New combo therapy aims to control advanced breast cancer

NCT ID NCT04288089

First seen Mar 04, 2026 · Last updated May 01, 2026 · Updated 10 times

Summary

This early-phase study tests a new drug (H3B-6545) combined with palbociclib in women with advanced or metastatic ER+ HER2- breast cancer. The main goal is to find the safest dose and understand side effects. About 31 women who have already received prior treatment will participate.

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Contacts and locations

Locations

  • Comprehensive Cancer Centers of Nevada

    Las Vegas, Nevada, 89169, United States

  • Florida Cancer Specialists South - SCRI - PPDS

    Sarasota, Florida, 34232, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Royal Marsden NHS Foundation Trust

    London, United Kingdom

  • Royal Marsden NHS Foundation Trust

    Sutton, United Kingdom

  • Saint Luke's Cancer Institute

    Kansas City, Missouri, 64111, United States

  • Sarah Cannon Research Institute UK - SCRI

    London, United Kingdom

  • Tennessee Oncology, PLLC - SCRI - PPDS

    Nashville, Tennessee, 37203, United States

Conditions

Explore the condition pages connected to this study.