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Could a common arthritis drug ease long COVID brain fog? new trial aims to find out

NCT ID NCT06631287

First seen Nov 01, 2025 · Last updated May 22, 2026 · Updated 29 times

Summary

This study tests whether baricitinib, an anti-inflammatory drug, can improve thinking, memory, and physical symptoms like fatigue and shortness of breath in people with Long COVID. About 550 adults who had COVID-19 at least 6 months ago will receive either baricitinib or a placebo for 6 months. The main goal is to see if the drug helps brain function, with additional checks on quality of life and inflammation.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

Locations

  • Brigham and Women's Hospital

    RECRUITING

    Boston, Massachusetts, 02115, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Emory University

    RECRUITING

    Atlanta, Georgia, 30322, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Illinois Research Network (ILLInet), University of Illinois Chicago

    RECRUITING

    Chicago, Illinois, 60608, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • NYU Langone Health - Brooklyn

    RECRUITING

    Brooklyn, New York, 11220, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Swedish Medical Center

    RECRUITING

    Seattle, Washington, 98104, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • The MetroHealth System

    RECRUITING

    Cleveland, Ohio, 44109, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University Hospitals Cleveland Case Western

    RECRUITING

    Cleveland, Ohio, 44106, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-••••

  • University of Arizona

    RECRUITING

    Tucson, Arizona, 85724, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of California San Francisco

    RECRUITING

    San Francisco, California, 94143, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of California, Los Angeles (UCLA)

    RECRUITING

    Los Angeles, California, 90024, United States

    Contact Email: •••••@•••••

    Contact Email: •••••@•••••

  • University of Colorado I Anschutz Medical Campus

    RECRUITING

    Aurora, Colorado, 80045, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Florida College of Medicine

    RECRUITING

    Gainesville, Florida, 32610, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Minnesota

    RECRUITING

    Minneapolis, Minnesota, 55455, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Texas at San Antonio

    RECRUITING

    San Antonio, Texas, 78229, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Vanderbilt University Medical

    RECRUITING

    Nashville, Tennessee, 37203, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • West Virginia Clinical and Translational Science Institute

    RECRUITING

    Morgantown, West Virginia, 26506-7015, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Yale University

    RECRUITING

    New Haven, Connecticut, 06510, United States

    Contact Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.