COVID-19

This study tested a new COVID-19 vaccine made with CHO cells in 3,100 healthy people aged 3 and older. The goal was to see if the vaccine is safe and triggers a strong immune response. Participants received either the vaccine or a placebo in two doses. The trial is now complete.

This large study tested the safety and effectiveness of the Pfizer-BioNTech COVID-19 vaccine in nearly 47,000 healthy volunteers aged 12 and older. Participants received two doses of the vaccine or a placebo, and researchers tracked how many got COVID-19. The vaccine proved highl…

This study tested whether giving a combined COVID-19 and flu vaccine as one shot is safe and helps the body build defenses against both viruses. It involved 644 healthy adults aged 50 and older. Researchers measured side effects and antibody levels to see how well the combo worke…

This study tested several updated COVID-19 booster vaccines in over 1,400 healthy people aged 12 and older who had already received prior COVID-19 vaccines. The goal was to see if these new boosters were safe and could improve the body's immune response against newer virus varian…

This large study tested whether giving extra doses (boosters) of the Pfizer-BioNTech COVID-19 vaccine to healthy people who already had the vaccine is safe and helps prevent COVID-19. Over 16,000 people took part, and the study looked at different booster schedules and doses. The…

This study tested a new booster vaccine called PHH-1V in 887 adults who had already received two doses of the Pfizer COVID-19 vaccine. The goal was to see if PHH-1V could safely boost immunity as well as or better than another Pfizer dose. The trial also looked at giving a fourth…

This early-stage study tested a new mRNA vaccine that aims to protect against both the flu and COVID-19 in a single shot. Researchers gave the vaccine to 106 healthy adults aged 18-64 to check for side effects and measure immune responses. The goal is to see if combining these va…

This study tested a single booster dose of the SpikoGen vaccine in 81 adults who had already received a full course of any COVID-19 vaccine at least 3 months earlier. The goal was to see if SpikoGen could safely boost the immune system's ability to fight the virus, regardless of …

This study tested three new self-amplifying RNA vaccines against COVID-19 in 72 healthy adults, including some who had already been vaccinated and some who had not. The main goals were to check safety and measure the immune response. The vaccines were designed to help the body fi…

This study tested how well two different 2023-2024 updated COVID-19 vaccines (Novavax and Pfizer mRNA) protect adults from getting sick with COVID-19. About 1,188 adults who had already received at least two mRNA vaccine doses took part. Some got the Novavax vaccine, some got the…

This study tested new COVID-19 mRNA booster vaccines in 692 healthy adults who had already received their primary vaccination series. The goal was to see how well the boosters boosted immunity and if they were safe. Participants received either an investigational booster or a con…

This study looked at whether a smaller (fractional) dose of the Pfizer-BioNTech COVID-19 booster works as well as the standard dose. It involved 601 healthy adults in Mongolia who had received two doses of Sinopharm, AstraZeneca, or Sputnik vaccines 6 to 9 months earlier. Researc…

This study tested a new COVID-19 booster vaccine called SpiN-Tec in 432 healthy adults aged 18 to 85 who had already received their primary COVID-19 vaccines and at least one booster. The goal was to see if SpiN-Tec is safe and triggers a strong immune response compared to an app…

This study tested updated COVID-19 vaccines designed to protect against new and emerging variants. About 1,270 adults who were already fully vaccinated received one or two doses of these variant-specific vaccines. The goal was to see how well the vaccines boosted the immune syste…

This study tested a new type of COVID-19 vaccine (ARCT-2303) in about 1,500 adults who had already received a COVID-19 vaccine. Some participants got the COVID vaccine and the flu shot at the same time, while others got only the COVID vaccine. The goal was to see if the new vacci…

This study tested the safety and immune response of Sanofi's COVID-19 vaccines (with an adjuvant called AS03) in over 3,000 adults aged 18 and older. Participants received either a two-dose primary series or a booster shot. The goal was to see if the vaccines produced strong anti…

This study tested a new COVID-19 vaccine (mRNA-1283) against an already-approved vaccine (mRNA-1273) in over 13,500 people aged 12 and older. The goal was to see if the new vaccine provides better protection against COVID-19. Researchers measured immune responses and tracked any …

This study tested updated mRNA vaccines designed to protect against new COVID-19 variants. Over 1,000 healthy people aged 12 and older received a single dose. Researchers monitored side effects and measured immune responses to see how well the vaccines worked.

This study tested a single combined vaccine that aims to protect against both COVID-19 and influenza. Around 8,800 healthy adults received either the combo shot or separate vaccines. Researchers checked for side effects and immune response over 6 months. The goal is to make vacci…

This study tested the CoviVac COVID-19 vaccine in 200 adults aged 60 and older. The goal was to see if the vaccine is safe and triggers a strong immune response. Researchers measured side effects and antibody levels after vaccination. The vaccine uses a killed virus to teach the …

This study tested the safety and immune response of different COVID-19 booster vaccines in about 1,900 adolescents and adults aged 12 to 64 in Kenya, Democratic Republic of Congo, and Rwanda. It included people with and without HIV to see how well the vaccines work in these group…

This study tested the Moderna COVID-19 mRNA vaccine in over 14,000 people living with HIV or other conditions that raise the risk of severe COVID-19. Researchers compared different vaccine schedules to see which best prevents COVID-19. The goal was to find the most effective way …

This early-stage study tested a new RNA-based COVID-19 booster vaccine (BNT162b4) in 383 healthy adults who had already received a COVID-19 vaccine. The goal was to find a safe dose and see how well the vaccine boosts the immune system. Participants received either the new vaccin…

This study tested an experimental vaccine called VBI-2901a in 103 healthy adults aged 18-64 who had already received at least two doses of a licensed COVID-19 vaccine. The vaccine uses virus-like particles to target three coronaviruses: SARS-CoV-2 (COVID-19), SARS-CoV-1, and MERS…

This study tested a new combination vaccine (mRNA-1083) that targets both COVID-19 and the flu in one shot. About 2,400 healthy adults aged 50 and older in Japan, Taiwan, and South Korea took part. The goal was to see how well the vaccine boosts immunity and whether it is safe, c…

This early-stage trial tested a new COVID-19 booster vaccine given as a nasal spray. The goal was to see if it is safe and how well it boosts the immune system. The study involved 60 healthy adults who had already received the standard COVID-19 shots. Researchers monitored side e…

This study tested a new DNA booster vaccine called Covigenix VAX-002 in 46 healthy adults aged 18 and older. The vaccine is designed to protect against newer Omicron variants of the virus that causes COVID-19. Participants had already received a primary COVID-19 vaccine or booste…

This study tested two types of short digital messages to see if they could encourage COVID-19 vaccination in adults with anxiety or depression. Over 1,400 undervaccinated participants received either standard public health messages, messages designed to build resistance to misinf…

This study looked at whether a recombinant COVID-19 booster vaccine can strengthen the immune response in people with weakened immune systems, specifically those with inflammatory bowel disease (IBD) or who have had an organ transplant. Researchers measured antibody levels before…

This study tested three different batches of the Novavax COVID-19 vaccine to make sure they all work the same. About 900 adults aged 18 to 49 who had already been vaccinated took part. Researchers measured their immune response and checked for safety issues.

This study tested a protein-based COVID-19 vaccine called SpikoGen in 39 adults who had never received a COVID-19 vaccine. Participants got two doses one month apart, followed by a third booster dose either one or three months later. The goal was to see how well the vaccine trigg…

This study tested whether having COVID-19 patients with serious breathing problems lie face down (prone position) while using a high-flow oxygen mask could reduce the need for breathing tubes and lower death risk. About 405 adults with COVID-19 pneumonia and low oxygen levels too…

This study tested whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve oxygen levels and reduce inflammation in adults with moderate to severe COVID-19. Thirty participants who needed extra oxygen and had risk factors like diabetes or hea…

This study tested an experimental antiviral drug called S-892216 in 282 adults with mild-to-moderate COVID-19. The goal was to see if the drug could lower the amount of virus in the nose and throat faster than a placebo. Participants had to have symptoms and a positive test for t…

This study tested whether giving a drug called abatacept early to hospitalized COVID-19 patients on low-flow oxygen could help them recover faster. The drug aims to calm an overactive immune response. 285 adults with COVID-19 pneumonia took part. The main goal was to see if abata…

This study tested a treatment made from horse antibodies (INM005) in 243 adults hospitalized with moderate to severe COVID-19. The goal was to see if it could help patients recover faster, measured by improvement on a standard illness scale 28 days later. The treatment was given …

This study tested whether colchicine, an inexpensive anti-inflammatory drug usually used for gout, can help patients with mild to moderate COVID-19 pneumonia. 66 patients in Lahore were given the drug to see if it shortens hospital stays and reduces the need for oxygen. The goal …

This study tested whether two common blood pressure medicines (ACE inhibitors or ARBs) could help high-risk COVID-19 patients avoid intensive care, a ventilator, or death. About 372 adults with COVID-19 and heart disease risk factors took part. Researchers tracked outcomes like I…

This study tested whether adding pegylated interferon lambda to standard care helps hospitalized COVID-19 patients recover faster. Nine adults with mild to moderate symptoms were randomly assigned to receive either the drug plus standard care or standard care alone. The main goal…

This study tested nearly 950 adults with COVID-19 symptoms to see how well different test methods work. Researchers compared saliva samples and nose swabs, using both a rapid antigen test (results in minutes) and a lab PCR test (results in hours). The goal was to find out which c…

This study checked how well a new test called VitaSIRO solo™ detects COVID-19, flu, and RSV from nasal swabs. Over 1,200 people with respiratory symptoms took part. The test was compared to standard lab tests to see if it is accurate and reliable.

This study tested two quick screening tools for tuberculosis (TB) in 1,400 adults with symptoms like cough or fever. The tools—a chest X-ray analysis software and a blood test for inflammation—aim to rule out TB without needing lab tests. Results will help decide if these methods…

This study collected CT scan images from over 10,000 people to find better ways to diagnose COVID-19 and predict how severe the disease might become. Researchers used deep learning (a type of artificial intelligence) to analyze the scans. The goal was to improve accuracy compared…

This study tested whether a shallow (2 cm) or deeper (4 cm) nasal swab is better at detecting COVID-19 using rapid antigen tests. Over 300 adults in Denmark each got both depths (one in each nostril) and a throat PCR test for comparison. The goal was to find the most accurate and…

This study checked how well a new rapid test (iHealth Flu A&B/COVID-19/RSV) works for people with respiratory symptoms. Over 1,100 participants gave nasal samples, which were compared to standard lab tests. The goal was to see if the test accurately detects influenza, COVID-19, a…

This study looked at whether testing saliva (spit) is as good as the standard nose swab for finding COVID-19. Over 5,000 people provided both a nose swab and a saliva sample. The goal was to see if saliva testing could make screening easier and more comfortable while still being …

This study checked how well a new rapid test (iHealth COVID-19/Flu A&B) can detect COVID-19 and flu A&B in people with respiratory symptoms. 588 people with two or more symptoms (like fever, cough, or sore throat) gave nose swabs for the test and a standard lab test. The goal was…

This study looked at whether a drug called Dimolegin can safely prevent blood clots in adults hospitalized with moderate COVID-19. A total of 184 patients took the medicine once a day as part of their regular care. Researchers tracked bleeding events and other side effects to see…

This study looked at whether a second booster (fourth dose) of the COVID-19 vaccine offers extra protection for people aged 60 and older. Researchers tracked hospitalizations, deaths, and side effects in over 490,000 seniors in Brazil, and also tested immune responses in a smalle…

This study tested whether infusions of a person's own stem cells could help prevent COVID-19 from causing serious illness. Researchers gave five IV infusions of these cells to 51 adults at high risk, such as those over 65 or with health conditions. The goal was to see if the trea…

This study tested whether showing a short video or asking a simple question in the emergency department could encourage more adults to get a COVID-19 booster shot. Over 900 people took part, and researchers checked if they got vaccinated within 30 days. The goal was to find easy …

This study tested whether a nasal spray containing heparin, a common and safe medicine, can reduce the spread of COVID-19 among people living in the same home. Over 500 adults and children who lived with someone who tested positive for COVID-19 used the spray or a dummy spray thr…

This study tested whether a dietary supplement called Mito-MES could prevent healthy adults from developing severe viral infections, like COVID-19, after being exposed to a sick person at home. 80 adults who had close contact with someone with respiratory symptoms took the supple…

This study tested a program to increase COVID-19 vaccination among pregnant women. COVID-19 during pregnancy raises risks for both mother and baby, yet many pregnant women remain unvaccinated. Researchers worked with OB/GYN offices to encourage vaccination and tracked vaccination…

This study looked at whether hydroxychloroquine, a medicine already used for lupus, could protect people from getting COVID-19 or make it less severe. Researchers compared 552 lupus patients who were either taking or not taking hydroxychloroquine during the pandemic. The goal was…

This study tested whether taking a moderate dose of vitamin D (4,000 IU daily) could lower the chance of getting COVID-19 compared to a low dose (400 IU daily). Over 2,000 adults from the Chicago area and other US communities took part. Participants reported any COVID-19 infectio…

This study tested whether taking a daily vitamin D3 supplement for 4 weeks could help people recently diagnosed with COVID-19 feel less sick and avoid needing doctor visits or hospital care. It also looked at whether the same supplement could protect their household members from …

This study tested whether five infusions of stem cells (HB-adMSCs) could prevent COVID-19 symptoms and hospitalizations in 53 high-risk workers like doctors and firefighters. Participants had no signs of COVID-19 at the start. The goal was to see if the stem cells could boost the…

This study tested a drug called thymalfasin (Ta1) to see if it could prevent COVID-19 infection in people with kidney failure who are on dialysis. These patients are at high risk because they spend time in dialysis centers and often have weak immune systems. The study involved 18…

This study tested whether a treatment called IMM-101 could help prevent severe respiratory infections, including COVID-19, in people with cancer. About 195 cancer patients at higher risk for severe COVID were randomly assigned to receive IMM-101 or just be observed. The goal was …

This study looked at whether the antiviral drug remdesivir can reduce symptoms of Long COVID. 73 adults with confirmed Long COVID received the drug for five days and were monitored for about 8 weeks. The main goal was to see if this treatment approach is practical and tolerable f…

This study tested whether a home-based exercise program, supported by video or phone calls every 1-2 weeks, could help 20 adults who had severe COVID-19. The program aimed to improve walking distance, muscle strength, and quality of life. Results showed that remote coaching can s…

This study tested whether high doses of vitamin E (alpha-tocopherol) could reduce C-reactive protein (CRP), a marker of inflammation, in 56 adults with COVID-19. Participants received either vitamin E or a placebo. The results suggest that vitamin E may help lower CRP levels, pot…

This study tested a breathing exercise program for people with long COVID who still feel short of breath. 40 adults who had COVID-19 and ongoing breathing problems took part. The goal was to see if the exercises work better than usual care for improving breathlessness and daily f…

This study tested if lying face down (prone positioning) helps hospitalized COVID-19 patients with low oxygen levels who are not candidates for breathing machines. About 600 adults took part. The goal was to see if this simple position change reduces deaths or the need for hospic…

This study tested whether a simple home program of breathing exercises and walking at least 6000 steps daily could ease long COVID symptoms like cough, shortness of breath, and fatigue. Forty adults with long COVID followed the program for six weeks. Researchers tracked symptom c…

This study tested whether two months of smell training could help people recover their sense of smell and taste after COVID-19. Forty adults who lost these senses due to COVID-19 were split into two groups: one did daily smell training, and the other did not. The goal was to see …

This study tested whether a smartphone app called Ghostly can help hospitalized patients—including those recovering from stroke, COVID-19, or frailty—do strength exercises to rebuild muscle. Fifteen participants used the app during their hospital stay, and researchers measured ch…

This study tested a noninvasive nerve stimulation device to see if it can reduce muscle and joint pain in people with long COVID. 40 adults who had COVID-19 in the last 3 months and still had pain were split into two groups: one received the real treatment and the other a fake (s…

This study tested a non-invasive radiofrequency treatment (448 kHz) to help people with ongoing breathing issues, cough, and fatigue after COVID-19. 96 adults who had COVID-19 and respiratory symptoms for over a month took part. The goal was to see if the treatment could improve …

This study looked at whether an e-health tool could help adults who had COVID-19 and still feel tired or out of shape. 77 people used the tool to guide their exercise and track progress. The goal was to see if it was easy to use and if it improved fitness and quality of life.

This study tested whether a daily breathing muscle training program could help adults with long COVID who have weak breathing muscles. 44 participants did breathing exercises twice a day for 8 weeks, combined with physical exercise. The goal was to see if this improved their lung…

This study tested a short, on-site mindfulness program for 1,000 frontline healthcare workers in a Madrid hospital during the COVID-19 outbreak. The goal was to see if it helped reduce stress and was safe and easy to use. Participants rated how helpful it was on a scale from 0 to…

This study looked at whether a 6-week breathing exercise program (inspiratory muscle training) can improve diaphragm strength and reduce shortness of breath in people who had COVID-19 and still feel breathless. 18 adults with confirmed diaphragm weakness participated. The goal wa…

This study aimed to find out which immune responses best predict protection against COVID-19 after vaccination. Researchers collected blood and nasal samples from over 2,500 people of all ages at retail pharmacies to measure antibody levels. The goal was to improve future vaccine…

This study looked at whether smoking or using nicotine products changes the chance of catching COVID-19. Researchers surveyed over 600 healthcare workers who had been tested for the virus. The goal was to see if current or past tobacco use was linked to a positive or negative tes…

This study looked at how often brainstem problems occur in COVID-19 patients who are on breathing machines and deeply sedated in the ICU. Researchers checked for nerve issues using a special scale and also examined heart rate signals. The goal was to better understand the brain's…

This study looked at blood product shortages during the COVID-19 pandemic at a Dallas hospital. Researchers tracked when emergency surgeries were delayed or couldn't get needed blood. The goal is to create better policies for handling blood supply during future health crises.

This study examined how often doctors use a special breathing technique called lung protective ventilation during non-cardiac surgeries in a large Canadian health region. Researchers looked at data from over 28,000 adults to see if practices changed before and after the COVID-19 …

This study looked at whether virtual coaching helps rural pharmacists better counsel people who are hesitant about getting the COVID-19 vaccine. Twenty pharmacies took part, first receiving standard training and then adding one-on-one video coaching. Researchers measured how well…

This study enrolled 760 adults who had tested positive for SARS-CoV-2 and recovered. Researchers measured antibodies and immune cells in blood samples over several months to understand how the body remembers the virus. The goal was to improve tests and help design better vaccines…

This study looked at how stress from the COVID-19 pandemic and changes in the food environment influenced eating behaviors and weight in adults. Over 5,000 English-speaking adults aged 18 and older completed online surveys about their mental health, eating habits, and weight chan…

This study followed 51 adults who survived severe COVID-19 pneumonia and needed a breathing machine in the ICU. Researchers checked their quality of life, ability to move, muscle strength, and nutrition at 1, 6, and 12 months after leaving the hospital. The goal was to understand…

This study used a special lung imaging technique called electrical impedance tomography (EIT) to see how air moves in the lungs of people with post-COVID breathing trouble. Researchers compared 100 patients who had COVID-19 and still felt short of breath with 50 healthy volunteer…

This study aimed to find simple blood markers that could predict if a person with suspected COVID-19 in the emergency room would later get sicker. Researchers followed 373 patients to see if routine lab tests could forecast worsening. The goal was to help hospitals better allocat…

This completed Phase 2 trial tested the safety and effectiveness of different drug combinations in people with COVID-19. It used a master protocol that allowed both hospitalized and non-hospitalized patients to join. Only 4 participants were enrolled, and the study focused on mea…

This study followed 917 adults who took Paxlovid for COVID-19 to see how often the virus rebounds—meaning a positive test after testing negative. Participants were already prescribed Paxlovid by their doctor. The main goal was to measure the rate of rebound, not to test a new tre…

This study looked at nearly 2,400 children aged 0-12 who had mild cold symptoms before planned non-heart surgery. Researchers wanted to see if the COVID-19 pandemic changed the risk of complications during and after surgery. The goal is to help doctors decide the best timing for …

This study looked at why Spanish-speaking Latinx communities face higher rates of COVID-19 infection and death. Researchers worked with community partners to understand social and ethical barriers to testing and vaccination. They tested a program that combined peer support and mo…

This study looked at how COVID-19 vaccination and boosters during pregnancy or breastfeeding affect immunity in 150 mothers and their infants. Researchers measured antibody levels and virus-fighting ability in maternal blood, infant blood, breast milk, and baby saliva over time. …

This study followed 622 veterans with chronic lung disease who had COVID-19 to understand what factors made their illness worse and what recovery and rehabilitation they needed. Researchers looked at medical records and surveyed patients and their caregivers about their health, d…

This study followed 530 working-age adults (18-70) who were hospitalized for COVID-19 to understand long-term disability. Researchers measured physical and mental impairments, activity limits, and social participation using standard checklists and patient surveys. The goal was to…

This study looked at 600 adults with severe COVID-19 lung failure who were treated with high-flow nasal oxygen and placed on their stomachs while awake. The goal was to see if this combination could reduce the need for a breathing tube and lower death rates. Researchers also want…

This study looked at whether a common blood test measure called RDW (red blood cell distribution width) can help predict how severe COVID-19 patients will do in the intensive care unit. Researchers followed 146 adults with severe or critical COVID-19 in the ICU and checked if hig…

This study aimed to count how many healthy adults in central North Carolina developed antibodies to the COVID-19 virus over one year. Researchers enrolled 643 people aged 18 and older who did not have COVID-19 at the start. Participants gave blood samples five times and completed…

This study looked at whether neck muscle activity during sleep affects breathing in ICU patients recovering from COVID-19-related lung injury. 17 patients had their sleep monitored the night before leaving the breathing machine. The goal was to understand why sleep is often poor …

This study watched 199 adults hospitalized with COVID-19 to learn more about the disease. Researchers collected information on patient backgrounds, treatments used, and how the illness progressed over time. The goal was to answer important questions about COVID-19 that were still…

This study looked at whether people infected with COVID-19 who never had symptoms still develop antibodies (immune response) compared to those who had symptoms. Researchers followed over 200 adults from households with a confirmed COVID-19 case. The goal was to understand if sile…

This study looked at whether getting a COVID-19 booster and a flu shot at the same time is safe and works well. 36 healthy Thai adults took part. Researchers measured immune responses and checked for side effects.

This study looked at what helps or stops Black/African American adults from getting tested for COVID-19. Researchers worked with beauty salons and barber shops to share culturally relevant videos and messages from trusted community leaders. The goal was to learn how to make COVID…

This study tested whether group discussions led by community members could change how people feel about COVID-19 testing and vaccines. Fifty-seven adults from housing agencies took part in Zoom meetings and filled out surveys over six months. The goal was to see if these talks co…

This study looked at whether medications used for COVID-19 or the COVID-19 vaccine can damage hearing. Researchers tested the hearing of 90 adults aged 18-35, comparing those who had COVID-19 and took medication, those who had COVID-19 but took no medication, and those who never …

This study tested a new tablet form of the experimental COVID-19 drug ALG-097558 in 51 healthy adults. Researchers checked how the drug interacts with other medications and whether food changes how it works. The goal is to gather safety and dosing information, not to treat the di…

This study looked at placentas and umbilical cord blood from 68 women who had COVID-19 during pregnancy. Researchers checked for changes in the placenta's structure, genes, and signs of inflammation to see if the infection affected the baby's health. The goal was to learn more ab…

This study tested a quick-start program where people with COVID-19 could get tested and treated right away. It took place in Ghana, Malawi, Rwanda, Zambia, and Zimbabwe with 148 participants. Researchers interviewed patients and health workers to see if the program was easy to us…

This study examined 1072 vaccinated adults who later caught COVID-19. Researchers analyzed the virus's genetic code and measured antibody levels to see if certain variants were more common in these cases. The goal was to understand why some vaccinated people still get infected, n…

This study looked at 100 fully vaccinated adults who later tested positive for COVID-19. Researchers compared infection rates between people who only had the initial vaccine series and those who also got a booster shot. The goal was to understand how often breakthrough infections…

This study tested two ways to encourage COVID-19 testing among people who use opioids: having friends refer friends (chain referral) and using trusted community messengers. About 500 adults who had used opioids in the past 6 months took part. The goal was to see which method got …

This study followed 201 adults with diabetes who were hospitalized for COVID-19 in Algeria. Researchers tracked their blood sugar control, weight, and kidney function for up to one year after leaving the hospital. The goal was to learn how COVID-19 affects diabetes management lon…

This study tested a new COVID-19 drug, ALG-097558, in 16 adults—some with moderate liver problems and some with healthy livers. The goal was to see how the liver affects drug levels in the body and check for side effects. It was an early-stage (Phase 1) study, not designed to mea…

This study looked at how two different COVID-19 booster vaccines affect immune cells in the lymph nodes. Researchers used a thin needle to take samples from the lymph nodes of 12 adults who had already received at least three COVID-19 mRNA vaccine doses. The goal was to understan…

This study tested whether giving long-term care and retirement home staff a personal 'resource navigator' could improve their wellness and reduce burnout. 123 workers in Ontario were split into two groups: one got one-on-one support to find health and wellness resources, the othe…

This study looked at 60 blood cancer patients who had a stem cell transplant and later developed a serious fungal infection called mucormycosis. Researchers compared cases before COVID-19 (2015-2020) and during the pandemic (2020-2024) to see how the virus, new tests, and treatme…

This study looked at how the COVID-19 pandemic changed healthcare and affected the quality of life of over 5,000 Dutch patients who had surgery or another medical procedure in 2020-2021. Researchers created a survey to capture patients' experiences and linked their answers to nat…

This study looked at how well different COVID-19 vaccines work in adults from 7 countries. About 5,400 people joined within a day of getting their vaccine. Researchers measured antibody levels to see how strong and long-lasting the immune response was.

This study looked at whether a person's genes affect how sick they get from COVID-19. Researchers collected blood or saliva samples from 721 people in the U.S. who tested positive for the virus. They also asked about health history and symptoms. The goal was to find genetic clues…

This study looked at how COVID-19 affected cancer patients and healthcare workers in French cancer centers. Researchers tracked infections, immune responses, and the impact on cancer care. Over 1,100 people took part, including patients on treatment, those in follow-up, and staff…

This early-stage study tested a new oral drug called MSP008-22 in 64 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo, and researchers monitored for side effects. This study does not test whether the drug treats…

This study tested a community-designed program to increase COVID-19 and flu vaccination among underserved groups in East London, including minority ethnicities, migrants, and low-income individuals. About 5,900 adults from six GP practices were randomly assigned to receive the pr…

This study looked at whether a health education program in schools could help students and their families learn more about COVID-19 and make safer choices. About 112 parents and children from several Miami-area schools took part. Researchers compared those who received the progra…

This study gathered information from 550 adults treated for COVID-19 at Methodist Health System facilities. Researchers looked at patient details, treatments given, and how well patients recovered. The goal was to learn more about the disease and improve future care.

This study looked at 283 adults who needed intensive care for severe COVID-19 lung problems. Researchers tracked who survived up to 4 years later and asked survivors about their quality of life, breathing, and ability to return to work. No new treatments were given—the goal was s…

This study looked at how many people in Punta Arenas, Chile, have persistent COVID-19 (long COVID) after a COVID-19 infection. Researchers surveyed and tested 282 adults who had COVID-19 to find out how common long-term symptoms are and what factors might increase the risk. The g…

This study examined blood clotting issues in 175 hospitalized COVID-19 patients. Researchers measured how well the blood forms clots (thrombin generation) to see if these tests could predict survival. The goal was to better understand why severe COVID-19 causes dangerous clotting…

This study looked at how worried people with rheumatic diseases were about COVID-19, depending on whether they took biologic or conventional medications. Researchers surveyed 200 adults by phone using a standard anxiety scale. The goal was to understand if one group felt more anx…

This early study tested a new PET/CT imaging agent in 5 adults who had recovered from COVID-19. The goal was to see if the tracer could detect lung damage caused by the virus. Participants had no prior lung disease and needed two negative COVID tests before each scan. The study w…

This study tested a blood test (ELISpot) to detect early immune responses to COVID-19. Researchers aimed to understand infection timing and predict disease severity. About 950 adults participated, including those with confirmed or suspected COVID-19, exposed contacts, and healthy…

This study looked at whether people with cystic fibrosis (CF) have different immune responses to COVID-19. Researchers tested blood samples from 331 children and adults with CF in Europe over two years to see how many had COVID-19 antibodies. They also tracked symptoms, lung func…

This study reviewed medical records of 84 hospitalized adults with severe COVID-19 who received remdesivir. Researchers tracked their recovery using a 7-point scale at different time points. The goal was to understand how well the drug worked outside of clinical trials.

This study looked at whether people hospitalized with severe COVID-19 are more likely to develop diabetes later. Researchers followed 23 adults who had no diabetes before their infection, measuring their blood sugar levels over time. The goal was to understand how COVID-19 might …

This study looked at how smoking changes immune cells and whether those changes make smokers more vulnerable to severe COVID-19. Researchers followed 132 healthy smokers and non-smokers aged 30-55 for up to 6 months, taking blood, saliva, and nasal swabs to track infections and i…

This study used health records from over 8 million people in Taiwan to understand the effects of COVID-19 and how well the oral treatment nirmatrelvir/ritonavir (Paxlovid) worked. Researchers looked at who got severely ill, needed hospital care, or died, and compared those who to…

This study looked at whether it is safe to give another dose of a COVID-19 mRNA vaccine to people who had a bad reaction to a previous dose, or to people with a history of allergies. It also included people with long COVID. A total of 137 adults took part and received either the …

This study looked at whether people with cystic fibrosis (CF) have different rates of COVID-19 infection and antibody responses compared to the general population. Researchers followed 75 adults and children with CF across Europe for two years, testing their blood for SARS-CoV-2 …

This study analyzed 818 adults hospitalized with COVID-19 to find links between their genes, inflammation, and other health markers and how severe their illness became. Researchers tracked who recovered and who died, aiming to identify risk factors for poor outcomes. The goal was…

This early-phase study tested the safety of an experimental drug called PA-001 in 47 healthy adults and older volunteers. The goal was to see if the drug is safe and how the body processes it, not to treat COVID-19. Results will help decide the right dose for future patient studi…

This study looked at how the experimental COVID-19 drug ALG-097558 is processed by the body in people with severe kidney problems compared to healthy volunteers. Twelve adults took the drug twice daily for several days. The goal was to measure drug levels in blood and urine, not …

This study looked at whether the virus that causes COVID-19 can be found in the saliva of people who have no symptoms or only mild symptoms. Researchers collected samples from the nose, mouth, eyes, and blood, and also tested how wearing a mask affects virus spread during speakin…

This study reviewed medical records of 200 adults from an endocrinology clinic to see if taking vitamin D3 supplements lowered their chances of developing Long COVID after a COVID-19 infection or getting COVID-19 after vaccination. Researchers compared patients who took vitamin D…

This study looked at whether community-led group discussions can help people feel more trusting and open to COVID-19 testing and vaccines. 49 adults from housing agencies took part in online meetings and filled out surveys over 18 weeks. The goal was to see if talking with peers …

This study followed more than 4,200 Dutch COVID-19 patients for up to two years to learn about long COVID. Researchers tracked symptoms like tiredness, breathing problems, and mental health issues, and how these affected quality of life. The goal was to better understand the cond…

This study tested a noninvasive device that measures breathing, heart rate, body temperature, and oxygen levels. Researchers wanted to see if it could help screen and monitor respiratory infections like COVID-19. Forty healthy adults performed breathing tasks while the device was…

This study looked at 120 hospitalized COVID-19 patients with severe breathing problems to understand how their immune systems were reacting. Researchers measured many immune markers in the blood to see if a specific immune pattern could predict who might die. The goal was to find…

This study looked at 20 children under 18 who had heart inflammation (myocarditis) possibly linked to COVID-19. Researchers wanted to describe the symptoms, lab results, and heart ultrasound findings, and to figure out if the virus directly damages the heart or if the body's own …

This study looked at 13 adults who had COVID-19 and still had symptoms like memory or smell problems after recovery. Researchers used brain scans, memory tests, and other exams to find possible long-term changes in the nervous system. The goal was to better understand how COVID-1…

This study followed over 1,100 high-risk COVID-19 patients in the Netherlands who received new antiviral drugs or monoclonal antibodies. Researchers collected blood samples and nasal swabs over 90 days to track how the virus changed, how the body responded, and whether side effec…

This study aimed to find early signs in the blood that could predict which COVID-19 patients would become severely ill. Researchers analyzed immune cells and inflammatory markers from 304 hospitalized patients and healthcare workers. The goal was to identify biomarkers that could…

This study looked at whether a blood test marker called NEU-SFL, which reflects immune cell activity, can help predict the risk of death in people hospitalized with COVID-19 in 2021. Researchers compared NEU-SFL levels between those who survived and those who did not. The goal wa…

This study reviewed medical records of 417 adults hospitalized with COVID-19 at four hospitals. Researchers wanted to find out how many patients also had other infections (co-infections) or got new infections later. They also looked at whether these extra infections affected deat…

This study looked at whether text message reminders can encourage people with diabetes or at risk for diabetes to get tested for COVID-19. About 290 people in Georgia took part, with half getting the text reminders and the other half not. The goal was to see if the reminders incr…

This study looked at stored blood samples from about 300 adults hospitalized with COVID-19 to see if a protein called suPAR could predict who would develop severe breathing failure needing a ventilator. Researchers measured suPAR levels and checked medical records for outcomes. T…

This study partnered with community organizations to make COVID-19 rapid testing easier and more effective for Latino communities in San Diego. Over 6,500 English- and Spanish-speaking adults from local clinics and neighborhoods took part. The goal was to find the best ways to of…

This study used advanced MRI scans to check for organ damage in 693 adults who had recovered from COVID-19. Researchers looked at the heart, kidneys, liver, lungs, pancreas, and spleen to see how often and how severely these organs were affected. The goal was to better understand…

This study looked at how COVID-19 causes organ failure in intensive care patients. Researchers tracked 380 adults with suspected or confirmed COVID-19 in the ICU, measuring kidney injury, breathing problems, and survival rates. The goal was to better understand the disease, not t…