Ischemic stroke

Researchers are comparing a drug-coated balloon procedure plus intensive medical care against intensive medical care alone in people with severely narrowed brain arteries that have caused stroke or mini-stroke symptoms. The trial enrolls 570 adults aged 18 to 80. Everyone receive…

Researchers are testing whether an educational and implementation tool helps hospitals follow best-practice guidelines for preventing second strokes caused by heart conditions. The trial enrolls about 2,400 patients who have had an ischemic stroke or a transient ischemic attack. …

This pilot study tests whether giving semaglutide (Ozempic) to 100 stroke patients who had a clot-removal procedure can improve recovery. Patients are randomly assigned to receive weekly injections for 12 weeks or no drug. The main goal is to see if a larger, definitive trial is …

Researchers are testing an experimental treatment called AB126, made from neural exosomes, in adults who have had a moderate to severe acute ischemic stroke and who showed limited improvement after a procedure to clear the blocked blood vessel. The trial aims to find out whether …

This study tests a new, simple procedure done right after doctors remove a blood clot from the brain in severe stroke patients. The procedure involves briefly inflating and deflating a tiny balloon to gently restore blood flow, which may prevent extra brain damage. About 288 to 4…

This study compares two methods to remove large blood clots from the brain during a stroke: using a super large suction catheter versus a stent retriever. About 708 adults with acute ischemic stroke will be randomly assigned to one of the two techniques. The goal is to see which …

This study tests a medicine called tenecteplase for people who have a stroke but don't know exactly when it started, like waking up with symptoms. About 352 adults will get either tenecteplase or standard care after a simple CT scan. The goal is to see if the drug helps them reco…

This study tests a new non-invasive brain stimulation method that targets deep brain structures through the scalp, without surgery, to improve arm and hand function in people who had a stroke at least 12 weeks ago. Participants receive either active stimulation or a sham version,…

This study looks at whether a clot-busting drug called prourokinase can improve recovery in people who have an acute ischemic stroke, when given within 4.5 hours of symptoms starting. About 3,000 adults will receive the drug intravenously and be followed for 90 days to see how we…

This trial tests whether a drug called recombinant human prourokinase (rhPro-UK) can improve recovery in people who have had a stroke caused by a blocked medium-sized blood vessel in the brain, when given 4.5 to 24 hours after symptoms begin. Participants are selected using brain…

This study tests whether a non-invasive brain stimulation technique called cTBS, guided by each patient's brain scan, can improve arm and leg movement after a stroke. About 584 adults who had a stroke within the past two weeks will receive either real or sham stimulation alongsid…

This study tests a personalized brain stimulation technique called cTBS to help people recover movement after a stroke. Researchers use each patient's brain scan to target the stimulation precisely. Sixty participants will receive either real or sham stimulation alongside standar…

This trial tests whether a non-invasive brain stimulation technique, called transcranial temporal interference stimulation, can improve swallowing in adults who have difficulty swallowing after an ischemic stroke. Participants will receive either active or sham stimulation combin…

This trial tests whether adding lumbrokinase, an enzyme derived from earthworms, to standard aspirin treatment can improve recovery in people who have had a moderate-to-severe ischemic stroke. Participants receive either lumbrokinase capsules or a placebo, along with aspirin, for…

This study tests a new, drug-free treatment for people having an ischemic stroke (a clot blocking blood flow to the brain). The treatment uses blood pressure cuffs on the arms and inflatable leg sleeves to temporarily reduce blood flow in the limbs, which may trigger the body to …

This study tracks the safety and effectiveness of J&J MedTech devices used to remove blood clots in people with acute ischemic stroke. It will follow about 5,000 adults who receive these devices as part of their routine care, measuring how well blood flow is restored and how pati…

This trial investigates whether adding tirofiban, a fast-acting anti-clotting drug, to standard aspirin treatment can improve recovery in people who have had a moderate ischemic stroke. Participants receive either tirofiban or a placebo, both with aspirin, within 24 hours of stro…

This trial tests whether Cerebrolysin, given after a procedure to remove a blood clot from the brain, can reduce tissue damage and improve recovery in people with acute ischemic stroke. The study involves 100 adults aged 18 to 80 who undergo successful clot removal within 6 to 24…

This phase II trial is testing whether an experimental drug called LT3001 can help people who have had an acute ischemic stroke, which happens when a blood clot blocks blood flow to the brain. The study will include about 300 participants who receive either a high or low dose of …

This trial tests whether the Adacolumn device, which filters certain white blood cells from the blood, can reduce brain swelling in people who have had a severe stroke. Ten patients will receive the treatment within 24 hours of their stroke. The goal is to see if it prevents wors…

This phase 3 trial is testing whether giving a clot-busting drug before mechanical thrombectomy (a procedure to physically remove a blood clot) improves outcomes for people with severe strokes caused by large vessel occlusion. Participants are randomly assigned to receive tenecte…

This trial is testing an experimental drug called NTS-521, given as an intravenous infusion, to see if it can help people recover better after an acute ischemic stroke. The study will include about 140 adults aged 45 to 80 who have moderate to severe weakness on one side of the b…

This trial is testing whether an experimental drug called HRS-4029 can improve outcomes for people who have had an acute ischemic stroke, which happens when a blood clot blocks blood flow to the brain. The study will compare the drug against a placebo in about 340 participants wh…

This trial investigates whether tirzepatide, a drug approved for diabetes and obesity, can improve recovery in people who have had a severe stroke caused by a large artery blockage. Participants receive two injections of tirzepatide—one before a clot-removal procedure and another…

This trial tests whether a TeleStroke network can help peripheral hospitals in Oman safely give clot-busting drugs (alteplase or tenecteplase) to people having an acute ischemic stroke. A remote neurologist will assess patients via video, review scans, and guide the local medical…

This trial tests whether giving high-concentration oxygen during a clot-removal procedure can improve recovery for people having a major stroke who arrive at the hospital 6 to 24 hours after symptoms began. Participants are randomly assigned to receive either the oxygen therapy o…

This phase 2b trial tests whether injecting allogeneic neural stem cells (CC-101) into the brain near a prior stroke lesion can improve motor function in adults with chronic ischemic stroke and lasting movement problems. About 36 participants will receive either stem cells plus s…

This study tests whether a single injection of Recaticimab, a cholesterol-lowering drug, can help people recover better after a stroke caused by narrowed brain arteries. About 1,200 participants will receive either the drug or a placebo, plus standard care. The main goal is to se…

This study tests whether a set of simple treatments—daily blood pressure checks, dietitian visits, hearing and vision tests, and mood screening—can help preserve thinking and memory after a stroke. About 50 adults who recently had a mild stroke will either receive this care bundl…

This trial tests whether ciprofol, a newer anesthetic, can keep blood pressure more stable than the standard drug propofol in people having general anesthesia for endovascular thrombectomy after an ischemic stroke. Stable blood pressure during the procedure may improve outcomes. …

This trial investigates whether adding Getong Tongluo Capsule, a traditional Chinese herbal medicine, to standard stroke care improves recovery in people who recently had an ischemic stroke. Researchers will also explore if the capsule works by affecting gut bacteria and brain co…

This trial tests whether giving a clot-busting drug directly into the brain arteries after mechanical clot removal can improve recovery in people having a severe stroke. About 1,500 adults with acute ischemic stroke who undergo endovascular thrombectomy will be randomly assigned …

This trial tests whether a sublingual (under-the-tongue) tablet of edaravone dexborneol, given within 6 hours of stroke onset during transfer between hospitals, can improve functional recovery in people with acute ischemic stroke. About 1,040 participants will receive either the …

This trial investigates whether a procedure to remove a blood clot from the basilar artery—a major vessel at the back of the brain—can improve recovery in people with severe stroke. Participants are adults aged 18 to 80 who have a large area of brain damage and can be treated wit…

This phase 3 trial tests whether a new emergency stroke unit, equipped with a hybrid CT and X-ray machine (NeuAngio-CT), can speed up clot removal in people having a severe stroke. About 232 adults aged 18-60 with acute ischemic stroke will be randomly assigned to either the new …

This phase 3 trial tests whether giving clot-busting drugs directly into the blocked brain artery (intra-arterial thrombolysis) helps people recover better from a medium-vessel stroke. About 306 adults aged 18-80 with acute stroke will be randomly assigned to receive either the d…

This phase 2 trial tests whether taking a probiotic supplement (OMNi-BiOTiC® SR-9) twice daily for 90 days can improve gut health and recovery in people aged 60 and older who have had an acute ischemic stroke. The study will compare the probiotic to a placebo in 220 participants,…

This study tests a specially designed suction tube that cleans deep throat secretions under direct laryngoscope guidance. The goal is to see if it reduces pneumonia within 28 days in stroke patients who have trouble swallowing or coughing. Participants are adults with acute ische…

This study tests whether people who have had a minor stroke or a high-risk mini-stroke can safely stop one of their two blood thinners earlier than usual. About 3,800 participants will have their blood tested to see how they respond to the drug clopidogrel. Those who are sensitiv…

This pilot study tests whether an active smartwatch that gives real-time feedback, combined with regular nurse coaching, can help people who had a minor stroke or TIA walk more each day. Fifty participants will be randomly assigned to either an active smartwatch or a passive one …

This early-stage trial tests whether stem cells from human umbilical cords are safe and might help people recover from a severe stroke. About 35 adults who had a stroke within the last 48 hours will receive either the stem cells or a placebo. The study will check for side effects…

This study tests a drug called pro-urokinase in people who have had a stroke in the back part of the brain (posterior circulation) and can be treated within 4.5 to 24 hours after symptoms start. About 586 participants will receive either the drug or a placebo, along with standard…

This study tests whether the clot-busting drug tenecteplase is safe and effective for people having a stroke who took a blood thinner (DOAC) within the last 48 hours. About 660 adults will receive either tenecteplase or a placebo within 4.5 hours of stroke symptoms. The goal is t…

This study looks at whether doing a balloon angioplasty or placing a stent right after removing a blood clot from the brain can help people who have a stroke caused by a hardened artery. About 420 adults will be in the study. The goal is to see if this extra step improves recover…

This study tests a new device, the SOFIA Flow 88 Aspiration Catheter, to treat acute ischemic stroke caused by a large blocked artery. About 200 adults with moderate to severe stroke will be enrolled. The goal is to safely restore blood flow to the brain using only this catheter,…

This study looks at whether starting blood thinners (DOACs) is safe and effective for people who have had a stroke, but also have a history of a brain bleed and an irregular heartbeat (atrial fibrillation). About 852 participants will be randomly assigned to receive either a bloo…

This study looks at 2,000 people who had a stroke to see which blood-thinning medicine works best to stop another stroke. The drugs being compared are indobufen, aspirin, cilostazol, and clopidogrel, used alone or in pairs. Researchers will track strokes and bleeding problems for…

This study tests two traditional Chinese medicines, Dengzhan Xixin and Dengzhan Shengmai, in 358 adults who recently had an ischemic stroke. The goal is to see if these treatments improve recovery and reduce disability at 3 months. Researchers will also study how the medicines wo…

This study tests a new device called the iNstroke 5F catheter to remove blood clots in people having an acute ischemic stroke. The goal is to see if it can safely restore blood flow to the brain within 24 hours of symptoms starting. About 45 adults with moderate to severe strokes…

This study looks at whether giving a low-dose aspirin just 2 hours after clot-busting treatment for stroke is better than waiting the standard 24 hours. About 210 adults aged 18-65 who had a stroke will be randomly assigned to get aspirin early or at the usual time. The goal is t…

This study tests whether a smartphone-supported care program can improve health outcomes for stroke patients who have trouble swallowing. The program includes diet monitoring, doctor communication, and education. Researchers will compare 600 patients who receive this enhanced sup…

This study tests a device called I-NIC that uses low-frequency magnetic pulses to treat people who have had a stroke. The goal is to see if it helps improve recovery when used alongside standard care. About 364 participants will receive either the real device or a placebo for 5 d…

This early-stage study tests the safety of a drug called pegcetacoplan (Empaveli) in 20 adults who have had a stroke from a large clot and already had a procedure to remove it. The drug aims to reduce swelling and inflammation that can occur when blood flow returns. Participants …

This study tests whether giving a drug called tirofiban directly into the artery right after a clot is removed can help people recover better from a severe stroke. About 344 adults who had a large-vessel blockage stroke will be randomly assigned to receive the drug or not. The ma…

This study tests whether managing blood pressure based on the brain's collateral circulation (backup blood flow) after stroke treatment leads to better recovery. About 544 adults who had a stroke due to a large artery blockage and received endovascular therapy will be enrolled. P…

This study tests whether giving a large amount of IV saline (about 2-2.5 liters) right after clot-busting treatment helps people recover from a stroke better than giving only a small amount. The trial will enroll 752 adults aged 18-80 who had an ischemic stroke and received throm…

This study tests whether the clot-busting drug tenecteplase can improve recovery in people with acute ischemic stroke when given 4.5 to 9 hours after symptoms start. It uses a special MRI pattern (DWI-FLAIR mismatch) to identify patients who might still benefit. About 564 adults …

This study tests a simple, non-invasive treatment called remote ischemic conditioning (RIC) for people who have had a stroke and also developed heart muscle injury. RIC involves using a blood pressure cuff on the arm to briefly restrict blood flow, which may trigger the body's ow…

This Phase 3 trial tests a new injectable drug, ongericimab, in about 4,800 people who recently had a stroke due to narrowed arteries. The goal is to see if lowering LDL cholesterol more than current standard care can prevent future strokes, heart attacks, or death from heart dis…

This study looks at stroke patients who have small clots remaining in smaller brain arteries after the main clot has been removed. Half will get an extra procedure to remove those leftover clots, while the other half will receive standard care without extra intervention. The goal…

This study tests whether a drug called edaravone dexborneol can help people who have a stroke while also having active cancer. The drug is given by IV twice a day for 10-14 days. Researchers will check if it improves recovery and is safe. About 144 adults aged 18-80 will take par…

This study tests whether the drug butylphthalide can reduce brain swelling in people who have had a severe stroke and undergone a procedure to reopen a blocked artery. About 100 adults will receive either the drug or a placebo for up to 14 days. Researchers will measure changes i…

This study tests whether cooling the head (using a special cap) during emergency stroke treatment can reduce the amount of brain tissue that dies. About 182 adults having a major stroke and undergoing a clot-removal procedure will be randomly assigned to receive either standard c…

This study will compare the safety of two clot-dissolving drugs, rhTNK-tPA and rt-PA, in 4500 adults having an acute ischemic stroke. Researchers will track how often each drug causes serious bleeding in the brain within 36 hours. The goal is to see if the newer drug, rhTNK-tPA, …

This study looks at whether using a continuous glucose monitor (CGM) can help manage high blood sugar better than standard finger-prick tests in people with type 2 diabetes who have had a stroke. High blood sugar after a stroke can lead to worse outcomes. The study will involve 8…

This early study tests whether a drug called RK-4 can be safely injected through the skull into the brain of people having a severe stroke. Only 6 participants will receive the injection once a day for 3 days, using a special device. The main goal is to see if the procedure is fe…

This study tests a smartphone app called StrokeApp designed to support people after a stroke or mini-stroke. The app provides educational content, medication reminders, and tools to track health. Researchers will compare quality of life and other health measures between 500 patie…

This study tests whether canagliflozin, a diabetes drug, can reduce dangerous brain swelling and bleeding in people who have had a severe stroke and are receiving clot-removal therapy. About 150 adults will be randomly assigned to take the drug for 14 days or receive standard car…

This study tests whether adding a drug called human urinary kallidinogenase to standard clot-busting therapy can improve recovery after a stroke. About 220 adults who have had a moderate stroke will be randomly assigned to receive the combination or standard care alone. The main …

This study compares two approaches for people who have had a stroke or mini-stroke due to a blocked brain artery that hasn't opened on its own. One group gets a procedure to reopen the artery plus medication, while the other gets medication alone. The goal is to see which approac…

This study tests whether giving the drug tenecteplase directly into the brain's arteries, along with standard care, helps people recover better after a stroke caused by a medium-sized blood clot. About 488 adults with stroke symptoms starting within 24 hours will take part. The g…

This study tests whether a clot-dissolving drug called tenecteplase works better than standard antiplatelet pills for people who have a mild but disabling stroke caused by a large blocked artery. About 864 adults who arrive at the hospital 4.5 to 24 hours after symptoms start wil…

This study tests whether sending people with suspected severe stroke directly to the angiography suite (instead of first getting a CT or MRI) can speed up treatment and improve recovery. About 568 adults with stroke symptoms within 6 hours will be randomly assigned to the direct …

This study tests whether adding the anti-inflammatory drug baricitinib to standard clot-removal treatment helps people recover better after a severe stroke caused by a blocked artery in the front of the brain. About 750 adults will receive either baricitinib or a placebo for five…

This study tests whether the drug anakinra can limit brain damage in people who have had a severe stroke and have already undergone a procedure to remove a blood clot. About 159 adults aged 18-80 will receive either standard care or anakinra at different doses. The main goal is t…

This study tests whether adding two common medicines—colchicine (an anti-inflammatory) and low-dose rivaroxaban (a blood thinner)—to standard care can prevent future heart attacks, strokes, or death in people who recently had a stroke. About 4,500 adults who had a stroke within t…

This early-stage trial tests a nasal spray made from human stem cell exosomes in 60 people who recently had a stroke. The spray is given once or daily for 14 days, alongside standard care. The main goal is to see if it is safe, and researchers will also check if it helps improve …

This study tests a new device called the iNstroke catheter, designed to remove blood clots from the brain in people having an acute ischemic stroke. About 160 participants will undergo a procedure where the catheter is used to suction out the clot. The main goal is to see how oft…

This Phase 2 trial tests whether giving human albumin directly into the artery supplying the brain, right after a clot is removed, can improve recovery in people with severe stroke. About 306 participants will be randomly assigned to receive either standard clot removal alone or …

This study tests whether adding a drug called Tafolecimab to standard cholesterol-lowering therapy can reduce the risk of another stroke in people who have had a recent stroke or mini-stroke and have high levels of Lp(a), a type of fat in the blood. About 242 participants will re…

This study tests whether adding the drug eptifibatide after standard clot-dissolving treatment can help people with acute ischemic stroke recover better. It includes 786 adults who arrive at the hospital 4.5 to 24 hours after stroke symptoms start. The goal is to see if this comb…

This study looks at how well certain drugs protect the brain after a mild to moderate stroke. Researchers will follow 600 adults who had a stroke within the last 48 hours and received edaravone or dexrazoxane. The goal is to see if these drugs help patients recover better and are…

This study tests whether adding the blood thinner tirofiban after standard stroke treatment helps people recover better from a severe type of stroke caused by a blocked large artery in the brain. About 564 adults in China will receive either tirofiban or usual care after their in…

This trial tests a new device called Supernova that removes blood clots from large brain arteries in people having a stroke. The goal is to restore blood flow within 24 hours of symptoms starting. The study will include 3,000 participants and measure how well the device works and…

This study tests whether a procedure to remove blood clots from the brain can help people who have had a severe stroke. The trial will include 308 adults aged 18 to 80 with a large area of brain damage. Doctors will use special tools to clear the blocked artery and then check how…

This study will test whether Vojta therapy, a technique that uses reflex movements to activate muscles, helps people who have had an ischemic stroke regain functional independence better than standard conservative therapy. 150 participants who had a stroke within the last 3 years…

This study tests a new biodegradable device that closes a common heart hole (PFO) in people who have already had a stroke or mini-stroke. The device is placed through a tube in the leg and dissolves over time, leaving no permanent implant. The trial will check if it safely and ef…

This study tests whether giving a protein called albumin directly into the artery during a stroke procedure can reduce brain damage. Sixty adults with a severe stroke will receive either standard treatment alone or standard treatment plus albumin. The goal is to see if albumin he…

This study tests a traditional Chinese medicine called Bovis Calculus Stativus (cultivated bezoar) in 220 adults who had a stroke and are now unconscious or barely responsive. Participants receive either the medicine or a placebo for 5 days, and are followed for 90 days. The goal…

This study tests whether two medicines, isosorbide mononitrate and butylphthalide, can reduce disability in people who recently had a lacunar stroke (a small stroke deep in the brain). About 3,156 adults aged 30 and older will receive one or both drugs or placebos for up to a yea…

This study tests whether a diabetes drug called sentagliptin (a DPP4 inhibitor) can improve thinking and memory in people who have had a mild stroke and also have type 2 diabetes. About 312 participants will receive either the drug or a placebo daily for 180 days. Researchers wil…

This early study tests whether nasal drops containing tiny particles from umbilical cord stem cells are safe for people who had an ischemic stroke. Nine patients will receive the drops four times over two weeks, alongside standard care. The main goal is to check for serious side …

This Phase 3 trial tests whether butylphthalide, a compound from celery seed, can improve long-term recovery in people who have had a minor ischemic stroke. 1,200 participants aged 40–80 will take either the drug or a placebo for 12 months. Researchers will measure survival, stro…

This study tests whether adding WhatsApp-based education and counseling to standard care helps stroke patients with type 2 diabetes improve their lifestyle, blood sugar control, and disease knowledge. 84 participants will be split into two groups: one gets routine education, the …

This early-phase study tests a new drug called RK-4 for people with a severe type of stroke (large hemispheric infarction) who cannot have standard clot-removal treatment. The drug is injected directly into the skull bone marrow once daily for three days. The main goals are to ch…

This study tests a new drug called RK-4, injected directly into the skull bone marrow, for people with a severe type of stroke (large hemispheric infarction) who cannot have standard blood vessel treatments. About 194 participants will either get the RK-4 injection daily for 3 da…

This study tests a new surgical technique called Expansion-floating Craniotomy (EC) for people with life-threatening brain swelling after a massive stroke. The standard surgery removes a piece of skull to relieve pressure, but requires a second surgery months later to replace the…

This study tests whether stem cells from umbilical cords can help people recover movement after a stroke. About 86 adults who had a stroke 2 weeks to 3 months ago will receive either the stem cells or a placebo. The main goal is to see if the treatment improves motor function and…

This study compares cilostazol, aspirin, and clopidogrel in 632 people who recently had a stroke due to cerebral small vessel disease. The goal is to see if cilostazol is better at preventing another stroke and slowing disease progression, with fewer bleeding risks. Participants …

This study tests whether adding the steroid methylprednisolone to standard clot-removal treatment helps people recover from severe stroke. About 912 adults aged 18–85 with a large clot in the front part of the brain will receive either the steroid or a placebo for three days. The…

This study tests whether adding a PCSK9 inhibitor (a cholesterol-lowering drug) to standard care helps people recover better after a stroke caused by a blocked artery. About 478 adults who had a stroke and received a procedure to reopen the blocked vessel will be randomly assigne…

This study tests whether the clot-busting drug tenecteplase can improve recovery in people who have a major stroke caused by a large blocked artery, but who cannot have a procedure to remove the clot. The trial includes 794 adults who arrive at the hospital 4.5 to 24 hours after …

This study tests a traditional Chinese herbal medicine called Xinglou Chengqi Granule for people who recently had a stroke. Researchers want to find the best dose and see if it helps improve recovery. Sixty adults aged 18-70 with moderate stroke symptoms will receive either a hig…

This large study will test whether giving stroke survivors personalized temperature warnings through a smartphone app can lower their chance of having another stroke. About 5,000 people who recently had an ischemic stroke will be split into two groups: one gets the app alerts and…

This study tests whether a mobile app that sends personalized temperature health warnings and risk management tips can reduce the chance of a second stroke. Over 10,000 people who recently had a stroke will use the app for one year. Researchers will track how many have another st…

This trial compares two imaging strategies—CT with CT angiography versus MRI with MR angiography—as the first test for people with suspected severe ischemic stroke. The goal is to see which approach is more cost-effective while still leading to good patient outcomes. Six hundred …

This study will test a new radioactive tracer called FBFP in 30 stroke patients and 20 healthy volunteers. The tracer is used with a PET/MR scanner to take detailed pictures of the brain. The goal is to see if FBFP can help doctors diagnose and understand stroke better. Participa…

This study tests whether using artificial intelligence (AI) along with a smartwatch and a heart monitor patch can find a hidden heart rhythm problem called atrial fibrillation (AF) in people who have had a stroke. AF can cause strokes, but it often comes and goes without symptoms…

This study will check if an artificial intelligence (AI) system can accurately score stroke severity as well as a trained doctor. About 297 adults with a recent stroke will have their speech and facial movements recorded. The AI will analyze these recordings to produce a G-FAST s…

This study will test a new rapid blood test that can be done at the bedside to help doctors quickly tell if a child is having a stroke. About 250 children with stroke symptoms will give a small blood sample, and the test's accuracy will be compared to standard brain scans. The go…

This study looks at whether a detailed MRI of the blood vessel wall can help doctors tell the difference between two common causes of stroke: hardening of the arteries (plaque buildup) and inflammation of the vessel wall (vasculitis). About 46 people who recently had a stroke wil…

This study will check if a non-invasive device can accurately detect high pressure inside the skull in 300 adults with traumatic brain injury or stroke. The device uses a sensor placed on the head to measure brain pressure and pulse waves. If successful, it could help doctors mak…

Researchers are testing whether a digital program that combines a smart bracelet and a mobile app can help people who have had an ischemic stroke avoid another one. The study enrolls adults who recently had a stroke and also have high blood pressure and diabetes. Half receive usu…

This trial tests whether an AI-driven health management program can reduce the chance of a first ischemic stroke in adults at high risk. Participants in Beijing communities will be randomly assigned to either AI-supported care or usual community health services. The AI program us…

This trial tests whether high-intensity cholesterol-lowering therapy prevents strokes and heart problems better than moderate therapy in adults with narrowing of brain arteries but no symptoms yet. Participants are randomly assigned to one of two treatment strengths and followed …

This phase 3 trial will test whether a low dose of the blood thinner rivaroxaban plus aspirin can prevent recurrent strokes better than the standard clopidogrel plus aspirin in people with narrowed brain arteries. About 1,172 participants who recently had a stroke or high-risk TI…

This pilot study tests two non-invasive methods to keep the airways clear in adults who are unconscious or severely ill and need a breathing tube. One method uses a special tube with continuous low-pressure suction, and the other delivers a programmed 'artificial cough' through t…

This trial tests whether anticoagulant medications (like rivaroxaban or apixaban) are better than aspirin at preventing a second stroke in people who have had an ischemic stroke of unclear cause. Participants are adults who had a stroke within the past two weeks and show signs th…

This trial tests whether combining electroacupuncture with a sedative drug called dexmedetomidine can prevent depression in people who recently had an ischemic stroke. Participants at high risk for post-stroke depression will receive either the combined treatment, a sham version,…

This phase 3 trial tests whether zastaprazan, a stomach-acid-blocking drug, can prevent upper gastrointestinal bleeding in adults who have recently had a transient ischemic attack (TIA) or ischemic stroke and are taking antiplatelet or anticoagulant medications. Participants take…

This study tests whether the drug cilostazol can prevent recurrent strokes and heart problems in 1100 recent stroke survivors in Ghana. Participants take either cilostazol or a placebo twice daily for 24 months. The goal is to see if this affordable drug, already used in Asia, ca…

This study compares two ways of feeding patients with severe ischemic stroke who have trouble swallowing. The goal is to see if feeding through a tube placed past the stomach (post-pyloric) reduces the chance of developing pneumonia compared to standard stomach feeding. About 174…

This study tests whether a tablet called edaravone dexborneol can prevent epilepsy in people who have had a stroke and are at high risk. About 160 adults will receive either the tablet or a placebo for three months, starting within 48 hours of their stroke. Researchers will track…

This study tests whether adding a very low dose (15 mg) of the blood thinner edoxaban to standard aspirin or clopidogrel can prevent repeat strokes in people aged 75 and older who have already had an ischemic stroke. About 1,200 participants will be randomly assigned to receive e…

This study compares apixaban alone versus apixaban plus clopidogrel for 30 days in people who have had a stroke and have both atrial fibrillation and atherosclerosis. About 586 participants will be randomly assigned to one of the two treatments. The goal is to see if the combinat…

This study tests whether adding cilostazol, a drug that improves blood flow, to standard aspirin or clopidogrel therapy can prevent another stroke or heart attack in people who have recently had a stroke or mini-stroke. About 2,000 participants will take either cilostazol or a pl…

This study tests whether a smartphone app that gives personalized tips on managing stroke risk factors can reduce the chance of having another stroke. Over 5,000 people who recently had a mild-to-moderate stroke will use the app for one year. Researchers will track how many have …

This study tests a new way to improve vision loss caused by a stroke. It combines low-intensity focused ultrasound (LIFUS) with virtual reality therapy to stimulate the brain's vision areas. The study will enroll 28 adults who had a stroke 6 to 24 months ago and now have partial …

This trial tests whether a non-invasive device that gently stimulates the vagus nerve through the ear is tolerable for children who have had a stroke. One child will receive ear stimulation paired with occupational therapy sessions over four weeks. The goal is to see if the child…

This trial investigates whether Benson Relaxation Technique (BRT), a 20-minute mind-body relaxation session, can reduce anxiety and depression in people who had an ischemic stroke 1-2 weeks earlier. Participants are randomly assigned to receive either BRT or health education twic…

This study tests whether a non-invasive technique called transcranial focused ultrasound can help stroke survivors recover movement and thinking skills. Researchers will use brain scans and EEG to guide stimulation to specific areas. 60 adults who had a first stroke within the la…

This study looks at whether combining Frenkel exercises (repetitive movements to retrain the brain) with electrical muscle stimulation can improve balance, coordination, and body awareness in people who have had a stroke. About 38 adults aged 50-65 who can walk independently will…

This study tests if a non-invasive device that stimulates the vagus nerve can improve blood flow in the brain and thinking skills in people who had a stroke 6-12 months ago. Forty participants aged 50-60 with mild cognitive issues will receive the stimulation. Researchers will me…

This study tests whether combining neuromuscular electrical stimulation with upper limb nerve exercises can improve hand grip strength and range of motion in people who have had a stroke. The trial will include 44 adults who had an ischemic stroke at least 3 months ago and have s…

This study tests whether using a virtual reality (VR) system during cycling exercise makes rehabilitation more motivating for adults with conditions like stroke, Parkinson's, multiple sclerosis, or frailty. About 70 participants will try cycling with and without VR over 4 weeks. …

This study tests whether a virtual home rehabilitation program helps stroke survivors in underserved Texas communities recover better than standard care alone. About 80 adults who recently had a stroke and are returning home will take part. The program uses video sessions to guid…

This study tests whether adding brain-computer interface (BCI) training to standard early rehabilitation helps people recover arm and leg movement after an acute ischemic stroke. Sixty adults aged 18 to 80 with one-sided limb weakness will receive either standard rehab alone or s…

This study will test a new type of rehabilitation robot that uses brain signals and mirror therapy to help stroke patients with arm weakness. The robot is non-invasive and designed to encourage the brain to re-learn movement. Researchers will enroll 40 adults aged 30 to 80 who ha…

This study tests a personalized brain stimulation technique called IAF-rTMS to help people recover movement after a stroke. Thirty-four adults who had a first ischemic stroke will receive either real or sham stimulation for two weeks each, in a crossover design. Researchers will …

This study tests whether a feeding tube placed in the upper esophagus (oro-esophageal) helps stroke patients with swallowing difficulties recover faster than the standard nasogastric tube (through the nose). The trial will include 422 adults who recently had a first ischemic stro…

This study tests whether playing interactive games on a smart tablet can improve hand dexterity and strength in people who have had a stroke. Forty chronic stroke patients will either do tablet hand exercises plus standard physical therapy, or standard therapy alone. The goal is …

This study compares a new 'one-stop' emergency stroke unit that combines CT scanning and treatment in one room to the usual process where scans and treatment happen in separate places. The goal is to see if this faster approach helps more people recover with little or no disabili…

This study tests a safe, non-invasive therapy that uses gentle pressure on the arms to improve sleep and mood in people who have had a stroke and suffer from insomnia. The treatment, called remote ischemic adaptation, aims to help the brain recover by briefly restricting and rest…

This early-phase study tests whether a combination of two drugs (chlorpromazine and promethazine) can safely put stroke patients into a hibernation-like state to protect the brain. The trial will enroll 57 adults with acute ischemic stroke who are eligible for clot-removal therap…

This study looks at whether a nurse-led health education program can improve quality of life, reduce depression, and help daily functioning in people who have had an ischemic stroke. About 70 participants will be split into two groups: one gets the education program, the other ge…

This study compares early task-oriented rehabilitation (practicing daily-life activities) to traditional physiotherapy in 158 adults who had a stroke within the past 48 hours. The goal is to see which approach leads to better motor function and quality of life after 3 months. Par…

This study looks at two ways to feed stroke patients who have trouble swallowing: a standard nasogastric tube (through the nose) and an oro-esophageal tube (through the mouth). The goal is to see which method better protects the airway and improves swallowing function. About 156 …

This study tests whether taking probiotics can improve quality of life, daily activities, and anxiety in people who have had a moderate stroke. Researchers will enroll 110 adults aged 18 to 80 who had a stroke within the past 3 months. Participants will take probiotics and be mon…

This study tests whether an artificial intelligence system can help therapists set better rehab exercises for a robotic arm trainer used by stroke patients. One hundred adults who had a stroke within the last six months will receive either AI-guided or therapist-guided robotic th…

This study will test a six-week rehabilitation program in one person who had a stroke more than six months ago. The program combines a special glove and electrical stimulation device (SaeboStim GO and Saebo Glove) with ultrasound therapy and balance exercises. The goal is to see …

This study tests whether listening to music for 30 minutes a day for 8 weeks can improve attention, language, and quality of life in people with aphasia after a stroke. Researchers will compare music listening to audiobook listening and a control group. The trial involves 45 adul…

This study tests whether adding occupation-based bilateral arm training (OBBT) to standard therapy helps stroke survivors improve arm movement and daily activities. 150 participants in inpatient rehab will either get OBBT plus standard care or standard care alone for 6 weeks. The…

This study will test whether using smart technologies like brain-computer interfaces and robotic hand therapy can improve recovery in people who recently had a stroke. 200 participants will be split into four groups: three using different high-tech devices and one receiving stand…

Researchers at Changhai Hospital are setting up a nationwide system to monitor how well devices and procedures for cerebrovascular conditions perform after they reach the market. The study plans to enroll about 2,000 adults with acute ischemic stroke, narrowed brain or neck arter…

This study will use transcranial Doppler (TCD) ultrasound to measure blood flow in the brains of 100 people who had a stroke and underwent endovascular therapy (clot removal). The goal is to see if TCD readings can predict complications like bleeding or brain swelling in the days…

This study investigates whether tiny particles called extracellular vesicles, released by brain cells into the blood, can serve as reliable markers of nerve damage in people with multiple sclerosis or stroke. Researchers will measure these particles in blood samples from 60 parti…

This study looks at whether inflammation levels differ on either side of a blood clot in the brain during a stroke treatment called mechanical thrombectomy. Researchers will compare blood samples taken from before and after the clot to see if the difference is linked to how well …

This study explores whether the type of symptoms a person has at the start of a stroke influences how quickly they get to the hospital and how well they recover. Researchers will follow 120 adults with a first-ever ischemic stroke, comparing those with classic, high-urgency sympt…

This study looks at whether patients recovering from a first acute stroke do better in a specialized stroke unit than in a conventional neurology ward. Researchers will follow 140 adults admitted within 48 hours of symptom onset, comparing outcomes like daily independence, disabi…

This study is testing whether a simple, non-invasive brain wave recording (EEG) taken within days of a stroke can help predict how well a person will recover. Researchers will record the brain activity of 400 stroke patients and track their recovery over three to six months. The …

This study tests whether a personalized video platform called MyStroke can improve stroke knowledge and reduce hospital use after discharge. About 690 stroke patients and their caregivers will either get standard education or also access to tailored videos. Researchers will check…

This study will follow up to 12,750 stroke patients in Germany to learn how care is given from the moment symptoms start through hospital treatment, rehab, and long-term recovery. It includes both adults and children with ischemic stroke or brain bleeding. The goal is to collect …

This study tests a computer system called LingBao that helps doctors decide the best treatment for people having a stroke. About 3,000 adults from 20 stroke centers will take part. The system uses patient data to give treatment suggestions, but doctors make the final call. The go…

This study looks at whether a substance in the blood called BDNF is linked to strokes caused by heart conditions like atrial fibrillation. Researchers will measure BDNF levels in 150 people who recently had a stroke and compare it with heart and brain scans. The goal is to better…

This study explores why stroke survivors often feel extreme muscle fatigue. Researchers will use a gentle, non-invasive brain stimulation technique called tACS to temporarily change brain activity in 120 stroke survivors. Participants will do leg exercises until tired while their…

This study tests if a non-invasive device called Electrical Impedance Tomography (EIT) can safely monitor brain blood flow in 100 ICU patients with conditions like stroke or brain bleeding. Currently, doctors must insert a probe into the skull to check this, which can cause infec…

This study will test a new tool called the Stroke Mimics Score (SMS) in 1000 adults who come to the emergency room with stroke-like symptoms. The goal is to see if the SMS can accurately tell the difference between a real stroke and a condition that looks like a stroke but isn't …

This observational study aims to understand how neuromuscular fatigue develops in stroke survivors compared to healthy individuals. Researchers will measure brain activity (EEG) and muscle activity (EMG) in 120 participants while they perform repeated leg exercises until fatigue.…

This pilot study will use advanced MRI scans to create detailed maps of brain connections in 10 people who have had a stroke in the middle cerebral artery. The goal is to understand how stroke disrupts the brain's network and whether these maps can help predict recovery and guide…

This study will observe 300 adults in the intensive care unit with serious brain conditions like bleeding, stroke, or injury. Researchers will use noninvasive monitors to track brain activity and blood flow, linking this data to patients' recovery. The goal is to better understan…

This study tests a new way to recruit women into stroke research using easy-to-understand materials like brochures and videos. Researchers will compare this approach to usual recruitment methods with 1,600 participants. The goal is to make stroke studies more inclusive so treatme…

This study will follow 1,000 children under 18 who have had a stroke to see which treatments work best in everyday hospitals. Researchers will check their recovery, brain scans, and daily life over 6 months. The goal is to learn what helps children recover the most after a stroke…

This study examines whether blood electrolyte levels are linked to kidney damage in people who have a stroke and undergo a clot-removal procedure. Researchers will review medical records from 250 patients treated between 2018 and 2026. The goal is to identify risk factors that co…

This study looks at whether a clot-dissolving medicine called tenecteplase is safe and effective for people having a stroke when given more than 4.5 hours after symptoms began. Researchers will follow 3000 patients in China to see how many recover with little or no disability aft…

This study will track 3,000 stroke patients in China who received clot-busting medication more than 4.5 hours after their symptoms began. Researchers want to see if this later treatment is still safe and helps reduce disability. The study is observational, meaning it simply watch…

This study aims to find brain activity markers that can predict how well people recover after an ischemic stroke. Researchers will first study healthy volunteers to establish normal brain patterns, then test 120 stroke patients. Patients will receive either real or sham brain sti…

This study tests whether a program called PEER-HOMEcare is practical and helpful for people recovering from stroke at home. The program involves therapists and family members working together to adapt the home environment and use wearable sensors to track movement. Researchers wi…

This study will follow 30 adults who have had a stroke and have arm weakness. Researchers will use functional MRI scans at several time points over six months to see how the brain reorganizes itself. The goal is to link different patterns of brain activity to different levels of …

This study compares two common head positions—lying flat (0°) versus raising the head 30°—for the first 24 hours after a severe ischemic stroke. Researchers want to see which position leads to better recovery and fewer complications. About 1,500 adults with severe stroke will be …

This study looks at whether certain blood test results can help predict how severe a stroke is and how well a person might recover. Researchers will check three different ratios in the blood of 60 adults with acute ischemic stroke. The goal is to see if these simple, routine test…

This study tests a 5-week support program for stroke survivors after they leave the hospital. The goal is to see if the program helps them feel more confident and independent in managing their daily health. Researchers will compare participants who get the program plus usual care…

This study will test whether mild electrical brain stimulation, combined with physical therapy, changes brain activity in people who had a stroke. Sixty participants will receive either direct or alternating current stimulation during rehab sessions. Researchers will measure bloo…

This study will collect detailed information from 200 adults with severe brain injuries treated at Örebro University Hospital. Researchers will track their recovery, including brain function and healthcare needs, for up to a year. No new treatments are being tested—the goal is to…

This study looks at blood clots removed from 500 stroke patients to understand their composition and how they relate to blood markers, treatment success, and patient recovery. The goal is to learn more about stroke causes and find new ways to dissolve clots. Participants are adul…

This study looks at blood markers related to inflammation and clotting in people who have had a stroke or a brain bleed. Researchers want to see how these markers change over time and differ between patients with complications. About 499 adults will give blood samples at five tim…

This study looks at how the body's immune and inflammatory systems change in people having a stroke who receive clot-busting drugs or mechanical clot removal. Researchers will take blood samples at several time points over a year to measure inflammation markers. The goal is to se…

This study will look at 300 adults with acute ischemic stroke to find out how many have a large vessel occlusion (a big clot in a major brain artery). Researchers at Assiut University Hospitals will use CT or MRI scans to identify these patients and describe their characteristics…

This large study in China will follow 5,400 people with minor ischemic stroke to see if clot-busting drugs or mechanical clot removal (reperfusion therapy) leads to better recovery than standard medications. Participants are treated based on their doctor's choice, and researchers…

This study will check how common thinking and memory problems are in people who have had their first stroke. Researchers will evaluate 400 adults aged 18 to 60 within three months of their stroke. The goal is to better understand the impact of stroke on the brain, not to test a n…

This study will observe 400 adults who have a stroke within 28 days of a heart procedure, such as a stent or valve replacement. The goal is to learn more about these strokes, including how severe they are and how well current treatments work. No new drugs or devices are being tes…

This study looks at whether giving different amounts of protein early on can help people with serious brain injuries or strokes recover better in the ICU. 216 adults will be split into three groups, each receiving a different protein dose through a feeding tube. The main goal is …

This study looks at 150 adults having emergency clot removal for a stroke. Researchers will measure substances in the blood that show blood vessel damage and inflammation. The goal is to learn how these changes relate to recovery, not to test a new treatment.

This study will test a new robotic and virtual reality system called NeglectARm 3D in 15 people who have spatial neglect after a stroke. The system uses a robot arm and VR headset to measure how well patients notice objects in 3D space. Researchers want to see if the device is ea…

This study looks at how changes in the GGCX gene relate to recovery after an ischemic stroke. Researchers will collect blood samples from 1,500 stroke patients and follow them for 12 months to track strokes, bleeding, and deaths. The goal is to understand if this gene can help pr…

This study will follow 500 people who recently had a stroke or mini-stroke to see how well they stick with cholesterol-lowering treatments like statins and diet changes. Researchers want to learn how many patients reach their LDL cholesterol goals and whether better control reduc…

This study follows 120 adults who had a stroke and underwent a procedure to remove a blood clot from a large brain artery. Researchers will test their thinking and memory at 3 and 6 months after the procedure. The goal is to find out which patients are more likely to develop cogn…

This study will compare how quickly stroke-related brain damage worsens in 135 Afro-Caribbean patients in Guadeloupe versus patients from mainland France. Researchers will use brain scans to track blood flow and collateral circulation. The goal is to learn if stroke progression d…

This study looks at whether waiting until day 3 after a stroke to start physical therapy is better for patients with a persistent blocked artery. Researchers will test if this delayed approach is feasible and if it helps prevent further brain damage. The study involves 50 adults …

This pilot study tests a new, faster MRI technique called Magnetic Resonance Fingerprinting (MRF) for people who have had an ischemic stroke. Standard MRI scans take 20-25 minutes, but for stroke, every minute matters. The study will enroll 10 adults with subacute stroke to see i…

This study will look at the genes of 1,000 people in Brazil—half who had a stroke and half who did not—to find genetic differences that may increase stroke risk. Researchers will use whole genome sequencing to analyze DNA and compare it with international data. The goal is to bet…

This study looks at whether a non-invasive ultrasound test, done within 24 hours of a stroke, can predict how well patients recover. Researchers will measure blood flow in the brain and compare it to neurological improvement over 72 hours. The study involves 50 adults with acute …

This study looks at how tightness in the ankle muscles (spasticity) after a stroke affects a person's balance, risk of falling, and ability to move around. Researchers will study 68 people who had a stroke at least six months ago, comparing those with mild versus moderate-to-seve…

This study tests a new way to use magnetic stimulation (TMS) to help stroke survivors recover thinking and memory. Instead of a one-size-fits-all approach, researchers will use brain scans to find the exact spot to stimulate for each person. The study will include 10 healthy peop…