COVID-19

This study tests an updated mRNA COVID-19 vaccine designed to target current virus variants. About 832 adults, especially those 65+ or with risk factors, will receive the vaccine to check how well it boosts immunity and to monitor for side effects. The goal is to ensure the vacci…

This study tests a new nasal spray COVID-19 vaccine (NDV-HXP-S-KP.2) to see if it's safe and tolerable compared to a standard mRNA booster shot. About 200 adults who have already been vaccinated against COVID-19 will receive either the nasal vaccine or an mRNA shot. Researchers w…

This study aims to find the best way to encourage more Latino adults and their friends to get the COVID-19 vaccine. Researchers will compare two methods: teaching people motivational interviewing skills versus simply providing vaccine information. The goal is to see which approac…

This early-stage trial tests a new booster vaccine called Boost-2867 in 140 healthy adults who have already been vaccinated against COVID-19. The vaccine is given either as a shot into the muscle (with or without an adjuvant) or as a nasal spray. The main goals are to check safet…

This study tests two experimental COVID-19 booster vaccines in 80 healthy volunteers aged 40 to 64. The goal is to see if one version, which includes an extra component called 's3', can produce a stronger and longer-lasting immune response. Participants will receive a single shot…

This early-stage trial tests a new booster vaccine called OCU500 for COVID-19. Unlike a shot, this vaccine is given as a nasal spray or inhaled mist. The study involves 80 healthy adults aged 18-64 who have already had their primary COVID-19 vaccines and at least one booster. The…

This early-stage trial tests two versions of a nasal spray vaccine called COV2, designed to protect against COVID-19. About 20 healthy adults who have already had at least two COVID-19 shots will receive two doses of the nasal vaccine. The study checks for side effects and measur…

This early-stage study tests a new type of COVID-19 booster vaccine made from a harmless sheep virus. It aims to see if it is safe and boosts the immune system in healthy adults aged 18 to 55 who have already been vaccinated or infected. The study will enroll 96 people and look f…

This study tests whether giving the antiviral drug remdesivir for 10 days can prevent severe COVID-19 in kidney transplant patients who have mild or no symptoms. The goal is to safely allow transplants to happen sooner, reducing time on dialysis. About 15 adults will receive remd…

This study is checking if people who already take antihistamines (like allergy meds) or amantadine (a Parkinson's drug) have milder COVID-19 and fewer hospital stays. Researchers will track over 140,000 patients to see if these drugs lower the chance of serious illness or death f…

This study tests an experimental drug called DAS181 in people with weakened immune systems who have a parainfluenza infection in their lungs. The goal is to see if the drug helps them breathe without extra oxygen and improves survival. About 274 participants will be randomly assi…

This study tests whether baricitinib, an anti-inflammatory drug, can improve thinking, memory, and physical symptoms like fatigue and shortness of breath in people with Long COVID. About 550 adults who had COVID-19 at least 6 months ago will receive either baricitinib or a placeb…

This study looks at whether giving a combination of two antiviral drugs (remdesivir plus nirmatrelvir/r) or a longer treatment course (10 days instead of 5) can help immunocompromised people clear COVID-19 faster. About 256 adults with mild to moderate COVID-19 and weakened immun…

This study looks at whether giving a combination of two antiviral drugs (remdesivir plus nirmatrelvir/r) works better than the standard single drug for COVID-19 in people with weakened immune systems. It also tests if taking the medication for 10 days instead of 5 helps clear the…

This study is testing a breathalyzer kiosk that can detect COVID-19, flu, and RSV by analyzing a person's breath. About 100 adults, both with and without symptoms, will breathe into the device for 8 seconds. The goal is to see if the breathalyzer is as accurate as the standard no…

This study checks if a new COVID-19 test (Metrix COVID Test) works well when used at home or in clinics. About 1,000 people with COVID-like symptoms will take the test, and results will be compared to a standard FDA-cleared test. The goal is to see if the new test accurately dete…

This early-phase study is testing a new radioactive tracer called 64Cu-FBP8 that lights up blood clots on PET-MR scans. Researchers want to see if it can safely and accurately find clots anywhere in the body, including in the heart of people with atrial fibrillation. The study in…

This study tests whether a pill called Mitoquinone can prevent COVID-19 in healthy adults who have had close contact with someone who has the virus. About 112 people will receive either the drug or a placebo. The goal is to see if it stops infection and reduces symptoms.

This early-stage study tests a new drug called MDX2301 to see if it can help prevent COVID-19 in healthy adults and those at higher risk for severe illness. About 80 participants will receive either the drug or a placebo by injection or IV. The main goal is to check safety and ho…

This study tests a new drug called VYD2311, a monoclonal antibody that blocks the COVID-19 virus from entering cells. About 1,770 adults and teens aged 12 and older will receive either VYD2311 or a placebo as a monthly shot for 3 months. The goal is to see if it safely prevents C…

This study aims to reduce COVID-19 illness and death among people who live and work in prisons. Researchers will test different ways to encourage COVID-19 vaccination in Pennsylvania prisons, involving over 37,000 participants. The goal is to find simple, effective methods to inc…

This study tests a home-based rehabilitation program using a smartphone app and high-intensity interval training for 120 people who were critically ill with COVID-19. Participants exercise at home while being monitored remotely. The goal is to improve walking distance, fitness, a…

This study tests whether Astepro nasal spray can help manage early COVID-19 symptoms and lower the amount of virus in adults. About 280 people with a positive COVID-19 test will use the spray or a placebo for 10 days. Researchers will track symptoms, viral load, and whether the s…

This study tests a new inhaled medication called Optate for people with mild COVID-19. About 40 adults will receive either Optate or a placebo spray. Researchers will measure virus levels in the nose and track symptom changes using a quality-of-life survey. The goal is to see if …

This study tests if a gentle ultrasound pulse to a specific brain area can improve thinking and memory in people with long COVID brain fog. 40 participants who have had brain fog for at least 4 weeks after COVID will receive either real or fake ultrasound. The goal is to see if t…

This study tests whether an 8-week program of supervised physical and mental exercises can improve daily function, thinking, and quality of life in adults with Long COVID who also have high blood pressure or diabetes. About 374 participants will be randomly assigned to either the…

This study tests a new drug called ratutrelvir in adults with mild to moderate COVID-19 who are not sick enough to be hospitalized. About 90 participants will take the study drug plus standard care to see if it helps them recover faster and is safe. The goal is to find the best d…

This study tests a small device that sends gentle electrical pulses to nerves in the ear to see if it can reduce pain and other symptoms in children with post-concussion syndrome or long COVID. About 125 children ages 11-18 will take part. The goal is to improve their daily funct…

This study tests whether adding music to guided mindfulness meditation helps reduce stress and anxiety better than meditation alone. It involves 70 people of African descent who have symptoms of anxiety or depression. Participants will join virtual sessions and report their stres…

This study is testing whether seawater nasal sprays can improve nasal symptoms like congestion, runny nose, and sneezing in people with colds, allergies, sinus infections, or after sinus surgery. About 1,065 people of all ages, including pregnant women, will use the sprays as par…

This small study tests whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can reduce fatigue and other symptoms in people with post-COVID condition. Researchers will enroll 40 adults who have had symptoms like chronic tiredness for at least 12 week…

This study tests whether giving arginine, a natural protein, can improve energy production in cells of children hospitalized with COVID-19. About 21 kids aged 3 to 21 will receive one of three doses of arginine three times a day for up to five days. Researchers will measure chang…

This study tests whether a diet rich in fermented foods (like yogurt, kimchi, and sauerkraut) is tolerable and can improve quality of life for people who survived a critical illness, including severe COVID-19. The goal is to help restore gut health and reduce inflammation, which …

This study follows 1800 healthcare workers from 8 countries to learn how COVID-19 infection and vaccination affect their immune systems. Researchers will analyze blood samples and health data to understand how different virus variants escape natural or vaccine-induced protection.…

This study looks at how pregnant and non-pregnant patients recover after being in the intensive care unit (ICU) for COVID-19 and lung failure. Researchers will track problems with movement, thinking, and mental health for up to 3 years after the ICU stay. The goal is to better un…

This study collects nose, blood, and saliva samples from 20,000 people aged 3 and older who have or may have a respiratory virus like flu or COVID-19. The goal is to learn more about these viruses and how the body fights them. Samples will be stored for future research, including…

This study follows 345 adults over four years to see how often COVID-19 leads to lasting lung, heart, or kidney problems. Researchers compare people who had COVID-19 with those who never got it. The goal is to find early warning signs and create better guidelines to prevent long-…

This study looks at whether community health workers can share true health information on social media using personal stories. About 1,400 health workers and their followers will take part. The goal is to see if this approach helps people decide to get vaccines and protect themse…

This study looks at how common COVID-19 infections are among healthcare workers by testing their blood for antibodies. It also checks their mental health and coping strategies during the pandemic. About 1,000 workers from NewYork-Presbyterian will take part. The goal is to learn …

This study aims to learn how the COVID-19 pandemic impacts patients with cancer by asking them to fill out surveys and participate in phone interviews. Researchers will track how many people take part over 12 months. The goal is to gather information, not to test a treatment.

This study explores how the COVID-19 pandemic and related social restrictions (like lockdowns) influenced suicidal thoughts and actions in children and adolescents aged 8 to 17 in the Auvergne-Rhône-Alpes region of France. Researchers will collect data from up to 6,500 participan…

This study aims to understand why the protection from COVID-19 vaccines decreases over time. Healthy adults aged 18 and older who are scheduled to receive a new vaccine or booster will give blood samples and health updates over one year. The goal is to learn how the immune system…

This study uses an online survey to identify health risks and medication problems in 2,000 adults aged 18 and older. Researchers will look at factors like drug interactions, polypharmacy (taking 5+ medications), and self-medication habits. The goal is to better understand how the…

This early-stage study tests a new tablet form of the experimental COVID-19 drug ibuzatrelvir in 18 healthy adults. Researchers want to see how well the body absorbs the new tablet compared to the original version, and whether taking it with food or as a drink changes absorption.…

This study looks at how changes in gut bacteria caused by COVID-19 might lead to long-lasting symptoms like fatigue, brain fog, and stomach issues. Researchers will collect stool and blood samples from 400 adults—half with long COVID and half without—to compare their gut health. …

This study looks at 320 adults who need strong immune-suppressing drugs and have already had at least two COVID-19 shots. Researchers want to find out if getting a booster right before starting treatment or waiting six months gives better protection. The goal is to help people wi…

This study is looking at how well antibodies in the blood and nose can neutralize the viruses that cause COVID-19 and monkeypox. Researchers will follow 30 adults who have received vaccines or antibody treatments for these diseases. The goal is to understand how long this protect…

This study looks at how COVID-19 immunity changes within households in Hong Kong. Researchers will track 1,350 people of all ages to see how vaccination, past infections, and exposure risk affect protection over time. The goal is to better understand how the virus spreads at home…

This study follows 2300 adults who had COVID-19 to learn how many develop lasting symptoms (like fatigue or organ damage) and why. Researchers will look at medical records and track participants over time. The goal is to find patterns and risk factors for long COVID, not to test …

This study tests different COVID-19 treatments to see how quickly they clear the virus from the body. It includes 3,800 adults aged 18-60 with mild symptoms. Participants receive either a small-molecule drug, monoclonal antibodies, or no treatment, and viral levels are measured d…

This study looks at how the immune system responds to flu and COVID-19 vaccines over a full year. About 150 NIH staff members who plan to get these vaccines will provide monthly blood and nasal samples. No vaccines are given as part of the study; it only observes natural immune c…

This study uses advanced heart MRI scans to understand why some COVID-19 survivors continue to have symptoms like shortness of breath and fatigue. Researchers will follow 510 adults who were hospitalized with COVID-19, scanning their hearts and lungs months after infection. The g…

This study follows 10,000 pregnant women in Nagpur, India, from early pregnancy through 42 days after birth. Researchers want to see if catching flu, COVID-19, or other respiratory viruses raises the risk of problems like preterm labor or severe preeclampsia. The goal is to gathe…

This study is a registry that collects information from up to 10,000 adults hospitalized with COVID-19. Researchers want to track serious outcomes like death, heart failure, and kidney problems. The goal is to better understand the disease and improve future care. Participants ar…

This study explores whether a virtual, community-based program combining music and mindfulness can help manage stress in People of African Descent (PADs) who have anxiety and depression, especially during COVID-19. Researchers will measure brain activity and feelings of social co…

This study follows 800 people who had COVID-19 to learn how long the virus can linger in different parts of the body, such as the nose, stool, semen, and breast milk. Researchers will also track how the immune system builds antibodies and any long-term health problems after infec…

This study looks at the best way to give COVID-19 booster and flu vaccines to people with weakened immune systems, such as those with rheumatoid arthritis, HIV, or organ transplants. Researchers will compare giving both vaccines at the same time versus one month apart, and also t…

This study looks at how COVID-19 infection and mRNA vaccines impact pregnant women, their newborns, and breastfeeding. Researchers will collect blood, placenta, and breast milk samples from 300 participants to understand immune responses and pregnancy outcomes. The goal is to fil…

This study looks at whether screening for social needs (like food or housing) and connecting people to free community services can improve health and reduce COVID-19's impact. About 1,500 adults from emergency rooms and testing sites will take part. Researchers will track changes…

This study aims to collect samples and health information from people of all ages who have or have been exposed to viral infections, including COVID-19 and herpes. Researchers want to learn how viruses behave differently in healthy individuals versus those with weakened immune sy…

This study looks at how the COVID-19 pandemic may have changed people's physical activity, sleep, blood pressure, and mental stress. About 100 adults aged 18 to 75 will visit a lab twice, wear activity trackers for two weeks, and complete fitness tests and questionnaires. The goa…

This study aims to track how common respiratory viruses like COVID-19, flu, and RSV spread in communities and households. Researchers will enroll up to 25,000 people of all ages, collecting nasal swabs and symptom reports over time. The goal is to better understand infection rate…

This study looks at whether placing a clear plastic box over a patient's head during CPR can reduce the spread of viruses, like COVID-19, to healthcare workers. Researchers will have 240 healthcare providers perform CPR on mannequins, with and without the box, to measure how well…