PREGNANCY

This study tests if giving C-section babies bacteria from their mother can help restore their gut microbiome to be more like babies born vaginally. Researchers will compare these maternal bacteria to standard probiotics. One hundred healthy infants will receive a daily oral bacte…

This study tests a digital tool called HMZ 2.0 to help pregnant women with overweight or obesity gain a healthy amount of weight. 144 women will either use the tool or receive standard pregnancy advice. The goal is to see if the platform improves weight gain, sleep, eating habits…

This study looks at whether taking coenzyme Q10 (a vitamin-like substance) and probiotics (good bacteria) can help improve gum health in pregnant women who are already getting standard dental cleanings. About 40 pregnant women will be split into two groups: one gets a special too…

This study tests whether automated insulin delivery (AID) systems can safely manage blood sugar during labor and delivery for pregnant people with type 1 diabetes. About 150 participants will be randomly assigned to use their own AID system or standard intravenous insulin. The go…

This study tests whether a natural supplement called inorganic nitrate can safely lower blood pressure in pregnant women with chronic hypertension. About 144 women will receive either the supplement or a placebo from the second trimester onward. The goal is to see if it reduces t…

This study looks at two ways to help pregnant people and new mothers with substance use disorder stay in treatment. One way is to screen for social needs like housing or childcare and connect them to community help. The other uses small rewards to encourage healthy behaviors. The…

This study compares three different programs to help pregnant women maintain a healthy weight. About 795 women at risk for obesity or diabetes will receive nutrition and exercise counseling, plus help overcoming barriers like food access. The goal is to see which approach works b…

This study compares a technology-enhanced therapy program (including a mobile app) to simple medication monitoring for pregnant people taking buprenorphine for opioid use disorder. About 37 participants will be randomly assigned to either four therapy sessions plus app access or …

This study tests whether giving monthly cash payments to pregnant women with HIV in Botswana helps them focus better, take their HIV medication regularly, and stay in care after giving birth. About 100 economically vulnerable women will receive the cash or usual care. The goal is…

This study looks at whether taking insulin glargine twice a day instead of once a day can help pregnant women with type 2 diabetes manage their blood sugar better. About 200 pregnant women between 24 and 28 weeks of pregnancy will be randomly assigned to one of two groups. Their …

This study tests whether MitoQ, a mitochondrial antioxidant, can improve blood vessel function in pregnant people with preeclampsia, a serious condition that can harm both mother and baby. Researchers will measure blood vessel health in the arm, skin, and placenta. The goal is to…

This study looks at whether adding a community health worker coach to remote blood pressure monitoring helps women who had high blood pressure during pregnancy better control their blood pressure and improve heart health after giving birth. About 240 women will be enrolled and fo…

This study looks at whether using a tourniquet (a tight band) during surgery for a condition called placenta accreta can improve newborn health scores right after birth. The trial will involve 100 pregnant women who are having a planned C-section. The main goal is to see if the t…

This study tests whether taking an iron pill every other day works as well as taking one every day for pregnant women with iron-deficiency anemia. About 120 pregnant women will be randomly assigned to one of two groups. The goal is to see if both schedules can raise hemoglobin an…

This study tests whether giving pregnant women farming tools, seeds, and training can reduce food shortages and improve health for them and their babies. About 410 pregnant women in Kenya, half living with HIV, will either get the farming help right away or after the study ends. …

This study aims to see if a short self-report questionnaire called T-ACE can correctly identify pregnant women who drink alcohol at risky levels. Researchers will compare the T-ACE results with a blood test that measures a biomarker of recent alcohol use. About 2,425 pregnant wom…

This study tests a new, portable device that uses a camera to look at blood vessels in the ear to detect anemia (low iron) in pregnant women. The goal is to see if this quick, painless method is as accurate as standard lab blood tests. The study will enroll 300 pregnant volunteer…

This study aims to see if a blood test can predict which pregnant women will develop postpartum depression (PPD). Up to 500 pregnant women will give a blood sample in their third trimester and then be checked for depression symptoms for 6 months after giving birth. The test is ex…

This study is testing a device that uses a blood or saliva sample to predict if a pregnant woman will develop postpartum depression (PPD) after giving birth. Researchers will enroll 1,000 pregnant women and collect samples during the third trimester, then follow up for three mont…

This study tests whether taking a probiotic called LP299V® twice daily can help pregnant women at risk of iron deficiency anemia absorb more iron from their diet. Researchers will enroll 250 women and follow them from early pregnancy through labor, measuring iron levels in blood …

This study tests whether taking vitamin D supplements can prevent preeclampsia from returning in pregnant women who had it before. About 146 women will be randomly assigned to take either vitamin D or a placebo pill until 36 weeks of pregnancy. Researchers will track blood pressu…

This study looks at whether different types of exercise (aerobic, resistance, or both) during pregnancy can improve the health of both mother and baby, especially in preventing childhood obesity. Researchers will follow 300 overweight or obese pregnant women and their infants for…

This study looks at whether it's better to give the RSV and Tdap vaccines together at one visit or separately at different visits during pregnancy. Researchers want to see if a larger trial is possible and will check safety and immune responses. About 60 healthy pregnant individu…

This study looks at whether giving pregnant women free organic vegetables and teaching them about healthy eating can reduce their exposure to pesticides. Researchers will measure pesticide levels in urine before and after the program. The goal is to see if this "green prescriptio…

This pilot study is testing whether eating one pound of fermented poi every day for four weeks can improve the balance of good bacteria in the body and lower the risk of gestational diabetes. The study involves 50 pregnant women between 10 and 24 weeks of pregnancy. Participants …

This study tests whether using a toothpaste and mouthwash made with lactoferrin (a natural protein) can prevent gum disease in pregnant women. Forty pregnant women in their second trimester will be split into two groups: one uses both the toothpaste and mouthwash, the other uses …

This study tests a non-drug device called NeuroCuple™ to see if it can reduce pain and the need for opioid painkillers after a cesarean delivery. About 180 women having a C-section will be randomly assigned to use the device, a sham device, or standard care. The goal is to find a…

This study tests a program that combines text message support with financial rewards to help low-income pregnant women stop smoking. About 30 women will either get texts plus incentives or texts alone. The goal is to see if the program is easy to use and acceptable, and to check …

This study aims to find the most effective dose of epidural medicine to relieve labor pain within 30 minutes. Researchers will test a combination of ropivacaine and fentanyl in 50 women in active labor. They will also monitor side effects and patient satisfaction to improve the c…

This study tests whether a gentle mind-body exercise called Baduanjin can help reduce low back and pelvic pain during pregnancy. About 84 pregnant women will do the exercise for 12 weeks. Researchers will measure pain levels and quality of life to see if it helps.

This pilot study tests a simple exercise program designed for high-risk pregnant women who are on bed rest in the hospital. The program includes resistance and strength exercises done in bed, aiming to improve physical health, mood, sleep, and quality of life. About 20 participan…

This study tests if a type of talk therapy called prolonged exposure, plus small financial rewards for attending sessions, can reduce PTSD symptoms in pregnant women. Thirty pregnant adults with PTSD will receive weekly therapy for 12 weeks. Researchers will measure symptom chang…

This study tests a virtual program called MOVIN that helps pregnant people and new parents manage depression and anxiety. About 570 participants will use an online platform to work with a care coordinator and get personalized treatment plans. The goal is to see if this approach i…

This study tests whether a program that includes a Fitbit, coaching texts, and a support partner can help pregnant women reduce sitting time and increase moderate physical activity. Researchers will track 60 women from early pregnancy through delivery to see if the program improv…

This study tests whether a 6-week mindfulness meditation program helps pregnant women feel less stressed, anxious, or depressed compared to standard pregnancy support. About 70 women in early to mid-pregnancy will take part. They will attend weekly group meditation sessions and p…

This study tests whether misoprostol or pitocin works better to start labor in pregnant people with a BMI of 30 or higher. About 300 participants will receive one of the two drugs along with a foley catheter. The goal is to see which approach leads to a shorter time from inductio…

This study is testing whether a small, non-invasive device that stimulates a nerve in the leg can safely and effectively relieve Restless Legs Syndrome (RLS) in pregnant women. Fifteen participants between 21 and 26 weeks pregnant will use the TOMAC™ device for 30-minute sessions…

This study tests whether a single dose of cabergoline can prevent breast symptoms like pain, swelling, and milk leakage after an abortion or pregnancy loss between 12 and 18 weeks. About 348 participants will receive either cabergoline or a placebo right after the procedure and r…

This study explores whether a moderate physical activity program (three 60-minute sessions per week, both in-person and online) is practical for pregnant women who are socially vulnerable. About 60 women will be invited to join, and researchers will track how many accept, why som…

This study looks at whether a flexible, step-by-step food support program can help pregnant women who struggle to afford enough food. About 60 pregnant women in their first trimester will receive different levels of help based on their needs. The goal is to see if this approach i…

This study looks at how exercise during and after pregnancy changes breast milk and whether those changes affect a baby's growth and risk of obesity. Researchers will measure breast milk composition and infant body fat in 200 mothers and their babies. The goal is to learn how phy…

This study looks at how tiny particles from the placenta, called extracellular vesicles, affect pregnancy health. Researchers will compare samples from healthy pregnant women, those with pre-eclampsia or gestational diabetes, and non-pregnant women. The goal is to better understa…

This study follows 400 pregnant women diagnosed with gestational diabetes to learn how the condition affects both mother and baby. Researchers will collect health data and samples during pregnancy, at birth, and a few months after delivery. The goal is to better understand the ri…

This study looks at whether microplastics in the body can cause or worsen gut inflammation, especially in people with Crohn's disease. Researchers will measure microplastics in stool samples from pregnant women, their babies, and family members. The goal is to understand how envi…

This study aims to create a large collection of data and biological samples (like blood or tissue) from 1,000 pregnant and postpartum individuals, including those with healthy pregnancies and those with complications. Researchers will use this resource to better understand pregna…

This study tests a nutrition education program designed with local foods for first-time pregnant women in northern Ghana. The goal is to help them eat a more varied diet with enough protein and iron, and to see if this improves their health knowledge and their babies' birth weigh…

This study is following 250 pregnant women diagnosed with preeclampsia, a serious condition involving high blood pressure and organ stress. Researchers will collect health data and samples from mothers and babies during pregnancy, at birth, and a few months after delivery. The go…

This study looks at bone density in 100 pregnant women (ages 30-45) during their third trimester, comparing those carrying one baby versus twins. Researchers use a special bone scan and questionnaires to see if twin pregnancies lead to greater bone loss. The goal is to better und…

This study looks at how different arm positions change blood pressure readings in pregnant women. About 300 participants will have their blood pressure taken with their arm at heart level, on their lap, and hanging at their side. The goal is to find out which position gives the m…

This study looks at how much leucine, a key protein building block, healthy pregnant women need during early and late pregnancy. About 40 women will eat special meals and give breath, urine, and blood samples so researchers can track how their bodies use leucine. The goal is to i…

This study looks at whether a continuous glucose monitor (CGM) helps pregnant women with type 2 diabetes track their blood sugar better than the standard finger-stick method. About 70 participants will be randomly assigned to use either a CGM or finger-stick testing from enrollme…

This study follows 200 pregnant women with severe mental illness to see how taking antipsychotic medication affects their mental health and their baby's development. Researchers will compare women taking antipsychotics, other psychiatric drugs, or no medication. They will track p…

This study aims to find out which factor—physical activity, diet, or anxiety—most influences excessive weight gain in pregnancy. Researchers will follow 150 pregnant women in their third trimester, collecting data through questionnaires. The goal is to better understand the cause…

This study is for pregnant people planning a vaginal delivery but who might need a C-section. Researchers want to see if asking for consent right when you arrive at the hospital or waiting until it seems necessary makes the experience better. About 200 participants will share the…

This study aims to create a prediction tool for pregnant women with aplastic anemia, a rare blood condition that raises risks for both mother and baby. Researchers will follow 300 women to identify factors that lead to complications like bleeding, preterm birth, or low birth weig…

This study follows 50 pregnant women who have taken the seizure medication Epidiolex (cannabidiol) to see if it affects pregnancy outcomes or the health of their baby up to 12 months old. Researchers will track complications like birth defects, miscarriage, and preterm delivery. …

This study monitors 75 pregnant or postpartum women who have taken Ultomiris for conditions like PNH or aHUS. Researchers will track pregnancy outcomes and infant health up to one year after birth. The goal is to better understand any risks or complications linked to the drug dur…

This study follows healthy women who are trying to get pregnant, as well as women who are not, to collect samples and data during the first two weeks after fertilization. The goal is to learn about the molecular signals between mother and embryo that lead to a successful pregnanc…

This study looks at whether doulas who receive extra training in supporting mental health (called PMADs) can help pregnant women in rural Montana feel more confident, supported, and less depressed or anxious. About 75 pregnant women will be split into three groups: one with a reg…

This study collects daily urine samples from 1,500 women who are actively trying to conceive. Participants use a Clearblue Ovulation test to identify their fertile window and provide samples for up to 3 menstrual cycles. The samples are stored in a biobank for future research on …

This study looks at how quickly the stomach empties in women during early labor when they drink either water or a carbohydrate sports drink. Researchers will also check if having an epidural changes this speed. The goal is to better understand what women in labor can safely drink…

This study looks at how the bacteria and diet of pregnant women with inflammatory bowel disease (IBD) may affect their baby's gut health. Researchers will collect samples from mothers and infants over one year after birth. The goal is to find patterns that could lead to better di…

This study collects placenta tissue, umbilical cord blood, and maternal blood from 1,250 pregnant women at delivery. Researchers will use these samples to learn how the placenta changes in conditions like preterm birth, diabetes, and obesity. The goal is to better understand preg…

This study looks at how two antibiotics, ceftriaxone and benzathine penicillin G, are processed by the body during pregnancy. About 78 pregnant women and 22 infants will take part across the United States. The goal is to understand the drugs' levels and safety at different stages…

This study tests whether pasteurized donor human milk (PDHM) is a practical feeding option for infants exposed to HIV. Ten caregivers in Saskatchewan will try PDHM as a supplement to breastfeeding or formula for 4 weeks. Researchers will track how often PDHM is used and ask careg…

This study looks at how a prenatal capsule affects iron levels compared to a gummy version in healthy pregnant women. About 40 women in their second trimester will take one of the two supplements daily for 12 weeks. The main goal is to see if the capsule leads to higher iron leve…

This study looks at how stress affects pregnant women and whether simple stress management techniques can help. Researchers will measure stress using saliva samples before and after practicing these techniques. The goal is to understand how social factors and chronic stress impac…

This study collects safety information from about 100 women with Pompe disease who used the medicine Nexviazyme during pregnancy or while breastfeeding, and from their babies. Researchers will watch for any health problems in mothers and track infant growth and development throug…

This study looks at whether sipping a carbohydrate-rich drink is better than sipping water while waiting for a planned C-section. About 190 women will be randomly assigned to one of two groups. Researchers will use stomach ultrasound to check safety and ask women about their reco…

This study looks at whether taking Perelel-brand prenatal supplements (designed for each trimester) is better than generic prenatal vitamins for the health of mothers and their unborn babies. Researchers will track nutritional markers in the blood of 600 pregnant women who have f…

This study looks at whether measuring blood pressure at the ankle works as well as the standard arm cuff during planned C-sections. About 110 women will have both arm and ankle readings taken. If ankle readings are reliable, moms could hold their babies skin-to-skin right after b…

This study is testing whether pregnant people at risk of depression will use a mobile app called HappyMums to track their mental health. The app collects data through questionnaires and phone usage. Researchers hope this information can help predict and identify antenatal depress…

This study looks at how vitamin D is absorbed and used in pregnant and non-pregnant women ages 20-39. Researchers will give a small dose of labeled vitamin D and track it with blood tests over 40 days. The goal is to understand how obesity, ancestry, and pregnancy affect vitamin …

This study looks at how drinking clear water two hours before a planned C-section affects stomach volume in pregnant women with and without diabetes. Researchers will use ultrasound to measure stomach contents before and after drinking. The goal is to better understand the risk o…

This study looks at whether two easy-to-calculate scores (Shock Index and Modified Shock Index) can predict which women will have dangerously low blood pressure after receiving spinal anesthesia for a planned C-section. Researchers will monitor 300 pregnant women and track how of…

This study looks at whether a fortified milk product, Super Mil Mamá, can improve the nutrient content of breast milk in vulnerable pregnant and lactating women. Researchers will compare nutrient levels like DHA, vitamins, and minerals in breast milk and blood between women who d…

This study compares an AI tool (iDAScore) to manual ranking by embryologists for selecting which frozen embryo to transfer first in IVF. About 1,325 patients will be randomly assigned to one method. The goal is to see if both approaches lead to a similar number of transfers neede…

This study looks at how the immune system helps the body accept a pregnancy during the first three months. Researchers will analyze blood samples from 100 women undergoing IVF to understand which immune cells and genes are linked to healthy pregnancies or miscarriages. The goal i…

This study looks at whether having groceries delivered can help low-income pregnant young women gain a healthy amount of weight and eat better. About 570 women in early pregnancy will take part. The goal is to learn if this simple support can make a difference.

This study is a worldwide registry that will follow about 10 women with Fabry disease who received the drug pegunigalsidase alfa around the time of pregnancy or while breastfeeding. Researchers will track pregnancy outcomes and infant health for up to one year after birth. The go…

This study aims to improve fetal MRI by designing special coils for pregnant women and testing new image-capture methods. Researchers will compare the quality of these research images to standard fetal MRI and ultrasound. About 300 pregnant women, both healthy and those with conc…

This study brings together hospitals, community health workers, and doulas to provide extra support for pregnant people in Rhode Island. The goal is to improve health for mothers and babies by addressing basic needs like food, housing, and transportation. About 3,000 participants…

This study looks at how historical trauma and everyday stress may impact pregnancy outcomes in Indigenous American women. Researchers will gather information from 80 pregnant women about their experiences and measure how their bodies respond to stress. The goal is to find new way…

This study follows 150 pregnant women infected with parvovirus B19 to see how often the virus passes to the baby and what complications may occur. Researchers will track problems like anemia, fluid buildup, and brain issues in the fetus or newborn. The goal is to better understan…

This study looks at how pregnancy, childbirth, and breastfeeding affect inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will follow 945 women from a French registry to count disease flare-ups during and after pregnancy. The goal is …

This study is creating a large collection of samples—like stool, saliva, blood, and skin cells—from up to 600 people of all ages, both healthy and with various conditions. Researchers will use these samples to learn how the tiny organisms living in and on our bodies (the microbio…

This study looks at how the body processes aspirin in pregnant women who are at risk for preeclampsia, a serious condition involving high blood pressure. Researchers will measure aspirin byproducts and markers of metabolic health in 50 participants. The goal is to better understa…

This study looks at whether Cambodia's health system is ready to give pregnant women a new type of vitamin that includes more nutrients than just iron and folic acid. Researchers will talk to healthcare workers, survey 630 pregnant women, and check vitamin supplies to find gaps a…

This study tests how easy and useful a new digital program called Hope-D is for managing weight during pregnancy and for 6 months after giving birth. It includes 30 pregnant women with a BMI of 30 or higher. The goal is to see if the program is user-friendly and ready for a large…

This study looks at how blood clots form and break down in pregnant women, and whether these changes can lead to complications like blood clots or high blood pressure. Researchers will study 100 women aged 18-40 with natural pregnancies. The goal is to use machine learning to fin…

This study follows 200 babies diagnosed with intra-uterine growth restriction (IUGR) using advanced imaging to track subtle changes in the brain, heart, and placenta over time. Researchers will link these findings to the babies' development after birth and in early childhood. The…

This study uses MRI scans to measure blood flow and oxygen levels in the placenta during the second and third trimesters of pregnancy. Researchers will compare women who were obese before pregnancy with those who had a normal weight, to see if there are differences in how the pla…

This study tests whether adding MRI to standard ultrasound can better detect and diagnose birth defects in unborn babies. About 1500 pregnant women will receive a fetal MRI to see if it provides clearer images of the baby's organs. The goal is to improve how doctors find and unde…

This study looks at why pregnant women living at high altitude have higher rates of poor fetal growth and preeclampsia. Researchers will collect tissue samples from 84 women having scheduled C-sections in Denver (low altitude) and Summit County (high altitude). By comparing blood…

This study is testing two new ultrasound techniques to see if they can better detect fetal growth restriction (FGR), a condition where a baby is smaller than expected. Researchers will compare these scans in 60 pregnant women, some with healthy pregnancies and some with FGR. The …

This study follows pregnant women with a severe hemophilia A gene and their babies after birth. The goal is to learn why some mothers have heavy bleeding after delivery and why some children develop antibodies that make hemophilia treatment less effective. By observing 500 mother…

This study looks at how the information given to mothers about labor induction affects their childbirth experience. Researchers will also examine if social media plays a role. The study involves 50 pregnant women who are scheduled for labor induction. Participants will answer que…

This study follows 60 women with cystic fibrosis (CF) who are planning a pregnancy, are pregnant, or have recently given birth. Researchers will track their lung function, nutrition, and mental health, as well as the health of their babies. The goal is to learn what extra care or…

This study looks at the long-term health of children (16 and older) whose mothers had a solid organ transplant before pregnancy. Researchers want to see if these children have higher risks for heart or kidney problems, possibly due to the mother's anti-rejection medications. Abou…

This study looks at how well 50 pregnant women in Kenya absorb iron from three different types of prenatal supplements. Researchers will test if taking iron every other day might work better than daily doses. The goal is to find the best way to prevent iron deficiency during preg…