Pancreatic cancer trial combines chemo with immune boosters
NCT ID NCT03727880
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether adding two immunotherapy drugs (pembrolizumab and defactinib) to standard chemotherapy before and after surgery could help the body fight pancreatic cancer better. It involved 28 people with early-stage, removable pancreatic cancer. The goal was to see if this combination could shrink tumors more effectively and improve long-term outcomes.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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28 people
The number who actually took part.
- Started
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Jun 2019
- Finished
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Jan 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 100 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥18 years. * Has pancreatic ductal adenocarcinoma * Has resectable disease at the time of diagnosis * Has not received any systemic therapy for pancreatic ductal adenocarcinoma * Has stage ≤ IIb disease at time of diagnosis and enrollment * Elevated tumor marker, CA (carbohydrate antigen) 19-9 \>200 * ECOG performance status 0 or 1 * Patient must have adequate organ function defined by the study-specified laboratory tests. * Must use acceptable form of birth control while on study. * Ability to understand and willingness to sign a written informed consent document. Exclusion Criteria: Patients who have received any prior chemotherapy, radiotherapy or investigational agents for pancreatic cancer. * Patients who have received prior treatment with anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA-4, or with an agent directed to another stimulatory or co-inhibitory T-cell receptor (e.g., CTLA-4, OX 40, CD137). * Has received prior therapy with FAK inhibitor. * Woman who are pregnant or breastfeeding. * Have received a live vaccine or live-attenuated vaccine within 30 days prior to study drug. * Is currently or has participated in another investigational study within 4 weeks prior to receiving study drug. * History or current use of immunosuppressive medications within 7 days prior to study medications. * Has a known additional malignancy that is progressing or has required active treatment within the past 2 years or that is expected to require active treatment within two years. * Has active autoimmune disease that has required systemic treatment in the past 2 years. * Has a history of (non-infectious) pneumonitis/interstitial lung disease or current pneumonitis. * Has an active infection requiring systemic therapy. * Infection with HIV or hepatitis B or C. * Patient with uncontrolled intercurrent illness including, but not limited to, uncontrolled infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. * Known allergy or hypersensitivity to the study drugs. * Received any growth factors including, but not limited to, granulocyte-colony stimulating factor (G-CSF), GM-CSF, erythropoietin, within 14 days of study drug administration. * Has history of any organ transplant, including corneal transplants.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Samuel Oschin Cancer Center at Cedars-Sinai
Los Angeles, California, 90048, United States
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Sidney Kimmel Comprehensive Cancer Center
Baltimore, Maryland, 21231, United States
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The University of Texas Health Science Center San Antonio
San Antonio, Texas, 78229, United States
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