BREAST NEOPLASMS

This early-stage study is testing the safety of a drug called abemaciclib when combined with various other breast cancer therapies. It involves 198 people whose breast cancer has spread to other parts of the body. The main goal is to see which drug combinations are safe and toler…

This early-stage study is testing the safety of combining two drugs, H3B-6545 and palbociclib, for women with advanced or metastatic breast cancer that is estrogen receptor-positive and HER2-negative. The main goal is to find the highest dose patients can tolerate without severe …

This study is testing whether certain breast cancer patients can safely skip radiation treatment after lumpectomy surgery. It focuses on postmenopausal women with specific low-risk tumor types who are taking hormone-blocking medication. The goal is to collect data showing these p…

This early-stage study is testing the safety of an experimental drug called E7090, both alone and combined with other cancer medications. It involves 51 women with advanced, hormone-sensitive breast cancer that has returned or spread. The main goal is to find safe dosage levels a…

This is a first-in-human study to find a safe dose and see how the body processes a new oral drug called ATV-1601. It is being tested in adults with advanced solid tumors, including certain breast cancers, that have a specific genetic change called an AKT1 E17K mutation. The main…

This early-stage study aims to check the safety and understand how the body processes the drug tucatinib in a small group of Chinese patients. It includes people with advanced breast, stomach, or colorectal cancers that have a specific marker called HER2+ and have stopped respond…

This study is testing whether adding different immune-boosting drugs before standard chemotherapy and immunotherapy can improve treatment for triple negative breast cancer. The trial involves 12 participants with early-stage breast cancer who will receive treatment before surgery…

This large Phase 3 trial tested whether adding a new drug called abemaciclib to standard hormone therapy (fulvestrant) works better for women with a common type of advanced breast cancer. The study involved 669 women whose cancer had progressed after prior hormone treatment. Rese…

This early-stage study is testing a new drug called BT8009 in people with advanced solid tumors that have a specific marker called Nectin-4. The main goals are to find a safe dose, see how the body processes the drug, and get a first look at whether it can shrink tumors. The drug…

This study is testing whether a newer targeted drug, either alone or in sequence with standard chemotherapy, works better than current standard chemotherapy when given before surgery for high-risk, early-stage HER2-positive breast cancer. It aims to see if more patients can achie…

This study tested if adding a new drug called PD 0332991 to a standard hormone therapy (anastrozole) could better control early-stage breast cancer before surgery. It involved 84 women with a specific type of breast cancer that is hormone-sensitive. The main goal was to see if th…

This study is testing a new drug, PF-07220060, to see if it is safe and can help control advanced cancers. It will be given alone and in combination with other standard hormone therapies. The trial is for people with certain advanced solid tumors, including breast, prostate, and …

This study is testing whether a shorter, 1-week radiation treatment is as effective as the standard 3-week treatment for breast cancer patients who need radiation after surgery. The main goal is to see if the shorter treatment causes less arm swelling (lymphedema) while still con…

This early-stage trial is testing whether adding an experimental oral drug called AZD6244 to standard chemotherapy is safe for people with advanced cancers like breast, lung, colon, and kidney cancer. The study will find the highest dose patients can tolerate and track how the bo…

This study is testing whether a shorter, more targeted radiation treatment can effectively prevent cancer from returning in early-stage breast cancer patients. The treatment delivers radiation only to the area where the tumor was removed, over just two weeks instead of the typica…

This study is testing if adding an immunotherapy drug called pembrolizumab to standard chemotherapy works better than chemotherapy alone for a specific type of advanced breast cancer. It is for people whose cancer has spread or returned, is no longer responding to hormone therapy…

This study is testing whether a new hormone therapy drug called imlunestrant works better than standard hormone therapy at preventing breast cancer from coming back. It involves 8,000 people with early-stage breast cancer who have already completed 2-5 years of hormone therapy bu…

This study is testing whether combining two or three different cancer drugs works better than single drugs to control advanced cancers that have come back or spread. It is for adults with advanced ovarian, breast, lung, prostate, or colorectal cancer who have few other treatment …

This study is testing if a combination of two pills (ribociclib and letrozole) can work as well as standard chemotherapy when given before surgery for certain types of breast cancer. It involves 100 postmenopausal women with hormone-sensitive, HER2-negative breast cancer. Doctors…

This study is testing if a special type of mammogram that uses a contrast dye is better at finding new or returning breast cancers in women who have already had the disease. It compares this new method to the standard mammogram to see if it finds more cancers without causing too …

This study aimed to test a 9-week physical therapy program focused on neck exercises for long-term breast cancer survivors. The goal was to see if improving neck muscle control could reduce pain, improve mood, and enhance quality of life. The trial was withdrawn before any partic…

This study is testing whether a combination of pain education and gradual activity training can better reduce chronic pain for breast cancer survivors compared to standard care. It involves 122 survivors who have finished their main cancer treatment but still experience significa…

This study aims to understand the genetic causes of cancer that run in families. Researchers are collecting blood or saliva samples from patients with certain cancers and their relatives to build a DNA bank. The goal is to identify genetic patterns that increase cancer risk, whic…

This study aims to collect and analyze information about how breast cancer is found, treated, and what the outcomes are for transgender and gender-diverse people. Researchers are looking at past medical records from 125 people to better understand the unique experiences and chall…

This study looks back at the medical records of 88 women who had two-stage breast reconstruction after a mastectomy for breast cancer. The goal is to understand if the type of tissue expander used (nano- or microtextured) or having had radiation therapy before surgery affects the…

This study aims to build a tool to predict which patients with a hard-to-treat type of breast cancer will benefit from immunotherapy. Researchers will analyze tumor samples, blood, and scans from 1000 patients to find patterns linked to treatment success. The goal is to help doct…

This research study aims to find better ways to detect breast cancer by testing different antibodies on blood samples. Researchers will collect blood from 84 women—some with early or advanced breast cancer and some healthy volunteers—to see which antibodies can identify cancer ma…

This study aims to understand why many middle-aged and older women in China do not perform regular breast self-exams, despite knowing they are important. Researchers will survey 3,000 women in their communities to learn about their awareness, knowledge, and the personal barriers …