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Head position showdown: flat or elevated after stroke?

NCT ID NCT07507097

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two common head positions—lying flat (0°) versus raising the head 30°—for the first 24 hours after a severe ischemic stroke. Researchers want to see which position leads to better recovery and fewer complications. About 1,500 adults with severe stroke will be randomly assigned to one of the two positions. The goal is to find a simple, safe nursing practice that improves long-term outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If it works, this could establish a simple, low-cost nursing standard to improve outcomes after severe stroke.
What could go wrong
This is an early-stage study comparing two routine positions; results may show no clear benefit or be limited to specific patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 1,508 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

Apr 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria 1. Age ≥ 18 years 2. Meeting the diagnostic criteria for acute ischemic stroke according to the "Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2023": ①Acute onset, ②Focal neurological deficits, with a few having global neurological deficits, ③Imaging shows a corresponding lesion or symptoms/signs persist for more than 24 hours, ④Exclusion of non-vascular causes, ⑤Brain CT/MRI excludes cerebral hemorrhage 3. Meeting the criteria for severe ischemic stroke patients: severe neurological deficits at admission \[for example, National Institutes of Health Stroke Scale (NIHSS) score≥15\] 4. First-time diagnosed ischemic stroke patients who undergo thrombolysis and/or thrombectomy reperfusion treatment 5. Time from onset to randomization within 24 hours 6. Informed consent obtained and signed by the patient or their family Exclusion Criteria 1. Known pregnancy or breastfeeding, or positive pregnancy test before randomization 2. Expected survival time less than 3 months (such as with malignant tumors, severe cardiopulmonary diseases, etc) 3. Already participating in other interventional clinical studies that may affect outcome assessment 4. Other situations deemed by the investigator as unsuitable for participation in this study or that may pose significant risks to the patient (such as inability to understand and/or comply with study procedures and/or follow-up due to mental illness, cognitive or emotional disorders) 5. Presence of brain midline shift or herniation, ventricular mass effect 6. Patients with limited head elevation (or patients unable to cooperate with postural intervention due to their condition/recovery needs, etc.) 7. Presence of respiratory infection symptoms such as fever, cough, or sputum production at the time of admission

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  3. A doctor treating you

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Contacts and locations

Locations

  • West China Hospital, Sichuan University

    Chengdu, Sichuan, 610041, China

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