BREAST NEOPLASMS

This study tests three drugs—durvalumab, olaparib, and cediranib—in different combinations for people with advanced solid tumors, including ovarian, breast, lung, prostate, and colorectal cancers. The goal is to see if these combinations can shrink tumors or slow their growth. Pa…

This study tests a new drug called BT8009, alone or with another drug (pembrolizumab), in people with advanced solid tumors that have a protein called Nectin-4. The goal is to see if the drug is safe and shrinks tumors. About 329 adults with cancers like bladder, breast, lung, or…

This study tests whether adding an extra immunotherapy drug at the start of standard treatment can help the immune system better attack triple negative breast cancer before surgery. About 12 adults with untreated, locally advanced TNBC will receive either standard chemo plus pemb…

This early-phase study tests a new drug called E7090, alone or with other cancer medicines, in people with a common type of advanced breast cancer (ER+, HER2-). The main goal is to find safe doses and understand side effects. About 51 adults whose cancer has returned or spread wi…

This phase 3 study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy helps people with a common type of advanced breast cancer (HR+/HER2-) live longer without their cancer getting worse. About 340 participants who have already tried hormone therap…

This study tests an experimental drug called 9-ING-41, which blocks a protein (GSK-3β) that helps cancers grow. It is given alone or with chemotherapy to 350 adults with advanced or hard-to-treat cancers like pancreatic, breast, lung, or bone cancer. The goal is to see if the dru…

This study compares a 1-week radiation treatment to the standard 3-week schedule for women with node-positive breast cancer after surgery. The goal is to see if the shorter course is just as effective at preventing cancer from coming back while reducing the risk of lymphedema (ar…

This study tests whether adding a targeted drug (PD 0332991) to standard hormone therapy (anastrozole) before surgery can better stop breast cancer cell growth in women with early-stage ER+ HER2- breast cancer. About 84 participants will receive the combination for several weeks …

This study tests a new drug called AZD6244 given with standard chemotherapy for people with advanced solid tumors (like breast, colon, lung, melanoma, or kidney cancer) that have no curative options. The main goal is to see if the combination is safe and tolerable, and to find th…

This early-phase study tests the safety of a drug called tucatinib in about 25 Chinese patients with advanced HER2+ breast, stomach, or colorectal cancers that have stopped responding to standard treatments. The main goal is to see what side effects occur and how the drug moves t…

This early-phase study tests a new drug called LY3484356 in 17 Chinese patients with a specific type of advanced breast cancer (ER+/HER2-). The main goal is to see how the drug moves through the body and how safe it is. Researchers will also check if the drug can shrink tumors or…

This early-phase study tested the safety of a new drug called abemaciclib when given with other breast cancer treatments (like letrozole, tamoxifen, or trastuzumab) for people whose breast cancer has spread to other parts of the body. About 198 participants with either hormone re…

This study tests a new drug called PF-07220060 in people with advanced solid tumors, including breast, prostate, lung, and liposarcoma cancers. The drug is given alone or with hormone therapies to see if it is safe and works well. About 362 participants will take part to find the…

This phase 3 study tested whether adding abemaciclib (a targeted therapy) to standard hormone therapy (fulvestrant) helps women with a common type of advanced breast cancer (HR+, HER2-). About 669 women whose cancer had spread or could not be removed by surgery took part. The mai…

This study tests a new drug called imlunestrant against standard hormone therapy in 8,000 people with early-stage, hormone-sensitive breast cancer who have already had 2 to 5 years of hormone treatment and still have a higher risk of their cancer returning. The goal is to see if …

This study tests a shorter, more targeted radiation therapy (accelerated partial breast irradiation) given after breast-conserving surgery in people with early-stage breast cancer. The goal is to see if this approach controls cancer recurrence and reduces side effects compared to…

This early-phase study tests a new drug (H3B-6545) combined with an existing drug (palbociclib) in 31 women with advanced or metastatic ER+ HER2- breast cancer. The main goal is to find the safest dose and understand side effects. Participants must have already received prior tre…

This study tests whether a combination of two drugs (ribociclib and letrozole) can replace chemotherapy before surgery for postmenopausal women with a common type of breast cancer (hormone receptor positive, HER2 negative). About 100 women with stage II or III breast cancer will …

This study tests whether adding alpelisib to standard fulvestrant therapy can delay cancer growth in Chinese men and postmenopausal women with a specific type of advanced breast cancer (HR+, HER2-, with a PIK3CA mutation) that worsened after prior hormone therapy. About 69 partic…

This study tests a drug called trastuzumab deruxtecan (T-DXd), given alone or with other treatments before surgery, in people with high-risk HER2-positive early breast cancer. The goal is to see if it can eliminate all signs of cancer by the time of surgery. About 927 adults with…

This is a first-in-human study to test the safety and find the right dose of an experimental pill called ATV-1601. It is for adults with advanced solid tumors, including certain breast, gynecologic, and prostate cancers, that have a specific genetic change called an AKT1 E17K mut…

This study compares how well ultrasound and breast MRI find cancer in women with dense breasts who have had breast cancer before. About 1,756 women will get both types of scans to see which one detects more cancers. The goal is to find the best way to check for new cancers in thi…

This study looks at whether a special type of mammogram using a contrast dye can find breast cancer more accurately than standard mammograms in women who have already had breast cancer. About 1,647 women will get both types of imaging to compare how many cancers are found and how…

This study looked at whether a physical therapy program focused on neck control exercises could help long-term breast cancer survivors (at least 5 years since diagnosis) with neck pain, mood, and quality of life. The program aimed to improve how well participants could control th…

This study tests a combination of pain neuroscience education and behavioral graded activity in 122 breast cancer survivors who have chronic pain. Participants in the intervention group attend six sessions to learn about pain and gradually increase activity, while the usual care …

This study looks at whether certain lab-made antibodies can spot breast cancer markers in blood samples. Researchers will collect blood from about 84 people, including breast cancer patients and healthy volunteers. The goal is to improve how we find and study cancer cells floatin…

This study collects blood and saliva samples from people with cancer and their family members to build a DNA bank. Researchers will use these samples to study how genes may increase the risk of developing certain cancers. The goal is to better understand inherited cancer tendenci…

This study looks at how aware and how often middle-aged and older women in China perform breast self-exams. Researchers will survey 3,000 women to find out what helps or hinders them from doing these exams. The goal is to use this information to create better community education …

This study looks at whether certain women with early-stage breast cancer can skip radiation after a lumpectomy. The participants are postmenopausal, have hormone receptor-positive, HER2-negative tumors, and a low Oncotype DX score. They will take hormone therapy but no radiation,…

This study reviewed medical records of 88 women who had two-stage breast reconstruction after mastectomy for breast cancer. Researchers compared complications between nano- and microtextured tissue expanders and looked at how prior radiotherapy affected results. The goal is to un…

This study gathers information from multiple hospitals about breast cancer in transgender and gender-diverse (TGD) adults. Researchers will look at how the cancer was found, what risk factors were present, what treatments were used, and how well patients did over time. The goal i…

This study follows about 1,400 people with a common type of advanced breast cancer (HR+/HER2-) who are receiving standard first-line treatment with palbociclib and hormone therapy. Researchers are collecting real-world data on how long the cancer stays under control and overall s…

This study uses tumor and blood samples from 1,000 breast cancer patients to build a model that predicts how well immunotherapy will work. Researchers will analyze genes, proteins, and other markers to find patterns linked to treatment success. The goal is to help doctors choose …

This study looks at how breast cancer and its treatments change the quality of life for 133 patients in Martinique. Researchers will track treatment times and use surveys to understand the main challenges patients face. The goal is to find ways to improve care and support for fut…