Age may alter vaccine immunity: new study investigates

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all of the following criteria: * Ability of subject to understand the study and stated willingness to comply with all study procedures and availability for the duration of the study. * Male or female aged 18 years or older. * Able to speak and read English. * Willingness and ability to come to the NIH/National Institute on Aging Clinical Research Unit at MedStar Harbor Hospital or the NIH/NIA/Biomedical Research Center at Johns Hopkins Bayview campus in Baltimore for study procedures. * No knowledge of having had SARS-CoV-2, the virus that causes COVID-19. EXCLUSION CRITERIA: An individual who meets any of the following criteria will be excluded from participation in this study: * Unable to verify identification of volunteer by state issued ID card, driver s license, or military ID. Participants earning greater than $600.00/year are issued a 1099 form, therefore, positive identification is required. * Unable to provide informed consent. * Current use of steroids, immunosuppressive medications, radiation therapy, or chemotherapy medications. * Pregnancy. In addition, eligible participants may not be immediately able to participate in the study but might be eligible at a later date. These include: * Symptoms of a viral infection on visit 1 (defer until resolved). * Medication: Volunteers taking the following medications would be deferred for 2 weeks after course has been completed and volunteer is feeling well: Antibiotics, antifungals, antimalarials, antivirals. * Temporary steroids (tapers): Deferred for 72 hours after symptoms are resolved and prescription is completed if taken orally, intravenously, or intramuscular. No deferral if taken intranasal, inhaled, or for joint injection. * Infection or Fever: Deferred until 2 weeks after antibiotics are completed and /or volunteer is feeling well. * We wish to only select healthy confirmed COVID-19 negative patients. Therefore, those who may have a household member (co-habitant) who is newly diagnosed with COVID-19 or who has symptoms will be deferred for 14 days. * Treatment with another investigational drug or other intervention within 14 days of visit 1 per the discretion of the Principal Investigator.