New drug combo aims to keep bladder cancer at bay after chemo

NCT ID NCT04678362

Recruiting now Disease control Sponsor: Centre Francois Baclesse Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 2 trial is testing whether a combination of two drugs, Talazoparib and Avelumab, can help keep advanced urothelial (bladder) cancer from growing after initial chemotherapy. About 50 adults with platinum-sensitive cancer will receive the drugs as maintenance therapy until the cancer progresses or side effects become too much. The main goal is to see how long patients live without their cancer worsening.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Talazoparib and Avelumab
What this could lead to: If successful, this combination could offer a new maintenance option to delay cancer progression after initial chemotherapy.
What could go wrong: This is a small, early-phase trial (50 patients) with no control group, so results may not be definitive. Side effects from the drugs could be significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

transitional cell carcinoma urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

UROTHELIAL CARCINOMA

Contacts and locations

Locations

CHU Jean Minjoz
RECRUITING

Besançon, France
Centre Antoine Lacassagne
RECRUITING

Nice, France
Centre Eugène Marquis
RECRUITING

Rennes, France
Centre François baclesse
ACTIVE_NOT_RECRUITING

Caen, 14000, France
Centre George-François Leclerc
RECRUITING

Dijon, France
Centre Jean Perrin
RECRUITING

Clermont-Ferrand, France
Centre Léon Bérard
RECRUITING

Lyon, France
Croix Saint-Simon Diaconesses
RECRUITING

Paris, France
Hopital Tenon
RECRUITING

Paris, France
Hospices civils de Lyon
ACTIVE_NOT_RECRUITING

Lyon, France
IUCT
RECRUITING

Toulouse, France
Institut Paoli Calmettes
NOT_YET_RECRUITING

Marseille, France
Institut de Cancérologie de l'Ouest
RECRUITING

Angers, France
Institut de Cancérologie de l'Ouest
RECRUITING

Nantes, France

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