PANCREATIC ADENOCARCINOMA

This early-phase trial tests a new drug combination for people with advanced pancreatic cancer that has a specific marker (mesothelin). The study combines a targeted therapy (anetumab ravtansine) with immunotherapy drugs (nivolumab, ipilimumab) and chemotherapy (gemcitabine) to s…

This study tests an experimental drug called 9-ING-41, which blocks a protein (GSK-3β) that helps cancers grow. It is given alone or with chemotherapy to 350 adults with advanced or hard-to-treat cancers like pancreatic, breast, lung, or bone cancer. The goal is to see if the dru…

This study tests whether adding two experimental drugs (elraglusib and losartan) to standard chemotherapy (FOLFIRINOX) can prevent metastatic pancreatic cancer from becoming resistant to treatment. About 70 adults with untreated, advanced pancreatic cancer are participating. The …

This early-stage study tests an experimental drug called SGN-MesoC2 in 19 adults with advanced solid tumors (like lung, ovarian, or pancreatic cancer) that have not responded to standard treatments. The drug is designed to stick to cancer cells and kill them. The main goals are t…

This early-phase study tests a new treatment called EGFR-BATs for people with advanced pancreatic cancer that has not responded to standard chemotherapy. The treatment uses the patient's own immune cells, which are trained in a lab to better attack cancer cells. The main goal is …

This early-phase study tests an experimental drug called DECOY20, given alone or with another drug (tislelizumab), in about 120 adults with advanced solid tumors like liver, colorectal, pancreatic, lung, head and neck, bladder, or MSI-high cancers. The main goals are to check saf…

This early-stage trial tests a new drug called sEphB4-HSA alongside standard chemotherapy in people with advanced or metastatic solid tumors (like head and neck, pancreatic, lung, and gallbladder cancers). The main goals are to find the best dose and check for side effects. About…

This study compares a three-drug chemotherapy combination (nab-paclitaxel, gemcitabine, plus cisplatin) against the standard two-drug combination (nab-paclitaxel plus gemcitabine) for people with metastatic pancreatic cancer that has spread to other parts of the body. Participant…

This study looks at whether adding a special pancreatic enzyme pill (Pancreaze) to usual treatment can help people with advanced pancreatic cancer who are losing weight and have trouble digesting food. About 36 adults with this condition will take the enzyme pills with meals and …

This study tests whether combining two drugs (atezolizumab and tivozanib) can help the immune system attack cancers that usually don't respond to immunotherapy, like certain prostate, pancreatic, and breast cancers. About 29 adults with advanced or metastatic disease who have alr…

This early-phase study tests whether adding the diabetes drug metformin and a specific dietary supplement mix to standard chemotherapy is safe and feasible for people with pancreatic cancer that cannot be removed by surgery. The supplement includes ingredients like curcumin, vita…

This early-phase study tests a personalized vaccine made from a patient's own immune cells, combined with standard chemotherapy and an immunotherapy drug (nivolumab), for people with pancreatic cancer that was surgically removed. The goal is to see if this combination is safe and…

This study tests a combination of three chemotherapy drugs (liposomal irinotecan, 5-FU, and oxaliplatin) given before surgery to people with pancreatic cancer that can be removed. The goal is to see if this approach is safe and helps reduce complications after surgery. About 45 a…

This study tests an experimental oral drug called IMM-1-104 in people with advanced solid tumors that have RAS mutations. The goal is to find the safest and most effective dose and see if it can shrink tumors. About 209 adults with certain cancers like pancreatic, melanoma, or lu…

This study tests a new drug called LP-184 in people with advanced solid tumors (like certain breast, lung, or pancreatic cancers) that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors. About 64 participan…

This study tests whether switching from one chemotherapy combination to another before surgery can help people with pancreatic cancer that can be removed or has spread nearby. About 42 adults with specific stages of pancreatic cancer will receive either FOLFIRINOX or gemcitabine/…

This study tests whether adding the drug durvalumab to standard radiation therapy can help control locally advanced pancreatic cancer. About 18 people who have already received chemotherapy will receive the combination. The goal is to see if the treatment is safe and can shrink t…

This study tests a new approach for advanced pancreatic cancer that cannot be removed by surgery. Doctors place a special device that releases alpha radiation directly into the tumor. The goal is to see if this procedure is safe and possible for patients. About 37 adults with adv…

This early-phase trial tests a combination of two drugs, naptumomab estafenatox and durvalumab, in adults with advanced solid tumors that have not responded to standard treatments. The main goal is to find a safe dose and check for side effects. About 120 people with various canc…

This study is checking if a computer model called PRISM can accurately predict who might get pancreatic cancer by looking at electronic health records. Over 6 million adults aged 40 and older from across the US are being tracked to see if the model's risk scores match real cancer…

This study tests whether a supervised, at-home resistance training program using a tablet is safe and helpful for people with advanced pancreatic cancer or those recovering from surgery. About 25 participants will do guided exercises while on chemotherapy or after surgery. The go…

This study tests two drug combinations in people with advanced colorectal, pancreatic, or leiomyosarcoma cancers that have not responded to standard treatments. Participants receive either olaparib plus durvalumab or cediranib plus durvalumab. The main goal is to measure changes …

This study aims to create a test that predicts how well pancreatic cancer will respond to different chemotherapy treatments. Researchers will analyze tumor cells from blood and tissue samples of 74 participants with advanced pancreatic cancer. The goal is to help doctors choose t…

This study looks at a specific surgical technique during pancreatic cancer surgery to see if it helps remove all cancer cells. About 102 adults with pancreatic cancer that hasn't spread will take part. The goal is to see if this method lowers the chance of leftover cancer cells n…