Preeclampsia

This study explores whether combining a high-protein Mediterranean diet with resistance exercise can help people with heart disease build muscle and lower their risk of future heart problems. The trial enrolls adults who have completed cardiac rehab and may have low muscle mass w…

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This study tested a coaching program called MACRO-I for adults aged 70 and older who had a heart event. The program used coaches to guide patients through starting cardiac rehab, either at a center, at home, or a mix of both. 416 participants were split into the coaching group or…

This study tested whether a stricter blood pressure goal (below 135/85) after a pregnancy complicated by high blood pressure is better than the usual care (below 150/100). About 60 new mothers were enrolled and followed for six months. The goal is to see if tighter control is pos…

This completed study compared two intravenous blood pressure medications, labetalol and hydralazine, in 132 pregnant women with severe preeclampsia. The goal was to see which drug more effectively lowered blood pressure to safe levels. Results could help doctors in the local sett…

This study tested two different blood pressure targets during cesarean section in 390 women with preeclampsia. One group kept blood pressure above 80% of their starting level, the other above 90%. The goal was to see which target led to better newborn outcomes, measured by umbili…

This study tested a once-daily pill called orforglipron against insulin glargine in nearly 2,750 adults with type 2 diabetes, obesity or overweight, and increased cardiovascular risk. The main goal was to see if orforglipron could reduce major heart events like heart attacks or s…

This early-stage trial tested the safety and tolerability of telpegfilgrastim injections in 18 non-pregnant women, including some with a history of preeclampsia. Researchers monitored side effects, drug levels in the blood, and immune markers. The goal is to see if the drug is sa…

This study tested whether taking low-dose aspirin (150 mg) daily, starting in the first trimester, could reduce pregnancy complications in women with type 1 or type 2 diabetes. The trial included 137 women and looked at outcomes like preeclampsia, early preterm birth, low birth w…

This study tested a program for women with high blood pressure after pregnancy. Participants monitored their blood pressure at home and reported it through an app. A nurse navigator helped adjust medications and coordinated follow-up care. The goal was to improve blood pressure c…

This study tested whether intensive dental cleaning and oral hygiene advice can improve gum health and also affect markers of heart disease and type 2 diabetes. About 200 adults with gum disease and either heart disease or diabetes (or prediabetes) took part. Researchers measured…

This small completed study looked at a blood filtering procedure called double-filtration plasmapheresis (DFPP) in 5 kidney dialysis patients with very high levels of lipoprotein(a), a fatty substance linked to heart disease and blood clots. The goal was to see if DFPP could lowe…

This study tested whether a drug called alirocumab, which lowers cholesterol, can reduce heart disease risk in people with HIV. The trial involved 118 adults aged 40 and older with well-controlled HIV and high heart disease risk. Participants received either alirocumab or a place…

This completed trial looked at whether taking two cholesterol-lowering drugs (rosuvastatin and ezetimibe) is more effective and safer than taking just one (rosuvastatin) for people with heart disease. 66 adults with high cholesterol were randomly assigned to one of the two treatm…

This study tested whether hydroxytyrosol, a natural antioxidant found in olives, can reduce inflammation and oxidative stress in pregnant women with high blood pressure. 42 women took either a daily 10 mg hydroxytyrosol capsule or a placebo for 4 weeks. Researchers measured chang…

This study looked at 170 women with severe pre-eclampsia in the ICU to see which blood pressure drug—phentolamine or glyceryl trinitrate (GTN)—better protects kidney function. Pre-eclampsia can harm the kidneys, and GTN has been linked to kidney injury in some cases. The research…

This pilot study tested two common blood pressure medications—a combination pill of hydrochlorothiazide and lisinopril versus extended-release nifedipine—in 70 new mothers with high blood pressure after delivery. The goal was to see which pill controls blood pressure better in th…

This study looked at 60 women with preeclampsia having a C-section to find the best doses of two drugs (phenylephrine and norepinephrine) to prevent dangerously low blood pressure after spinal anesthesia. The goal was to identify doses that work in 90% of patients. The findings c…

This study tested a medical device that filters a harmful protein called sFlt-1 from the blood of pregnant women with preeclampsia, a serious condition causing high blood pressure. The goal was to see if the treatment is safe and can help control the disease. The trial involved 2…

This study tested whether community health workers can help Black postpartum patients who had preeclampsia or other pregnancy complications. 61 participants were split into two groups: one received usual care, the other also got support from a community health worker. The goal wa…

This trial tested a program where community health workers used a tablet app to screen pregnant women in rural India for anemia, high blood pressure, and diabetes. Over 3,400 women took part. The goal was to see if this screening and referral system could lower anemia rates and i…

This study looked at whether giving magnesium sulfate for 12 hours after delivery instead of the usual 24 hours is safe and effective for preventing seizures in women with mild preeclampsia. Researchers enrolled 200 women and compared the two treatment lengths. The goal was to se…

This study uses a non-invasive ultrasound called transcranial Doppler (TCD) to measure blood flow in the brains of pregnant women with preeclampsia. Researchers will compare 50 women with preeclampsia to 50 healthy pregnant women to see if TCD can detect early signs of serious co…

This study tested whether a special ultrasound score (called VEXUS) can predict acute kidney injury in women with severe preeclampsia when they are admitted to the hospital. Researchers examined 70 women using Doppler ultrasound to check blood flow in key veins. The goal was to s…

This study looked at whether a special eye scan (SS-OCTA) can detect signs of cardiovascular disease. Researchers compared retinal blood vessel changes to results from a standard carotid ultrasound in 42 adults. The goal was to see if the eye scan could predict the presence or se…

This study looked at whether measuring homocysteine levels in the blood can help predict how severe preeclampsia will become in pregnant women. Researchers measured homocysteine in 70 critically ill preeclampsia patients and analyzed its link to complications. The goal is to see …

This completed study looked at whether measuring blood flow in the fetal lung artery using ultrasound can predict breathing difficulties in newborns. Researchers studied 86 pregnant women with severe preeclampsia between 28 and 37 weeks. The goal was to see if a specific ultrasou…

This study looked at whether a protein called Cadherin-6 in the blood of pregnant women could help predict preeclampsia, a dangerous condition involving high blood pressure. Researchers measured Cadherin-6 levels in 150 women between 15 and 20 weeks of pregnancy and tracked who l…

This study tested whether a blood test measuring the sFlt-1/PlGF ratio can help doctors decide the best care for pregnant people with suspected preeclampsia before 35 weeks. 84 participants were randomly assigned to have their care guided by the test or usual care. The goal was t…

This study looked at whether a protein called EG-VEGF in the blood of pregnant women could predict pre-eclampsia or poor fetal growth. Researchers took blood samples and performed ultrasound scans on 142 women early in pregnancy. The goal was to see if EG-VEGF levels could serve …

This study looked at whether a blood test measuring the sFlt-1/PlGF ratio can help doctors decide if women with suspected pre-eclampsia need to be hospitalized. Pre-eclampsia is a serious pregnancy condition that can harm both mother and baby, but diagnosing it is tricky. The stu…

This study looked at how often older adults with heart disease risk factors should exercise to improve fitness and blood pressure. Twenty-two participants did combined training either twice or three times a week for 12 weeks. The goal was to see which frequency worked better for …

This study tested whether taking a low-dose aspirin (160 mg) each night, starting before 16 weeks of pregnancy, could prevent pre-eclampsia and small babies in first-time mothers at high risk. Over 1,100 women with abnormal blood flow in the uterine artery were randomly assigned …

This study tested an 8-week digital lifestyle program called MYCardio-PEER for low-income adults at risk of heart disease. Participants received weekly videos and infographics on healthy eating and exercise, plus group chats with peer leaders. The goal was to see if the program i…

This study looked at whether a home-based physical activity program and computer-based cognitive training could help prevent memory loss in older women with heart disease. 253 women aged 65 and older participated. The goal was to see if these lifestyle changes could improve memor…

This study looked at how aspirin affects platelet function in 130 pregnant women at high risk for preeclampsia. Researchers measured platelet response and genetic factors to see if they could predict who develops high blood pressure disorders. The goal is to eventually personaliz…

This completed study tested whether sending behavioral nudges through Denmark's official electronic letter system could increase flu vaccination among adults aged 18-64 with chronic diseases. Over 300,000 participants were randomly assigned to receive different types of letters o…

This study looked at whether adding nonsteroidal anti-inflammatory drugs (NSAIDs) to standard pain relief is safe for women with severe preeclampsia after giving birth. 287 women participated, and researchers measured their blood pressure and need for blood pressure medication. T…

This study looked at two methods to reduce pain after heart surgery through a cut in the chest bone. 120 adults received either a nerve block near the breastbone, pain medicine injected into the wound, or standard painkillers. Researchers measured pain levels using a saliva test …

This completed trial tested an 8-week program called Healing Hearts Together (HHT) for couples where one partner has heart disease. 474 couples attended weekly group sessions focused on communication, emotional support, and heart health. The goal was to see if the program improve…

This study tested whether a 20-minute session of nurse-led spiritual care, including prayer and relaxation techniques, could help heart surgery patients feel less anxious and have more stable blood pressure and heart rate before their operation. 248 adults in Indonesia took part.…

This study tested a self-management app for women who had high blood pressure during pregnancy. 99 new mothers used the app to track their blood pressure, stress, and mood, or received usual care. The goal was to see if the app helps lower blood pressure and improve mental health…

This study tested whether a 3-month yoga program could improve physical and mental health in adults over 65 who had recently finished cardiac rehab. Participants attended yoga twice a week. Researchers measured balance, muscle strength, anxiety, and mood. The goal was to see if y…

This study tested a 9-week internet-based cognitive behavioral therapy (CBT) program designed to reduce stress, anxiety, and depression in people with stable heart disease. 215 adults with heart disease and elevated stress or mood symptoms took part. The program was personalized …

This study tested whether adding virtual reality (VR) driving simulations to standard cardiac rehabilitation helps heart surgery patients feel less anxious and depressed. Sixty adults recovering from heart surgery took part. The results suggest VR can improve emotional well-being…

This study explored how family members share health information about genetic diseases like sickle cell, diabetes, and cancer. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand social and relational factors…

This study looked at whether using concept maps—diagrams that show how ideas connect—helps third-year medical students learn and remember information better. 26 students were split into three groups: one with no concept map, one with a map made by the teacher, and one where stude…

This pilot study tested whether giving inhaled nitric oxide gas during laparoscopic surgery could protect blood vessels and organs in 40 adults with heart disease. Half received the gas through their breathing tube during surgery, and half received standard care. Researchers meas…

This study looked at 150 Caribbean Hispanic adults with heart disease or stroke risk who take the blood thinner clopidogrel. Researchers wanted to see if certain gene variants affect how well the drug works. The goal is to understand why some people get less benefit and to pave t…

This study tested whether a pop-up alert in electronic health records could increase doctors' recommendations for low-dose aspirin in pregnant women at high risk for preeclampsia. Over 800 women were included, and the alert was shown during prenatal visits. The goal was to see if…

This study checked how well over 5,000 heart patients follow their prescribed medicine routine. Researchers asked patients about their medication habits and any side effects. The goal was to understand how many patients do not take their medicines as directed.

This study looked at whether special ultrasound measurements of the baby's kidney and placenta can help predict health problems in newborns. Researchers compared 114 pregnant women with and without preeclampsia. The goal was to see if these scans could warn doctors about complica…

This study tested a special nursing program that teaches pregnant women with preeclampsia about climate-related health risks, like heat and pollution. 104 women took part, with half receiving the program plus usual care and half receiving usual care alone. The goal was to see if …

This study tested a program where doctors refer inactive people with chronic diseases (like diabetes, heart disease, or obesity) to an exercise professional for personalized counseling. The goal was to see if this referral scheme helps people become more active compared to just g…

This completed study investigated why low-dose aspirin helps prevent preeclampsia in some high-risk pregnant women but not others. Researchers took blood samples from 35 women at four points during pregnancy to study their immune cells, particularly neutrophils. The goal was to i…

This study looked at 89 obese pregnant women to find out how common sleep apnea is and whether it is linked to high blood pressure, preeclampsia, or poor fetal outcomes. Participants had a sleep test (polysomnography) to detect apnea. The goal was to understand the connection and…

This study checked whether the Turkish version of the Cardiac Depression Scale (CDS) works well for people with heart disease. Researchers tested 360 Turkish adults with various heart conditions to see if the scale accurately measures depression. The goal is to give doctors a rel…

This completed study looked at 400 people with both heart disease and a mental health condition (like depression or anxiety). Researchers used questionnaires, blood tests, and imaging to find shared risk factors and biological markers. The goal was to better understand how these …

This study looked at whether a 4-week resistance training program is doable for women who had pregnancy complications like preeclampsia or preterm birth. Seven new moms participated, and researchers measured how well they stuck with the exercises and how they felt about them. The…

This completed study looked at why some pregnant women in France choose not to join randomized clinical trials about pregnancy and childbirth. Researchers surveyed 526 women to find out what factors — like age, education, or how the study was explained — might influence their dec…

This completed study observed 72 pregnant women with HELLP syndrome in the ICU. Researchers tracked daily changes in platelets, liver enzymes, and lactate dehydrogenase before and after delivery. The goal was to understand how these biological markers evolve, not to test a treatm…

This study examined 33 preterm babies born before 30 weeks to mothers with preeclampsia. Researchers measured certain proteins in the mother's blood, umbilical cord blood, and amniotic fluid to see if they were linked to a lung condition called bronchopulmonary dysplasia (BPD). T…

This study collected blood samples from 236 pregnant women with and without preeclampsia. The goal was to test a new approach that filters out a protein called sFlt-1 from the blood, which may help restore normal blood vessel function. The research is a first step toward a possib…

This study looked at whether wearing an activity monitor (like a Fitbit) after heart surgery helps patients get moving sooner and return to their normal activity levels faster. Researchers tracked motivation, length of hospital stay, and readmission rates in 12 adults who had car…

This study tested whether special communication training for pharmacists and general practitioners helps them involve older patients in decisions to stop or lower medications for heart disease and diabetes. Researchers enrolled 310 patients aged 75 and older who were taking certa…

This study tested whether a theory-based motivational letter mailed six months in advance could increase attendance at a one-year post-cardiac rehabilitation check-up. Researchers compared 102 adults who received the letter to those who got usual care. The goal was to see if a si…

This study looked at whether combining virtual simulation with hands-on practice helps midwifery students learn better than virtual training alone. Thirty-two students were split into two groups to practice managing severe preeclampsia. The goal was to see if the combined approac…

This study looked at how giving IV fluids during a C-section affects heart function in women with preeclampsia. Researchers used ultrasound to measure heart output in 34 women. The goal was to better understand how to manage fluids safely in these patients.

This study looked at how well a daily low-dose aspirin works in people who have both immune thrombocytopenia (low platelets) and heart disease. Only 4 adults took part. Researchers measured platelet function after aspirin to see if the standard dose is enough to prevent blood clo…

This study tested whether a systematic phone call from a medical student, supervised by a general practitioner, could reduce hospitalizations in patients with chronic heart or mental health conditions during the COVID-19 lockdown in France. Over 22,000 patients aged 70 and older …

This study looked at 320 adults who had heart surgery to see how well two different risk scores (EuroSCORE-II and POSPOM) predict the chance of dying in the hospital. Researchers calculated each patient's scores before surgery and compared them to what actually happened. The goal…

This study looked at whether orienteering (a navigation-based walk) is as good as regular walking for heart rehab. 40 people with stable heart disease took part. Researchers measured heart rate and enjoyment during both activities. The goal was to see if orienteering could be a f…

This study looked at how certain immune cells (neutrophils) form web-like structures in women with preeclampsia compared to those with normal pregnancies. Researchers analyzed stored blood samples from 26 women to understand two different ways these webs are made. The goal was to…

This study measured certain proteins (histones and HMGB1) in the blood of 115 pregnant women to see if they could help detect placenta-related complications like pre-eclampsia. Researchers compared women with normal pregnancies, those with complications, and healthy non-pregnant …

This completed study investigated levels of a protein called CD71 in placentas from 39 women with preeclampsia and 39 healthy pregnant women. Researchers also looked at newborn outcomes. The goal was to better understand how preeclampsia develops. No treatment was tested; this is…

This study measured the amount of free-floating DNA and nucleosomes in the blood of 137 women to see if these levels differ between those with pregnancy complications (like preeclampsia or blood clots) and healthy women (both pregnant and non-pregnant). The goal was to better und…

This study looked at whether low vitamin D levels in the first trimester of pregnancy are linked to developing preeclampsia later on. Researchers measured vitamin D in over 3,000 pregnant women in France. The goal was to understand how common vitamin D deficiency is and if it rel…

This study tested an indoor air pollution intervention called AIRWISE in 20 adults aged 55 and older with heart disease. Participants received personal air cleaners, a color-changing air quality monitor, and educational materials. The goal was to see if they would use these tools…

This completed study tested whether healthcare claims data can predict the results of a major heart trial (SURPASS-CVOT) comparing two diabetes drugs, tirzepatide and dulaglutide. Researchers analyzed records from over 44,000 people with type 2 diabetes and heart disease to see i…

This study examined how well the heart relaxes between beats in 80 pregnant women—40 with preeclampsia and 40 healthy. Researchers used ultrasound to measure heart function. The goal was to see if preeclampsia is linked to early signs of heart strain, which could help doctors cat…

This completed study looked at why some pregnant women chose not to take part in a larger trial on early screening for pre-eclampsia, a serious pregnancy condition. Researchers surveyed 472 women to find factors linked to refusal and to understand their reasons for saying yes or …

This study looked at two ways to assign care coordinators to older adults (65+) with heart disease or risk factors. One method used patients' own reports of difficulty coordinating care, while the other used usual triggers like hospital discharge. The goal was to see which approa…