University Of North Carolina, Chapel Hill

This study tested two ways to help people with type 2 diabetes get more support. First, it tried sending automatic reminders to doctors to refer patients to diabetes education classes. Second, it tested whether connecting patients with a peer who also has diabetes would make them…

This study tested whether a supplement made from a cow's milk protein (recombinant bovine lactoferrin or rbLf) could help the body regulate iron better in healthy adults. Over 14 weeks, 92 participants took either the rbLf supplement, a similar milk-derived supplement, or a place…

This study tested a new community-based support program for people living with psychosis in Malawi. The program, delivered by nurses, aimed to help patients manage their condition and improve daily functioning after leaving the hospital. Researchers enrolled 60 participants to se…

This study tested if a 12-week time-restricted eating plan was practical and acceptable for older adults with mild memory problems and obesity. Participants worked with a psychologist to fast for 16 hours on 2-3 days each week. Researchers measured changes in memory, thinking ski…

This study tested whether a mobile phone program could help young adults reduce heavy drinking episodes. Researchers enrolled 40 adults aged 18-25 who reported recent heavy drinking and randomly assigned them to receive either the text-message intervention or regular surveys only…

This study tested whether an online family support program could work well alongside a standard weight loss program for Black adults. Researchers wanted to see if adding family skills training online would be practical and acceptable to participants. The program focused on improv…

This study tested a two-week antibiotic treatment to clear a dangerous bacteria called MRSA from the lungs of people with cystic fibrosis. Thirty-seven participants aged 2 to 45 received oral antibiotics, a nasal ointment, and mouthwash. Researchers checked if the treatment succe…

This study looked at whether adding an inhaled powder called Bronchitol could help clear sticky mucus from the lungs of adults with moderate-to-severe cystic fibrosis who were already taking a highly effective triple-drug therapy (E/T/I). Researchers wanted to see if the extra tr…

This study tested a new 2-year weight loss program called 'Med-South,' which adapts a Mediterranean-style diet for Southern U.S. preferences. Researchers compared it directly to the popular WW (Weight Watchers) program. The goal was to see which approach helped 360 adults with ob…

This study tested the safety of the drug sildenafil in premature babies at risk for a serious lung disease called bronchopulmonary dysplasia (BPD). It involved 109 very premature infants in the hospital. Researchers gave different doses to see how the babies' bodies handled the d…

This study tested whether sending specific, well-timed messages through a phone app could help young adults with overweight or obesity stick to daily weight loss behaviors. Over 200 participants used an app with lessons, tracking, and daily goals for weighing, activity, and food.…

This study tested a support program designed for transgender women living with HIV in the Dominican Republic. The program, called 'Gender-affirming Abriendo Puertas,' offered individual counseling, peer support, and community activities to help participants stay on their medicati…

This study tested whether giving surgeons video-based feedback on their hernia repair techniques could improve patient outcomes. It involved 59 surgeons who were randomly assigned to receive either live video coaching, written feedback on their surgery videos, or no extra trainin…

This study tested different ways to encourage more men in China to get tested for gonorrhea and chlamydia. Researchers compared a standard 'pay-it-forward' model (where a person's test is paid for by a previous donor, and they can choose to donate for the next person), a more com…

This study tested a culturally tailored program designed to help African American women manage stress, improve nutrition, and increase physical activity to reduce their risk of heart disease, stroke, and diabetes. 175 women participated in this completed trial. The program focuse…

This study tested if watching a short, culturally tailored online soap opera could encourage HIV prevention behaviors in Latina women. Researchers enrolled 95 women in North Carolina to watch four episodes about HIV risks and prevention. The goal was to see if the show increased …

This study tested whether linking schools with clinics for a single 'Adolescent Wellness Visit' could encourage teens to get tested for HIV and use contraception. About 1,500 students in their final year of primary school in Tanzania were involved, with half receiving the wellnes…

This study tested whether a special group prenatal care program, focused on healthy eating and physical activity, could help prevent gestational diabetes and improve outcomes for mothers and babies. It involved 305 pregnant women who were at high risk for developing diabetes duri…

This study tested a simple way to prevent mothers from passing hepatitis B to their babies during birth. In the Democratic Republic of Congo, 317 pregnant women with hepatitis B received either a real medication or a placebo pill during late pregnancy. All their newborns got a he…

This pilot study tested a new counseling approach to help HIV-negative pregnant women in Malawi make personal decisions about using daily medication (PrEP) or condoms to prevent HIV. Researchers compared the new counseling method, which involved a structured decision-making tool,…

This study tested a new way to encourage male partners of pregnant women to get tested for HIV. Researchers gave some women a standard invitation for their partner to get tested at a clinic, and gave other women that invitation plus a take-home oral HIV test kit for their partner…

This study tested if a stretching program is better than standard exercise advice for lowering heart and blood pressure risks in pregnant women with obesity. It involved 224 women from 27 to 37 weeks of pregnancy. The goal was to see if stretching could help prevent serious pregn…

This study tested if a brief, virtual writing therapy could help prevent post-traumatic stress disorder (PTSD) in women after a recent sexual assault. Researchers enrolled 30 women who received care from a sexual assault nurse examiner. Participants were randomly assigned to eith…

This small, completed study tested if a single large dose of vitamin D, given right after a serious burn, could prevent patients from developing long-lasting chronic pain. Researchers gave 40 adult burn patients either vitamin D or a placebo pill and tracked their pain, medicatio…

This study tested a two-part program designed to lower the risk of developing chronic diseases like diabetes and high blood pressure in unemployed adults. It worked by adding a health prevention program to existing job training services and by training workplace supervisors to be…

This study aimed to find the safest and most effective daily pill dose to prevent HIV in pregnant women in Africa. Researchers tested three different strengths of the prevention medication in 54 pregnant women to see how their bodies processed the drug and to check for safety. Th…

This study tested if a vaccine already approved to prevent meningitis (Bexsero) could also protect against gonorrhea. Researchers gave healthy male volunteers either the meningitis vaccine or standard flu/tetanus shots, then exposed them to the gonorrhea bacteria in a controlled …

This pilot study tested whether a new care model called PREVAIL could be successfully integrated into routine rheumatology visits for adults with rheumatoid arthritis (RA). The model used a screening tool to identify patients who might benefit from exercise guidance or a physical…

This study tested whether simple tools could help teens with ADHD have better conversations with their doctor. Researchers gave 126 teens and their parents either a video, a list of suggested questions, both, or just usual care before a doctor's visit. The goal was to see if thes…

This small pilot study tested whether six weeks of high-intensity strength training, with or without creatine supplements, could help perimenopausal women. Researchers measured effects on muscle strength, brain function, metabolism, and menopausal symptoms like mood changes and f…

This study tested if women could safely remove their own urinary catheters at home one day after pelvic surgery, instead of waiting three to four days and returning to the clinic. Researchers wanted to see if early removal worked as well at preventing problems like being unable t…

This study tested a specialized palliative care program for people hospitalized with late-stage Alzheimer's or related dementias and their family caregivers. The program aimed to provide better symptom management, support decision-making, and coordinate care after leaving the hos…

This study tested a new Virtual Reality (VR) program designed to help teenagers hospitalized for suicidal thoughts. The VR program lets them safely practice the skills needed to return to their regular school. Researchers worked with 54 teens to see if the program was practical t…

This study tested a new online support platform called Altitudes for parents and caregivers of young people with psychosis. It aimed to see if the platform was easy to use and helpful for reducing caregiver stress and burnout. About 50 caregivers used the moderated site for six m…

This study tested whether Spanish-language educational videos about colorectal cancer, delivered in a church setting, could increase knowledge and willingness to participate in cancer clinical trials among Latino adults. Researchers recruited 60 Spanish-speaking Latino churchgoer…

This study tested whether different warning labels on foods containing artificial sweeteners help parents identify these products and influence what they choose to buy for their children. Nearly 4,000 parents in Chile viewed products with different labels online and were asked to…

This study aimed to see if a common MRI scan could accurately detect brown fat in healthy adults. Brown fat is a special type of fat that burns calories to generate heat. Researchers compared MRI results against a more established PET scan method, using mild cold exposure to acti…

This study tested whether professional deep dental cleaning for gum disease could improve oral health and if those improvements were linked to better markers for heart health and blood sugar control. It involved about 200 adults who already had heart disease or type 2 diabetes (o…

This study tested whether giving rural pharmacists video coaching helps them counsel patients hesitant about COVID-19 vaccines better than standard training alone. Researchers worked with 20 pharmacies in the southeastern U.S. to compare two approaches: online training versus onl…

This study compared how two different hand muscles recover from anesthesia drugs used during surgery. Researchers monitored 57 patients to see if the muscle at the base of the thumb recovers differently from the muscle at the base of the little finger. The goal was to gather info…

This study aimed to find the best way to deliver healthy, 'medically tailored' meals to people. Researchers tested whether it's better to send meals just for one person or for their entire household, and whether a personal delivery driver or standard shipping works best. They mea…

This study aimed to understand how specific brain wave patterns help us control what we remember. Researchers used a safe, non-invasive magnetic stimulation technique on the brains of 71 healthy young adults while they performed memory tasks. The goal was to see if stimulating ce…

This study tested whether a fitness program led by fellow firefighters is a practical and acceptable way to improve health. Researchers recruited 52 firefighters to see if they could stick with a 6-week, peer-led exercise routine. The main goal was to gather information on how we…

This small, completed study explored whether a dietary supplement containing fiber and green tea extract could make people feel fuller and change how they respond to alcohol. Researchers gave 64 social drinkers either the supplement or a placebo before a controlled alcohol sessio…

This study aimed to understand why some women become irritable during the menopause transition. Researchers tested if stabilizing estrogen levels with a skin patch changed brain activity linked to irritability. They measured brain waves and mood in 40 women during periods using e…

This study tested the safety and effects of two different prebiotic supplements in 60 healthy adults. Participants took either a standard prebiotic, a modified 'humanized' version, or a placebo daily for four weeks. Researchers measured gut symptoms, changes in gut bacteria, and …

This study aimed to understand why some people with Primary Ciliary Dyskinesia (PCD) have milder symptoms than others. Researchers measured how quickly 27 participants (both with PCD and healthy volunteers) could clear mucus from their lungs using a safe, inhaled tracer and medic…

This study aimed to understand how different types of exercise affect metabolism in women going through perimenopause. Researchers compared high-intensity interval training (HIIT) to traditional aerobic exercise in 28 overweight or obese perimenopausal women. They measured how th…

This small, early-stage study aimed to understand how the immune system in the nose responds to the nasal flu vaccine in people with COPD, a chronic lung disease. Researchers compared people with COPD who get frequent symptom flare-ups to those who don't, and to healthy people, b…

This study tested whether adding a special warning label for ultraprocessed foods affects what parents buy for their children. Researchers showed over 3,600 Chilean parents pictures of snack foods with different warning labels and asked about their purchase plans. The goal was to…

This study aimed to gather detailed information about respiratory flare-ups in people with primary ciliary dyskinesia (PCD), a rare genetic condition affecting the lungs. Researchers followed 105 children and adults with PCD for about a year, measuring their lung function and sym…