New drug combo shows promise for Tough-to-Treat cancers

NCT ID NCT02495896

First seen Nov 10, 2025 · Last updated May 01, 2026 · Updated 27 times

Summary

This early-phase study tested a new drug called sEphB4-HSA combined with standard chemotherapy in 61 people with advanced or metastatic solid tumors (like head and neck, pancreatic, lung, and gallbladder cancers). The goal was to find the best dose and check for side effects. Researchers also looked at whether the tumors shrank or stopped growing. This is not a cure, but aims to better control the disease.

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Contacts and locations

Locations

  • Hoag Memorial Hospital Presbyterian

    Newport Beach, California, 92663, United States

  • USC / Norris Comprehensive Cancer Center

    Los Angeles, California, 90033, United States

Conditions

Explore the condition pages connected to this study.