University Of North Carolina, Chapel Hill

This study tests whether dupilumab, an FDA-approved drug, can help people with severe eosinophilic esophagitis (EoE) who have narrowing of the esophagus. 23 participants will receive weekly injections for one year. The goal is to see if the drug reduces inflammation and improves …

This study tests whether baricitinib, a drug that calms the immune system, can help people with moderate to severe oral lichen planus—a painful mouth condition. Ten adults who haven't improved with other treatments will take baricitinib daily for six months. Researchers will meas…

This study tests a freezing device (CryoBalloon) to treat Barrett's esophagus in people who still have abnormal cells after several standard heat treatments. About 70 adults will receive the freezing treatment during an endoscopy. The goal is to see if it can safely remove all pr…

This early-stage study tests whether a person's own lung stem cells, grown from a small biopsy and given through an IV, are safe for treating idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and breathing problems. Twenty-four adults aged 40 to 80 with IPF…

This study looks at whether a program called Heart Matters can help Black adults in rural eastern North Carolina lower their blood pressure. About 173 people with heart disease risk factors like high blood pressure or obesity will take part. Community leaders will run the program…

This study tests whether a brief alcohol intervention (a few counseling sessions) helps people who are starting or restarting PrEP (HIV prevention pills) to drink less and keep taking their medication. About 562 adults in Hanoi who report unhealthy drinking will be randomly assig…

This study looks at whether teachers in rural primary schools in the Indian Himalayas can be trained to deliver mental health support to children with behavior problems. Over 20,000 children, their teachers, and parents will take part. The goal is to see if this approach improves…

This study tests whether anifrolumab, a drug that blocks certain immune processes, can help people with hidradenitis suppurativa (HS) — a painful skin condition causing boils and tunnels. About 15 adults with moderate-to-severe HS will receive the drug intravenously over 24 weeks…

This study tests whether adding low, horizontal and vertical lights around bathroom and entry doorframes can help prevent nighttime falls in people with Alzheimer's or related dementias living in assisted living. About 335 residents will take part, and researchers will compare ho…

This study tests a mobile health program to help young Air Force personnel prevent weight gain over two years. About 350 active-duty members aged 18-39 with a BMI of 21-30 will use a Fitbit and a smartphone app to track their weight and activity. The goal is to see if this approa…

This study looks at how to best roll out a brief alcohol counseling program in HIV clinics across Vietnam. The goal is to reduce unhealthy drinking, which can lead to risky behaviors and HIV spread. Over 3,200 people living with HIV and clinic staff are taking part. One group of …

This study tests a program called Thriving Hearts that helps pregnant people and new mothers in 10 North Carolina counties. The program provides support at the individual, healthcare provider, and community level to reduce high blood pressure disorders during pregnancy. About 17,…

This study tests whether a 2-minute perineal massage before a pessary check can reduce pain and improve comfort for women using a pessary for prolapse or incontinence. About 68 participants will each receive both the massage and a standard gel-only application at separate visits,…

This study tests whether special colored light shown to the eyes can lower pain levels in people with chronic low back pain or fibromyalgia. About 60 adults will wear a light device for 2 hours daily over 5 days. The goal is to see if this approach is practical and helps reduce p…

This study follows 40 adults aged 55 and older with osteoarthritis who are receiving low-dose radiation as part of their usual care. Researchers will track changes in pain, function, and quality of life over a year to see if this treatment helps when other options haven't worked.…

This study looks at how to bring non-drug pain management programs to community health centers that serve low-income people. About 70 patients with chronic pain will take part in group visits that teach techniques like mindfulness and movement. The goal is to see if these program…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help people with depression that hasn't improved with standard treatments. Twenty adults with treatment-resistant depression will receive one or two psilocybin sessions a…

This study looks at whether omega-3 supplements (like fish oil) can reduce migraine pain and improve daily life for children and teens aged 10 to 17. Over 12 weeks, researchers will measure changes in blood omega-3 levels and track pain, disability, and emotional well-being. The …

This study aimed to compare two pain medicines given during spinal anesthesia for cesarean delivery in patients with opioid use disorder who take buprenorphine. The goal was to see which provides better pain relief after surgery. However, the study was withdrawn before enrolling …

This study compares two suicide prevention programs designed specifically for autistic youth aged 12-24. The goal is to see which program better reduces suicidal thoughts and behaviors. Researchers will track participants for one year to measure effectiveness.

This study tests a program called Forging New Paths for adults with mental illness who have been involved with the criminal justice system. About 72 participants will either get the program plus usual care or usual care alone. Researchers will check if the program lowers aggressi…

This study looks at how small electrical pulses to the brain can change working memory—the kind you use to remember a phone number. Researchers will work with 50 epilepsy patients who already have electrodes in their brains for monitoring. Participants will play a memory game whi…

This study aimed to see if moving the knee joint in a specific way could improve how the brain and muscles communicate in people who had ACL reconstruction surgery. Researchers planned to enroll 30 people aged 18-35 who were 4 months to 10 years post-surgery. The study was withdr…

This study looks at how nontuberculous mycobacteria (NTM) — hard-to-treat lung infections — spread among people with cystic fibrosis. Researchers will collect dust and water samples from clinics and patients' homes to find possible sources. The goal is to better understand transm…

This study follows 770 people who have had endovascular repair for aortic aneurysms (bulging of the main artery). The goal is to see how kidney function and other organ health change over two years after the procedure. Researchers will use scans and blood tests to gather informat…

This study looks at whether encouraging young adults (ages 18-29) to have more in-person chats with strangers and acquaintances can help reduce feelings of loneliness and social isolation. About 1,900 participants will use a smartphone app for 6 weeks to track their location and …

This study looks at how people who had a complex or conversion hip replacement are doing many years later. Researchers will review medical records and ask about pain, movement, and daily activities. The goal is to understand long-term outcomes and improve future care.

This study follows 9,000 pregnant women in Zambia from early pregnancy through one year after birth. Researchers collect medical details and biological samples to learn why some babies are born too early. The goal is to find new ways to prevent preterm birth and stillbirth.

This study looks at the genes of 600 people with cystic fibrosis to find out why some have more severe lung disease than others. It does not test any new treatment. Instead, it collects genetic information to help researchers understand the disease better. Participants must have …

This study tests whether an artificial intelligence (AI) tool can help outpatient doctors reduce time spent on medical records and lower their stress. About 150 doctors will be randomly assigned to use the tool right away or wait eight weeks. The study does not involve patients o…

This study looks at how breathing in low levels of ozone (like what you might encounter on a typical day in Chapel Hill) affects lung function and airway inflammation in adults with mild asthma. Researchers will compare changes in breathing tests and sputum samples after ozone ex…

This study follows nearly 3,000 people with COPD (a chronic lung disease) over several years to better understand how the disease progresses. Researchers measure lung function, mucus, and CT scans, and also look at how things like air pollution and home environment affect health.…

This study explores why some people with cystic fibrosis develop severe liver disease while others do not. Researchers are analyzing blood samples and medical records from 154 participants to find 'modifier genes' that may influence liver disease severity. The goal is to better u…

This study looks at how drugs like cocaine, alcohol, marijuana, and cigarettes taken during pregnancy affect the bond between mother and baby and the baby's brain development. Researchers will follow 150 mothers and their newborns to understand these effects. The goal is to learn…

This study tests whether a mobile health tool used by community health workers can improve follow-up care for women after cesarean sections in rural Rwanda. About 1,350 women who had a c-section at Kirehe District Hospital will be randomly assigned to either home visits using the…

This study aimed to see if rhythmic electrical stimulation of the brain could improve working memory in people with drug-resistant epilepsy. Researchers planned to test this in patients already undergoing brain surgery monitoring. However, the study was withdrawn before any volun…

This study compares two programs for parents of teens and young adults (ages 11-27) with intellectual or developmental disabilities. One program teaches advocacy skills, the other connects parents with peers for shared learning. Researchers will measure changes in parent confiden…

This study looks at whether training and coaching for clinic staff can improve how they measure blood pressure and educate patients about hypertension during and after pregnancy. About 4,000 providers and staff from prenatal clinics in North Carolina will take part. The goal is t…

This study looks at whether people with inflammatory bowel disease (IBD) have better outcomes and feel more in control of their health when they can text their medical team and regularly report symptoms via text surveys. About 900 participants will be split into two groups: one g…

This study follows 250 former NFL players (ages 50–70) for 5 years to see how concussions and repeated head hits affect long-term brain health. Researchers use brain scans, blood tests, and thinking/mood questionnaires to track changes. The goal is to use these findings to design…