New drug cocktail shows promise for Tough-to-Treat breast cancer

NCT ID NCT02057133

First seen Jan 31, 2026 · Last updated May 13, 2026 · Updated 15 times

Summary

This early-phase study tested the safety of a new drug called abemaciclib when given with other breast cancer treatments (like letrozole, tamoxifen, or trastuzumab) for people whose breast cancer has spread to other parts of the body. About 198 participants with either hormone receptor-positive or HER2-positive breast cancer took part. The main goal was to see how many people had side effects from the drug combinations.

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Contacts and locations

Locations

  • Columbia University College of Phys & Surgeons

    New York, New York, 10032, United States

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Highlands Oncology Group - Duplicate 2

    Rogers, Arkansas, 72758, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905-0002, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Peggy and Charles Stephenson Oklahoma Cancer Center

    Nashville, Tennessee, 37203, United States

  • Providence Cancer Center Oncology Hematology Care

    Portland, Oregon, 97213, United States

  • South Texas Accelerated Research Therapeutics (START)

    San Antonio, Texas, 78229-3307, United States

  • Tennessee Oncology PLLC

    Nashville, Tennessee, 37203, United States

  • Univ of Pittsburgh Cancer Inst. (UPCI)

    Pittsburgh, Pennsylvania, 15213, United States

  • University of California - San Diego

    La Jolla, California, 92037-0845, United States

  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, 27514, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232-6307, United States

Conditions

Explore the condition pages connected to this study.