Can Clot-Busting drugs help minor stroke patients? major study aims to find out
NCT ID NCT07322835
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This large study in China will follow 5,400 people with minor ischemic stroke to see if clot-busting drugs or mechanical clot removal (reperfusion therapy) leads to better recovery than standard medications. Participants are treated based on their doctor's choice, and researchers will compare outcomes like disability and bleeding risk at 90 days. The goal is to provide real-world evidence to guide treatment decisions for minor strokes.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- reperfusion therapy (intravenous thrombolysis and/or endovascular intervention)
- What this could lead to
- If successful, this study could clarify whether clot-busting drugs or mechanical clot removal help people with minor strokes recover better than standard medications alone.
- What could go wrong
- This is an observational study, not a randomized trial, so results may be less definitive. The study is still recruiting, and outcomes depend on real-world treatment choices, which can vary.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
About 5,400 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
-
Jan 2026
An estimate. Start dates often move.
- Expected to finish
-
Jun 2027
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients with minor ischemic stroke (NIHSS ≤ 5) within 24h from onset
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age \>18 year 2. Pre-stroke mRS ≤1 3. Diagnosis of ischemic stroke, confirmed by imaging (CT or MRI) 4. Stroke onset or last seen well (LSW) to visit ≤ 24h 5. NIHSS ≤ 5 6. Receive standard medication or IVT (TNK or rtPA) ± EVT, or EVT alone; for IVT beyond standard time window, initiation of treatment must occur within 4.5-24h of last seen well and ASPECTs≥7 or Perfusion lesion-ischemic core mismatch (ischemic core volume \<70mL, mismatch rate \>1.2, mismatch volume \>10mL or mismatch between the presence of an abnormal signal on DWI and no visible signal change on FLAIR) 7. Patients or their eligible surrogates provided informed consent Exclusion Criteria: 1. Pregnant or breastfeeding women 2. Patients who already received reperfusion therapy for the current stroke before arriving at the hospital 3. Participation in another interventional clinical trial that could interfere with the outcomes of this study
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Minor ischemic stroke are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
The First Affiliated Hospital, Sun Yat-Sen University
Guangzhou, Guangdong, 510080, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.