PANCREATIC ADENOCARCINOMA

This is a first-in-human safety study testing a new two-part treatment for people with advanced HER2-positive solid tumors that have stopped responding to standard therapies. First, a specially designed virus is injected directly into one tumor to help alert the immune system. A …

This study is testing if adding a drug called anakinra, which reduces inflammation, to standard chemotherapy can better control pancreatic cancer in patients who are candidates for surgery. The goal is to see if this combination helps shrink tumors before surgery, improves surviv…

This study is testing a new drug called GTAEXS617 in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors in cancers like head & neck, lung, pancreatic, ovarian, and bre…

This study is testing whether tiny radioactive seeds can be safely placed directly into pancreatic tumors to deliver radiation. It's for 15 patients with advanced pancreatic cancer who have already tried chemotherapy or cannot have surgery. The main goals are to see if doctors ca…

This early-stage study is testing the safety and effects of an experimental cancer drug called PF-08046876 in adults with advanced solid tumors. The drug is an antibody drug conjugate designed to target and kill cancer cells. Researchers will give the drug through an IV to about …

This study is testing whether a new drug called daraxonrasib, given alone or with standard chemotherapy, works better than chemotherapy alone for people with advanced pancreatic cancer that has spread. About 900 participants will be randomly assigned to receive one of three treat…

This study is testing a new three-drug combination (GCN) together with a device that uses electric fields (TTF) to treat metastatic pancreatic cancer. The goal is to see if this combined approach is safe and can help control the cancer for longer. It will involve about 40 adults …

This study is testing if an immunotherapy drug called dostarlimab works better than standard chemotherapy as a first treatment for adults with certain rare, advanced cancers that have spread or cannot be surgically removed. About 120 participants will be randomly assigned to rece…

This study is testing an experimental oral medication called ESK981 for people with advanced pancreatic cancer and certain neuroendocrine cancers that have stopped responding to standard treatments. The trial will enroll 66 patients across three groups to see if taking ESK981 on …

This early-stage study aims to find the safest dose of a powerful combination of five chemotherapy drugs for people with advanced cancers of the stomach, pancreas, and related areas. It uses a patient's genetic test results to personalize the dose of one key drug, hoping to reduc…

This is a first-in-human study to test the safety and find the right dose of a new oral drug, OKN4395, for people with advanced solid tumors. The trial will give the drug alone and combined with an existing immunotherapy (pembrolizumab) to about 166 participants with cancers like…

This early-stage study is testing a new drug called RMC-5127 in adults with advanced cancers that have a specific genetic change called KRAS G12V. The main goals are to find a safe dose and see how the body processes the drug, both when given alone and when combined with other ca…

This early-stage study is testing the safety of combining two new investigational drugs with a standard chemotherapy regimen for advanced pancreatic cancer. It will enroll up to 12 adults who have not yet received any treatment for their advanced disease. The main goal is to find…

This is a first-in-human study testing a new drug called CLSP-1025 for adults with advanced solid tumors that have a specific genetic change called the p53 R175H mutation. The main goals are to find a safe dose and see if the drug can help control the cancer. The drug works by en…

This is a first-in-human study testing a new personalized cell therapy called NT-175. It is for adults with advanced solid cancers (like lung, colorectal, or breast cancer) that have spread and have a specific genetic mutation (TP53 R175H). The main goals are to find a safe dose …

This study is testing the safety of a new treatment for advanced pancreatic cancer. It combines tiny radioactive implants placed directly into the tumor with standard chemotherapy. The goal is to see if this approach can help control the cancer, reduce pain, and potentially make …

This trial is testing a very intensive treatment for pancreatic cancer that has spread to the lining of the abdomen. It combines major surgery to remove all visible tumors with a special procedure where heated chemotherapy is washed around inside the abdomen during the operation.…

This early-stage study is testing a new drug called APL-5125 in adults with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find a safe dose, check for side effects, and see if the drug can shrink tumors, especially in colorectal canc…

This is a first-in-human study to test the safety and find the right dose of a new drug called PF-08046054/SGN-PDL1V for people with advanced solid tumors. It will be tested alone and in combination with another cancer drug, pembrolizumab. The study is recruiting 714 participants…

This study is testing a new way to treat advanced pancreatic cancer by placing tiny radioactive seeds directly into the tumor. The seeds release a short-range radiation designed to kill cancer cells while sparing nearby healthy tissue. The main goals are to see if doctors can saf…

This study is testing a new drug called BMS-986340 to see if it is safe and can help control advanced cancers. It will be given alone or combined with two other cancer drugs to about 950 people whose cancers have grown despite standard treatments. The main goal is to find the rig…

This study is testing a new drug called ASP2138 for people with advanced stomach, gastroesophageal junction (GEJ), or pancreatic cancer. The drug works by guiding the body's own immune cells to attack cancer cells that have a specific marker called CLDN18.2. Researchers will test…

This is the first study in people of an experimental pill called MRTX1719. It is for adults with advanced solid tumors that have a specific missing gene called MTAP, which is found in some lung cancers, mesothelioma, and other cancers. The main goals are to find a safe dose, see …

This study is testing a two-part treatment for advanced pancreatic cancer that cannot be removed by surgery. First, doctors use a procedure called irreversible electroporation, which uses electrical pulses to destroy the tumor. After that, patients receive an immunotherapy drug c…

This study is testing a new fluorescent dye designed to help surgeons see pancreatic cancer cells more clearly during surgery. The dye is attached to an antibody that seeks out cancer cells. During the operation, a special camera makes the dyed cancer cells glow, potentially help…

This study aims to confirm if a new blood test can find pancreatic cancer at its earliest, most treatable stages. Researchers will test the method in 2,000 people, including those with and without pancreatic cancer. The test looks for tiny genetic signals in the blood that may in…

This study is testing if a special exercise and nutrition program, started during chemotherapy before surgery, can help older adults with advanced ovarian or pancreatic cancer. The goal is to see if patients can stick to the program and if it helps them get stronger, improve thei…

This study is testing whether data from wearable activity monitors (like Fitbits) can be collected from cancer patients and used by doctors. Researchers want to see if a patient's daily activity levels are connected to their overall health status and survival. The goal is to gath…

This study is creating a large collection of medical information and biological samples from people with various pancreatic conditions. Researchers will collect blood, saliva, leftover tissue, and survey data from up to 20,000 participants. The goal is to build a resource that he…