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New drug targets hard-to-treat cancers with missing MTAP gene

NCT ID NCT05245500

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests an experimental drug called MRTX1719 in adults with advanced solid tumors that have a missing MTAP gene. The study aims to find a safe dose and see if the drug can shrink tumors or slow their growth. About 336 participants with cancers like mesothelioma, lung cancer, or pancreatic cancer will take part.

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Conditions

The condition(s) this trial relates to.

malignant peripheral nerve sheath tumor mesothelioma neoplasm neurofibrosarcoma non-small cell lung carcinoma pancreatic adenocarcinoma pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR MALIGNANT PERIPHERAL NERVE SHEATH TUMORS MESOTHELIOMA NON-SMALL CELL LUNG CANCER PANCREATIC ADENOCARCINOMA SOLID TUMOR

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

Locations

  • Cancer and Hematology Centers of Western Michigan

    RECRUITING

    Norton Shores, Michigan, 49444, United States

    Contact Phone: •••-•••-••••

  • Dana-Farber Cancer Institute

    RECRUITING

    Brookline, Massachusetts, 02251, United States

    Contact Phone: •••-•••-••••

  • David H Koch, Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 10021, United States

    Contact Phone: •••-•••-••••

  • Local Institution - 108

    COMPLETED

    Milwaukee, Wisconsin, 53226, United States

  • Local Institution - 124

    WITHDRAWN

    Chicago, Illinois, 60637, United States

  • Local Institution - 129

    NOT_YET_RECRUITING

    Mineola, New York, 11501, United States

    Contact

  • Local Institution - 134

    WITHDRAWN

    Seattle, Washington, 98109, United States

  • MDACC

    RECRUITING

    Houston, Texas, 77030, United States

    Contact

  • Mayo Clinic

    RECRUITING

    Phoenix, Arizona, 85054-4502, United States

    Contact Phone: •••-•••-••••

  • Mayo Clinic

    RECRUITING

    Jacksonville, Florida, 32224, United States

    Contact Phone: •••-•••-••••

  • Mayo Clinic

    RECRUITING

    Rochester, Minnesota, 55905, United States

    Contact Phone: •••-•••-••••

  • New york cancer and blood specialists - Oncology

    RECRUITING

    Port Jefferson Station, New York, 11776, United States

  • New york cancer and blood specialists - Oncology

    RECRUITING

    Port Jefferson Station, New York, 11776, United States

    Contact Phone: •••-•••-••••

    Contact

  • Rocky Mountain Cancer Centers, LLP - Oncology

    RECRUITING

    Lone Tree, Colorado, 80124, United States

    Contact Phone: •••-•••-••••

  • Rutgers Cancer Institute of New Jersey

    RECRUITING

    New Brunswick, New Jersey, 08901, United States

    Contact Phone: •••-•••-••••

  • Sarah Cannon Research Institute (SCRI) - HealthONE Location

    RECRUITING

    Denver, Colorado, 80218-1238, United States

    Contact Phone: •••-•••-••••

  • Sarah Cannon Research Institute at Florida Cancer Specialists

    RECRUITING

    Orlando, Florida, 32827, United States

    Contact

  • South Texas Accelerated Research Therapeutics

    RECRUITING

    San Antonio, Texas, 78229, United States

    Contact

  • Texas Oncology - DFW

    RECRUITING

    Fort Worth, Texas, 76104, United States

    Contact Phone: •••-•••-••••

  • Texas Oncology, P.A. - Oncology

    RECRUITING

    Tyler, Texas, 78503, United States

    Contact Phone: •••-•••-••••

  • University of North Carolina

    RECRUITING

    Chapel Hill, North Carolina, 27599, United States

    Contact

  • University of North Carolina - Gastroenterology and Hepatology

    RECRUITING

    Chapel Hill, North Carolina, 27599, United States

    Contact

  • Ut Southwestern

    RECRUITING

    Dallas, Texas, 75235, United States

    Contact

  • Vanderbilt - Ingram Cancer Center

    RECRUITING

    Nashville, Tennessee, 37232-5505, United States

    Contact Phone: •••-•••-••••

  • Virginia Cancer Specialists, PC

    RECRUITING

    Fairfax, Virginia, 22031, United States

    Contact Phone: •••-•••-••••

More trials for these conditions

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