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Vitamin d shows promise in preventing chronic pain after burns

NCT ID NCT05619289

Prevention Sponsor: University of North Carolina, Chapel Hill Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tested whether giving vitamin D shortly after a burn injury could prevent chronic pain. Forty adults with burns took either vitamin D or a placebo and were followed for six months. Researchers also studied how vitamin D affects the immune system after a burn. The main goals were to see if the study plan worked and if vitamin D was safe.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

40 people

The number who actually took part.

Started

Apr 2023

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * ≥ 18 years and ≤ 70 years of age * MThBI severe enough to warrant admission to Burn Surgery Service (NOTE: surgery may or may not be indicated) * Admission and subsequent enrollment occurs within 1 week of MThBI * Patients experience a thermal burn injury, not an electrical or chemical burn. * Has a smartphone with continuous service \>1 year * Alert and oriented * Willing to take study medication (6 capsules of Vitamin D or placebo) * Point of care Vitamin D level \<100 ng/mL * Able to speak and read English * Burn survivors with acute pain severity ≥ 7/10 on the Numeric Rating Scale (initial pain severity reported by patient on screening) * Total Body surface area burned \<30% Exclusion Criteria * Substantial comorbid injury (e.g. long bone fracture) * Pregnancy/Breastfeeding * Prisoner status * Active psychosis, suicidal ideation, or homicidal ideation * Requires an emergency/bedside escharotomy or fasciotomy for the treatment of burn injury. * Known Child-Pugh liver disease severity classification B or C. * Known chronic kidney disease stage 4 or higher (GFR≤29). * No other history or condition that would, in the investigator's judgment, indicate that the patient would very likely be non-compliant with the study or unsuitable for the study (e.g. might interfere with the study, confound interpretation, or endanger patient). * Intubated and sedated at time of enrollment. * Hypersensitivity to Vitamin D3, ergocalciferol, calcitriol, alfacalcidol, calcipotriol * Known hypercalcemia (based on routine admission laboratory assessment). * Sarcoidosis * Hyperphosphatemia (based on routine admission laboratory assessment) * Taking Vitamin D supplements in excess of 800 IU daily.

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Conditions

The condition(s) this trial relates to.

burn Chronic Pain chronic pain syndrome prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Burn injury Chronic pain

Contacts and locations

Locations

  • University Of North Carolina

    Chapel Hill, North Carolina, 27517, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.