BREAST NEOPLASMS

This early-stage study is testing a new radioactive cancer drug called LY4337713 in adults with advanced solid tumors that have spread. The drug is designed to seek out and deliver radiation directly to cancer cells that have a specific protein marker called FAP. Researchers will…

This study tests whether personalized chemotherapy can better control advanced breast cancer that has progressed after standard treatments. Doctors will choose from several chemotherapy drugs based on each patient's specific situation and preferences. The trial aims to see if thi…

This is the first study in people to test a new oral medication called CID-078 for advanced solid tumors. The main goals are to find a safe dose and see how well the body handles the drug. The study will enroll adults with cancers like triple-negative breast cancer, small cell lu…

This study is testing a new drug combination for premenopausal women with a common type of breast cancer (ER+/HER2-) before they have surgery. The goal is to see if taking the drug (Z)-endoxifen with a monthly injection (goserelin) can slow or stop tumor growth, potentially shrin…

This study is testing whether adding a new drug called patritumab deruxtecan to standard chemotherapy and immunotherapy before surgery works better for certain aggressive breast cancers. Researchers want to see if this combination helps eliminate more cancer cells before surgery …

This study is observing patients in Germany and Austria who are already taking a specific drug combination (ribociclib plus an aromatase inhibitor) to prevent their early-stage, hormone-sensitive breast cancer from coming back. It aims to see how well the treatment works, what si…

This study is testing a new combination of two cancer drugs, disitamab vedotin and tucatinib, for people with advanced or spreading breast or stomach cancer. The main goals are to find a safe and effective dose and to see if the combination can shrink tumors. It is for people who…

This study is testing a new targeted drug called izalontamab brengitecan against standard chemotherapy for people with advanced triple-negative or low-estrogen breast cancer who cannot receive common immunotherapies. The goal is to see if the new drug can better control the cance…

This study is testing a new drug called patritumab deruxtecan for people with advanced HER2-positive breast cancer that has spread or cannot be removed by surgery. The main goals are to find a safe dose and see if the treatment can shrink or eliminate the cancer. It is for people…

This study allows patients with ovarian or breast cancer who are already benefiting from the drug niraparib in previous trials to continue receiving it. The main goal is to monitor the long-term safety of continued treatment. Researchers will track side effects and health changes…

This large study is testing whether adding a new targeted drug called sacituzumab tirumotecan to standard chemotherapy and immunotherapy works better before surgery for certain aggressive, early-stage breast cancers. Researchers want to see if this three-drug combination helps el…

This study is testing if adding the weight loss medication tirzepatide to standard hormone therapy can help prevent breast cancer from spreading in overweight patients. It focuses on people with early-stage, hormone-positive breast cancer who have a high risk of recurrence, as sh…

This study is testing a new targeted radiation treatment called LY4257496 for people with advanced cancers that have a specific protein (GRPR). The main goals are to find a safe dose and see if the treatment helps shrink tumors. It is for adults with certain advanced breast, pros…

This study aims to make a common chemotherapy treatment safer by using a genetic test. It will check if adjusting the drug dose based on a patient's specific gene (DPYD) reduces severe side effects compared to the standard dose. The trial includes 100 adults with cancers like col…

This study is testing if changing the order of breast cancer treatments improves how women feel about their bodies after surgery. It compares giving radiation therapy before breast removal and reconstruction (the new approach) to the standard method of radiation after surgery. Th…

This study is testing an experimental drug called disitamab vedotin for people with advanced breast cancer that has spread and has a protein called HER2 on the tumor cells. It is for patients whose cancer has continued to grow despite receiving standard treatments, including othe…

This early-stage study is testing the safety of a new cell therapy for advanced stomach and esophageal cancers that have spread to the abdominal lining. Doctors collect a patient's own immune cells, modify them in a lab to better target cancer cells, and then infuse them directly…

This study is testing whether adding an experimental drug called Tersolisib to standard breast cancer medications works better for people with advanced hormone-positive breast cancer that has a specific genetic change called PIK3CA mutation. The trial will involve about 920 adult…

This study is testing if combining two drugs, capecitabine and elacestrant, works better than just capecitabine alone for people with advanced, hormone-sensitive breast cancer. It's for patients whose cancer has stopped responding to a common class of prior medications. The main …

This large, late-stage study is testing whether a new drug called sacituzumab tirumotecan, given alone or with an existing immunotherapy (pembrolizumab), works better than standard treatments for people with a specific type of advanced breast cancer that has stopped responding to…

This trial aims to find the best drug combinations for different types of breast cancer before surgery. It tests new drugs alongside standard chemotherapy in 5,000 women with early-stage or locally advanced breast cancer. The study uses tumor analysis and MRI scans to match treat…

This study is testing whether two drugs, elacestrant and abemaciclib, work together to control breast cancer that has spread to the brain. It will involve about 73 adults whose cancer is fueled by estrogen and has spread to the brain. The first part finds the safest dose, and the…

This study is testing a new decision-making tool for women aged 70 and older who have a common, low-risk type of early breast cancer. The goal is to see if giving patients a detailed guide and training their surgeons in shared decision-making leads to fewer aggressive treatments …

This study is testing a new drug called patritumab deruxtecan for people with a common type of advanced breast cancer that has stopped responding to standard hormone therapies. It will compare the new drug to other treatments chosen by doctors, like chemotherapy, to see if it hel…

This study is testing whether a handheld robotic device called HandX can help surgeons safely perform a type of mastectomy that uses a small side incision. The goal is to remove breast tissue while preserving the nipple and skin, aiming for less scarring and better cosmetic resul…

This study is testing whether adding an experimental drug called BNT327 to standard chemotherapy works better than chemotherapy alone for advanced triple-negative breast cancer. The trial will involve 558 patients whose cancer has returned or spread and who can't receive standard…

This study is testing two new imaging agents for PET/CT scans to see if they can better detect and characterize breast cancer tumors. The goal is to see if these new scans can more accurately show where cancer is located and how much of certain proteins the tumors have. This coul…

This study is testing whether a newer type of PET scan (using a tracer called 68Ga-FAPI-46) is better at finding where estrogen-positive breast cancer has spread compared to the standard scan (18F-FDG). Researchers will enroll 20 women with this type of breast cancer to see if th…

This study is testing whether an augmented reality (AR) imaging system can help surgeons locate and remove breast tumors as accurately as the current standard method, which uses ultrasound to mark the skin. About 94 women with early-stage breast cancer will be randomly assigned t…

This study is testing if adding a special type of mammogram that uses contrast dye every two years helps find returning breast cancer more effectively in women with a personal history of the disease. It will involve 1,500 women who get their regular annual mammogram plus this ext…

This study is testing a new artificial intelligence (AI) tool designed to help identify women at high genetic risk for breast cancer. The tool, accessed via WhatsApp, asks women about their family history of cancer. Researchers will compare the AI's risk predictions to the result…

This study aims to find out if a supervised exercise program that includes relaxation techniques is better than doing exercises at home alone for breast cancer survivors. It focuses on helping people regain muscle mass and strength lost during cancer treatment and improving their…

This study is testing if a steroid mouthwash can prevent painful mouth sores, a common side effect of a cancer drug called datopotamab deruxtecan. It will enroll 60 adults with advanced breast or lung cancer who are receiving this drug. The main goal is to see if using the mouthw…

This study aims to understand why breast cancer outcomes differ among women, especially focusing on Black and American Indian/Alaska Native women. It will enroll 3,300 women with invasive breast cancer in North Carolina to collect biological samples, health records, and survey da…

This study aims to understand the side effects and quality of life changes experienced by people undergoing treatment for early-stage breast cancer. It will follow 3000 Chinese patients for up to 5 years, collecting health data and asking them to complete regular surveys about th…

This study aims to create a better tool to predict which cancer patients might develop heart problems from certain powerful chemotherapy drugs. Researchers will use a computer program (machine learning) to analyze data from 600 patients receiving treatment. The goal is to identif…

This study aims to see if small, lab-grown models of a patient's tumor, called organoids, can predict how well cancer treatments will work for them. Researchers will create these models from tissue samples of 20 breast cancer patients whose cancer has spread. They will test diffe…

This study aims to understand how breast cancer treatment affects body composition over time. Researchers will follow 100 patients for 2 years after surgery and therapy to track muscle loss, fat changes, and physical function. The goal is to gather detailed information about the …

This study aims to understand how radiation therapy for breast cancer affects the body's lymphatic drainage system, which can sometimes lead to painful arm swelling called lymphedema. Researchers will use a special imaging dye to map the lymphatic system in 40 patients before and…

This study is testing how easy it is to use a mobile tool that helps breast cancer patients learn about breast reconstruction options after surgery. Twenty breast cancer patients will try the tool on their phones while researchers observe and ask questions about their experience.…

This study aims to understand why some breast cancer patients develop heart damage from a common chemotherapy drug called anthracycline. Researchers will test if a specific protein in the blood (SGLT2) can serve as an early warning sign for this heart risk. The goal is to find a …

This study observes how patients with advanced breast cancer respond to an existing medication called trastuzumab deruxtecan in real-world settings. Researchers will track 800 patients in Germany to understand how long the treatment works before patients need new therapy and how …

This study aims to understand why breast cancer risk and outcomes vary among different people. Researchers will collect surveys, blood, and tissue samples from 800 participants in South Florida to look for genetic and lifestyle factors. The goal is to gather knowledge that may he…

This study aims to understand why some breast cancer cells survive chemotherapy and how they might cause the cancer to return. Researchers will compare genetic markers on cancer cells found in the bone marrow and blood before and after treatment in 300 patients. The goal is to id…