West China Hospital

This early-stage study tests a new vaccine called YMN-136 in 9 people with advanced colorectal cancer that has spread to the liver and no longer responds to standard treatments. The main goals are to check the vaccine's safety and find the best dose. Researchers will also watch f…

This study looks at 120 children with a rare blood vessel tumor called kaposiform hemangioendothelioma (KHE) who are taking the drug sirolimus. The goal is to find the best way to stop the drug to prevent the tumor from growing back. Participants will be randomly assigned to one …

This early-phase study tests a new mRNA-based drug for people with relapsed autoimmune diseases. The drug targets two proteins (CD19 and BCMA) to clear the B cells and plasma cells that mistakenly attack the body. Up to 27 participants aged 18-70 will receive the treatment to fin…

This early-stage trial tests a new RNA-based drug called YMN-A02 in 10 adults with advanced liver cancer that has not responded to standard treatments. The drug aims to boost the immune system by blocking two key pathways that help tumors hide. The main goal is to check safety an…

This study looks at a newer, less invasive way to rebuild a breast after mastectomy, called endoscopic direct-to-implant reconstruction. It will compare this method to the standard flap surgery (using tissue from the belly) in about 588 women across China. The goal is to see whic…

This study tests whether adding a powerful cholesterol-lowering drug (PCSK9 inhibitor) to standard statin therapy soon after a heart attack can make artery plaques thicker and more stable. About 212 adults who recently had a heart attack and underwent stenting will be randomly as…

This study looks at 100 adults with liver cancer that was initially too advanced for surgery but shrank after conversion therapy. Researchers want to see if removing the remaining tumor with surgery is better than continuing maintenance therapy. The goal is to find which approach…

This study tests whether giving a drug called becotatug vedotin, alone or with immunotherapy (penpulimab or ivonescimab), before surgery can help shrink advanced head and neck cancers. About 120 adults aged 18-70 with resectable tumors will take part. The main goal is to see if t…

This study tests a combination of two drugs (vedotin-tislelizumab and toripalimab) in people with advanced bile duct cancer that has a specific marker (EGFR) and has not responded to prior treatment. The goal is to see if the combination can shrink tumors. About 44 adults aged 18…

This early-stage study tests whether injecting tiny tantalum particles into tumors before radiation is safe for people with a rare, recurring soft tissue sarcoma in the abdomen. Nine adults who have already had standard treatments will receive one of three doses. The goal is to f…

This study tests whether adding desiccated thyroid extract (DTE) to standard levothyroxine can help people with intermediate-to-high risk thyroid cancer reach their TSH goals faster and more safely. About 646 adults who have had surgery will be enrolled. The goal is to improve ho…

This early-phase study will test whether spending time in a cool room can make standard immunotherapy work better for people with solid tumors. Twenty-four adults will receive their usual PD-1/PD-L1 inhibitor treatment while also being exposed to mild cold (around 18°C) for 12 ho…

This study is for people with a specific type of advanced stomach cancer (HER2-positive) that has stopped responding to standard treatments. It tests a new drug (disitamab vedotin) combined with immunotherapy and targeted radiation to see if it can control the cancer longer. Abou…

This study tests a combination of two drugs, Becotatug vedotin and Pucotenlimab, as a first treatment for people whose nasopharyngeal cancer has come back or spread. The goal is to see if the combo can shrink tumors and delay cancer growth. About 30 adults aged 18-75 with advance…

This study tests a new device designed to help the aorta heal better after surgery for a life-threatening aortic tear (Type A dissection). About 198 adults who recently had surgery will either get the new device or standard care. The goal is to see if the device reduces the risk …

This early-phase study tests an mRNA vaccine that targets the Epstein-Barr virus (EBV) in people with HIV-related lymphoma. The vaccine aims to help the immune system fight cancer cells that are driven by EBV. The trial will enroll 6 adults and primarily check for safety and immu…

This early-phase trial tests a new drug that helps the immune system recognize and attack cancer cells by blocking a 'don't eat me' signal. It is for people with advanced solid tumors that have not responded to standard treatments. The main goal is to check safety and find the ri…

This early-phase study tests a new drug called WGb-0301 for people with autoimmune diseases (like lupus or autoimmune hepatitis) that have not responded to standard treatments. The drug uses mRNA technology to target and clear certain immune cells (B cells) that are causing the d…

This early-phase study tests a new mRNA treatment (NCP-IL-22BP mRNA) in 9 people with advanced solid tumors that have not responded to standard therapies. The treatment is injected directly into tumors to help the body fight cancer. The main goal is to check safety, and researche…

This study tests whether adding focused radiation (SBRT) and an immunotherapy drug (serplulimab) to standard chemotherapy can help people with advanced pancreatic cancer live longer. About 198 adults who have not had prior treatment for their metastatic disease will be randomly a…

This study tests a treatment that combines a modified virus (H101) with a procedure called TACE (chemoembolization) for people with recurrent or metastatic head and neck cancer that hasn't responded to at least two prior treatments. The goal is to kill tumor cells and activate th…

This study tests a new handheld scanner that helps surgeons see cancer cells at the edges of removed breast tissue during surgery. Current methods can miss some cancer, leading to repeat operations. The scanner gives results in under five minutes. About 165 women with early-stage…

This study tests whether a spray containing superoxide dismutase (SOD) can prevent severe radiation dermatitis (skin burns) in 140 head and neck cancer patients undergoing radiotherapy. The spray aims to neutralize harmful free radicals produced during treatment. If effective, it…

This study tests whether a spirulina-based product can prevent severe esophagitis (throat inflammation) caused by radiation therapy in 70 esophageal cancer patients. Participants will receive either the spirulina derivative or a placebo during their radiation treatment. The goal …

This study tests whether a superoxide dismutase (SOD) spray can prevent severe skin reactions (radiation dermatitis) in 140 head and neck cancer patients receiving high-dose radiation. The spray works by removing harmful free radicals produced during treatment. Patients will be c…

This study tests whether adding a bile acid pill (UDCA) to standard treatment (lactulose) can prevent serious brain confusion (hepatic encephalopathy) after a liver shunt procedure (TIPS). About 270 adults with cirrhosis will receive either UDCA plus lactulose or lactulose alone …

This early-phase study tests whether a diet that strictly limits vitamin B6 can make immunotherapy work better for people with solid tumors. About 20 adults aged 18-80 will follow this special diet for 6 weeks while continuing their regular immunotherapy. The main goal is to chec…

This study tests whether mecobalamin, a form of vitamin B12, can speed up recovery of the nerve that controls the vocal cords after thyroid surgery. About 528 adults having open thyroid surgery will receive either mecobalamin or a placebo for several weeks. The goal is to see if …

This study compares two common head positions—lying flat (0°) versus elevating the head of the bed 30°—for people with severe acute ischemic stroke. The goal is to see which position is safer and leads to better recovery 90 days later. About 1,500 participants will be randomly as…

This study tests a special anti-fog drainage device during nose-to-pituitary tumor surgery. The goal is to see if it reduces fogging of the camera lens and lowers the risk of brain-fluid infection. About 20 adults with pituitary adenoma or craniopharyngioma will take part. The de…

This study looks back at medical records of 700 adults with severe pancreatitis and sepsis who had surgery to remove dead tissue. The goal is to see how their organ function changed after the operation. It does not test a new treatment, but aims to better understand patient outco…

This study looks back at medical records to see how quality of life changed after parathyroid surgery in 60 adults with kidney failure and secondary hyperparathyroidism. Researchers will measure changes in physical and mental health using a standard survey. The goal is to underst…

This study tests a new system using wearable devices and a smartphone app to help people with non-small cell lung cancer recover after chest surgery. About 126 participants will either use the wearable system or get standard care. The goal is to see if the wearable approach impro…

This study aims to develop an AI model that analyzes neck ultrasound images and reports to predict if papillary thyroid cancer has spread to lymph nodes. Researchers will enroll 3,200 patients and compare the AI's predictions with standard pathology results. The goal is to improv…