PREGNANCY

This study tests the safety and immune response of the MVA-BN mpox vaccine in 359 pregnant and postpartum women in the Democratic Republic of the Congo. Some women receive the vaccine during pregnancy, others right after giving birth, and a small group gets it as an emergency sho…

This study tests whether having obstetric providers manage a mother's care for a full year after childbirth can better control high blood pressure and diabetes. About 100 mothers with these conditions will receive extended monitoring and treatment. The goal is to prevent long-ter…

This study tests a collaborative care model where doctors, nurses, and support staff work together to help pregnant women with opioid use disorder. Researchers will track whether more women start and stay on medication, have fewer overdoses, and keep their children out of foster …

This study tests whether adding a substance called cpFT to the liquid used to grow eggs and embryos can improve the chance of a live birth after a common fertility treatment called ICSI. The trial involves 366 couples where the woman is under 37 years old. Researchers will compar…

This study tests whether combining text message support for pregnant women who smoke with special training for their doctors can help them quit. About 840 women at Duke and Pitt will take part. All receive smoking cessation texts, and some doctors get extra counseling training. T…

This study tests whether attending prenatal care in a group setting helps women with type 2 or gestational diabetes control their blood sugar and manage weight after giving birth. About 117 pregnant women will be randomly assigned to either group or traditional one-on-one care. R…

This study looks at two short courses of medicine to prevent tuberculosis (TB) in pregnant women who also have HIV. About 252 pregnant women will take either a daily pill for one month or a weekly pill for three months. Researchers will check if these treatments are safe and how …

This study tests whether a mobile app called i-PregMom can help pregnant women control their blood sugar and weight gain. About 160 first-time mothers will use the app from weeks 10-14 to weeks 24-28 of pregnancy. Researchers will track weight and blood sugar changes to see if th…

This study looked at whether providing home-delivered meals to Black, low-income pregnant women with overweight or obesity could improve their diet and help them gain a healthy amount of weight during pregnancy. Seventeen women received meals, and researchers measured changes in …

This study tests whether giving extra riboflavin (vitamin B2) and folate to pregnant women with a specific gene variant can prevent high blood pressure. About 2250 women in early pregnancy will be screened for the MTHFR gene, and those with the TT or CT variant will receive suppl…

This study tests whether screening pregnant women for malaria early in the first trimester using a highly sensitive rapid test, followed by treatment if positive, can reduce serious problems like low birth weight, preterm birth, stillbirth, or newborn death. Over 2,000 pregnant w…

This study is testing a lifestyle physical activity program to help pregnant women reduce or stop using cannabis. About 50 women who are 12-25 weeks pregnant and use cannabis at least once a week will take part. The program focuses on increasing daily steps and activity, and rese…

This study tests whether using a virtual reality (VR) headset to watch relaxing scenes can reduce nausea and vomiting, improve sleep, and increase comfort in pregnant women. About 90 women in early pregnancy (6-14 weeks) will either use VR relaxation or get standard care. The goa…

This study looks at whether a mindfulness program called Mindfulness-Based Childbirth and Parenting (MBCP) can help lower anxiety in pregnant women. About 60 pregnant women with elevated worry will be randomly assigned to either MBCP or a standard childbirth class. Researchers wi…

This study looks at whether giving calcium carbonate to pregnant women during labor induction can help shorten the time needed and reduce the need for C-sections. Researchers will compare 250 women who receive calcium carbonate to a historical group. The goal is to find a low-ris…

This study looks at whether a supervised exercise program during the second and third trimesters can improve fitness, blood pressure, and weight gain in first-time mothers, and also benefit the baby's health. Researchers will measure heart and lung fitness, blood markers, and new…

This study looks at whether laughter yoga or emotional freedom technique (EFT, a tapping therapy) can lower anxiety in pregnant women. About 120 women with moderate to high anxiety will be randomly assigned to one of these two methods or standard care. The goal is to see if these…

This study tests whether eating date fruit can reduce vomiting from morning sickness and improve iron levels in pregnant women. Forty pregnant women in their first trimester will either eat dates, take standard anti-nausea medication, or follow their usual diet. The goal is to se…

This study looks at whether teaching first-time pregnant women a meditation method called ThetaHealing can help reduce pain and fear during childbirth. Forty healthy women in their first pregnancy will learn the technique before labor and use it during delivery. Researchers will …

This observational study follows 728 pregnant women who took Wegovy for weight management and compares their babies' health to those not exposed. Researchers will track birth defects and infant development through the first year of life. The goal is to understand if Wegovy poses …

This study tests whether watching a short video about anesthesia before a scheduled C-section helps patients make more informed decisions. About 70 English-speaking adults will watch the video at least 24 hours before their procedure. Researchers will then measure how well patien…

This study gathers expert doctors to create clear guidelines on which skin care products and ingredients are safe to use during pregnancy. It focuses on protecting both the mother and the baby by recommending gentle cleansers, mineral sunscreens, and safe ingredients like vitamin…

This study looks at health records of about 100 pregnant women with constipation to check if taking prucalopride is safe. Researchers will compare women who took prucalopride, those on other constipation meds, and those on no prescription drugs. The goal is to see if the medicine…

This study looks at how mental health and stress impact the way pregnant women process sugar. Researchers will track 150 women early in pregnancy to see if stress levels predict gestational diabetes. The goal is to better identify at-risk women and improve prevention and treatmen…

This study looks at whether a brief home visitation program, delivered by non-nurse visitors, can help pregnant and postpartum women connect to community resources, feel more confident about their health, and reduce stress. About 450 women will be randomly assigned to either rece…

This study was designed to see if teaching obstetric providers about workplace accommodations during pregnancy helps patients get the support they need at work. Researchers planned to compare counseling rates and health outcomes between providers who received the training and tho…

This study was designed to see if a non-invasive device called ClearSight™ could accurately measure heart function in pregnant women at term. The goal was to help doctors give the right amount of fluids during labor, avoiding unnecessary or harmful fluid administration. However, …

This study follows 9,000 pregnant women in Zambia from early pregnancy through one year after birth. Researchers collect medical details and biological samples to learn why some babies are born too early. The goal is to find new ways to prevent preterm birth and stillbirth.

This study uses insurance records to compare health outcomes for mothers and babies when Wegovy is taken during pregnancy versus when it is not. Researchers will look at birth defects and other issues in about 1,139 women aged 15-45. The goal is to help patients and doctors make …

This study looks at whether a special education program based on hypnobreastfeeding ideas can help first-time mothers feel more confident and knowledgeable about breastfeeding. About 80 healthy pregnant women will take part. The program aims to improve breastfeeding skills and mo…

This study planned to use special MRI scans to measure blood flow in the placenta of pregnant women, especially those with poor fetal growth (IUGR). The goal was to see if MRI could help doctors understand placental health better. However, the study was withdrawn before any parti…

This study aims to measure how much of the drug sugammadex crosses from a pregnant woman to her baby through the placenta. Researchers will use donated placentas from healthy pregnancies in a lab model. The results will help doctors understand potential risks to the fetus when th…

This study looks at how the body's response to insulin changes during pregnancy in people with type 1 diabetes. Researchers will analyze data from continuous glucose monitors and insulin pumps used by 100 participants from before pregnancy to six months after birth. The goal is t…

This study looks at sleep health in 50 pregnant women with low income. Researchers will use a home sleep test and a wrist monitor to measure sleep. They want to see how sleep relates to heart health and social factors. The goal is to create better sleep guidelines and treatments …

This study looks at how drugs like cocaine, alcohol, marijuana, and cigarettes taken during pregnancy affect the bond between mother and baby and the baby's brain development. Researchers will follow 150 mothers and their newborns to understand these effects. The goal is to learn…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. It involves 20 VA sites across 4 regions, testing two different support strategies. The goal is to see which approach gets more women …

This study brings together 15 pregnancy experts to agree on the best ways to use vitamins and supplements during pregnancy. The goal is to create clear, evidence-based recommendations on which supplements to take, how much, and when. This research does not test a new treatment bu…

This study looks at whether using virtual reality (VR) during a C-section can lower the risk of postpartum depression and anxiety. Researchers will compare 98 pregnant women who use VR during surgery to those who don't, and also check how it affects certain brain chemicals. The g…

This study is creating a large collection of biological samples and health data from 3,000 people. The goal is to help researchers better understand gynecological disorders, male and female infertility, and pregnancy-related conditions. Participants provide samples and informatio…