West China Hospital

This early-stage trial is testing the safety and effectiveness of a new two-drug combination (JDB153 and serplulimab) for people with advanced pancreatic cancer that has stopped responding to standard treatments. It will enroll about 10 patients to see if the treatment can shrink…

This early-stage study is testing a new type of drug that uses mRNA technology (similar to some COVID-19 vaccines) to treat people with autoimmune diseases that have come back or haven't responded to other treatments. The drug is designed to target and remove specific immune cell…

This study is testing whether a combination of two immunotherapy drugs is safe and effective for people with advanced bile duct cancer that has stopped responding to standard treatments. It will enroll about 44 adults whose cancer has a specific marker (EGFR-positive). The main g…

This study is testing whether giving new drug combinations before surgery can help shrink tumors in people with advanced head and neck cancer. The goal is to see if these pre-surgery treatments can kill more cancer cells, potentially leading to better long-term results. About 120…

This study is testing a new two-drug combination as the first treatment for people with advanced nasopharyngeal cancer that has come back or spread. It aims to see if the treatment can control the cancer for longer and is safe for patients. The trial will enroll about 30 adults w…

This study is testing a three-part treatment for people with advanced HER2-positive stomach cancer that has worsened after two prior standard treatments. It combines a targeted drug (disitamab vedotin), an immunotherapy drug, and a specialized form of radiation therapy. The goal …

This study is testing whether giving two cancer drugs together before surgery is safe and effective for people with a type of esophageal cancer that can be removed. One drug boosts the immune system to fight cancer, and the other blocks cancer cell growth. The main goal is to see…

This early-phase study is testing whether strictly limiting vitamin B6 in the diet while receiving immunotherapy is safe and might help control solid tumors. It will enroll 20 patients with advanced solid tumors who are already on immunotherapy. The main goal is to check for side…

This study aims to determine whether patients with liver cancer who respond well to initial drug therapy should undergo surgery to remove remaining tumors or continue with ongoing drug treatment. Researchers will follow 100 patients across multiple hospitals to see which approach…

This study tests a new anti-fog suction device designed to keep the surgical camera lens clear during minimally invasive pituitary tumor removal through the nose. Researchers want to see if it reduces surgery delays caused by fogging and lowers the risk of brain fluid infection c…

This study is testing if adding a second thyroid hormone (desiccated thyroid extract) to the standard medication (levothyroxine) works better to prevent thyroid cancer from coming back after surgery. It will involve 646 people across China who have an intermediate or high risk of…

This study is testing a two-part treatment for head and neck cancer that has returned or spread after standard treatments. Doctors will inject a modified virus (H101) designed to attack cancer cells directly into the tumor, combined with a targeted chemotherapy procedure (TACE) t…

This early-stage study is testing a new vaccine called YMN-136 in people with advanced colorectal cancer that has spread to the liver and has stopped responding to at least three previous treatments. The main goals are to check if the vaccine is safe and to find the right dose fo…

This early study is testing a new injection called WGb-0301 for people with autoimmune diseases like lupus or autoimmune hepatitis that have come back or haven't responded to standard treatments. The drug uses mRNA technology to target a specific part of the immune system (B cell…

This study is testing if adding a PCSK9 inhibitor drug to standard cholesterol treatment right after a heart attack helps make artery plaque more stable and less likely to cause another event. It will involve 212 patients who recently had a heart attack. Doctors will use advanced…

This study is for children with a rare tumor called kaposiform hemangioendothelioma (KHE) who are ready to stop taking the drug sirolimus. The goal is to find the safest way to stop the medicine to prevent the tumor from growing back. Researchers will compare three different stop…

This early-stage study is testing a new type of mRNA vaccine designed to target a specific protein (FAP) found in the supportive tissue around tumors. The goal is to see if the vaccine, given with standard immunotherapy drugs, is safe and can help the immune system attack advance…

This study is testing whether adding targeted radiation and an immunotherapy drug to standard chemotherapy helps people with advanced pancreatic cancer live longer. It will involve about 200 adults who haven't had prior treatment for their metastatic cancer. The goal is to see if…

This study is testing a new digital recovery program for people having surgery for lung cancer. It uses smartwatches and a phone app to guide patients through exercises and track their health before and after surgery. Researchers want to see if this tech-supported approach helps …

This study tests whether adding a new internal stent device after major aortic surgery helps the damaged blood vessel heal better. It will enroll 198 patients who recently had surgery for a torn aorta (type A dissection) but still have significant remaining damage. Half will rece…

This study aims to develop and test a computer program (a deep learning model) that analyzes neck ultrasound images and reports to predict whether papillary thyroid cancer has spread to nearby lymph nodes. It will involve 3,200 adults who have had surgery for this cancer, compari…

This study is testing a new handheld scanner called the EndoSCell Scanner. It uses a special light to help surgeons see cancer cells in real-time during breast tumor removal surgery, aiming to ensure all cancerous tissue is removed. The scanner's accuracy will be compared to stan…

This study tests if adding ursodeoxycholic acid (a bile acid pill) to the standard laxative treatment (lactulose) can better prevent brain fog (hepatic encephalopathy) after a liver shunt procedure (TIPS). It will involve 270 adults with severe liver cirrhosis who are getting the…

This study is testing whether a spray containing an antioxidant enzyme (Superoxide Dismutase or SOD) can prevent or reduce the severity of painful skin burns (radiation dermatitis) in patients receiving radiotherapy for head and neck cancer. The spray is applied to the skin and a…

This study is testing whether a form of vitamin B12 (mecobalamin) can help patients recover their voice after thyroid surgery. It will involve 528 adults who are scheduled for thyroid surgery and are at risk for temporary voice problems. Participants will be randomly assigned to …

This study is testing whether a proactive, nurse-led program to manage symptoms can help people with head and neck cancer complete their planned radiation therapy without unplanned breaks. It will compare this new approach to standard care in 170 patients. The main goal is to see…

This study is testing if a product made from spirulina, a type of algae, can prevent or reduce the severity of painful swallowing (esophagitis) caused by radiation therapy in people with esophageal cancer. About 70 participants will be randomly assigned to receive either the spir…

This study is testing whether a special antioxidant spray can prevent painful skin burns (radiation dermatitis) in people receiving radiation treatment for head and neck cancer. The spray aims to neutralize harmful molecules produced during radiation. Researchers will compare ski…

This study examines past medical records of 700 patients who had severe pancreatitis with infection and underwent major surgery. Researchers want to understand how different organs (like lungs, kidneys, and liver) function before and after this surgery. By analyzing these pattern…

This study aims to understand how a specific surgery affects the daily lives of people with advanced kidney disease. Researchers will look back at existing medical records for 60 patients who had surgery to remove overactive parathyroid glands. They will track changes in quality …