New pill shows promise against tough cancers in early trial
NCT ID NCT05988918
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 2 trial tests an oral drug called ESK981 in people with advanced pancreatic cancer, neuroendocrine tumors, or neuroendocrine prostate cancer. The goal is to see if the drug can keep the cancer from growing for at least 4 months. Participants take the drug for 5 days, then rest for 2 days, repeating in 4-week cycles. The study is small (17 people) and is not yet recruiting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ESK981 (a drug taken by mouth in 5-days-on, 2-days-off cycles)
- What this could lead to
- If successful, this could point toward a new treatment option for certain hard-to-treat cancers like pancreatic and neuroendocrine tumors.
- What could go wrong
- This is an early Phase 2 trial with only 17 participants, so results may not apply broadly. The drug may not shrink tumors or improve survival, and side effects are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Rogel Cancer Center
Ann Arbor, Michigan, 48109, United States
-
University of Wisconsin Carbone Cancer Center
Madison, Wisconsin, 53792, United States
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