West China Hospital

This early-stage trial tests a new vaccine called IMP3-saRNA (YMN-136) in 9 people with advanced non-small cell lung cancer who have run out of standard options. The vaccine uses self-amplifying RNA to train the immune system to attack cancer cells. The main goal is to check safe…

This early-stage trial is testing a new type of cancer vaccine for people with advanced colorectal cancer that hasn't responded to standard treatments. The vaccine is made from the patient's own tumor cells and aims to train the immune system to attack the cancer. The main goal i…

This early-stage trial tests a new type of vaccine made from engineered mitochondria (the cell's powerhouses) that carry a tumor-specific antigen. It is for people with advanced solid tumors like lung or colorectal cancer who have no other good treatment options. The main goal is…

This study is testing whether a team of doctors from different specialties can create better treatment plans for older adults (ages 60-90) with lung cancer. Each patient will get a personalized plan based on a full health assessment. The goal is to see if this team approach helps…

This study tests a special dye that makes liver cancer cells glow during surgery, helping surgeons see exactly where the tumor is and remove it more precisely. About 30 adults with early-stage liver cancer will get the dye injected before their operation. The goal is to improve c…

This early-phase study tests a new drug called GV20-0251 in people with advanced solid tumors (like liver, lung, or skin cancer) that have stopped responding to standard therapies. The main goal is to check the drug's safety. About 10 participants will receive one of two dose lev…

This early-stage study tests a new type of cancer vaccine made from a person's own tumor cells. The goal is to see if it is safe and can help control advanced solid tumors like bone, pancreatic, or liver cancer. About 54 people with different cancers will receive the vaccine, and…

This study tests a combination of three treatments—chemotherapy (NALIRIFOX), an immunotherapy (adebrelimab), and a special type of radiation (PULSAR)—as a first treatment for people with advanced pancreatic cancer that cannot be removed by surgery or has spread. The goal is to se…

This study tests whether a short course of radiation combined with immunotherapy and chemotherapy can shrink advanced gastroesophageal junction cancer enough to allow surgery. About 88 adults with locally advanced or unresectable disease will participate. The goal is to improve t…

This early-phase study tests a new nasal vaccine (WSK-IM05) combined with an immunotherapy drug (tislelizumab) given before surgery for HPV-positive throat cancer. About 9 participants will receive two cycles of the combination, then undergo surgery, followed by standard treatmen…

This study tests whether adding low-dose radiation to standard targeted therapy and immunotherapy before surgery helps shrink head and neck tumors more effectively than the drugs alone. About 98 adults with operable head and neck squamous cell carcinoma will be randomly assigned …

This study tests a powerful combination of internal radiation and four drugs (nivolumab, ipilimumab, lenvatinib) in people with liver cancer that cannot be removed by surgery. The goal is to see if this approach is safe and can shrink tumors or help people live longer. About 33 p…

This study tests a new first-line treatment for people with advanced intrahepatic cholangiocarcinoma, a type of bile duct cancer that cannot be removed by surgery. The treatment combines chemotherapy directly into the liver artery (HAIC) with two drugs: durvalumab (an immunothera…

This study tests a new drug called DCSZ11 combined with standard treatments in people with advanced or metastatic solid tumors. The goal is to see if the combination is safe and can shrink tumors or keep them from growing. About 9 adults with certain cancers, including head and n…

This study looks at 200 adults with liver cancer to compare two ways of using a special dye during surgery. The dye helps surgeons see and remove only the diseased part of the liver. One method injects the dye through an artery, the other through a vein. The goal is to see which …

This study tests a new treatment for a type of head and neck cancer that is hard to cure. It combines an experimental vaccine that targets a protein called IMP3 with an immunotherapy drug. The goal is to shrink tumors before surgery and prevent them from coming back after. The tr…

This early-stage trial tests a new drug called IL-22BP in about 6 adults with advanced solid tumors that have not responded to at least two prior treatments. The main goals are to check the drug's safety and find the right dose, while also seeing if it can shrink tumors. The stud…

This study tests a combination of two drugs, HRS-4642 and nimotuzumab, in 20 adults with advanced pancreatic cancer that has come back or spread. The goal is to see if the combo is safe and can shrink tumors or slow the disease. This is an early-stage trial, so it focuses on find…

This early-stage trial tests whether giving a second round of radiation therapy along with a drug called chidamide is safe for people whose head and neck cancer has come back after previous radiation. The study involves 6 adults aged 18 to 75 with a specific type of cancer. The m…

This study is testing whether giving two drugs (lucanoximab and tagolimab) before surgery can help shrink tumors in people with head and neck cancer. About 30 adults with resectable cancer will receive the drugs intravenously every two weeks for two cycles, then undergo surgery. …

This study is testing whether a short course of radiation combined with immunotherapy and chemotherapy before surgery can safely and effectively treat a type of cancer where the stomach meets the esophagus. About 84 adults with locally advanced but removable cancer will receive t…

This early-stage trial tests a new mRNA vaccine designed to help the immune system fight advanced liver cancer. It is for people whose cancer has not responded to standard treatments. The main goal is to check safety, and researchers will also see if the vaccine can shrink tumors…

This study looks at whether eating a high-fiber diet (over 21 grams per day) can improve treatment response and quality of life in people with solid tumors like colorectal cancer. Researchers want to see if fiber changes gut bacteria and boosts the immune system to fight cancer b…

This early-phase trial tests a single injection of JWK010 gene therapy in 18 children aged 5 to 12 with oculocutaneous albinism type 1 (OCA1), a condition causing little to no pigment in the eyes, skin, and hair. The therapy is designed to help eye cells produce the missing pigme…

This early-phase study tests whether a new gold nanoparticle treatment (Au-TMP) is safe when injected into tumors, followed by radiation and an immunotherapy drug (Toripalimab). It involves 6 adults with advanced melanoma that cannot be surgically removed. The main goal is to che…

This study is for people with early- or intermediate-risk low rectal cancer. It tests whether patients who respond well to chemotherapy and radiation can safely avoid surgery and instead be closely monitored (watch-and-wait). The goal is to preserve the rectum and improve quality…

This study tests whether adding targeted radiation (SBRT) to standard chemotherapy and immunotherapy can improve outcomes for people with early-stage triple-negative breast cancer (TNBC). TNBC is a hard-to-treat type of breast cancer with fewer treatment options. The trial will e…

This early-phase trial tests whether combining two drugs (GV20-0251 and sintilimab) before surgery is safe and can shrink tumors in adults with advanced head and neck cancer. Nine participants will receive two cycles of the drug combo, then undergo surgery. The study focuses on s…

This study tests a new imaging probe that makes liver cancer cells glow when viewed with a special camera. Researchers will apply the probe to liver tissue removed during surgery and check if it can accurately show where the cancer ends. The goal is to help surgeons remove all ca…

This study tests a special cream made from amino acids that may prevent skin damage caused by radiation therapy in people with head and neck cancer. About 40 participants will use the cream during their radiation treatment to see if it reduces redness, peeling, and pain. The goal…

This study tests a liquid made from cockroach extract (Meilian Fuxin) to prevent severe skin reactions in head and neck cancer patients getting radiation therapy. About 60 participants will apply the solution to their skin during treatment. The goal is to see if it reduces the ch…

This early-phase study tests whether a protein called CFH, delivered through ice microneedles, can safely prevent radiation-induced skin fibrosis (hardening and scarring) in people with head and neck cancer. Nine participants will receive the patch twice a week during their radia…

This study tests whether traditional Chinese medicine oral liquids and mouthwashes can reduce severe mouth sores caused by radiation therapy in head and neck cancer patients. About 118 adults aged 18-65 who need radiation will receive either the Chinese medicine or a placebo. The…

This study tests a web-based platform that helps cancer patients report their pain levels and track medications. The goal is to improve pain management and quality of life, especially for patients in rural areas with limited healthcare access. About 100 adults with cancer-related…

This study tests a new treatment for severe skin burns caused by radiation therapy in head and neck cancer patients. The treatment uses tiny particles (nanozymes) combined with a special light therapy to help heal the burns. Only 5 patients will be enrolled to see if this approac…

This study looks at whether different starting doses of the medicine propranolol can help heal painful ulcers in babies with infantile hemangioma (a type of birthmark). About 40 children will be split into groups receiving different doses. The main goal is to see how quickly the …

This study tests a traditional Chinese herbal solution used as a mouthwash and oral drink to see if it can shorten the time patients suffer from severe mouth sores caused by radiation therapy. The trial involves 128 adults with head and neck cancer who are receiving radiation. Th…

This study tests a nurse-led program that helps head and neck cancer patients manage symptoms early during radiation therapy. The goal is to see if this approach reduces treatment interruptions compared to standard care. About 170 adults with head and neck cancer will take part. …

This study follows 1,200 people with atrial fibrillation (AF) in China who are getting a newer, gentler type of ablation called pulsed field ablation. Researchers want to see if early heart rhythm issues in the first few months can predict if AF comes back later. Participants wil…

This study looks at whether a common technique used during liver surgery—temporarily clamping blood vessels to reduce bleeding—increases the chance of developing gallbladder diseases like gallstones or inflammation later on. Researchers will review medical records of 2,000 adults…

This study looks at 1300 adults who had a heart procedure (PCI) and are at high risk for bleeding. Researchers will use artificial intelligence to find which blood-thinning medicines work best and for how long to prevent heart attacks and strokes while avoiding dangerous bleeds. …

This study looks at patients who are critically ill for a long time in the ICU. Researchers want to find out how many survive after one year and what factors lead to worse outcomes. About 459 adults who have been in the ICU for 8 days or more will be followed by phone interviews.

This study follows 300 critically ill children who had sepsis for five years after they leave the hospital. Researchers want to see how sepsis affects their growth, brain development, survival, and quality of life. The goal is to better understand the long-term challenges these c…