UROTHELIAL CARCINOMA

This study is comparing two standard surgical methods for bladder cancer. It will see if patients do better with or without a temporary plastic tube (a ureteral stent) placed during surgery to remove the bladder. Researchers will track 70 patients for a year to measure complicati…

This is an early-stage study to test the safety and initial effectiveness of a new drug called RO7502175 for people with advanced solid tumors that have spread or cannot be cured. The drug will be tested both by itself and combined with other approved cancer drugs. The main goals…

This study is testing whether a new drug, either alone or combined with an immunotherapy drug, can help control advanced bladder cancer that has spread and has a specific marker called HER2. It will involve about 96 adults whose cancer has progressed despite prior treatments. The…

This is an early-stage study testing a new drug called MT-4561 in people with various advanced solid tumors who have run out of standard treatment options. The main goals are to find a safe dose, see how the body processes the drug, and check for any early signs that it might hel…

This early-stage study is testing the safety and effects of an experimental cancer drug called PF-08046876 in adults with advanced solid tumors. The drug is an antibody drug conjugate designed to target and kill cancer cells. Researchers will give the drug through an IV to about …

This early-stage trial is testing a new drug called ALE.P03 in adults with advanced or spreading cancers that have a specific protein marker (CLDN1+). The study aims to find a safe and effective dose and see if the drug can shrink tumors. It will enroll 180 patients with cancers …

This study is testing if patients with advanced bladder cancer who respond well to an initial 6-month combination treatment can safely switch to a single, less intensive drug. The goal is to see if this simpler maintenance therapy can control the cancer while reducing side effect…

This study is testing whether a combination of two drugs, 9MW2821 and toripalimab, can help shrink or eliminate tumors in patients with non-metastatic bladder cancer before they have surgery. The goal is to see if this treatment makes surgery more effective and helps prevent the …

This study compares two approaches to prevent cancer from returning after surgery for upper urinary tract cancer. Researchers are observing whether a combination of radiation and immunotherapy works better than standard chemotherapy for patients at high risk of recurrence. The go…

This large study is testing whether adding a new immunotherapy drug called tislelizumab to standard chemotherapy helps people with advanced bladder cancer live longer. About 420 patients who haven't had prior chemotherapy will receive either the new combination or standard treatm…

This study aims to find out if removing lymph nodes during surgery for a rare type of kidney and urinary tract cancer helps prevent the cancer from coming back. Researchers will compare two groups of patients: one that has the standard surgery and another that has the standard su…

This study is testing whether the drug enfortumab vedotin is safe and effective when given before surgery to people with aggressive cancer in their upper urinary tract (kidney or ureter). The trial is for patients who are not eligible for or have chosen not to receive the standar…

This study is testing whether a combination of two immunotherapy drugs, enfortumab vedotin and pembrolizumab, can effectively treat people with advanced bladder cancer that has spread to nearby lymph nodes. The drugs are given before surgery to remove the bladder, with the goal o…

This study is testing a new oral medication called NEO212 for adults with specific aggressive brain tumors (like glioblastoma) or brain metastases from other cancers. The main goals are to find a safe and effective dose, see how the body processes the drug, and check if it can he…

This study is testing whether a liquid medication called UGN-104 can effectively treat low-grade cancer in the upper part of the urinary system (kidneys and ureters). About 70 patients will receive the treatment, which is delivered directly to the cancer site through a catheter o…

This study is testing a new, experimental drug called GI-101 in people with advanced cancers that have spread. The main goals are to find a safe dose and see if the drug, given alone or with other approved cancer medicines, can help shrink tumors. The trial will enroll about 317 …

This study is testing if combining immunotherapy drugs (called PD-1/PD-L1 inhibitors) with targeted radiation is more effective for controlling several advanced cancers, including lung and head/neck cancers. It aims to help patients live longer and also tries to find patterns in …

This is a first-in-human study testing a new cancer drug called AVA6000 in patients with advanced solid tumors that have spread or cannot be removed by surgery. The drug is a modified version of a common chemotherapy (doxorubicin) designed to be activated only inside tumors, pote…

This study is testing two new drug approaches for people with advanced bladder cancer and other solid tumors that have stopped responding to standard treatments. It will enroll 52 participants to see if either a single drug (SI-B003) or a combination of two drugs (BL-B01D1+SI-B00…

This study is testing an experimental drug called zanidatamab for people with advanced cancers that have a specific marker called HER2 and have stopped responding to prior treatments. It will enroll about 200 adults with various cancers including breast, lung, stomach, and ovaria…

This trial is testing whether a two-drug combination (talazoparib and avelumab) can help keep advanced bladder cancer from getting worse after initial chemotherapy. It will involve 50 patients whose cancer responded to or was stable after platinum-based chemo. The goal is to see …

This study is testing whether a new drug called disitamab vedotin works to treat advanced bladder cancer that has spread and expresses a protein called HER2. It will be given alone or combined with another drug, pembrolizumab, to about 372 people. The main goals are to see if the…

This is the first human study of an experimental cancer drug called GEN1106 for people with advanced solid tumors, particularly bladder cancer that has spread. The trial aims to find safe doses and see if the drug helps shrink tumors in patients who have already tried standard tr…

This study is testing a new drug called BMS-986340 to see if it is safe and can help control advanced cancers. It will be given alone or combined with two other cancer drugs to about 950 people whose cancers have grown despite standard treatments. The main goal is to find the rig…

This early-stage study is testing a new drug called BL-M07D1 for people with advanced cancers that have a specific marker called HER2. The trial aims to find the safest dose and see if the drug helps control cancer growth in patients who have already tried standard treatments. Re…

This program provides access to an investigational treatment called cretostimogene for people with a specific type of bladder cancer that has not responded to the standard BCG therapy. It is for patients who are not eligible for or refuse surgery to remove their bladder. The trea…

This study is testing whether giving a cancer immunotherapy treatment called nivolumab as an injection at home is a safe and practical alternative to receiving it at a clinic. It aims to see if home treatment reduces the burden of travel and improves quality of life for patients …

This large, late-stage trial is testing whether a new drug called BL-B01D1 works better than standard chemotherapy for people with advanced bladder cancer that has come back or spread. It is for patients whose cancer has continued to grow despite receiving two common types of tre…

This study aims to find the best treatment approach for older adults with advanced bladder cancer who cannot tolerate standard chemotherapy. Researchers will compare two different treatment combinations to see which provides better quality of life with fewer side effects. The stu…

This is the first study in people for a new oral drug called DCC-2812. It aims to find a safe dose and see if it can help control advanced kidney, bladder, or prostate cancer that has spread. The study will enroll about 60 people to check for side effects and see if the drug show…

This is a very early, small study to see if a new type of immune cell therapy is safe and possible to give to people. It will test a treatment made from a patient's own 'natural killer' immune cells, which are collected and specially prepared in a lab to potentially fight cancer.…

This is the first study in people to test a new drug called LB-LR1109. The main goal is to find a safe and tolerable dose for patients with advanced or metastatic solid tumors, including lung, head and neck, kidney, bladder cancers, and melanoma. The study will test the drug alon…

This is an early-stage study to check the safety and initial activity of an experimental drug called DR-0202. It is for adults with advanced cancers that have spread, returned, or stopped responding to at least two prior treatments. The main goal is to find a safe dose and see ho…

This study is testing whether specially trained dogs can detect bladder cancer by smelling urine samples. Researchers will collect urine from 340 adults scheduled for bladder-related procedures to see how accurately the dogs identify cancer. The goal is to explore if a dog's sens…

This study is testing whether a new urine test that looks for cancer DNA can replace many invasive cystoscopies. Cystoscopy is a common but uncomfortable procedure where a thin tube with a camera is inserted into the bladder to check for cancer. Researchers will enroll 3000 peopl…

This study is testing whether a new combination of tests can better identify invasive bladder cancer before a patient has surgery to remove their bladder. Researchers will check if a special blood test and urine test, used alongside a standard scope exam, can accurately predict w…

This study aims to find out if women aged 50 and older who have blood in their urine from a sudden bladder infection need to go through the full set of tests to check for cancer. Researchers will follow 300 women for a year after they get standard tests like a bladder scope and a…

This study is testing a new imaging agent for PET/CT scans to see if it can better detect and locate bladder cancer, especially when it has come back or spread. The agent is designed to stick to a specific protein (nectin-4) that is often found on bladder cancer cells. Researcher…

This study is testing a new urine test called Cxbladder Triage-Plus. It aims to help doctors decide which patients with hidden blood in their urine need a follow-up camera exam of the bladder to check for cancer. The goal is to reduce unnecessary invasive procedures for people at…

This study is testing a new urine test that looks for cancer DNA to find bladder and urinary tract cancers early in people with Lynch syndrome. Lynch syndrome is a genetic condition that makes people much more likely to develop several types of cancer. The goal is to see if this …

This study is testing whether cancer patients prefer to receive their standard drug treatments at home instead of in a clinic. Researchers want to see if home-based care reduces the burden of travel and improves treatment satisfaction and quality of life for patients. A specializ…

This study is testing if wearing a medical compression stocking on one foot during cancer treatment can prevent nerve damage, a common and painful side effect. The trial involves 58 patients with advanced cancers who are receiving a specific type of targeted drug therapy. Researc…

This study is testing if a personalized home exercise program, delivered through a smartphone app, can help people with bladder cancer get stronger before their surgery. About 128 patients will be randomly assigned to either use the exercise app or receive standard educational ma…

This study aims to understand how kidney and bladder cancers use different nutrients from the blood to grow and survive. Researchers will study tissue samples from 600 patients who are already scheduled for surgery or biopsy for their cancer. By tracking specially labeled nutrien…

This study is testing a new artificial intelligence (AI) tool designed to help match people with advanced cancer to suitable clinical trials. It will enroll up to 50,000 patients to see if using this AI system makes it easier for patients to find and join trials. The researchers …

This study aims to understand and improve how hospitals around the world treat patients who are urgently admitted with blood in their urine (hematuria). Researchers will observe the care of about 1,050 adult patients to see how different treatment approaches affect hospital stay …

This study aims to collect and store blood, urine, stool, saliva, and tumor samples from 500 bladder cancer patients at Toulouse University Hospital. Researchers want to understand how bacteria in the bladder and gut might affect how patients respond to cancer treatments like BCG…

This study aims to understand how a bladder cancer drug called enfortumab vedotin affects patients' nerves. Researchers will follow 50 adults with advanced bladder cancer who are starting this treatment. They will use nerve tests to measure changes over 12-15 weeks to learn about…

This study is a national registry that will follow nearly 2,000 patients in Germany with advanced kidney or bladder cancer. Its purpose is to document the real-world treatments patients receive, track how the disease progresses, and measure patients' quality of life over time. Th…