle aspiration (FNA) without needing a cytologist on site. Fifty-two adults wit…

This study tested a digital chatbot (called CATALYST) to help cancer survivors learn about genetic testing for inherited cancer risk. Fifty adults who had certain cancers (like breast, ovarian, or prostate) used the chatbot or received usual care. The goal was to see if the chatb…

This study looked at hospital records from Germany over 14 years to see how often surgeons remove both the pancreatic tumor and any liver metastases in a single operation. The goal was to understand current practice and check whether adding liver surgery increases the risk of dea…

This study looked at how safe and effective a precise type of radiation therapy (SBRT) is for treating liver tumors, liver metastases, and pancreatic tumors. It involved 65 adult patients who were already scheduled for SBRT. The goal was to monitor and improve the treatment proce…

This study looked back at over 2,400 pancreatic cancer patients who had surgery with vein reconstruction. It compared those who had open surgery to those who had minimally invasive surgery (like laparoscopy or robot-assisted). The goal was to see which approach leads to fewer com…

This study looked at 40 patients with pancreatic cancer to measure circulating tumor DNA (ctDNA) in blood from a vein near the pancreas and in the arm, as well as in fluid from the belly, during surgery. The goal was to see if these DNA levels could help predict how the disease p…

This study looked at 236 adults with breast, colorectal, or pancreatic cancer who sought a second opinion at the University of Colorado. Researchers reviewed medical records to see if patients stayed for treatment or went elsewhere. The goal was to understand what factors influen…

This study looked at 35 people having surgery for pancreatic cancer to see if moving the tumor during the operation causes more cancer DNA to enter the bloodstream. Researchers took blood samples before, during, and after surgery to track these DNA levels. The goal was to better …

This study looked at how patients recover after robotic surgery to remove part of the pancreas (pancreaticoduodenectomy). It included 91 adults with tumors in the pancreas or nearby areas. The main goal was to see how long they stayed in the hospital and how quickly they returned…

This study tested a computer model (XGBoost) to predict whether suspicious spots on CT scans in people with chronic pancreatitis are cancerous. Researchers analyzed data from 113 patients to see how accurate the model was. The goal is to help doctors make better decisions without…

This study looked at whether it is safe and possible to grow mini-tumors (organoids) from pancreatic cancer samples in the lab. 60 patients with pancreatic cancer provided tumor tissue during surgery or biopsy. The goal was to see if these organoids could be used to test differen…

This study tested whether removing surgical drains early (4 days after surgery) instead of the usual 10-15 days reduces infections after pancreaticoduodenectomy, a major operation for pancreatic tumors. 141 patients were included, and those without a pancreatic leak were randomly…

This completed study looked at data from over 723,000 older adults (70+) worldwide to understand how common pancreatic cancer and pancreatitis are, and how deadly they are. Researchers analyzed trends from 1990 to 2021 and made projections to 2040. The goal was to see how these d…

This study observed 799 adults with advanced or metastatic pancreatic cancer in Korea to see which chemotherapy treatments doctors actually use and why. Researchers tracked treatment choices, survival times, and quality of life. The goal was to understand real-world practice, not…

This completed study followed 44 adults who had Whipple surgery for cancers near the pancreas. Researchers measured changes in the remaining pancreas, including its size, metabolism, and nutrition levels, before surgery and at 3 and 6 months after. The goal was to learn how the b…

This study looked at whether the types of bacteria in the gut are linked to whether pancreatic cancer has spread to nearby lymph nodes. Researchers compared stool samples from 55 patients with and without lymph node spread. They hope to find bacterial and chemical clues that coul…