New pill aims to speed COVID-19 recovery in early trial
NCT ID NCT07157007
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new drug, ratutrelvir, in adults with mild to moderate COVID-19 who are not in the hospital. About 90 participants will take the drug plus standard care to see if it is safe and helps symptoms go away faster. The goal is to find the right dose for future studies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 90 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2025
- Expected to finish
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Mar 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Confirmed SARS-CoV-2 infection for 120 h prior to randomization. 2. Initial onset of signs/symptoms attributable to COVID-19 within 5 days prior to randomization. 3. At least one of the symptoms attributable to COVID-19 present within 24 hours prior to the Day 1 with the severity score of 1 or higher according to the following scoring system for the assessment of severity of: Exclusion Criteria: Medical Conditions: 1. History, current need for hospitalization or anticipated need for hospitalization for the medical treatment of COVID-19. 2. Urgent or expected need for nasal high-flow oxygen therapy or positive pressure ventilation, invasive mechanical ventilation or ECMO. 3. Known medical history of active liver disease . 4. Receiving dialysis or history of moderate to severe renal impairment. 5. Compromised immune system. 6. Acute episode of chronic respiratory diseases, including bronchial asthma, chronic obstructive pulmonary disease within 30 days before screening. 7. Suspected or confirmed concurrent active systemic infection.. Prior/Concomitant Therapy: 8. Has received or is expected to receive any dose of a SARS-CoV-2 vaccine within 4 months of screening and during the participation in the study. 9. Concomitant use of any medications or substances that are strong inducers of CYP3A4
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
15 sites in 4 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Chang Gung Memorial Hospital, Linkou Branch
NOT_YET_RECRUITINGTaoyuan, Taoyuan, 333, Taiwan
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Chonnam National University Hospital
NOT_YET_RECRUITINGGwangju, Donggu, 61469, South Korea
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Hallym University Sacred Heart Hospital Gangnam
NOT_YET_RECRUITINGSeoul, Seoul, 07441, South Korea
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Inha University Hospital
NOT_YET_RECRUITINGIncheon, Jung-gu, 22332, South Korea
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Kaohsiung Medical University Hospital
NOT_YET_RECRUITINGKaohsiung City, Kaohsiung, 807, Taiwan
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Key Health
RECRUITINGSydney, New South Wales, 2000, Australia
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Momentum Clinical Research Taringa
RECRUITINGBrisbane, Queensland, 4068, Australia
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Novatrial
RECRUITINGCharlestown, New South Wales, 2290, Australia
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Paratus Clinical(Clinical Trials Institute, Torquay)
NOT_YET_RECRUITINGTorquay, Victoria, 3228, Australia
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Research Institute of Virology
RECRUITINGTashkent, Tashkent, 100194, Uzbekistan
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Taichung Veterans General Hospital
NOT_YET_RECRUITINGTaichung, Taichung, 407, Taiwan
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Taipei Medical University Hospital
NOT_YET_RECRUITINGTaipei, Taipei, 110, Taiwan
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Taoyuan General Hospital
NOT_YET_RECRUITINGTaoyuan, Taoyuan, 33004, Taiwan
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The Catholic University of Korea, Eunpyeong St. Mary's Hospital
NOT_YET_RECRUITINGSeoul, Eunpyeong-gu, 07441, South Korea
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Wonju Severance Christian Hospital
NOT_YET_RECRUITINGWŏnju, Gangwon-do, 26426, South Korea
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Home antibody tests put to the test: can you read your own COVID-19 result?
- Can lung ultrasound reveal COVID-19's signature in the lungs?
- When the immune system Can't fight back: tracking three respiratory viruses
- The household maze: how does COVID-19 move between family members?
- Can an oral drug stop COVID-19 from turning deadly?
- Can COVID-19 rapid tests slip into HIV and TB clinics without disrupting care?