Centre Hospitalier Universitaire Dijon

This study tests if a weekly injection of semaglutide (a GLP1 drug used for type 2 diabetes) can help people with 'double diabetes' — a mix of type 1 diabetes and inherited insulin resistance. About 76 adults with type 1 diabetes, a BMI of 27 or higher, and a family history of ty…

This study tests a new breathing machine strategy for people with a specific type of severe lung injury called focal ARDS. The strategy uses lung ultrasound to guide settings and includes techniques to reopen collapsed lung areas. The goal is to reduce the number of days patients…

This study tests whether a medication called OM-89 (made from parts of E. coli bacteria) can reduce the number of antibiotics needed for urinary tract infections (UTIs) in people with neurogenic bladder. About 110 adults who use catheters and have had at least 6 UTI treatments in…

This study tests whether adding argipressin to standard norepinephrine treatment helps people in intensive care with severe vasoplegic shock (a type of shock where blood vessels widen dangerously). About 390 adults will be randomly assigned to get argipressin or a placebo alongsi…

This study tests whether a chemotherapy combination called FOLFIRINOX works better than the standard platinum-etoposide regimen for people with advanced, aggressive neuroendocrine cancer of the digestive system or unknown origin. About 218 participants will receive one of the two…

This study tests a drug called alpelisib in 20 people aged 2 to 40 with MCAP syndrome, a rare condition causing an enlarged brain and developmental delays. For the first 6 months, some get the drug and some get a placebo to see if it improves daily living skills like communicatio…

This study is testing a new device that acts like a tiny blood vessel to measure how well a person's blood clots under realistic flow conditions. Researchers want to see if it can better identify bleeding risk in people with von Willebrand disease, platelet disorders, or those ta…

This study is testing whether a new blood test that measures a protein called hPG80 can help detect neuroendocrine tumors (NETs) earlier in people with MEN1, a rare genetic condition that raises the risk for these tumors. About 297 participants with MEN1 will give blood samples, …

This study looks at whether measuring a protein called thrombomodulin in the blood can help doctors rule out giant cell arteritis (GCA) in people with polymyalgia rheumatica (PMR). About 78 adults over 50 with PMR will give a blood sample before starting steroids. If the test wor…

This study aims to reduce the long and frustrating search for a diagnosis in people with developmental abnormalities. Researchers will look back at past cases and also offer new, advanced genetic tests (like whole genome sequencing) to find the cause. The goal is to give patients…

This study aims to find the most effective way to screen for diabetes in people who take glucocorticoids (steroids) for more than three months. Steroids can raise blood sugar and cause diabetes, but current screening methods vary. Researchers will compare three tests—fasting bloo…

This study tests whether taking a blood thinner for 12 weeks can prevent dangerous blood clots in people with autoimmune hemolytic anemia (AIHA), a rare disease where the immune system destroys red blood cells. About 72 adults with newly diagnosed or relapsed AIHA will be randoml…

This study tests whether gentle muscle vibration can prevent or reduce muscle stiffness (spasticity) in people who recently had a stroke. Researchers will compare standard rehabilitation plus vibration versus standard rehab plus a placebo vibration in 100 early-stage stroke patie…

This study tests whether virtual reality (VR) therapy can improve walking and movement in elderly people with psychomotor disadaptation syndrome, a condition that makes moving safely difficult and raises fall risk. Fifty hospitalized patients aged 65 and older will either receive…

This study tests whether adding motor imagery—mentally practicing movements without actually doing them—to a standard 3-week rehab program helps people with chronic low back pain improve their movement control and quality of life. About 72 adults with pain lasting over 6 months w…

This study tests whether lithium carbonate, a drug used for mood disorders, can improve behavior and thinking in people with a rare genetic condition caused by changes in the TBR1 gene. The trial will include 12 participants aged 6 and older who will take lithium for 24 months. R…

This study tests whether a non-invasive brain stimulation technique called tDCS can help people who have lost control over their internet gaming. Researchers will give 50 participants five sessions of tDCS or a fake treatment and measure changes in gaming behavior. The goal is to…

This study is testing a new smartphone app called eMind that teaches mindfulness to help people stop smoking. About 40 adult smokers who want to quit will use the app for 8 weeks. Researchers want to see if people find the app easy and helpful to use, and if it can reduce relapse…

This study looks at skin cells called fibroblasts from people with scleroderma and compares them to cells from healthy people. The goal is to find which genes are turned on or off, especially those linked to aging. No treatment is tested—just observation to better understand the …

This study follows 100 adults with blood cancers who are taking newer targeted drugs called second-generation BTK inhibitors (acalabrutinib or zanubrutinib). The goal is to track how often heart problems like high blood pressure and irregular heartbeat occur, and to find out whic…

This study looks at how cancer and its treatments change taste and smell, and how these changes affect eating habits and nutrition. Researchers will follow 306 adults newly diagnosed with certain cancers (mouth, throat, colon, or liver) to understand these links. The goal is to f…

This study looks at psychiatric symptoms in people with White-Sutton syndrome, a rare genetic disorder that can cause developmental delays and other health issues. Researchers want to better understand common mental health problems like anxiety, autism, and attention disorders in…

This study looks at how changes in thinking skills (like memory) with age affect movement and the risk of falling. Researchers will compare healthy younger adults, healthy older adults, and older adults with mild memory problems. The goal is to better understand falls and improve…

This study looks at whether a simple leg-raising test, combined with ultrasound, can help doctors predict how well ICU patients will handle extra fluids. Giving too much fluid can cause harm, so finding a better way to guide treatment is important. The study will involve 100 adul…

This study looks at whether the 'good' cholesterol (HDL) in people with depression works differently, which might explain their higher risk of heart attacks. Researchers will compare blood samples from 90 adults with depression and healthy controls. The goal is to better understa…

This study aims to create a digital twin—a computer model—for people with chronic aortic dissection, a tear in the aorta wall. The model will combine imaging, blood flow, and other factors to better predict if an aneurysm will form and need surgery. Researchers will enroll 400 ad…

This study looks at how people with lower-limb amputations adjust their walking when going up or down slopes and stairs. Researchers will use machine learning to analyze movement patterns, with the goal of creating prosthetics that can anticipate changes in terrain. The study inv…

This study tests whether it is practical and acceptable to screen newborns' entire genome for rare diseases that appear in early childhood. Researchers will offer the screening to parents of 5000 newborns in five French hospitals. The goal is to see how many families agree and wh…

This study looks at whether quick, easy walking tests can help doctors better track walking problems in people with facioscapulohumeral muscular dystrophy (FSH). Researchers will compare these simple tests with the standard, time-consuming assessment. The goal is to find a faster…

This study tests whether small wearable sensors (IMUs) placed on the feet and body can accurately measure walking in children. Researchers will first check the sensors in healthy children aged 7-17, then in children with cerebral palsy who can walk without aids. The goal is to se…

This study looks at how a person's income, job, education, and social support affect their recovery after a stay in the intensive care unit (ICU). Researchers will follow 180 patients and their families to see who develops Post-Intensive Care Syndrome (PICS)—a set of physical, me…

This study aims to find new genes or genetic changes that cause rare diseases. Researchers will study up to 850 people, including patients with suspected genetic rare diseases and their healthy relatives. By using advanced DNA sequencing, they hope to improve diagnosis and provid…

This study looks at why some premature babies develop an eye condition called retinopathy of prematurity (ROP). Researchers think fatty acids from the mother may play a role. They will measure certain receptors in the placenta and compare them between mothers of premature and ful…

This study is testing a new smartphone app that can analyze how children with cerebral palsy move, like jumping or walking. The goal is to see if the app works as well as the expensive motion-capture systems used in hospitals. If it does, families could use it at home to help doc…

This study looks at whether low blood sugar during the night is connected to muscle loss (sarcopenia) in people with cirrhosis. Researchers will monitor blood sugar continuously in 200 adults with cirrhosis and measure muscle mass and strength. The goal is to gather data that cou…