Centre Hospitalier Universitaire Dijon

This study tested a drug called sirolimus in 16 people with a rare condition causing parts of their body to grow too much due to a PIK3CA gene change. The goal was to see if sirolimus could stop or slow this overgrowth. Participants took the drug and were monitored with scans and…

This study looked at whether a two-year intensive monitoring program involving nurses, doctors, and pharmacists could improve outcomes for people who had a stroke or heart attack. The program aimed to better control risk factors like high blood pressure and cholesterol, prevent c…

This early-phase study tested a new way to deliver a chemotherapy drug (idarubicin) directly to liver tumors in 15 people with advanced liver cancer that could not be surgically removed. The drug was mixed with a special oil (lipiodol) and injected into the liver artery to concen…

This study tested whether using a special CO2 measurement (called pCO2gap) to guide treatment of high lactate levels in shock patients works better than standard care. High lactate can signal poor blood flow, but current methods don't always pinpoint the cause. The trial involved…

This study looked at how well a drug-coated balloon works for people with blocked arteries above the knee. The goal was to see if it improves walking ability and reduces pain. About 293 adults in France took part, and the results will help doctors understand if this treatment is …

This study tested whether adding the cholesterol-lowering drug pravastatin to the standard cancer drug sorafenib could help people with advanced liver cancer live longer. It included 474 adults with Child-Pugh A cirrhosis who could not have curative treatments. The goal was to se…

This study looked at 405 ICU patients with sudden kidney failure who needed dialysis through a temporary catheter. It compared two solutions used to keep the catheter working: citrate and heparin. The goal was to see which solution helps the catheter last longer without problems.

This study looked at whether a special PET/CT scan of the head arteries can accurately diagnose giant cell arteritis, a condition that causes inflamed blood vessels in adults over 50. Currently, doctors often need to do a small biopsy (taking a tiny piece of tissue) from the temp…

This study tested a powerful genetic test called exome sequencing to find the cause of severe epilepsy with developmental delays in 15 children whose standard tests were normal. The goal was to see if this approach could identify more genetic causes and improve genetic counseling…

This study tested whether the anesthetic sevoflurane protects the heart more than propofol during planned aortic valve replacement surgery. 82 adults having open-heart surgery were randomly assigned to receive one of the two drugs. The main goal was to measure troponin levels, a …

This study tested whether using no opioids during heart surgery could lower the need for morphine afterward and reduce complications. 110 adults having heart surgery with a heart-lung machine took part. The approach aimed to control stress and inflammation with other drugs, avoid…

This study tested whether doing laser treatment for diabetic eye disease in one session is better than splitting it into four sessions. 83 adults with diabetes and early severe eye changes took part. The main goal was to see if one session causes less swelling in the center of th…

This pilot study tested whether low-frequency repetitive transcranial magnetic stimulation (rTMS) to a specific brain area could reduce cravings in heavy smokers who had failed multiple quit attempts. 39 highly nicotine-dependent adults received rTMS alongside nicotine replacemen…

This study tested a new method to adjust cochlear implant settings using a computer algorithm. Nine adults with one cochlear implant and a hearing aid in the other ear participated. The goal was to see if changing how sound frequencies are assigned could improve speech understand…

This study tested a new method to adjust cochlear implant settings for people who are deaf in one ear but have some hearing in the other. The goal was to help them understand speech better in noisy environments. Researchers used a computer algorithm to find the best frequency set…

This study tests whether a non-invasive brain stimulation technique called TMS can help people quit smoking and avoid relapsing. About 88 adult smokers who have tried and failed to quit before will receive either real or fake TMS sessions, first daily then weekly, to reduce cravi…

This study tested whether a full-body bandage can help reduce fluid buildup in ICU patients with severe sepsis or septic shock. The idea is that compression might limit fluid leakage from blood vessels, improving fluid balance and possibly outcomes. 64 patients on mechanical vent…

This study tested whether monitoring pupil size during heart surgery helps doctors give less opioid pain medicine. 50 adults having planned heart surgery were included. The goal was to see if this approach reduces total opioid use while keeping patients comfortable and safe.

This study looked at whether using virtual reality and tablet games can improve movement and thinking in frail older adults. 37 people in a rehabilitation program either did standard training or played specially designed games. The goal was to see if the game group would have bet…

This study looked at whether adding a painkiller called tramadol to a local anesthetic delivered through a small tube near the surgical wound could reduce the need for morphine after heart surgery. The trial involved 160 adults undergoing heart surgery through a breastbone incisi…

This study looked at 60 parents of infants at high risk for cerebral palsy, such as premature babies or those with certain brain injuries. Researchers measured parental stress, satisfaction, and how often families used healthcare services during the first two years after the baby…

This study looked at whether tasting fatty acids triggers the release of gut hormones in healthy people, and if this response is different in those with type 2 diabetes or obesity. Researchers measured hormone levels in the blood after a taste test and also checked each person's …

This study looked at how diabetes changes the way fatty acids are processed in artery plaques of the neck. Researchers compared plaque samples from 204 diabetic and non-diabetic patients undergoing surgery. The goal was to understand why diabetic plaques are more inflamed and lik…

This study reviewed 198 patients who received a sutureless aortic valve to see if they developed heart rhythm problems after surgery. The goal was to better understand the risks of these newer, easier-to-implant valves. No new treatments were tested; the study simply looked back …

This study looked at the use of antiTNFα drugs in pregnant women with inflammatory bowel disease (IBD) to see if doctors followed guidelines and what the risks and benefits were for both mother and baby. Researchers analyzed data from over 8,700 pregnancies in France between 2011…

This study looked at whether GLP-1 agonist drugs (like liraglutide) can reduce fat buildup in the hearts of people with type 2 diabetes. 42 adults over 50 with diabetes and at least one heart risk factor were enrolled. Researchers used MRI scans to measure heart fat before and af…

This study looked at the sticky layer (biofilm) that forms inside breathing tubes of ICU patients on ventilators. Researchers wanted to see if the biofilm's structure and germs are linked to a higher chance of developing pneumonia. The study involved 61 adults who had been on a v…

This study looked at how being socially or economically vulnerable affects patients in intensive care units (ICUs). Researchers followed 1,417 patients in France to see if those with fewer resources had worse health when admitted and poorer recovery. The goal is to use this infor…

This study examined how psychological and ethical support affected the mental health of over 4500 hospital professionals during the COVID-19 crisis. Researchers measured stress levels using a standard questionnaire. The goal was to understand what support worked best and how it c…

This study looked at 598 people who had surgery to remove colorectal cancer. Researchers wanted to learn how often the cancer comes back after five years. By understanding this, doctors hope to create better follow-up plans and improve survival.

This study looked at 165 patients in the intensive care unit after major abdominal or urinary surgery. Doctors used lung ultrasound to measure fluid in the lungs, along with heart ultrasound, to see if it could predict who would develop severe breathing problems. The goal was to …

This study looked at 40 adults with lumbar spinal stenosis (a narrowing in the lower spine that causes pain and trouble walking) who were scheduled for surgery. Researchers measured how fast they could walk before and after the operation using a 6-minute walk test. The goal was t…

This study looked at 543 people who survived severe COVID-19 lung damage (ARDS) to see how their social and economic background affected their recovery. Researchers measured physical and mental health six months after leaving the hospital. The goal is to create personalized suppo…

This study checked the mouth and teeth of 110 adults with schizophrenia in France. Researchers did a dental exam, took a blood sample to check vitamin C levels, and asked about dental care and eating habits. The goal was to understand their oral health and find ways to help.

This study examined how the body processes fats (lipids) in patients with severe pneumonia caused by COVID-19 versus other germs. Researchers wanted to see if fat metabolism changes are linked to obesity, inflammation, and patient outcomes. The study included 62 adults with sever…

This study looked at 72 people with lumbar stenosis, a condition where the spine narrows and causes leg pain when walking. Researchers wanted to see if decompression surgery (which relieves pressure on nerves) also improves forward-leaning posture. They measured spine alignment b…

This study aims to understand why dapagliflozin, a diabetes medication, can increase bad cholesterol levels in people with type 2 diabetes. Researchers will track how the body produces and removes cholesterol in 28 patients over 6 months. The findings could help doctors choose th…

This study looked at how often low blood sugar (hypoglycemia) happens in elderly diabetic patients living in nursing homes. Researchers used continuous glucose monitors to track blood sugar levels in 29 participants over 60 years old. The goal was to find out how common these eve…

This study looked at 770 adults who had pancreas surgery to see if measuring an enzyme called lipase in their surgical drains could help doctors spot a common complication called pancreatic fistula earlier. A pancreatic fistula is a leak of digestive juices that can cause serious…

This study looked at two different ways to treat sudden bleeding under the retina in people with age-related macular degeneration (AMD). One approach was surgery followed by anti-VEGF injections, and the other was a gas bubble injection followed by anti-VEGF injections. The goal …

This study looked at health records of over 4 million children aged 0 to 5 in France to estimate how often physical abuse occurs and what leads to it. Researchers used existing national databases to find cases of abuse and compare them with other children. The goal was to better …

This study examined how the COVID-19 lockdowns changed health habits and medication use in over 1,300 people with chronic conditions like heart disease, multiple sclerosis, and macular degeneration. Researchers wanted to understand if isolation, stress, and difficulty accessing c…

This study looked at whether personality type (Type A or B) is linked to foot wounds in people with type 2 diabetes. Researchers compared 66 patients with and without foot wounds using a simple questionnaire. The goal was to see if psychological profile affects wound development,…

This study looked at 202 people who had surgery for retinal detachment, a condition where the light-sensitive layer at the back of the eye pulls away. Researchers used high-tech eye scans to see how the retina heals and how that relates to vision improvement. The goal was to bett…

This study tested whether using simulation (like role-play or practice scenarios) in patient education helps adults with insulin-dependent diabetes learn to use the FreeStyle Libre glucose monitor. 27 patients who had already completed standard training took part. The goal was to…

This study looked at 39 people with a rare skin condition called syndromic poikiloderma, which also affects other parts of the body. Researchers used advanced genetic tests to find new genes that cause the condition. The goal is to give patients a clear diagnosis, better follow-u…

This study tested a fast genetic test (exome sequencing) on 61 fetuses with ultrasound abnormalities to see if it could quickly find the cause. The goal was to help parents understand the problem and make decisions during pregnancy. The study also looked at how parents feel about…

This completed study examined the link between dietary polyunsaturated fatty acids and colorectal cancer risk in 551 adults aged 45 and older. Researchers measured fatty acid levels in abdominal fat and red blood cells to find reliable biomarkers. The goal was to better understan…

This study looked at how families of children with rare developmental disorders feel about receiving extra or unclear results from advanced genetic testing. Researchers surveyed and interviewed over 500 parents to understand their preferences and experiences. The goal is to help …

This study looked at how well the Cor-Knot® device works during heart valve surgery. The device automatically ties knots in the stitches that hold the new valve in place, which may shorten surgery time. Researchers collected information from 557 adults to check for leaks around t…

This study looked at whether measuring muscle thickness in the thigh and breathing muscles with ultrasound before heart or lung surgery can help predict complications like kidney failure, breathing trouble, or infection. Researchers followed 301 patients aged 65 and older. The go…

This study looked at whether the COVID-19 lockdowns in France caused delays in treating diabetic foot ulcers, leading to more amputations. Researchers analyzed over 3 million hospital stays of diabetic patients from 2017 to 2020. They compared amputation rates before, during, and…

This study looked at the fluid between cells (interstitial fluid) in 26 intensive care patients with septic shock or non-septic shock. The goal was to understand how this fluid changes during sepsis, which could explain why severe swelling occurs. Researchers measured components …

This study aims to develop a test that uses time estimation to detect early emotional disorders in people with neurological diseases. Researchers first need to establish normal reference values by testing 150 healthy volunteers aged 20 to 92. Participants watch emotional video cl…

This study explored whether the amount of omega-3 fatty acids in premature babies' bodies is linked to a serious eye condition called retinopathy of prematurity (ROP). Researchers measured omega-3 levels in 62 premature infants born before 29 weeks. The goal was to see if higher …

This study looked at 34 older adults who had fallen recently to see if ankle muscle strength is related to balance. Researchers measured ankle strength and balance using special tests. The goal is to find better ways to screen for fall risk and design exercises to strengthen weak…

This study compared two high-tech embryo culture systems used in IVF with ICSI. The goal was to see which system leads to more embryos successfully implanting in the womb. 388 people took part, and researchers tracked implantation rates and miscarriage rates.

This study looked at 26 very premature babies (born before 32 weeks) to see if a non-invasive light monitor (NIRS) could detect changes in a key heart vessel (the ductus arteriosus) as well as ultrasound does. Researchers compared NIRS readings of oxygen in the brain and kidneys …

This study looked at a type of immune cell called regulatory T cells in people with giant cell arteritis (Horton's disease), a condition that causes inflamed blood vessels. Researchers wanted to see if these cells are not working properly, which could lead to better treatments. T…

This study looked at 278 adults on a heart-lung machine (VA ECMO) to find out why some patients have dangerous bleeding. Researchers collected information on patients' health history, treatments, and lab results at the start of support. The goal was to identify early warning sign…

This study looked at whether a continuous glucose monitor (Freestyle Libre) can help track blood sugar levels in diabetic patients who are starting chemotherapy. About 103 adults with diabetes and cancer participated. The goal was to see how often blood sugar went too low or too …

This study looked back at medical records of 65 people who had a cardiac arrest that didn't respond to standard CPR and were placed on a heart-lung machine (ECLS). The goal was to find factors that might predict who survives. Researchers checked things like how long the heart was…

This study looked at how often vein congestion (backed-up blood in veins) happens in intensive care patients and whether it leads to organ problems like kidney or liver failure. Researchers observed 185 adults in the ICU, checking for signs of congestion using ultrasound and othe…

This study looked at how immune cells change in people with coronary atherosclerosis (plaque buildup in heart arteries). Researchers compared blood samples from 61 heart surgery patients with and without plaque to find a new way to detect these changes without invasive procedures…

This study looked at how certain immune cells, called T CD8 lymphocytes, might be involved in Horton's disease, a condition that causes inflammation in blood vessels. Researchers examined blood samples and artery biopsies from 30 patients to measure these cells and other markers.…

This study looked at whether malnutrition makes it harder for foot sores to heal in people with diabetes. Researchers followed 75 patients with type 1 or 2 diabetes who had a foot sore for 1 to 24 months. They measured how many sores healed and checked how many patients were maln…

This study looked at whether nutritional status influences death risk in adults aged 70 and older hospitalized with COVID-19. Researchers compared patients with and without the virus to see if poor nutrition made outcomes worse. The goal was to better understand why older adults …

This study tested a special rocking chair designed to stimulate the body's balance system (vestibular system) in 30 adults. The goal was to see if the chair could make people consciously feel movement and cause eye reflexes, helping researchers better understand balance disorders…

This study analyzed 360,000 French patients who received eye injections for conditions like age-related macular degeneration or diabetic eye swelling. Researchers tracked how many developed endophthalmitis, a serious eye infection, within 28 days after the injection. The goal was…

This study looked at 36 intensive care patients to see if severe infections (sepsis) change how immune cells produce energy. Researchers focused on mitochondria, the cell's power plants, in monocytes and macrophages. The goal was to understand why some patients' immune cells beco…

This study reviewed the records of 1772 adults who had heart surgery with a heart-lung machine. Researchers compared those who received opioid-free anesthesia (using lidocaine and other drugs) to those who got standard opioid anesthesia. The goal was to see if avoiding opioids le…

This study looked at how people with long-term mental disorders and their caregivers can work together to reduce heart disease risks. Researchers interviewed 127 participants to understand their experiences and ideas. The goal is to design better care that involves patients and c…

This study looked at 50 people who had a recent ischemic stroke (a clot blocking blood flow to the brain). Researchers measured levels of a protein called BDNF in their blood before and after they received a standard clot-busting drug (rt-PA). The goal was to see if BDNF levels r…

This study looked at whether improving blood sugar levels can help a protein called apoC1 work better to manage cholesterol in people with type-1 diabetes. Researchers compared 160 patients with poorly controlled diabetes to 80 healthy controls. They measured blood samples to see…

This study aimed to find out how often fatigue happens after a stroke and what might cause it, including the effects of early treatments. Researchers followed 126 adults who had a recent stroke. The goal was to help doctors better understand and address this common, disabling sym…

This study looked at 67 women who experienced domestic violence to see if a specialized center (Maison des Femmes) helps reduce post-traumatic stress disorder (PTSD) more than a regular shelter. The researchers measured PTSD rates at the start and again 6 months later. The goal i…

This study looked at 39 hospitalized COVID-19 patients to measure their immune system's T-cell response. The goal was to see if a strong immune reaction is linked to worse symptoms. Researchers hope this helps understand why some people get very sick.

This study tested a new questionnaire to understand how people with schizophrenia feel about their oral health. Researchers asked 59 patients to fill out surveys about their teeth, gums, and quality of life. The goal is to create a reliable tool that can help doctors design bette…

This study tested a new DNA test called high-throughput exome sequencing on 100 fetuses with multiple birth defects whose cause was unknown after standard exams. The test looks at all the coding parts of DNA to find genetic causes. Researchers compared how many extra diagnoses th…

This study looked at 552 adults who had planned colorectal surgery to see if a blood test called procalcitonin could detect infections earlier than the standard C-reactive protein (CRP) test. The goal is to catch complications like internal infections sooner, which could lead to …

This study looked at whether the liquid used to keep dialysis catheters open (heparin or citrate) leaks into the bloodstream. 76 adults with acute kidney failure were checked before and after the lock was injected. The goal was to see if leakage affects bleeding risk or calcium l…

This study looked at fluid samples from the eyes of 137 people undergoing surgery for retinal detachment or other macular conditions. Researchers measured fats and proteins in the fluid to understand inflammation and cell damage. The goal is to find clues that could lead to bette…

This study looked at why obese women may have trouble during childbirth. Researchers took blood and uterine tissue samples from 38 women having C-sections. They studied how certain cells and chemicals affect the uterus's ability to contract. The goal was to better understand the …

This study tested a new plan to manage patients who have high levels of C-reactive protein (CRP) after surgery for colorectal cancer. High CRP can signal a dangerous leak where the intestine was reconnected. The goal was to see if a proactive care plan could help these patients l…

This study looked at 748 adults having retina or vitreous eye surgery to see if taking blood thinners (anticoagulants or antiplatelet drugs) increases the risk of dangerous bleeding during or after the operation. The goal was to find out whether it is safe to continue these medic…

This study looked at how the beliefs and attitudes of doctors, nurses, and other caregivers influence the success of therapeutic education programs for people with mental health conditions like schizophrenia. Researchers interviewed 21 caregivers to understand what helps or hinde…

This study looked at how patients in the ICU, their family and friends, and the healthcare team decide who should be the contact person. The goal was to see if they use the same criteria. 42 people participated by filling out questionnaires. The results help understand how to bet…

This study tested a new thinking and memory exam called the CASP, designed for stroke patients who have trouble speaking or understanding language. The goal was to see if the test works well and gives reliable results. Researchers studied 263 people, including stroke survivors an…

This study looked at 101 ICU patients to see if stopping their tube feeding before removing a breathing tube affects stomach fullness. Doctors used ultrasound to measure stomach content. The goal was to find ways to lower the risk of food or liquid entering the lungs during tube …

This study examined blood samples from 300 people to see if depression is linked to faster cell aging. Researchers measured telomere length and stress levels in white blood cells. The goal was to find genetic markers that could help doctors better understand the severity and phys…

This study tested whether virtual reality (VR) is safe and tolerable for people with a leg amputation and for healthy volunteers while walking on flat ground and slopes. Researchers want to see if VR can help improve rehabilitation and reduce falls. The study included 25 healthy …

This study looked at the immune cells of people with autoimmune hemolytic anemia, a condition where the body attacks its own red blood cells. Researchers compared blood samples from 27 patients and healthy volunteers to understand how certain T cells behave. The goal was to learn…

This study looked at whether giving water through a feeding tube can help stabilize blood flow in ICU patients on breathing machines, compared to standard IV saline. 50 adults with low blood pressure were included. The goal was to see how water affects heart function and to gathe…

This study looked at 210 pregnant women hospitalized for threatened preterm labor between 24 and 34 weeks. Researchers measured specific immune cells in the blood to see if they could predict which women would deliver within 7 days. The goal is to find better markers than current…