University Of North Carolina, Chapel Hill

This study tests whether vonoprazan, a newer type of acid-suppressing medication, reduces acid reflux in the esophagus better than standard proton pump inhibitors (PPIs) in people with Barrett's esophagus. Participants will first take their usual PPI for a week, then switch to vo…

This study tests whether upadacitinib, a drug already used for other conditions, can help adults with eosinophilic esophagitis (EoE) who still have symptoms despite using topical steroids. Over 12 weeks, 52 participants will take either upadacitinib or a placebo, then all will re…

This trial tests whether tirzepatide (Zepbound) can reduce daily bowel frequency in adults with an ileal pouch-anal anastomosis (IPAA) who have chronic high bowel frequency despite standard anti-diarrheal therapy. Participants will be assigned to receive tirzepatide or standard c…

This study tests a 6-month digital program that combines appetite awareness training with behavioral weight loss techniques, delivered remotely via Zoom. It aims to help Black women with obesity who binge eat at least once a week relearn hunger cues and prevent weight gain. The t…

This study tests a treatment called sublingual immunotherapy (SLIT) for children ages 1-11 with cashew allergy. For 18 months, children receive daily drops under the tongue to see if they can safely eat more cashew without a reaction. The goal is to reduce allergy severity, not c…

Researchers are testing whether sex work managers, called queen mothers, can hand out and collect HIV self-tests and self-collected STI test kits at places where female sex workers meet and work in Lusaka. The study compares this peer-supported approach with the current standard …

This trial tests whether baby wraps (called lesus) treated with long-lasting insecticide can protect young children from malaria. About 1,300 mothers and their infants (2-4 months old) will be randomly assigned to receive a wrap treated with permethrin, etofenprox, or an untreate…

This study tests a personalized support program called PTBCARE+ for pregnant individuals at high risk of delivering early. The program includes a stress reduction toolkit, a website/app, care coordination, and optional massage. Researchers will compare stress levels and birth out…

Researchers at the University of North Carolina at Chapel Hill are testing whether daily exposure to S-cone stimulating colored light can reduce pain severity and pain sensitivity in adults with fibromyalgia or chronic widespread pain and fatigue. Participants use programmed ligh…

This pilot trial tests whether a single session of personalized brain stimulation, called PandA-tACS, is safe and tolerable for pregnant women with depression. Researchers will compare it to a standard brain stimulation method and a sham (placebo) to see if it changes brain activ…

This pilot study tests whether a 16-week Mediterranean-style diet program is practical and acceptable for adults with hidradenitis suppurativa, a chronic skin condition. All 30 participants receive the same program, which includes video counseling, cooking education, and food sup…

Researchers are testing whether taking creatine monohydrate daily for four weeks helps postpartum women improve exercise performance, recover faster after workouts, and sharpen thinking. The trial compares two doses, 5 grams and 10 grams per day, in 40 women who are 6 weeks to 12…

This study tests whether a special omega-3 supplement can reduce pain in adults with chronic temporomandibular disorder (TMD), a condition causing jaw pain. One hundred participants will take either the supplement or a placebo daily for 8 weeks. Researchers will measure changes i…

This study tests a program called ICU-SUCCEED, designed to help survivors of acute respiratory failure and their family caregivers cope and manage recovery together. The program includes one in-person session and four follow-up sessions by phone or video, focusing on communicatio…

This pilot study tests whether anakinra, a drug that reduces inflammation, can help people with moderate asthma attacks. 60 adults at high risk for asthma attacks will either receive anakinra or a placebo at home when they feel an attack starting. The study will check if this app…

This early-stage study will test if a brief, breath-focused therapy called Acceptance and Commitment Therapy (ACT) is practical and safe for adults with chronic cough. Researchers will enroll 30 people to see if they can stick with the program and find it helpful. The goal is to …

This study tests whether medications that calm mast cells (ketotifen and cromolyn) can safely reduce persistent symptoms like fatigue, pain, and brain fog in people who had a tick-borne illness. Fifty adults aged 21-65 will receive either one of these drugs or a standard antihist…

This study looks at how natural hormone changes during the menstrual cycle may make some teenage girls more irritable or depressed, especially those at risk for suicide. Researchers will give 50 girls ages 12-16 either a birth control pill to keep hormones steady or a placebo for…

This study looks at how exercise and a saltwater mist (hypertonic saline) affect mucus clearance in people with primary ciliary dyskinesia (PCD), a rare lung condition where tiny hairs in the airways don't work properly. Researchers will measure how fast the lungs clear inhaled p…

This study aims to find out which cannabis warning messages are most effective at raising awareness and changing perceptions. Researchers will show US adults (both users and non-users) seven different warning messages covering topics like dependence, cognitive function, and cardi…

This study tests whether a training program helps surgeons and hospital staff reduce the number of opioid painkillers they prescribe after surgery. About 40 healthcare workers and patient representatives from hospitals in North Carolina will take part. The goal is to see if the p…