Hematopoietic and lymphoid cell neoplasm

This study compares three different flu vaccines in 60 adults with blood cancers like leukemia or lymphoma. The goal is to see which vaccine triggers the strongest immune response in people with weakened immune systems. Participants will receive one of the vaccines and have their…

This study tests whether a combination of three drugs (cyclophosphamide, bortezomib, and maraviroc) can safely prevent graft-versus-host disease after a half-matched bone marrow transplant in people living with HIV who also have a blood cancer. The trial involves 265 participants…

This study tests whether giving donor white blood cells (lymphocytes) soon after a stem cell transplant can lower the chance of cancer returning in people with high-risk blood cancers like leukemia or lymphoma. Participants receive chemotherapy, a stem cell transplant, and then a…

This early-phase trial is testing an experimental cell therapy called GT719 in 46 adults with relapsed or treatment-resistant B-cell lymphoma or leukemia that tests positive for CD19. The study aims to see if the treatment is safe and how well it works. Participants receive a sin…

This early-phase trial tests a personalized treatment for people with blood cancers like leukemia. Doctors take a patient's own T cells, modify them in the lab to recognize unique cancer mutations, and infuse them back after a short course of chemotherapy. The goal is to see if t…

This study is checking the long-term safety and effectiveness of the cancer drug pembrolizumab (Keytruda) in 3500 people with various solid tumors or blood cancers. Participants are moving from earlier Merck studies into this one, continuing their treatment or follow-up. The goal…

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and an advanced cancer that has spread or cannot be removed by surgery. It tests the safety and effectiveness of the immunotherapy drug nivolumab, given alone or…

This study tests whether a non-invasive ventilation mask (NIPPV) can reduce the need for intubation in cancer patients with respiratory failure. Researchers will compare NIPPV plus standard oxygen therapy to standard oxygen therapy alone in 256 participants. The goal is to see if…

This study tests a new way to do stem cell transplants for adults with high-risk blood cancers who don't have a fully matched donor. Doctors will use stem cells from a half-matched (haploidentical) donor and remove certain immune cells to try to prevent severe graft-versus-host d…

This early study tests whether adding special cells from donated umbilical cord blood (called mesenchymal stromal cells) to the drug ruxolitinib can help control severe graft-versus-host disease (GVHD) that hasn't improved with steroids. GVHD is a serious complication where donor…

This early-stage trial tests whether specially grown donor T cells can safely treat adenovirus infections in people with weakened immune systems, such as cancer patients. The cells are designed to target and kill the virus. The study will check for side effects and see if the inf…

This study tests whether starting tube feeding right after a stem cell transplant can reduce severe gut graft-versus-host disease (GVHD) in people with blood cancers or disorders. About 112 participants will be randomly assigned to either standard care or early tube feeding. The …

This study tests a new way to do a stem cell transplant for children with a hard-to-treat type of leukemia (ALL). Doctors will use special immune cells (CAR T cells) after the transplant to try to kill any remaining cancer cells. The goal is to see if this approach is safe and wo…

This trial tests whether giving anti-thymocyte globulin (ATG) at a dose tailored to each patient's body can improve outcomes after a half-matched stem cell transplant. ATG is used to prevent graft-versus-host disease, a serious complication where donor cells attack the patient's …

This early-stage trial is testing an experimental drug called JNJ-95804306 in people with blood cancers like leukemia that have come back or not responded to standard treatments. The study has two parts: first, finding a safe dose, and then checking if the drug shrinks tumors whe…

This study tests a new CAR-T therapy made from donor cells, so it's ready to use without waiting for a patient's own cells to be modified. It targets two proteins on cancer cells to lower the chance of the cancer coming back. About 178 adults with relapsed or refractory B-cell ly…

This study tests a new drug called talquetamab in people with multiple myeloma that has come back or stopped responding to treatment. Talquetamab is a bispecific antibody designed to help the immune system attack cancer cells. The trial aims to find the best dose and see how well…

This trial tests whether changing from acid-blocking drugs to a stomach-lining protector called teprenone after a stem cell transplant can reduce the risk of acute graft-versus-host disease (aGVHD), a serious complication where donor immune cells attack the recipient's body. Abou…

This early-phase trial tests whether giving anti-CD19 CAR T cells together with a half-matched bone marrow transplant can safely treat aggressive blood cancers like leukemia and lymphoma. About 155 adults aged 18 to 75 with CD19-positive cancers will receive the combined therapy …

This trial tests a new drug called DS3790a for people with certain blood cancers, including B-cell non-Hodgkin lymphoma. The drug is designed to find and attack cancer cells while sparing healthy ones. The study will check safety and how well it works in about 420 adults.

This study tests whether low-intensity mechanical stimulation (LIMS) vibration therapy can help blood cancer patients who are about to receive a stem cell transplant or cell therapy. The vibration board sends gentle waves through the bones, which may stimulate bone growth, improv…

This study tests a new treatment using immune cells (NK cells) from donated cord blood that are engineered to target a protein called CD5 found on certain cancer cells. The treatment is given after chemotherapy to prepare the body, and the goal is to see if it is safe and effecti…

This early-stage trial is testing a new drug called ziftomenib combined with standard chemotherapy or another targeted drug for people with relapsed or treatment-resistant acute myeloid leukemia (AML) that has specific genetic changes. The main goal is to see if these combination…

This study tests an experimental drug, REGN7508, to see if it works better than the standard blood thinner apixaban for treating and preventing blood clots in people with cancer. The trial will include about 1,600 participants with or without cancer who have deep vein thrombosis …

This trial tests whether two approved drugs, dabrafenib and trametinib, can treat rare cancers that have a specific genetic change called BRAF V600. These drugs are already used for melanoma and lung cancer, but researchers want to see if they help people with other cancer types.…

This early-phase trial tests whether injecting special immune progenitor cells (HTLPs) can help the immune system recover faster after a cord blood transplant in adults with blood cancers. Ten participants will receive the injection alongside their transplant. The goal is to see …

This early-phase trial is testing whether adding a patient's own blood stem cells to standard CAR T-cell therapy is safe and doable for people with relapsed or refractory blood cancers like lymphoma, leukemia, and myeloma. Twenty participants will receive their own stem cells 10 …

This study is the first time the experimental drug KK2430 is being tested in humans. It aims to find out if KK2430 is safe, how the body processes it, and whether it can help treat blood cancers. About 72 adults with blood cancers that have not responded to other treatments will …

This study is for people aged 65 and older with blood cancers who are getting a stem cell transplant. Researchers want to see if giving a lower dose of the drug cyclophosphamide after the transplant can reduce serious side effects while still controlling the cancer. The trial wil…

This trial tests whether a drug called ATLG, used before a stem cell transplant, can help the immune system recover better and reduce viral infections compared to the standard drug ATG. The study involves adults with blood cancers like leukemia, lymphoma, or MDS who are receiving…

This study tests an experimental inhaled drug called PUL-042 in 100 people with blood cancers or who have had a stem cell transplant and have a viral lung infection. Participants receive either the drug or a placebo three times over six days. The goal is to see if PUL-042 can red…

This trial tests whether a compound from the herb ashwagandha, called withaferin A, can help prevent graft-versus-host disease (GvHD) in people receiving a stem cell transplant for blood cancer. GvHD is a serious complication where donated immune cells attack the recipient's body…

This trial investigates whether giving a reduced dose of the drug cyclophosphamide after a half-matched stem cell transplant can prevent graft-versus-host disease (GVHD) while causing fewer side effects. The standard dose often leads to infections and slow immune recovery. Resear…

This early-phase study is testing a new cell therapy called GT801 in 28 adults with relapsed or hard-to-treat B-cell blood cancers (like leukemia and lymphoma) or autoimmune hemolytic anemia (AIHA). The therapy uses a patient's own immune cells, modified to attack CD19-positive c…

This study tests the safety and best dose of bendamustine, given with or without cyclophosphamide, to prevent graft-versus-host disease (GVHD) in people with blood cancers receiving a stem cell transplant. About 25 participants will receive the drug after transplant, along with s…

This phase 2 trial tests whether combining two antiviral drugs, baloxavir and oseltamivir, works better than oseltamivir alone for severe flu in people with weakened immune systems (such as blood cancer patients or stem cell transplant recipients). The study will measure how quic…

This phase 2 trial tests whether a standardized extract from the ashwagandha plant, called Withaferin-A, can help people who develop graft-versus-host disease after a stem cell transplant and whose condition does not improve with steroids. The study enrolls 34 patients aged 12 an…

This study tests a program where clinical pharmacists provide personalized counseling to cancer patients taking oral anticancer drugs. The goal is to see if this support helps patients take their medication more consistently. Researchers will compare two groups of 80 patients eac…

This phase 3 trial compares an anti-CD25 monoclonal antibody (daclizumab) with methotrexate for preventing acute graft-versus-host disease (GVHD) in people with blood cancers receiving a half-matched stem cell transplant. GVHD is a serious complication where donor immune cells at…

This study tests whether switching to the drug ruxolitinib after a stem cell transplant can better prevent chronic graft-versus-host disease (GVHD) compared to standard treatment. About 40 adults with blood cancers who are in remission will receive either a medium dose of cycloph…

The DETERMINE trial is testing whether drugs already approved for some cancers can help people with rare cancers or common cancers that have rare genetic mutations. It will enroll 825 adults, teenagers, and children whose cancers have specific DNA changes. The goal is to find new…

This study tests a program called OPTIMISE that helps cancer patients manage other chronic conditions like diabetes or high blood pressure during treatment. It assigns a nurse navigator to improve communication between cancer doctors and primary care doctors. About 340 patients w…

This study tests whether adding the drug belumosudil to standard care can better prevent graft-versus-host disease (GVHD) in adults with blood cancer who have had a stem cell transplant. About 46 participants will receive belumosudil along with their usual GVHD prevention medicin…

This study tests whether giving patients special donor immune cells (called CD45RA-depleted DLI) can treat viral infections that persist after a stem cell transplant. The trial involves 30 participants who have not improved with standard antiviral drugs. Researchers will measure …

This study tests a new drug called CCS1477 (inobrodib) in people with advanced blood cancers like leukemia, lymphoma, and myeloma that have not responded to standard treatments. The drug is given as an oral capsule, either alone or combined with other cancer medicines. The goal i…

This study tests a radioactive antibody (211At-BC8-B10) that seeks out and attacks cancer cells, followed by a donor stem cell transplant for people with high-risk leukemia or myelodysplastic syndrome (MDS) that has returned or not responded to treatment. The goal is to find the …

This phase 1 trial tests an experimental drug, DXC006, in people with advanced solid tumors (like small cell lung cancer and neuroblastoma) or blood cancers (like multiple myeloma) who have not responded to standard treatments. DXC006 is an antibody-drug conjugate designed to del…

This study tests whether giving anti-thymocyte globulin (ATG) based on individual patient levels can reduce viral infections after stem cell transplants from unrelated donors. About 324 patients will receive either personalized or fixed doses of ATG. The goal is to find a dose th…

This study looks at the long-term safety and benefits of the drug pelabresib in people with blood cancers, solid tumors, or advanced cancers. It includes up to 50 adults who were in earlier pelabresib studies and are still benefiting from the drug. Some participants who received …

This early-phase trial tests whether stem cell transplants from donors whose tissue type does not fully match the patient can be safe and effective for people with blood cancers who have no other donor options. About 29 adults aged 18-60 will receive chemotherapy followed by the …

This study tests a new treatment made from specially engineered immune cells (T cells) donated by healthy people. The cells are designed to better recognize and kill cancer cells while lasting longer in the body. The trial includes 24 adults with blood cancers or solid tumors tha…

This early-phase study tests a new way to give immune cells (T-cells) after a stem cell transplant in children with high-risk blood cancers. The goal is to see if giving special memory T-cells early can help fight cancer while reducing dangerous side effects like graft-versus-hos…

This study tests whether a combination of three drugs (cyclophosphamide, bortezomib, and abatacept) can prevent graft-versus-host disease (GvHD) in people receiving a stem cell transplant for blood cancers. About 74 adults will take part. The goal is to reduce severe immune react…

This study looks at how the cancer drug ASTX727 (decitabine and cedazuridine) works in people with moderate or severe liver problems. About 27 adults with certain blood cancers or solid tumors will take the drug for up to 8 weeks. The goal is to understand how the liver affects t…

This early-stage study looks at how the body handles the cancer drug ASTX727 (decitabine and cedazuridine) in people with severe kidney problems compared to those with normal kidneys. It includes 18 adults with acute myeloid leukemia, myelodysplastic syndromes, or solid tumors. T…

This study tests whether giving more doses of the drug abatacept over a longer period can better prevent graft-versus-host disease (GVHD), a serious complication where donor immune cells attack the patient's body. About 160 people receiving stem cell transplants from partially ma…

This study tests a drug called romiplostim N01 in children, adolescents, and young adults (ages 6-24) with cancer who develop low platelet counts from chemotherapy. The drug is given as a weekly shot to help the body produce more platelets. The goal is to see if it can safely and…

This study tests whether the antiviral drug letermovir can prevent cytomegalovirus (CMV) infection in children and teens who have had a stem cell transplant. About 105 participants aged 2 to 17 will receive letermovir and be monitored for 14 weeks. The goal is to see if the drug …

This study tests whether combining two oral drugs, pirtobrutinib and venetoclax, can control mantle cell lymphoma (MCL) in patients whose cancer has come back or hasn't responded to prior treatments. About 30 adults with confirmed MCL will take these pills to see how many achieve…

This study looks at whether providing free bags of groceries to patients undergoing stem cell transplants or CAR-T cell therapy can help improve their nutrition and treatment results. Many patients face high medical costs that make it hard to afford enough food, which can hurt th…

This study tests whether giving the immune-suppressing drug tacrolimus earlier than usual can lower the risk of cytokine release syndrome (CRS), a severe inflammatory reaction, in patients receiving a half-matched stem cell transplant for blood cancer. About 20 adults will receiv…

This study tests whether using a patient's genetic profile to dose the antifungal drug voriconazole can help more patients reach the right drug levels faster. It will enroll 104 children and adults with blood cancer who have a fungal infection. Participants are randomly assigned …

This study tests whether a drug called sargramostim can help restore white blood cells as quickly as the standard drug (G-CSF) after a half-matched stem cell transplant for blood cancers, while possibly lowering the risk of serious infections. About 38 adults with blood cancers l…

This study is for people with blood cancers like leukemia who are getting chemotherapy or a stem cell transplant, which can cause very low white blood cell counts (neutropenia) for over a week. The goal is to see if the antibiotic eravacycline can prevent serious bacterial infect…

This trial tests a reduced-intensity stem cell transplant for people with blood cancers like leukemia or lymphoma. The approach uses lower doses of chemotherapy and radiation before a half-matched donor transplant. Researchers hope this gentler method will help the body accept th…

This study is for people with cancer that has spread to the spine. It tests whether adding a procedure called vertebroplasty (which repairs broken spine bones) to standard radiation and immunotherapy can help prevent fractures and improve survival. About 200 participants will rec…

This study tests a special stem cell transplant for children and adults with blood cancers like leukemia. The transplant uses stem cells that have had certain immune cells removed to lower the risk of graft-versus-host disease, a serious complication. About 70 participants will r…

This study looks at the best length of treatment with the drug maribavir for a hard-to-treat CMV infection that can happen after a stem cell transplant. About 218 adults who have already had a transplant and have this infection will be randomly assigned to different treatment dur…

This early-stage trial is testing whether adding two drugs, decitabine and venetoclax, to a standard reduced-intensity stem cell transplant can safely help control high-risk myeloid cancers like acute myeloid leukemia. About 20 adults aged 18-75 with a matched donor will receive …

This early-phase trial is testing a new drug called AZD2962, which blocks a protein called IRAK4 involved in cancer growth. The study includes about 72 people with certain blood cancers (myelodysplastic syndromes or chronic myelomonocytic leukemia) that have not responded to prio…

This early-phase study tests whether adding a drug made from urine (uhCG/EGF) to standard therapy can safely prevent graft-versus-host disease (GVHD) in stem cell transplant patients with partially matched donors. About 18 adults with blood cancers who lack a fully matched donor …

This study tests a stem cell transplant using a half-matched (haploidentical) donor for people with blood cancers who don't have a fully matched donor. The approach uses chemotherapy and radiation before transplant, plus drugs like cyclophosphamide and bortezomib after to prevent…

This study tests two different pre-transplant conditioning plans combined with a single drug combination (cyclophosphamide and methotrexate) to prevent graft-versus-host disease (GVHD) in blood cancer patients receiving a stem cell transplant from a matched donor. About 82 adults…

This phase 2 trial tests whether the antifungal drug posaconazole can prevent serious fungal infections in 30 adults with blood cancer who are receiving a stem cell transplant from a donor. These patients are at high risk because of newer transplant methods. The study will check …

This early-phase trial tests a new type of immune therapy called CD70-CAR T cells in children and young adults up to age 21 with blood cancers that have come back or not responded to treatment. The therapy involves taking the patient's own immune cells, engineering them to recogn…

This study looks at whether liposomal amphotericin B (AmBisome) can safely treat breakthrough fungal infections in children and teens with blood cancers who are already on antifungal prevention. About 38 participants will receive the drug as part of their regular care, and resear…

This early-stage trial tests whether adding abatacept to standard anti-rejection drugs can safely prevent graft-versus-host disease (GVHD) in 10 adults with blood cancers receiving a special type of stem cell transplant (omidubicel). Participants will receive the drug combination…

This study tests a new injection called UTAA07 for adults with CD7-positive blood cancers that have come back or not responded to treatment. The main goals are to check safety and find the best dose. Only 15 people will take part in this early-stage trial.

This study tests whether a drug called tranexamic acid can safely replace routine platelet transfusions in adults receiving a stem cell transplant for blood cancers. About 662 participants will either get tranexamic acid or standard platelet transfusions. The goal is to see if th…

This early-phase trial is testing an experimental immune cell therapy called GT719 in 34 adults with relapsed or refractory CD19-positive B-cell blood cancers (certain leukemias and lymphomas). The treatment uses specially engineered cells to target and destroy cancer cells. The …

This study tests a higher dose of a molecule called UM171 to grow more stem cells from donated cord blood for transplant. It is for adults with high-risk blood cancers like leukemia who have no suitable donor. The goal is to help patients recover blood counts faster, reduce infec…

This study compares two types of blood thinners taken as pills (apixaban and rivaroxaban) against a standard daily injection (enoxaparin) to prevent dangerous blood clots in people with blood cancers like lymphoma, leukemia, and multiple myeloma. About 100 participants will be ra…

This phase 3 trial is testing whether changing the timing of stem cell infusion after a single umbilical cord blood transplant can lower the risk of severe acute graft-versus-host disease (aGVHD) in people with blood cancers. The study will enroll 134 participants who are in remi…

This study is for adults aged 60 and older with blood cancers who need a stem cell transplant. It compares a standard high dose of a drug (cyclophosphamide) with a lower dose, both combined with another drug (sirolimus), to prevent graft-versus-host disease (GVHD). The goal is to…

This trial tests two drugs, trastuzumab and pertuzumab, already approved for breast cancer, in people with rare cancers that have a specific genetic change called HER2 amplification or mutation. About 30 adults and children with various rare or hard-to-treat cancers will receive …

This trial is testing two drugs, vemurafenib and cobimetinib, already approved for melanoma, in adults with other rare cancers that have a specific genetic change called BRAF V600 mutation. The goal is to see if the combination can shrink tumors or stop them from growing. About 3…

This trial tests capmatinib, a drug already approved for certain lung cancers, in adults with rare cancers that have specific MET gene changes. About 30 participants will receive the drug to see if it can shrink tumors or stop them from growing for at least 24 weeks. The goal is …

This trial tests the drug entrectinib (Rozlytrek) in people with rare cancers that have a specific genetic change called ROS1 fusion. The drug is already approved for some lung cancers, but researchers want to see if it works for other tumor types. About 30 adults, teens, and chi…

This study tests a drug called alectinib, already approved for some lung cancers, in people with rare cancers that have a specific genetic change called ALK. About 30 adults, teens, and children with ALK-positive cancers will receive alectinib to see if it shrinks tumors or stops…

This study tests a new treatment called SNIPR001, which uses specially designed viruses to kill a type of antibiotic-resistant E. coli bacteria. The trial includes 24 adults with blood cancer who are scheduled for a stem cell transplant and already carry these resistant bacteria.…

This early study tests an experimental oral drug called HMPL-506 in about 132 adults with specific types of leukemia (AML or ALL) that have come back or not responded to treatment. The main goal is to check safety and find the right dose. Researchers will also look for signs that…

This early-phase study tests whether Darzalex Faspro can safely lower donor-specific antibodies (DSAs) in 8 adults with blood cancers or bone marrow failure who are at high risk of rejecting a stem cell transplant. The goal is to reduce DSA levels enough to allow the transplant t…

This study tests a combination of two antifungal drugs—liposomal amphotericin B plus either posaconazole or isavuconazole—in 60 adults with blood cancers who also have a serious fungal infection called mucormycosis. The goal is to see if the combo can clear the infection better a…

This early-stage study tests an experimental drug called ICP-248, taken as a pill, for people with certain blood cancers (like leukemia or lymphoma). The drug is given alone or with another drug, orelabrutinib. The main goals are to check safety, find the right dose, and see if i…

This study is testing a new radioactive tracer called 68Ga-EV203 for PET/CT scans in people with blood cancers like multiple myeloma, lymphoma, and leukemia. The goal is to see how the tracer spreads in the body, how much radiation it gives off, and whether it can find tumors bet…

This study is testing a new blood test that looks for DNA from cancer cells. The goal is to see if an artificial intelligence program can accurately detect many different types of cancer at an early stage. The study will include 6,000 adults, some with cancer and some healthy vol…

This study looks at how well the shingles vaccine works in people with weakened immune systems, such as those with cancer or autoimmune diseases. Researchers will measure immune responses and track side effects in 300 adults. The goal is to see if the vaccine can effectively prev…

This study is testing a new way to manage care for 33 cancer patients who take oral chemotherapy at home. Instead of going to the hospital every month just to pick up medicine, a nurse will visit them at home twice in six months. An advanced practice nurse will coordinate everyth…

This pilot trial tests a new approach to support cancer patients and their caregivers. The intervention combines social prescriptions—connecting people to community resources—with short online learning modules and regular symptom check-ins. The goal is to see if this package can …

This study tests whether a tailored physical activity program can help older adults maintain thinking and memory after a stem cell transplant for blood cancers. Participants aged 60 and older will follow a progressive, light-to-moderate exercise plan with support from therapists …

This study tests whether alteplase, a drug that dissolves blood clots, can improve drainage of fluid around the lungs and reduce shortness of breath in people with cancer-related pleural effusion that is not draining well. About 30 participants will receive either alteplase or a …

This study tests whether expressive writing—reading and writing about positive experiences—can help cancer survivors manage stress. About 414 survivors will participate from home using a computer or smartphone. The goal is to see if this simple activity can lower stress and impro…

This study tests whether using an aromatherapy inhaler (with lavender or peppermint) can help reduce distress and improve coping for patients recovering from a stem cell transplant. About 50 adult patients will use the inhaler during their hospital stay. The goal is to see if thi…

This study looks at whether a culturally tailored Latin dance program can help Hispanic cancer survivors sleep better. Researchers will enroll 40 adults who have finished their main cancer treatment but still have trouble sleeping. Participants will either take dance classes or c…

This trial tests whether using a weighted blanket during a first cancer infusion (like chemotherapy) can lower anxiety and distress compared to a regular blanket. The idea is that the deep touch pressure from the blanket may calm the nervous system and increase feelings of well-b…

This trial tests whether a specially designed website, called Mosaic, can help blood cancer patients who are about to undergo a stem cell transplant feel less distressed and have a better quality of life. Participants are randomly assigned to use either the Mosaic website or a st…

This study tests whether a structured exercise program, with or without nutritional advice, can lower the risk and severity of neurotoxicity (brain-related side effects) caused by CAR-T cell therapy in adults with blood cancers. One hundred participants will be randomly assigned …

This phase II trial tests whether a plant-derived supplement called chlorophyllin can reduce severe mouth sores caused by high-dose radiation given before a stem cell transplant. People aged 12 to 65 with blood cancers who need total body irradiation as part of their transplant p…

This study is testing a program called MyCarePulse and ASCENT to help cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either receive the program or standard care. The goal is to see if the program improves food secur…

This study tests whether wearing a virtual reality headset during a bone marrow biopsy can reduce pain and anxiety. 160 adults with blood cancers will be randomly assigned to either standard care or standard care plus a VR headset. The goal is to see if this simple, non-drug tool…

This study tests a program called Step Up that combines in-person coaching with a mobile app to teach coping skills and encourage physical activity. It includes 177 adults who have had a stem cell transplant or CAR-T therapy for blood cancers like leukemia or multiple myeloma. Th…

This study tests a program called Nite2Day+ that uses mindfulness and sleep tips to help people with blood cancers sleep better and manage fatigue, stress, and pain. About 60 adults hospitalized for treatment will either get the program or standard care. The program includes a mo…

This study tests two oral medications—diosmin-hesperidin (a flavonoid supplement) and loratadine (an allergy drug)—to prevent bone pain caused by G-CSF, a drug that boosts white blood cells in blood cancer patients. Researchers will compare each drug alone and in combination agai…

This study tests whether eating all food within a 10-hour window each day can reduce severe, long-lasting fatigue in blood cancer survivors. About 96 adults who finished cancer treatment at least 2 months ago will either follow this time-restricted eating plan or receive standard…

This study tests whether a token-based exercise program called TEAM Me can help children and young adults (ages 6-29) with cancer stay active while undergoing a stem cell transplant. Participants earn stickers for walking and other activities, which they can trade for rewards. Th…

This study tests a program called Sentinel that trains stem cell transplant doctors to provide palliative care—like managing symptoms and coping strategies—as part of routine care. The goal is to see if it's feasible and acceptable for patients. Forty adults undergoing stem cell …

This study tests whether a special palliative care program (called PEACE) can improve quality of life for people with blood cancers like lymphoma, leukemia, or multiple myeloma who are receiving adoptive cellular therapy (ACT). About 90 participants will be randomly assigned to e…

This study tests whether a computer brain-training program (Lumosity) can improve memory and thinking in adults who had a stem cell transplant for blood cancer. About 60 survivors, 3 to 6 months after transplant, will either start training right away or wait 12 weeks. The goal is…

This study tests whether a mind-body group program can help reduce fatigue in people who have finished treatment for blood cancers like leukemia or lymphoma. The program includes relaxation, gentle exercise, and stress management techniques. Researchers will compare fatigue level…

This study tests a mobile app called THRIVE-CAR-T designed to support patients during CAR-T cell therapy. Researchers want to see if the app is easy to use and acceptable to patients. About 100 adults with blood cancer receiving CAR-T treatment will participate. The app provides …

This study tests whether specially trained nurses can help children with cancer and their families by starting conversations about palliative care early. About 120 children recently diagnosed with cancer will be randomly assigned to either receive these nurse-led talks or standar…

This study tests a special rehab program for adults with blood cancer who are getting a bone marrow transplant. The program includes exercise, nutrition support, and self-management skills starting before the transplant and continuing for 6 months after. Researchers want to see i…

This study tests whether giving blood transfusions at home is practical and acceptable for cancer patients who need regular transfusions. About 30 adults with blood cancers or bone marrow failure will receive 1-5 blood product units at home. Researchers will track how often trans…

This study tests whether combining a modified ketogenic diet (using a meal replacement drink) with online brain training can improve memory and thinking in blood cancer survivors. About 80 adults with mild to moderate cognitive issues will either get the combined program for 12 w…

This study looks at whether doing adapted physical activity every day can improve sleep quality in children aged 5 to 16 who are being treated for blood cancer. About 30 children will take part, with some exercising daily and others just once over four days. Parents will track sl…

This study tests a 6-session counseling program called BMT-CARE for caregivers of people receiving a bone marrow transplant. The goal is to see if it improves the caregiver's quality of life compared to standard support. The study will enroll 800 caregivers and also look at what …

This study looks at whether a 12-week home exercise program with remote coaching can help lymphoma survivors improve their heart and lung fitness and stay active after cancer treatment. About 80 adults who finished chemotherapy for lymphoma will either exercise at home with remot…

This study tests a new program that gives blood cancer patients access to blood transfusions at home while they receive hospice care. The goal is to see if this improves their quality of life, mood, and reduces hospital visits near the end of life. The trial will include 700 adul…

This study is testing whether hypnosis can reduce anxiety in adults recently diagnosed with certain blood cancers (lymphoma). Fifty participants will have their anxiety levels measured before starting hypnosis sessions and again after two and three sessions. The goal is to see if…

This study collects blood, tissue, and medical information from 240 cancer patients who have had serious side effects from immunotherapy. The goal is to store these samples in a national biorepository for future research. By studying these samples, scientists hope to better predi…

This study tests whether a video and personal guidance can help Black, Latinx, and older adults with cancer get genetic testing. Genetic testing is often needed to join precision cancer trials. The goal is to make trial enrollment more equitable. About 210 people with gastrointes…

This study collects blood, urine, bone marrow, and tumor samples from people with hairy cell leukemia and other blood cancers, as well as from healthy volunteers. Researchers will use these samples to study the diseases and develop new treatments called immunotoxins, which use an…

This study tests whether a telementoring program called ECHO can improve the quality of palliative care for advanced cancer patients in underserved areas of Kenya, Nigeria, Ghana, South Africa, India, and Ethiopia. Researchers will train local doctors through online clinics and w…

This study collects blood and tissue samples from 2000 people—some with cancer and some without—to create a blinded reference set. Researchers will use these samples to evaluate how well new blood tests can detect many types of cancer early. The goal is to improve the accuracy of…

This study collects blood samples from people with cancer or at high risk for cancer to create a large, well-organized repository for research. The goal is to provide scientists with a valuable resource to study cancer through liquid biopsies, which may lead to better detection a…

This study tests tumor tissue from up to 12,000 cancer patients to find gene changes (mutations). The goal is to match each patient with a clinical trial or therapy that targets their specific cancer type. Researchers will also build a database of mutations to help future patient…

This study is testing whether wearable activity trackers like Fitbits and iPhones can help predict when cancer patients undergoing radiation therapy might need emergency care or hospitalization. Researchers will collect step counts and other health data from 260 participants to b…

This study is building a large collection of blood, saliva, urine, stool, and tissue samples from people who are at increased risk of cancer, including those with genetic predispositions, survivors of childhood or adult cancer, or those with precancerous conditions. The goal is t…

This study tests a decision-support tool called PRIME for adults aged 60 and older with blood cancers like leukemia or lymphoma. The tool helps patients clarify their values and shares that information with their doctors. The goal is to see if using PRIME leads to treatment decis…

This study looks at whether simple frailty assessments can predict how older patients (60+) with acute leukemia or MDS will fare after intensive treatments like chemotherapy, CAR T-cell therapy, or stem cell transplants. Researchers will track frailty status and compare outcomes …

This study surveys pulmonologists across the US to understand how the COVID-19 pandemic changed their lung procedure practices, staffing, and operations. Researchers hope the findings will help guide future pandemic responses and improve care. About 250 doctors who are members of…

This study tracks 170 advanced cancer patients receiving anti-VEGF therapies to record side effects and see how the disease responds. Researchers hope to find patterns linking complications to treatment success. The goal is to help doctors better understand and manage these thera…

This study watches people with blood cancers like CLL who take BTK inhibitors or venetoclax to see how these drugs affect heart rhythm. Researchers will use EKGs, stress tests, and heart monitors to track abnormal rhythms and sudden death risk. The goal is to better understand an…

This study looks at whether social support can protect against accelerated biological aging in people who have had a hematopoietic cell transplant (a stem cell transplant for blood cancers). Researchers will measure markers of cellular aging in blood samples and compare them with…

This study collects blood samples from children and adults receiving the chemotherapy drug busulfan before a stem cell transplant. The goal is to compare a new, faster test with standard lab methods for measuring drug levels in the blood. If the new test works well, it could help…

This study tests whether a survivorship care plan is practical for blood cancer patients who have had a stem cell transplant. Researchers will track how many patients stick with the program and measure their quality of life, unmet needs, and caregiver burden. The goal is to see i…

This study looks at whether blood cancer patients with a serious infection can safely stop antibiotics sooner if they are stable for 72 hours, instead of the usual 10-day course. About 172 adults will be randomly assigned to either a personalized short course or standard long cou…

This study looks for better ways to detect lung inflammation and infections early in people who have received a stem cell transplant from a donor. About 40 participants aged 5 to 70 will get regular lung scans, breathing tests, blood draws, and a procedure where a tube collects f…

This study follows about 546 people who have already received a Galapagos CAR T-cell therapy for blood cancers. Researchers will check for long-term side effects and how well the treatment works over 15 years. No new treatment is given—just regular monitoring to meet safety guide…

This study looks at the genes in cancer tumors to find mutations that might be important for how the cancer grows. Researchers will use leftover tissue from surgeries or biopsies, along with a blood or saliva sample, to compare cancer genes to normal genes. The goal is to underst…

This study asks 3000 teens and young adults (ages 15-39) with cancer, along with their caregivers, to answer survey questions about body image, fertility, and financial stress. The goal is to create better tools to measure quality of life for future patients. Participants include…

This study follows 500 adults in the Languedoc-Roussillon region of France who have or are suspected of having a blood cancer (hematologic malignancy). Researchers will collect medical records, blood samples, and quality-of-life questionnaires to track survival at 2, 5, and 10 ye…

This study follows 100 children and young adults who received CAR T cell therapy to understand short- and long-term side effects like infections, slow blood cell recovery, and nerve problems. Researchers will check participants at 3, 6, 12, and 24 months after treatment. The goal…

This study looks at whether we can safely remove the "beta-lactam allergy" label from blood cancer patients who are not truly allergic. By doing so, doctors can use more effective antibiotics. The study will enroll 3,800 hospitalized adults with blood cancers and a reported aller…

This study looks at blood samples from 350 adults with blood cancer who develop a fever and have very low white blood cells (a condition called febrile neutropenia). The goal is to find patterns of proteins in the blood that can predict if a patient will develop serious complicat…

This study is collecting information on side effects from proton therapy in 5,000 adults with many types of cancer. Researchers will track both short-term and long-term side effects and link them to the details of each patient's treatment plan. The goal is to better predict who m…

This study looks at whether watching a short video can help people understand cancer clinical trials better and feel more willing to join one. About 384 adults in the Detroit area will take a quiz before and after the video to see if their knowledge and interest change. The goal …

This study aims to understand how well the seasonal flu vaccine works in children with blood cancers like leukemia. Researchers will measure the immune response in up to 150 children at St. Jude Children's Research Hospital. The goal is to see if the vaccine triggers enough prote…

This study tests a new communication tool called 'Let's Get REAL' that helps children and teens (ages 8-17) and their families talk together about stem cell transplant or cellular therapy decisions. The goal is to see if the tool is easy to use and helpful for families. About 60 …

This study tests whether a patient navigator (a health coach) and a website called PACT help blood cancer survivors who had a stem cell transplant plan their future medical care. About 40 adults who are 1 to 5 years post-transplant will be assigned to usual care, the website, the…

This study looks at how the body processes venetoclax when the tablet is crushed and mixed into a liquid. It includes 30 children and young adults with blood cancers who already take venetoclax this way. The goal is to measure drug levels in the blood and spinal fluid to ensure t…

This study collects blood and tissue samples from 200 adults with HIV and certain cancers (like Kaposi sarcoma, lymphoma, or anal cancer) to help researchers understand how HIV and cancer are connected. Participants donate samples, which are stored for future research. There is n…

This study looks at how the COVID-19 pandemic impacted the emotional, financial, physical, and social well-being of adolescent and young adult (AYA) cancer patients and survivors. Researchers will survey 600 participants to measure COVID-related distress and changes in health beh…

This study brings together a panel of prostate cancer specialists to agree on the most important pieces of information that should be included in medical records. The goal is to create a standard way to report key data, making it easier for doctors to manage patients from diagnos…

This study looks at how a stem cell transplant changes a person's DNA and how that affects drug dosing. Researchers will collect blood, skin, hair, and other samples from 88 adults before and after transplant. The goal is to find the best way to test a patient's genes for safe an…

This study collects blood and tumor samples from 700 adults receiving approved CAR-T therapy for blood cancers. Researchers will analyze these samples to identify biological markers that predict whether the therapy will work or if the cancer will return. The goal is to improve fu…

This study follows 100 adults with blood cancers (like lymphoma or leukemia) who receive whole brain radiation. Researchers will test memory, thinking, and quality of life over time using MRI scans and questionnaires. The goal is to understand how radiation affects the brain, not…

This study aims to find early signs that a patient is developing serious complications, like cytokine release syndrome, after immunotherapy for blood cancer. Researchers will track vital signs and immune responses in 100 adults receiving CAR-T or bispecific antibody therapy. The …

This study is a worldwide registry that follows 5,000 adults with breast cancer, blood cancers, or those on immune checkpoint inhibitors. Researchers collect medical records, lab results, and imaging to identify who is at risk for heart problems during or after cancer treatment. …

This study looks at genetic changes in people with early-stage blood cancers or conditions that may lead to cancer. Researchers will analyze blood, bone marrow, or cheek cell samples from up to 10,000 participants to find DNA errors linked to cancer risk and progression. The goal…

This study is collecting information from 100 adults with blood cancers who receive CAR-T therapy, radiation therapy, or both within a 90-day window. Researchers will review medical records to track outcomes like disease progression, side effects, and survival. The goal is to lea…

This study tests whether using artificial intelligence (AI) to rewrite medical discharge letters into plain language helps cancer patients better understand their diagnosis, treatment, and next steps. About 150 adults with blood cancer or other cancers will be randomly assigned t…

This study enrolls up to 10,000 adults with cancer to see how a special team of experts (a molecular tumor board) uses genetic testing to recommend personalized treatments. Researchers will track whether doctors follow these recommendations and if patients benefit. The goal is to…

This study follows children and teens who had radiation to the brain before age 16 to check for hormone problems. Researchers will measure hormone levels and track fatigue to create better follow-up guidelines. About 230 participants in remission from cancer will be monitored for…

This research study collects blood, bone marrow, and tissue samples from people with cancer, blood disorders, and healthy volunteers. The goal is to study how the immune system changes during different treatments, including immunotherapy and chemotherapy. By comparing samples fro…

This study is collecting medical data and biological samples from 15,000 people receiving radiation therapy for solid tumors or blood cancers. Researchers aim to understand how radiation affects quality of life, side effects, and survival. The goal is to learn from real-world out…

This study will analyze the genes of 25,000 adults who have cancer or are at risk for it. Researchers will use advanced testing to find genetic changes linked to cancer and track health records over time. The goal is to learn more about cancer biology and discover new ways to per…

This study from Mayo Clinic is looking at how the bacteria in your gut (the microbiome) might influence how well cancer treatments work. Researchers will collect blood and stool samples from 3,000 cancer patients undergoing therapy or stem cell transplants. The goal is to find li…

This study looks at how sleep and physical activity change for blood cancer patients and their caregivers after a stem cell transplant. Researchers will use a Fitbit to monitor activity, sleep, and heart rate, and ask participants to complete questionnaires about their quality of…

This study looks at whether people with multiple myeloma who have achieved a very deep remission (called MRD-negative) can stop their maintenance therapy without the cancer coming back quickly. It involves 70 adults who have been on maintenance therapy for at least two years. Res…

This study looks at 320 adults who are about to start strong immune-suppressing therapy and have already had at least two COVID-19 shots. Researchers want to find out if giving a COVID-19 booster right before starting therapy or waiting six months provides better protection. Part…

This study looks at how antibiotics given during a stem cell transplant change the bacteria in your gut. Researchers will track these changes in 255 adults getting a transplant for blood cancers or bone marrow failure. The goal is to understand the link between antibiotics and gu…

This study is looking at 2,000 people who have early warning signs of blood cancers or bone marrow failure. Researchers use a special genetic test (next generation sequencing) to find changes in cancer-related genes. The goal is to better understand who is at risk and to catch th…

This study looks at whether adding an oncology research navigator (ORN) to standard cancer navigation helps patients with cancer. About 686 adults with new cancer appointments will take part. Some will get the usual navigation, while others also get an ORN who helps them find sup…

This study aims to find biological markers (biomarkers) that can predict how well patients will respond to treatment for a serious complication called gut graft-versus-host disease (GvHD) after a stem cell transplant for blood cancer. Researchers will collect samples from 90 pati…

This study tests whether an AI-powered chatbot can help people with blood cancers like leukemia and lymphoma better understand clinical trials and feel more willing to join them. Researchers will compare patients who get standard education plus AI chatbot sessions to those who on…

This study looks at how metabolism in cancer and immune cells influences the bone marrow environment and treatment resistance in blood cancers like leukemia and myelofibrosis. Researchers will analyze samples from 350 participants to measure metabolites, lipids, and gene activity…

This study aims to find out if certain blood markers can predict how well cancer patients respond to immunotherapy. Researchers will collect blood samples from 1500 people with different types of cancer before and during treatment. Participants will be followed for up to 6 months…

This study is testing whether cancer patients undergoing chemotherapy can use an iPhone app and Apple Watch to report symptoms from home. Researchers will enroll 100 adults with solid tumors or blood cancers to see if they can consistently use the technology. The goal is to learn…

This study tracks 100 cancer survivors aged 18–74 to see how common muscle loss (sarcopenia) and cognitive problems ('chemo brain') are after treatment. Participants undergo physical and mental assessments. The goal is to better understand these long-term side effects and guide p…

This study is testing whether an artificial intelligence (AI) tool can help match cancer patients with the right clinical trials. Researchers will enroll up to 50,000 people with various cancers to see if the AI improves trial enrollment rates and patient outcomes. The goal is to…

This study looks at how cancer affects not just patients, but their entire family. Researchers will survey 240 Danish patients with breast, prostate, colorectal cancer, or lymphoma, along with their caregivers. They will measure family health, stress, depression, and quality of l…

This study looks at whether CAR-T cell therapy, a new immunotherapy for blood cancers like leukemia and lymphoma, can cause early heart problems. Researchers will measure heart function with ultrasound before and a few days after treatment in 60 patients. The goal is to find out …