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Preeclampsia
MONDO:0005081Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia.
Also known as: pre-eclampsia, pre-eclamptic toxaemia, pre-eclamptic toxemia, preeclampsia, preeclampsia/eclampsia, pregnancy toxaemia, proteinuric hypertension of pregnancy, toxaemia of pregnancy
352 clinical trials for this condition and its sub-types.
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Can a common water pill keep blood pressure in check after childbirth?
Disease control TerminatedThis study tested whether a 14-day course of hydrochlorothiazide (a water pill) could prevent high blood pressure from returning after delivery in women with preeclampsia or gestational hypertension. Over 450 women were planned, but the trial was stopped early. The main goals wer…
Phase: PHASE3 • Sponsor: The University of Texas Medical Branch, Galveston • Aim: Disease control
Last updated Jun 27, 2026 14:03 UTC
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Promising preeclampsia drug trial halted early – what happened?
Disease control TerminatedThis study tested an experimental drug called AMAG-423 (Digoxin Immune Fab) in pregnant women with severe preeclampsia, a dangerous condition of high blood pressure during pregnancy. The goal was to see if the drug could reduce serious health problems in babies, such as bleeding …
Phase: PHASE2, PHASE3 • Sponsor: AMAG Pharmaceuticals, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:36 UTC
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Heart drug tested to fight COVID-19 complications
Disease control TerminatedThis study tested a drug called CardiolRx in 90 hospitalized COVID-19 patients who also had heart disease or risk factors like diabetes or high blood pressure. The goal was to see if the drug could lower the chance of death, needing intensive care, or having heart problems. The t…
Phase: PHASE2, PHASE3 • Sponsor: Cardiol Therapeutics Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New approach aims to protect new Moms' brains after preeclampsia
Disease control TerminatedThis study tested a new way to manage blood pressure in new mothers with severe postpartum preeclampsia. Participants received standard blood pressure medications, but one group had personalized blood pressure targets based on real-time brain monitoring. The goal was to keep bloo…
Phase: NA • Sponsor: Columbia University • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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New blood pressure gadget put to the test in pregnancy
Diagnosis TerminatedThis study aimed to see if the CONNEQT Pulse blood pressure monitor gives accurate readings in pregnant women, including those with high blood pressure or pre-eclampsia. Researchers compared it to a standard blood pressure cuff in 41 pregnant volunteers. The study was stopped ear…
Sponsor: Mount Carmel Health System • Aim: Diagnosis
Last updated Jun 27, 2026 09:11 UTC
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Cholesterol drug tested to stop dangerous pregnancy complication
Prevention TerminatedThis study tested whether the cholesterol-lowering drug pravastatin could prevent preeclampsia in women who had a previous early preterm delivery due to the condition. The trial planned to enroll 1,550 women but was terminated early with only 102 participants. Because it stopped …
Phase: PHASE3 • Sponsor: The George Washington University Biostatistics Center • Aim: Prevention
Last updated Jun 27, 2026 08:06 UTC
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Pill vs. IV: which works faster for postpartum hypertension?
Symptom relief TerminatedThis study aimed to compare two blood pressure medications—oral nifedipine (a pill) and intravenous labetalol (given through a vein)—for treating dangerously high blood pressure in women who have just given birth. The goal was to see which drug lowers blood pressure faster. Howev…
Phase: PHASE4 • Sponsor: Columbia University • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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Painkiller showdown: which is safer for the heart?
Knowledge-focused TerminatedThis study looked at how two common pain relievers—celecoxib (a Coxib) and naproxen (an NSAID)—affect blood clotting in people with rheumatoid arthritis who also have heart disease or are at high risk for it. All participants took low-dose aspirin daily. The goal was to see if on…
Phase: PHASE4 • Sponsor: Platelet and Thrombosis Research, LLC • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC