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Former NFL players join brain study to uncover concussion effects

NCT ID NCT04263337

Knowledge-focused Sponsor: University of North Carolina, Chapel Hill Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 250 former NFL players and healthy volunteers aged 50-70 over 5 years. Researchers use brain scans, blood tests, and thinking/memory assessments to understand how concussions and repeated head impacts affect long-term brain health. The goal is to gather information that could lead to future treatments, but no experimental therapy is given.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help identify early signs of brain problems in former NFL players and guide future treatments.
What could go wrong
This is an observational study, not a treatment trial. It may not lead directly to any new therapies, and results may not apply to all athletes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 250 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2020

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 70 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for Former NFL Player Group: * At least 1 year of participation in National Football League (NFL groups) * Retired from professional football * Ages between 50-70 Inclusion Criteria for Healthy Controls: * No prior exposure to football, collision sports, or prior concussions * They will be matched to former NFL players by age and estimated premorbid intellectual functioning. * Ages between 50-70 Exclusion Criteria: * Any contraindications to MRI, PET, or biological study procedures * History of Moderate or Severe TBI * Current primary Axis I diagnosis of Psychotic Disorder * History or clinical suspicion of other conditions (e.g., epilepsy, stroke, dementia) known to cause cognitive dysfunction * Diagnosis /associated treatment that would preclude participation in full study protocol (e.g., terminal cancer)

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Conditions

The condition(s) this trial relates to.

Brain Concussion Neurologic Manifestations traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Concussion, brain

Contacts and locations

Locations

  • Boston Children's Hospital

    Waltham, Massachusetts, 02453, United States

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, 27599, United States

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