BILIARY TRACT CANCER

This large global study is comparing two different immunotherapy drugs (rilvegostomig and durvalumab) when combined with standard chemotherapy for people with advanced bile duct cancer who haven't had previous treatment. The main goal is to see which combination helps patients li…

This early-stage study is testing whether adding two experimental treatments—deep heat therapy and a special type of radiation—to standard chemotherapy and immunotherapy is safe and feasible for people with advanced bile duct cancer that cannot be removed by surgery. The goal is …

This study is testing a new treatment called RP2, which is a modified virus designed to attack cancer cells and boost the immune system. It is for people with advanced liver cancer or bile duct cancer that has continued to grow despite standard treatment. The goal is to see if RP…

This early-stage trial is testing a new drug called BL-M05D1 in people with advanced cancers that have spread and stopped responding to standard treatments. The study will enroll 120 patients with specific cancers like stomach, pancreatic, and esophageal cancer to determine the s…

This is an early-stage study testing a new drug called MT-4561 in people with various advanced solid tumors who have run out of standard treatment options. The main goals are to find a safe dose, see how the body processes the drug, and check for any early signs that it might hel…

This study is testing whether two new drug combinations work better than the current standard treatment for advanced bile duct cancer. It will enroll about 620 adults with a specific protein marker (HER2) on their cancer cells who haven't had prior treatment for their advanced di…

This is the first human study of LNCB74, a new targeted cancer drug designed to deliver chemotherapy directly to cancer cells. Researchers will test different doses in 145 adults with advanced solid tumors (including ovarian, breast, lung, and other cancers) to find the safest an…

This study is testing a personalized approach to prevent bile duct cancer from coming back after surgery. For each patient, tiny pieces of their tumor are tested in mice to see which chemotherapy drugs work best against it. The goal is to see if using this 'mini lab' test to choo…

This study is testing whether a combination of two immunotherapy drugs, ligufalimab and cadonilimab, can help control advanced liver or bile duct cancers that have worsened after prior immunotherapy. It will enroll about 64 adults whose cancer has spread and is no longer respondi…

This early-stage study is testing a new drug called AZD4360 in adults with advanced cancers of the stomach, pancreas, and related areas. The main goals are to find a safe dose and see if the drug shows any signs of helping to control the cancer. The drug is designed to target a s…

This study is testing the safety and effectiveness of a new two-drug combination (AK130 + AK112) for people with advanced bile duct cancer that has worsened after initial treatment. The first part finds the safest dose, and the second part sees how well the drugs work together. I…

This study is monitoring the safety of Tasfygo tablets in real-world patients with advanced bile duct cancer that cannot be surgically removed. It includes 60 patients who have a specific genetic change (FGFR2 fusion) and whose cancer worsened after standard chemotherapy. The mai…

This study is testing an experimental drug called AZD0901, both by itself and combined with standard chemotherapy, for people with advanced cancers of the stomach, pancreas, and bile ducts. The main goals are to see if the treatment is safe and if it can shrink tumors. It is for …

This study is testing whether new immune-boosting drugs, given alone or with other cancer drugs, can help control advanced liver or bile duct cancer. It will enroll about 294 adults whose cancer has spread and is no longer responding to standard treatments. The main goals are to …

This study is testing if a new combination of chemotherapy drugs works better than the current standard for advanced bile duct cancer when the first treatment stops working. It combines a pill called trifluridine/tipiracil with an IV drug called oxaliplatin. The goal is to see if…

This study is testing whether a new drug called ivonescimab works better than standard chemotherapy for people with advanced bile duct cancer whose first treatment has stopped working. It will involve 72 patients who previously took part in a related screening study. Participants…

This study is testing an experimental drug called TQB2102 for people with advanced bile duct cancer that has a specific marker called HER2. The main goals are to find the safest and most effective dose and to see if the drug helps shrink tumors. The trial is for adults whose canc…

This early-stage study is testing a new drug called BL-M07D1 for people with advanced cancers that have a specific marker called HER2. The trial aims to find the safest dose and see if the drug helps control cancer growth in patients who have already tried standard treatments. Re…

This study is testing a new drug called MK-2870, both by itself and combined with other cancer treatments, for people with advanced colorectal, pancreatic, or biliary tract cancers. The main goals are to see if the treatment is safe and if it helps shrink or eliminate tumors. The…

This study is testing whether a targeted drug called ivosidenib, when combined with other cancer therapies, can help control advanced bile duct cancer in patients who have a specific genetic change called an IDH1 mutation and whose cancer has worsened after standard chemotherapy.…

This study is testing whether giving two immunotherapy drugs (Tuvonralimab and Iparomlimab) plus chemotherapy before surgery can improve outcomes for people with bile duct cancer. Researchers want to see if this approach helps surgeons remove more of the cancer completely and red…

This study is testing whether adding a new targeted drug called zanidatamab to standard chemotherapy works better for people with advanced HER2-positive bile duct cancer. Researchers will compare the combination treatment against standard chemotherapy alone in 286 participants. T…

This study is testing whether virtual reality (VR) can help reduce pain and improve quality of life for people with gastrointestinal cancers. Researchers will compare three approaches: VR that teaches pain management skills, VR designed to distract from pain, and a basic VR contr…

This study aims to find the most effective pain management approach for patients undergoing minimally invasive cancer surgery. Researchers will randomly assign 48 participants to one of three pain control methods used during their operation. The study will compare pain levels, me…

This study compares how well the cancer drug T-DXd works compared to standard treatments for patients with advanced HER2-positive solid tumors. Researchers will analyze existing medical records from about 105 patients who received either T-DXd in previous trials or standard care …

This study aims to see if analyzing tiny bits of tumor DNA found in blood and stool (called ctDNA) can help doctors better manage treatment for people with cancers of the digestive system, like pancreatic, colon, and bile duct cancer. It will observe 100 patients to see if these …

This study aims to understand why some patients with advanced bile duct cancer respond better than others to a specific two-drug treatment (lenvatinib plus pembrolizumab). Researchers will follow 100 patients receiving this treatment in real-world clinics to see how well it works…

This study aims to understand if infections from Helicobacter bacteria (like the kind that can cause stomach ulcers) are linked to cancers of the bile ducts and gallbladder. Researchers will compare the presence of these bacteria in tissue samples from 250 people: those with bile…

This study is testing whether a simple blood test can be as good as a tissue biopsy at finding specific genetic changes in advanced bile duct cancer. Researchers will enroll 200 patients to see if the blood test results match the traditional tissue test and if they help doctors c…