New drug combo shows promise in Hard-to-Treat cancers
NCT ID NCT04752215
First seen Feb 02, 2026 · Last updated May 24, 2026 · Updated 19 times
Summary
This early-stage study tested two experimental drugs, BI 765049 and ezabenlimab, in 67 adults with advanced solid tumors (like colorectal, lung, or pancreatic cancer) that hadn't responded to prior treatments. The goal was to find the highest safe dose of BI 765049 alone and combined with ezabenlimab, both given by IV every 3 weeks. Participants could stay in the study for up to 3 years if they benefited, with doctors monitoring side effects and tumor size.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Baylor University Medical Center
Dallas, Texas, 75246, United States
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Florida Cancer Specialists-Sarasota-61670
Sarasota, Florida, 34232, United States
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HealthONE
Denver, Colorado, 80218, United States
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MD Anderson Cancer Center Orlando
Orlando, Florida, 32806, United States
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Mary Crowley Cancer Research Center
Dallas, Texas, 75230, United States
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New York University Langone Medical Center
New York, New York, 10016, United States
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Northwestern University
Chicago, Illinois, 60611, United States
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Norton Healthcare - Norton Cancer Institute - Louisville
Louisville, Kentucky, 40202, United States
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Princess Margaret Cancer Centre
Toronto, M5G 1Z5, Canada
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Stephenson Cancer Center
Oklahoma City, Oklahoma, 73104, United States
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Tennessee Oncology, PLLC-Nashville-52568
Nashville, Tennessee, 37203, United States
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University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
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University of California Irvine
Orange, California, 92868, United States
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Valkyrie Clinical Trials
Los Angeles, California, 90067, United States
Conditions
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