New PET scan tracer aims to spot blood cancers more clearly
NCT ID NCT07670949
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing a new radioactive tracer called 68Ga-EV203 for PET/CT scans in people with blood cancers like multiple myeloma, lymphoma, and leukemia. The goal is to see how the tracer spreads in the body, how much radiation it gives off, and whether it can find tumors better than the standard FDG tracer. Thirty participants will receive one injection and have four scans over two hours, plus a follow-up FDG scan a few days later.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- 68Ga-EV203 injection (a radioactive tracer for PET/CT imaging)
- What this could lead to
- If successful, this could lead to a more accurate imaging method for detecting certain blood cancers, potentially improving diagnosis and treatment planning.
- What could go wrong
- This is an early-phase study with only 30 participants, so results may not apply to everyone. The new tracer may not prove significantly better than existing scans, and there are unknown risks from the radioactive injection.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2026
- Expected to finish
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Jun 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 18 to 75 years (inclusive) at screening. * Able to lie still on the scanning bed for 0.5 hours. * Willing to sign informed consent and able to comply with protocol requirements. * Histologically/cytologically confirmed diagnosis of multiple myeloma (MM), non-Hodgkin lymphoma (NHL), or acute myeloid leukaemia (AML) according to the 2022 WHO Classification of Haematolymphoid Tumours. Exclusion Criteria: * Has claustrophobia or any other condition that prevents tolerance of imaging procedures * Has undergone major surgery within 3 months prior to screening, or plans to undergo surgery during the study period. * Has received any other radiopharmaceutical imaging agent or therapeutic radiopharmaceutical within 30 days prior to screening. * Is pregnant or lactating at screening. * Is a woman of childbearing potential or a man who does not agree to use effective contraception during the study (from signing informed consent) and for 3 months after study drug administration. * Has a known allergy to alcohol or any component of the investigational product, or has other allergies judged by the investigator to increase the participant's risk. * Has clinically significant cardiovascular disease within 6 months prior to screening (e.g., myocardial infarction, unstable angina, symptomatic congestive heart failure, uncontrolled severe arrhythmia). * Has uncontrolled hypertension, or a history of coagulopathy or coagulation disorders. * Has been diagnosed with another malignancy (other than the target haematological disease) within 5 years prior to 68Ga-EV203 administration. * Has received any systemic anti-cancer therapy within 2 weeks prior to planned 68Ga-EV203 administration, or radiotherapy within 8 weeks prior to planned administration. * Has any other condition that, in the investigator's judgment, makes the participant unsuitable for participation in the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Zhejiang Cancer Hospital
RECRUITINGHangzhou, Zhejiang, 310022, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Bispecific antibody combo aims to deepen myeloma responses
- Can a stronger drug cocktail give older myeloma patients a better start?
- Can a p53-Targeting drug boost chemotherapy in Hard-to-Treat blood cancers?
- Cheap blood count ratios eyed as window into Myeloma's inflammatory grip
- Can a t-cell engager rescue myeloma that outsmarted CAR-T?
- Can myeloma treatment work without steroids?