University Of North Carolina, Chapel Hill

This early-stage study tests the safety of a single dose of a new experimental drug, IAP086, in 30 people with HIV whose virus is already well-controlled by their regular antiretroviral therapy (ART). Participants will receive one infusion of IAP086 and be closely monitored for s…

This study tests whether a daily liquid drop placed under the tongue (sublingual immunotherapy or SLIT) can help children ages 1 to 11 safely eat more cashew without having an allergic reaction. About 45 children with confirmed cashew allergy will receive the treatment for 18 mon…

This study tests whether the drug upadacitinib can help adults with eosinophilic esophagitis (EoE) who still have symptoms despite using standard steroid treatments. Participants will take upadacitinib or a placebo daily for 12 weeks, then all receive upadacitinib for another 12 …

This study will see if a simple questionnaire given at the dentist can identify children ages 8-13 who are at risk for sleep-disordered breathing (including sleep apnea). Kids will be grouped as low- or high-risk based on the questionnaire, then wear a home sleep monitor to check…

This early-stage study tests whether giving malaria medication to everyone living with a pregnant woman can help protect her from getting malaria. Researchers will enroll 300 households in Uganda to see if this approach is practical and acceptable. The goal is to find a better wa…

This study tests a personalized support program (PTBCARE+) for pregnant individuals at high risk of delivering early. The program includes stress-reduction tools, a website/app, and extra support during clinic visits. Researchers will compare stress levels and birth outcomes betw…

This study tests a special omega-3 supplement (marine lipid supplement) to see if it safely reduces pain in adults with chronic temporomandibular disorder (TMD), which causes jaw pain. Researchers will give 100 adults either the supplement or a placebo daily for 8 weeks. They wil…

This study will test if a special type of talk therapy that focuses on breathing control is practical and safe for adults with chronic cough. Researchers will enroll 30 people to see if they can stick with the program and if it helps. The goal is to find better ways to manage thi…

This early-stage study tests whether a drug called anakinra, already used for arthritis, can help adults with moderate asthma attacks breathe easier. About 60 people at high risk for asthma flare-ups will use anakinra or a placebo at home when symptoms start. The goal is to see i…

This study tests whether two drugs that calm mast cells (ketotifen and cromolyn) can safely reduce ongoing symptoms like fatigue, pain, and brain fog in people who had a tick-borne illness. 50 adults aged 21-65 who were treated for Ehrlichiosis or Rocky Mountain Spotted Fever in …

This study tests a three-part training program for older adults (65+) with diabetes who use insulin. The program teaches CGM technology, data skills, and lifestyle adjustments to improve glucose monitoring and reduce diabetes-related distress. 150 participants will be compared to…

This study looks at how natural hormone changes during the menstrual cycle impact brain areas linked to mood and irritability in teenage girls at risk of suicide. Fifty girls aged 12-16 will take either a birth control pill to stabilize hormones or a placebo for 8 weeks each, whi…

This study tests a virtual parenting program called AMP-CARE for parents of teens aged 11-14. Researchers want to see if it helps parents feel more confident and learn more about teen mental health. Half of the 60 participants will take the program right away, while the other hal…

This study looks at how cartoon characters and warning labels on food packages influence what Colombian children aged 12 to 17 think about the product and whether they want to buy it. About 1,960 kids will take an online survey where they see different package designs. The goal i…

This study will test two types of food package labels among 1,000 Indonesian adults to see which one better helps people spot unhealthy products and avoid buying them. Participants will compare nutrient warning labels with the Nutri-Level label. The goal is to find the most effec…

This study in rural Guatemala tests whether a special nutrition program and a caregiver training, alone or together, can improve brain development in young children. About 400 mothers and their babies will join from pregnancy until the child is 2 years old. The goal is to see if …

This study looks at whether a special training program can help surgeons and hospital staff reduce the number of opioid painkillers they prescribe after surgery. About 40 healthcare workers and patient representatives at hospitals in North Carolina will take part. The goal is to …