New chemo cocktail shows promise in shrinking pancreatic tumors before surgery

NCT ID NCT03483038

Ongoing Disease control Sponsor: University of Florida Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase II trial is testing a combination of liposomal irinotecan (Onivyde) and FOLFOX chemotherapy given before surgery to people with pancreatic cancer that can be removed. The study includes 45 adults with early-stage disease. The goal is to see if this approach is safe and helps patients complete surgery with fewer complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: liposomal irinotecan (Onivyde) plus FOLFOX chemotherapy (oxaliplatin, leucovorin, 5-fluorouracil)
What this could lead to: If successful, this combination could become a standard pre-surgery treatment to improve surgical outcomes and survival for pancreatic cancer patients.
What could go wrong: This is a small, early-phase study with no control group. The treatment may cause significant side effects, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pancreatic adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PANCREATIC ADENOCARCINOMA

Contacts and locations

Locations

Indiana University Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202, United States
Orlando Health UF Health Cancer Center

Orlando, Florida, 32806, United States
Tallahassee Memorial Health Care

Tallahassee, Florida, 32308, United States
University of Florida

Gainesville, Florida, 32608, United States

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