COVID-19

This study tests an updated COVID-19 vaccine designed for the 2025-2026 season in people 12 and older who are at higher risk of severe illness, including those 65+. About 760 participants will receive one shot and be monitored for safety and immune response over 6 months. The goa…

This study is testing a new version of the COVID-19 vaccine that is designed to work better against newer virus variants. It includes over 4,000 healthy children from 6 months to 12 years old, some who have had prior COVID-19 vaccines and some who have not. The goal is to see if …

This study tests an experimental oral COVID-19 vaccine tablet (taken by mouth) against currently approved mRNA booster shots. About 10,400 adults who have already received at least two mRNA COVID-19 vaccines will be randomly assigned to get either the tablet or a booster shot. Th…

This early-stage study tests a new type of COVID-19 booster vaccine called PepGNP-COVID19 in 60 healthy adults aged 18-64. Unlike current vaccines that focus on antibodies, this one uses tiny gold particles to train the body's T cells to recognize and fight the virus, potentially…

This study tests a single-dose nasal spray COVID-19 vaccine (CVXGA) against a standard mRNA shot in about 432 healthy adults who have already had a primary COVID-19 vaccine series. The goal is to see if the nasal vaccine is safer and better at preventing symptomatic COVID-19 over…

This study tests a new COVID-19 vaccine given as a single nasal spray. It aims to see if it is safe and triggers a strong immune response. About 227 healthy adults aged 18 to 80 are taking part. The vaccine is designed to fight the virus right where it enters the body.

This study tests how well two different COVID-19 booster vaccines (Moderna and Novavax) work as a fourth dose in healthy adults who have already had three doses. About 496 participants in Australia will receive one of the two vaccines and be monitored for immune response and side…

This large, late-stage study is testing a new combination vaccine that aims to protect against both COVID-19 and the flu with a single shot. About 9,300 adults aged 65 and older will receive either the combo vaccine or a standard flu vaccine. Researchers will compare how well eac…

This study looked at 14 kidney transplant recipients whose immune systems are suppressed to prevent organ rejection. Because of this suppression, standard COVID-19 vaccines often don't work well for them. Researchers tested whether temporarily reducing their immunosuppressive med…

This study tests an updated COVID-19 vaccine (2025/2026 formula) in 343 children aged 5 to 11 who have health conditions that put them at high risk for severe COVID-19. Each child receives one shot and is followed for about 6 months to check safety and immune response. The goal i…

This study compares how well two FDA-approved COVID-19 vaccines (Novavax and Pfizer-BioNTech) trigger the immune system and their side effects. About 54 healthy adults aged 18-79 with certain risk factors will receive one of the vaccines and be followed over time. The goal is to …

This study tests a new vaccine designed to protect against the Omicron JN.1 variant of COVID-19. About 120 adults aged 65 and older, and teens and adults aged 12 to 64 with health conditions that raise their risk for severe COVID, will receive a single shot. Researchers will chec…

This study tests whether an updated COVID-19 vaccine can safely protect healthy adults aged 50 to 64 from the virus. About 5,240 participants will receive either the variant-adapted vaccine or a placebo. Researchers will monitor side effects and track how many people get COVID-19…

This study tests a single dose of a new COVID-19 vaccine designed to protect against the JN.1 variant. About 6,500 healthy adults aged 50 to 64 who are not at high risk for severe COVID will receive either the vaccine or a placebo. Researchers will track who gets sick with COVID …

This study tests whether a COVID-19 vaccine (mRNA-1273) can prevent severe illness in healthy adults aged 50-64 who have no known risk factors. About 285,000 participants will be randomly assigned to receive the vaccine or no vaccine. The main goal is to see if the vaccine reduce…

This was an early safety study for a personalized COVID-19 vaccine. The vaccine would have been made using each participant's own immune cells, trained in a lab to recognize the coronavirus. The study was withdrawn before any participants were enrolled, so no results are availabl…

This study tests several experimental drugs at once in critically ill COVID-19 patients who need high-flow oxygen or a ventilator. The goal is to quickly find treatments that reduce deaths and shorten the time patients need breathing support. About 1,500 adults in the hospital ar…

This study tests whether a probiotic called Lp299v can improve blood vessel function in people with long COVID (PASC). The trial will enroll 80 adults who had COVID-19 in the past 30 to 180 days. Participants will take the probiotic daily, and researchers will measure changes in …

This study tested a device called Seraph 100, a blood filter that removes the COVID-19 virus from the bloodstream. It involved 42 severely ill adults with COVID-19 who had organ failure. The goal was to see if the filter could reduce organ damage and improve survival.

This study tests whether N-acetylcysteine, a drug already used for liver protection and lung mucus thinning, can help severe COVID-19 patients by boosting their immune system. About 48 adults with confirmed COVID-19 who are in intensive care or on a ventilator (Arm A) or need ext…

This study aimed to see if the drug sarilumab could help hospitalized COVID-19 patients with severe breathing distress. It planned to compare one or two doses of sarilumab against a placebo. However, the trial was withdrawn before enrolling any participants, so no results are ava…

This study aimed to see if adding TADIOS to standard care helps people with mild to moderate COVID-19 recover faster and feel better. Researchers planned to measure inflammation markers, symptom improvement, and quality of life in hospitalized adults aged 18-65. However, the stud…

This study uses health records from nearly 99,000 adults in Ontario to see if the antiviral drug Paxlovid reduces the risk of severe COVID-19 outcomes like hospitalization or death. Researchers compared people who took Paxlovid with those who did not, tracking their health for up…

This study tests whether inhaling a protein called interferon beta 1b can help hospitalized COVID-19 patients who need oxygen. The goal is to see if it reduces how much oxygen they require over 15 days. The trial involves 74 adults with confirmed COVID-19 who are on oxygen therap…

This study aimed to test the safety and effects of an experimental stem cell treatment (BX-U001) for adults hospitalized with severe COVID-19 pneumonia and serious breathing problems (ARDS). The trial was designed in two parts: first to find a safe dose, and then to compare that …

This study tests two new e-stethoscope devices that use sound waves to detect COVID-19, flu, and RSV without needles or nasal swabs. About 300 adults at a Texas military base will have a quick, painless scan and fill out a symptom questionnaire. The goal is to see if these device…

This early-stage study tests a new booster vaccine, STX-S, in 60 healthy adults who have already had their primary COVID-19 shots and at least one booster. The goal is to check if different doses are safe and how well they boost the body's immune defenses against the virus. Parti…

This study aimed to see if hydroxychloroquine could safely prevent COVID-19 in older adults living in long-term care homes. It planned to give the drug to people who were at high risk due to age and health conditions. However, the trial was withdrawn before any participants were …

This study tests whether taking Paxlovid early during a COVID-19 infection can prevent long COVID symptoms like fatigue, shortness of breath, and brain fog. About 2000 adults aged 18-64 with a recent positive test and symptoms will receive either Paxlovid or a placebo. Researcher…

This study aimed to see if the BCG vaccine, originally for tuberculosis, could help healthcare workers fight off severe COVID-19. The idea was that the vaccine might broadly boost the immune system. However, the study was withdrawn before any participants were enrolled, so no res…

This study looks at whether health messages and community support can increase COVID-19 vaccination rates in 15 counties in Appalachian Kentucky. About 2,250 adults will take part. Researchers will compare vaccination rates before and after the strategies are used.

This study aimed to see if hydroxychloroquine could prevent COVID-19 hospitalizations in adults on dialysis for kidney failure. It was planned as a randomized trial but was withdrawn before any participants were enrolled. No results are available.

This study tests whether a single, low-dose radiation treatment to the lungs can reduce inflammation in hospitalized adults with COVID-19 pneumonia. The goal is to see if this approach lowers the need for breathing machines and shortens hospital stays. About 37 participants will …

This study looks at whether a 10-week exercise program can help adults aged 18 to 80 who still have symptoms after a COVID-19 infection. Participants will do cardio exercise three times a week and attend weekly education classes. The goal is to see if exercise improves physical c…

This study looks at whether joining community drum circles can lower anxiety and boost feelings of connection in people of African descent who are dealing with stress, anxiety, or depression made worse by COVID-19. About 90 people aged 16 and older will take part. Researchers wil…

This study tests a health pathway designed to help people with persistent COVID-19 symptoms (long COVID) improve their quality of life. Researchers will follow 400 participants for 6 months, measuring physical, mental, and social well-being. The goal is to see if structured suppo…

This study looks at whether a virtual program combining music and mindfulness can reduce stress, anxiety, and depression in people of African descent. About 300 participants aged 16 and older will take part. The goal is to see if culturally relevant, community-based activities im…

This study follows 1,520 mostly Black and Latinx adults who had COVID-19 to understand long-term health problems. Participants complete surveys and some give blood and nasal swabs up to 12 months after infection. The goal is to learn how infection severity affects recovery and im…

This study aims to find out if lung blood vessel damage is a key reason why some people feel short of breath long after a COVID-19 infection. Researchers will measure lung function, exercise capacity, and heart performance in 200 adults who had COVID-19. The goal is to better und…

This study collected information on 7,500 adults admitted to Swedish ICUs with COVID-19 during the first two years of the pandemic. Researchers looked at patient characteristics, treatments, and survival rates at 30 days and one year. The goal is to understand the disease's impac…

This study looks at how the COVID-19 pandemic changed the number and severity of syphilis cases in 240 patients treated at an Italian hospital between 2017 and 2025. Researchers want to understand if lockdowns and fear of COVID-19 led to delayed diagnoses and more advanced infect…

This study aims to understand why COVID-19 is more dangerous for older adults by looking at specific immune cells called CD8 T cells. Researchers will study blood, urine, and saliva samples from 83 adults in Maryland who have recovered from COVID-19. The goal is to learn how thes…

This study surveys 1,000 radiation oncology providers at Duke Cancer Center to understand their experience using telehealth instead of in-person visits during COVID-19. Researchers want to know if virtual visits led to missed appointments or more emergency room visits. The goal i…

This study looks at whether a virtual drum circle and mindfulness program can help Black adults manage stress, anxiety, and depression made worse by COVID-19. About 30 people will join online sessions and rate their feelings of connection and synchrony. The goal is to learn if cu…

This study looks at how the immune system, specifically CD8 T cells, responds to Pfizer or Moderna COVID-19 vaccines in healthy adults aged 18 and older. Researchers want to see if age affects this response. Participants do not receive the vaccine through the study but provide bl…

This study looks at how COVID-19 changes the bacteria in the gut of hospitalized patients. Researchers want to see if these changes are linked to the amount of virus in the stool and how sick patients get. The goal is to better understand the disease, not to test a new treatment.

This study aims to learn more about the symptoms and health effects of COVID-19 and influenza in adults. About 1,000 people with a positive test and mild symptoms will complete online surveys over six months. No treatment is given; the goal is to understand how these illnesses af…

This study uses anonymous health records from California and Louisiana to see how effective the Pfizer-BioNTech COVID-19 vaccine is at preventing post-COVID conditions (long COVID). Researchers will also look at who gets vaccinated. The study includes adults with a COVID-19 diagn…

This study talks to 40 people who use opioids in Baltimore to understand their views on COVID-19 vaccines and why some are hesitant. Researchers will use a simple survey to measure willingness to get vaccinated. The goal is to learn what barriers exist so that future vaccine effo…

This study aims to safely infect up to 20 healthy adults aged 21-30 with the Delta variant of SARS-CoV-2 using nasal drops. The goal is to create a controlled human infection model in Singapore that can be used to test new vaccines and treatments faster. Participants are closely …

This study is building a registry of up to 20,000 people living in the United States who are interested in taking part in future research, especially about COVID-19. Participants sign up online and share their email to receive updates about upcoming studies and health information…

This study follows about 583 adults who recovered from COVID-19 or were in close contact with someone who had it. Over 3 years, researchers will check for lasting health problems, mental health changes, and whether the body builds immunity that prevents reinfection. Participants …

This study looks at the medical records of adults hospitalized with COVID-19 to see how the virus affects the heart. Researchers will check for conditions like heart failure, inflammation, and abnormal heart rhythms. No treatments or tests are given—just a review of existing data…

This study looks at why more than half of people who recover from COVID-19 still feel very tired. Researchers will measure fatigue using surveys and muscle tests in 398 adults who had COVID-19. The goal is to better understand who is most affected and how fatigue impacts their da…

This study aims to create a test that predicts how hospitalized COVID-19 patients will fare in the short and long term (up to one year). Researchers will enroll 600 adults from hospitals and a national veterans' population, using both clinical data and molecular markers. The goal…

This study looks at whether people can collect their own blood and saliva samples at home to measure how well COVID-19 vaccines protect them. About 4,000 adults who recently got a COVID-19 vaccine will take part. Most will do everything remotely, while a small group will visit a …

This study looks at how having certain gut worms (helminths) and COVID-19 antibodies changes the immune system and gut bacteria. Researchers will collect blood and stool samples from 1500 people in India to measure infections and immune markers. The goal is to understand how thes…

This study tests whether computer-assisted X-rays and other simple tests can help find undiagnosed tuberculosis (TB) and COVID-19 in African communities. About 26,200 adults will be screened using these tools to see if they speed up detection and reduce the number of missed cases…

This study follows 500 adults who were in the ICU with breathing failure. Researchers want to see if COVID-19 patients have different long-term mental and physical problems compared to those without COVID-19. The goal is to understand these differences so doctors can better treat…

This study examines whether people with certain blood cancers (myeloproliferative neoplasms) have autoantibodies that block a key immune protein, type I interferon. Researchers want to see how common these autoantibodies are and if they relate to worse COVID-19 outcomes. About 21…

This study compares how people feel after getting either the Novavax or the mRNA COVID-19 vaccine. About 1000 adults who are eligible for a COVID-19 booster will report any symptoms like fever or fatigue for a week after vaccination. The goal is to see which vaccine causes fewer …

This study looks at insurance and vaccine records to see how well the yearly updated COVID-19 vaccines protect adults and children. Researchers will compare people who got the vaccine to those who did not, tracking doctor visits, emergency care, and hospital stays. No one receive…

This study asks 1,668 young African American women (ages 23-35) already enrolled in a long-term health study about their COVID-19 experiences. Participants fill out a 15-20 minute online or paper survey covering infection, vaccination, access to care, and pandemic impacts on work…

This study is tracking the safety of the BNT162b2 COVID-19 vaccine (including the bivalent version) in 12,000 people in Korea who received the vaccine as part of routine care. Researchers are collecting information on side effects that happen within a week and up to 28 days after…