New drug combo shows promise in early cancer trial
NCT ID NCT02495896
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests a new drug called sEphB4-HSA combined with standard chemotherapy in people with advanced or metastatic solid tumors, including head and neck, pancreatic, lung, and gallbladder cancers. The goal is to find the best dose and see if the combination is safe and works better than chemo alone. About 61 participants are enrolled, and the study is active but no longer recruiting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- recombinant EphB4-HSA fusion protein (sEphB4-HSA) combined with standard chemotherapy drugs (cisplatin, gemcitabine, docetaxel, paclitaxel)
- What this could lead to
- If this works, it could point toward a more effective treatment for several advanced cancers that are hard to treat, like pancreatic and lung cancer.
- What could go wrong
- This is a very early (Phase 1) pilot study with only 61 people, so it's mainly checking safety and dosing. The combination may not work better than chemo alone, and side effects could be significant.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hoag Memorial Hospital Presbyterian
Newport Beach, California, 92663, United States
-
USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033, United States
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