ASTHMA

This study is testing whether dupilumab, an injectable medication, can improve how well the lungs clear mucus in people with moderate to severe asthma. About 30 adults will receive either dupilumab or a placebo for 12 weeks. The main goal is to see if the drug helps the lungs rem…

This study tests whether a digital inhaler (Whizz spacer) helps children aged 5-16 with asthma take their medication more consistently compared to a standard spacer. Researchers will also look for biomarkers in blood and breath to improve diagnosis and see how things like allerge…

This study looks at whether a smart device (SiA® system) that attaches to an asthma inhaler and connects to a phone app can help adults with poorly controlled asthma use their inhaler correctly and take their medicine as prescribed. About 60 participants will use the system for o…

This study is testing whether adding an extra medication called glycopyrronium to standard asthma treatment can improve lung function in children aged 4 to under 12. About 69 children with asthma will receive two different doses of glycopyrronium and a placebo in random order to …

This study tests a new medicine called SHR-1905 for people with severe asthma that is not well controlled by current treatments. About 408 adults will receive either the drug or a placebo to see if it reduces asthma attacks and improves breathing. The goal is to find a safer and …

This study tests whether using one inhaler (budesonide/formoterol) for both quick relief and daily control can reduce asthma attacks in South African children aged 6-18, compared to the usual separate inhalers. About 1,038 children with asthma who had an attack in the past year w…

This study is testing two doses of an inhaled medicine called glycopyrronium in children aged 6 to 12 with moderate to severe asthma. The goal is to see how well it opens up the airways and how safe it is compared to a placebo. The results will help decide the right dose for a fu…

This study tests whether weekly phone calls with education, relaxation exercises, and motivational coaching can help adults with asthma who are anxious about using their inhalers. 216 participants will be split into two groups: one gets the extra phone support, the other gets sta…

This study looks at whether a special education program called 'Asthma School' can help adults with asthma have fewer attacks, emergency room visits, and hospital stays. About 92 people will take part, with half attending the school and the other half receiving usual care. The go…

This study tests a mobile health program designed to help African American young adults (ages 18-30) better control their asthma. Participants use a smartphone app, video chats with an asthma nurse, text messages, and activity tracking. The goal is to improve asthma symptoms and …

This study is a required safety check for the asthma inhaler Enerzair, already approved for use. It will follow 600 adults with asthma for 24 weeks to see how well the drug works and what side effects occur in everyday medical practice. The goal is to confirm the drug's safety an…

This study tests a drug called depemokimab in 150 adults with severe asthma caused by a type of inflammation linked to high levels of certain white blood cells (eosinophils). The goal is to see if the drug can reduce mucus plugs and airway thickening in the lungs over 26 to 52 we…

This study tests a program called BREATHE that helps Black adults with uncontrolled asthma work together with their doctors to make treatment decisions. About 400 participants from community health centers will take part. The goal is to see if this approach improves asthma contro…

This study tests whether metformin, a common diabetes medication, can improve asthma control in overweight or obese adults whose asthma is not well-managed by their current inhalers. About 100 participants will take either metformin or a placebo for 24 weeks, with remote check-in…

This study tests whether a combination inhaler (budesonide/albuterol) works better than a standard albuterol inhaler for teens aged 12 to 18 with asthma. The goal is to see if it reduces the number of severe asthma attacks over one year. Participants must have had at least one se…

This study tests whether semaglutide, a drug already approved for diabetes and weight loss, can improve asthma control and reduce airway inflammation in adults with obesity who still have asthma symptoms despite using inhaled steroids. About 100 participants will receive either s…

This study tests whether a three-drug inhaler (FF/UMEC/VI) works better than a two-drug inhaler (FF/VI) for teens aged 12-17 with asthma that is not well controlled. About 292 participants will use the inhalers for 24 weeks, and doctors will measure lung function and symptom cont…

This study compares a new asthma inhaler that uses a climate-friendly propellant to the current inhaler. About 780 adults with mild to moderate asthma will try both versions to see if they work equally well. The goal is to ensure the greener option is just as effective at control…

This study tests whether giving the inhaler Airsupra to adults in the emergency department, instead of usual care, can prevent asthma flare-ups and improve control over the next 3 months. About 1,860 people aged 18 to 54 with acute asthma will take part. The goal is to see if sta…

This study tests whether escitalopram, a common antidepressant, can reduce the number of severe asthma attacks in adults with moderate to severe asthma who have had at least three attacks in the past year. Participants will take either escitalopram or a placebo for a period, and …

This study looks at how well Airsupra works compared to albuterol for preventing serious asthma attacks in everyday life. Researchers will study about 4,000 people with asthma who use rescue inhalers. The goal is to see which medicine helps people have fewer severe asthma episode…

This study tests a drug called benralizumab in 200 children aged 6 to 17 with severe eosinophilic asthma that is not well controlled by current treatments. The goal is to see if the drug can reduce asthma attacks and improve daily symptoms. Participants will receive injections an…

This study tests a new inhaler (PT027) against a standard one (PT007) for Chinese adults with asthma. About 790 people who have had at least one severe asthma attack in the past year will use the inhaler as needed. The goal is to see if PT027 can delay or reduce severe asthma att…

This study tests a new inhaler that combines two medicines (fluticasone and albuterol) to see if it can prevent severe asthma attacks better than albuterol alone. About 2,700 adults with asthma who have had at least one severe attack in the past year will take part. The study las…

This study looks at whether placing a temporary balloon in the stomach, along with diet and exercise, can improve asthma control in obese adults whose asthma is not well managed by standard inhalers. About 84 participants will be randomly assigned to receive either the balloon pl…

This study tests two different triple-combination inhalers in 20 adults with moderate to severe asthma that is not well controlled. Researchers will use special MRI scans to see which drug reaches the small airways better and improves breathing. The goal is to find out which trea…

This study tests an investigational drug called lunsekimig in adults with mild-to-moderate asthma who are at high risk for attacks but not eligible for current biologic treatments. About 1,147 participants will receive either the drug or a placebo as an add-on to their usual asth…

This study looks at how well a triple-combination inhaler (Trimbow) works for adults with asthma in everyday life. Researchers will track symptom scores and medication adherence in 200 participants over 6 months. The goal is to see if this therapy improves asthma control beyond w…

This study tests an investigational drug called tezepelumab in children aged 5 to 11 with severe asthma that is not well controlled by their current medicines. The goal is to see if adding tezepelumab can reduce serious asthma attacks and improve lung function. About 231 children…

This study tests whether adults with sudden illnesses like infections, heart failure, or asthma can be safely treated at home instead of in a hospital. About 3,000 participants will receive hospital-level care in their own homes, with a caregiver present for the first 24 hours. T…

This study tests an experimental medicine called PF-07275315 for adults aged 18-70 with moderate-to-severe asthma that is not well controlled. Participants receive either the study drug or a placebo as injections over 12 weeks, with 9 clinic visits over about 7.5 months. The goal…

This study tests two ways to prevent asthma attacks in people with persistent asthma: using inhaled steroids as a rescue treatment (called R-ICS) or taking the antibiotic azithromycin regularly. Researchers want to see which approach works best, alone or together, to reduce the n…

This study tests a new drug called brenipatide in adults with moderate-to-severe asthma that is not well controlled by current treatments. About 531 participants will receive either brenipatide or a placebo for 52 weeks to see if it reduces asthma attacks and improves breathing. …

This study tests a new medicine called tozorakimab for adults whose asthma is not well controlled even with medium-to-high dose inhaled steroids. About 540 participants will receive either the drug or a placebo as a shot under the skin. The main goal is to see if tozorakimab can …

This study tests whether extra support from an asthma navigator after a child's hospital stay can reduce asthma-related readmissions. About 340 children aged 4-12 and their caregivers will be randomly assigned to standard care or standard care plus navigator support. The study fo…

This study tests a new drug called 610 in 480 Chinese adults with severe eosinophilic asthma. The goal is to see if it reduces the number of serious asthma attacks over one year compared to a placebo. Participants must have had asthma for at least a year and be using regular inha…

This study looks at how well tezepelumab works for adults with chronic sinusitis and nasal polyps (with or without asthma). About 110 people will be followed for up to a year to see if their nasal polyps shrink and congestion improves. The drug is already approved, and this resea…

This study tests an experimental pill called ENV-294 in 50 adults with moderate-to-severe asthma who already use inhalers. Participants take the pill or a placebo once daily for 12 weeks. Researchers will check if the drug is safe and helps control asthma symptoms and lung functi…

This study looks at whether connecting youth (ages 12-25) with community programs rooted in Native Hawaiian culture can improve their mental and physical health. Participants will take part in activities that strengthen their connection to the land and culture, and complete surve…

This study tests a new inhaler that combines two common asthma medicines (fluticasone and albuterol) to see if it works better than each medicine alone or a placebo. About 724 people aged 12 and older with asthma will use the inhaler four times daily for four weeks. The goal is t…

This study tests an injectable medicine called dupilumab in children aged 2 to under 6 years whose asthma or wheezing is not well controlled with standard inhalers. The goal is to see if it can reduce severe asthma attacks and improve breathing safety over a year. About 90 childr…

This study compares a new combination inhaler (QMF149) to a standard asthma inhaler (budesonide) in 200 children aged 6 to 12 with asthma. Each child will try both treatments for 12 weeks to see which one improves lung function and symptom control more. The goal is to find a more…

This study looks at the long-term safety and effectiveness of a drug called lunsekimig for adults with asthma. Participants who finished a previous study can join this one and receive the drug for up to 96 weeks. The goal is to see if the drug continues to help control asthma and…

This study looks at whether two simple, non-invasive tests—a breath test (FeNO) and a blood test (eosinophil count)—can accurately diagnose asthma in children aged 6 to 17. Currently, diagnosing asthma often requires a hospital-based breathing challenge test that is hard to acces…

This study will test if a smartphone app called AWARE can accurately detect and monitor lung diseases like asthma, COPD, and cystic fibrosis by analyzing breathing sounds. Researchers will enroll 800 people aged 8-70, including healthy volunteers, to compare the app's results wit…

This study looks at whether measuring inflammation in the breath and blood can help prioritize who gets asthma tests first. About 1,500 people aged 6 and older with suspected asthma will take a simple breath test and a blood test before their regular lung function tests. The goal…

This study is testing a small, wearable device called AeviceMD that listens to lung sounds to detect wheezing. Researchers want to see if the device can find wheezes as accurately as a doctor using a stethoscope. The study will include 160 people aged 3 and older who are having a…

This study looks at whether two easy breathing tests—oscillometry and FeNO—can help family doctors accurately diagnose asthma and COPD without needing complex spirometry. About 600 adults with symptoms like wheezing or shortness of breath will take these tests at their primary ca…

This study tests a device called fenoTRACK that measures a gas in your breath (FeNO) to check airway inflammation. It involves 160 adults and children with asthma, some with uncontrolled symptoms and some with controlled asthma. The goal is to see if the device can accurately tra…

This study is testing whether giving pregnant women high doses of fish oil can reduce the risk of their children developing asthma or persistent wheezing in the first three years of life. The researchers are recruiting 2,000 pregnant women in Denmark who have low blood levels of …

This study is testing whether giving pregnant women higher doses of vitamin D than currently recommended can prevent asthma and persistent wheezing in their children during the first three years of life. Researchers will enroll 2,000 pregnant women in Denmark and follow their chi…

This early-stage study is testing a new drug called IBI3002 in adults with asthma to see if it is safe and how the body handles it. About 12 to 27 participants will receive either the drug or a placebo by injection. The study lasts about 24 weeks and focuses on side effects, not …

This study compares two types of exercise—energy conservation techniques and circuit training—to see which better reduces shortness of breath, improves physical ability, and boosts quality of life in people with asthma. Researchers will enroll 32 adults with mild-to-moderate asth…

This study is testing a serious video game designed to help teenagers aged 12 to 16 develop emotional skills and improve their quality of life. The game includes special modules for teens with type 1 diabetes, asthma, food allergies, or allergic rhinitis. Researchers will measure…

This study tests a mobile app called ASTHMAXcel Voice that helps adults with asthma track their symptoms using voice recordings and simple questionnaires. About 200 English-speaking adults who own a smartphone and take daily asthma medication will either use the app or receive st…

This study tests a device that teaches people with COPD or asthma how to use their inhalers correctly. 140 adults will be trained with either the device or standard brief instruction. After 6 weeks, their inhaler skills and lung function will be checked to see if the device helps…

This study tests whether a questionnaire that measures how confident teens feel about managing their asthma can help doctors give better support. About 98 teenagers aged 12-18 with asthma will either get this tailored approach or a standard check-up. After three months, researche…

This study tests whether giving intravenous magnesium early to children aged 2 to 17 with severe asthma in the emergency room helps them breathe better. About 192 children who still have moderate-to-severe breathing trouble after standard treatment will receive either magnesium o…

This study compares two breathing techniques—alternate nostril breathing and using an incentive spirometer—to see which better improves lung function in people with asthma. Researchers will measure how much air participants can exhale and their asthma control. The study involves …

This study tests a new inhaled drug called LQ036 in about 216 people aged 12 to 75 whose asthma is not well controlled despite using standard inhalers. The goal is to see if LQ036 improves lung function and reduces asthma attacks over 24 weeks. Participants will inhale the drug o…

This study looks at whether adding physical exercise to a restricted diet can improve lung function and weight in women who have both polycystic ovary syndrome (PCOS) and asthma. About 40 obese women with these conditions will take part. The goal is to see if this combination hel…

This early-stage study tests whether a new drug called AMG 691 is safe for people. It includes healthy volunteers and people with mild-to-moderate asthma. Researchers will give single or multiple doses and watch for side effects. The goal is to see if the drug is safe enough for …

This study tests an inhaled medicine called ARO-RAGE in 36 adults with mild asthma. The goal is to see if it can improve small airway function after breathing in an allergen. Participants will receive either the drug or a placebo and have their lung function measured over time.

This study looks at whether combining neck exercises with special breathing techniques can improve lung function and chest movement in adults with asthma who also have poor posture. 22 people will take part in a 4-week program. The goal is to find a simple, drug-free way to help …

This study looks at whether a new propellant (HFA-152a) in salbutamol inhalers works as well as the current one (HFA-134a) for people with mild asthma. About 84 adults aged 18 to 65 will take single doses of the inhaler and have their lung function measured. The goal is to make s…

This study tests a device called the Lung Master to see if it can help people with breathing problems like COPD or asthma increase their lung capacity. Twenty adults (ages 19-35 or over 65) will use the device daily at home for a month and have their lung function measured before…

This study tests whether an online therapy program can help children aged 8-17 with asthma who also feel anxious or worried about their condition. The therapy is designed to improve quality of life, reduce anxiety, and help manage asthma better. About 30 children and their parent…

This study looks at whether using a CPAP machine at night can improve asthma control in adults with severe, hard-to-control asthma and obstructive sleep apnea. Researchers will measure asthma symptoms and lung function in 138 participants over time. The goal is to see if treating…

This study looks at whether tongue images and pulse wave data can help doctors better understand and monitor asthma in children. Researchers will collect these non-invasive measurements from 1,000 kids aged 5-18 during routine check-ups and compare them with standard lung functio…

This study aims to find out how many adults with mild-to-moderate asthma in Thailand experience remission, meaning their asthma goes away or becomes inactive. Researchers will also look for factors linked to remission. About 289 adults will fill out a symptom questionnaire, take …

This study tracks 30 adults with asthma to see if daily changes in indoor and outdoor air pollution are linked to asthma attacks. Participants will have sensors placed in their homes to measure pollutants like fine particles and volatile organic compounds. The goal is to better u…

This study is not testing a new treatment. Instead, it gathers up to 10 years of medical records and a one-time questionnaire from 3,500 people with asthma or COPD who were in an earlier study. The goal is to learn more about how these lung diseases progress and respond to treatm…

This study looks at how asthma-related inflammation might change brain activity and contribute to depression or anxiety. Researchers will compare brain scans, breathing tests, and blood samples from 100 adults with and without asthma. The goal is to understand the link between ai…

This study aims to find people who have asthma or COPD but don't know it yet. Participants will complete an online questionnaire to see if they are at risk. Those at risk will be randomly assigned to receive early diagnosis and treatment from their doctor or usual care. The goal …

This study looks back at medical records of 360 adults in Hong Kong with severe asthma who received biologic therapy. Researchers want to understand which biologics are used, how well they control asthma, and any side effects. The goal is to see if local practices match internati…

This study aims to understand what causes airway inflammation in people with allergic asthma. Researchers will expose participants to allergens and measure how immune cells respond. The goal is to identify key factors that drive asthma, not to test a new treatment. About 313 adul…

This study looks at whether salbutamol, a common asthma medication, can improve exercise performance in non-asthmatic endurance athletes. Researchers will test if a select group of athletes with breathing limitations might benefit from the drug. The study involves 64 healthy, hig…

This study is testing a wearable device called C-mo System to see how well it can automatically detect and describe coughs in people with conditions like asthma, COPD, or chronic cough. About 300 participants aged 2 and older will wear the device for 24 hours and complete diaries…

This study looks at how well the diaphragm works in 800 people with lung diseases like asthma, COPD, fibrosis, or pulmonary hypertension. Researchers want to understand if diaphragm problems are linked to shortness of breath. No new treatments are being tested—this is an observat…

This study will check how many workers in an industrial zone in Thailand have asthma or COPD. About 310 adults will answer a questionnaire and take a breathing test. The goal is to find out how common these lung problems are in this group, not to test a treatment.

This study follows 1,000 people with eczema and related allergies (like asthma or food allergies) to learn why some get better and others don't. Researchers collect health data and samples over time to find patterns and possible biomarkers. No new treatments are given—participant…

This study looks at how fungi in the environment (like mold in homes) affect people with asthma, allergic bronchopulmonary aspergillosis (ABPA), and bronchiectasis. Researchers will collect dust and sputum samples from 125 adults aged 18-80, including healthy volunteers, and trac…

This study follows 6,000 children in Switzerland who have breathing issues like wheezing, coughing, or trouble breathing during exercise. Researchers collect information from doctor visits and surveys to learn more about these problems and how to better diagnose and treat them. N…

This study uses special lung scans to measure how air and blood move through the lungs of adults with asthma before and after taking common inhalers. Researchers want to understand how these medications improve lung function at a detailed level. The study involves 40 adults aged …

This study aims to understand how asthma works by comparing cells from the airways of people with and without asthma. Researchers will look at the genetic activity in these cells to learn more about mucus production. The study involves 24 adults and uses a bronchoscopy to collect…

This study is testing a new MRI technique that uses a special gas called hyperpolarized xenon to take detailed pictures of lung function. It will include 260 healthy volunteers and people with various lung diseases like asthma, COPD, and cystic fibrosis. The goal is to see if thi…

This study tests two new types of lung MRI (using special gases) to see if they can better detect lung problems in people with cystic fibrosis and asthma compared to healthy volunteers. About 30 people aged 8 and older will have these scans to check how well the images show lung …

This study looks at how tiny organisms in the airways, like bacteria and viruses, are linked to different types of asthma in adults. Researchers will collect samples from 140 adults with asthma to see if certain germ patterns are tied to asthma severity and control. The goal is t…

This study is a global registry that collects health information from 500 adults with severe asthma. The goal is to track how patients respond to treatments and understand the disease better. The data will help researchers develop improved care and therapies for severe asthma.

This study is gathering information from 470 adults with various inflammatory lung diseases, including asthma, COPD, and cystic fibrosis, as well as healthy volunteers. Researchers will analyze medical history, lung function, and other health data to identify different disease pa…

This study looks at how genes play a role in lung diseases like cystic fibrosis, asthma, and pulmonary fibrosis. Researchers will study the DNA of up to 3,500 people with and without lung disease to find genetic differences. The goal is to better understand what causes these dise…

This study looks at how mucus buildup in the airways affects people with asthma, COPD, and chronic cough. Researchers will use CT scans and breathing tests to compare 240 adults and 50 children with these conditions to healthy volunteers. The goal is to find patterns and markers …

This study aims to find specific substances (metabolites) in the blood and urine of children aged 12-17 with asthma that could signal an asthma flare-up. Researchers will analyze samples from 100 children who are already receiving standard asthma care. The goal is to better under…

This study tracks 500 adults with moderate-to-severe asthma in Hong Kong over two years to see how well their symptoms are controlled and how often they have flare-ups. Researchers will also monitor patients using newer biologic drugs to gather real-world data. The goal is to hel…

This study aims to describe the characteristics, treatment burden, and quality of life of 2,500 people with asthma across all severity levels. It does not test a new drug or treatment. Instead, researchers will collect data through surveys and lung function tests over time to bet…

This study looks at how the body processes high doses of the steroid prednisolone in people with inflammatory diseases like thyroid eye disease, asthma, and vasculitis. Researchers will measure drug levels in the blood and urine to compare short-term and long-term use. The goal i…

This study follows 400 nonsmoking adults aged 18 to 60 with moderate to severe asthma for up to 5 years. Researchers collect blood, urine, stool, dust, saliva, and lung samples to see how bacteria and other environmental factors affect asthma symptoms and flare-ups. Participants …

This study looks at why some people with asthma don't get better with standard inhalers. Researchers will use MRI and CT scans to see if blocked or narrow airways stop the medicine from reaching the lungs. They will test if oral medications work better for these patients. The goa…

This study follows 500 adults in Taiwan with severe asthma who are taking biologic medications. Researchers want to see how well these drugs control asthma in everyday life, what happens when patients switch biologics, and which factors predict the best treatment. The goal is to …

This study tests whether computer alerts in the electronic health record can help doctors avoid prescribing antibiotics when they aren't needed for children with lower respiratory tract infections like pneumonia, bronchiolitis, or asthma flare-ups. Most of these infections are ca…

This study looks at how genes are linked to different types and severities of asthma in Chinese people. Researchers will collect genetic data from 2,000 asthma patients to find common gene variations. The goal is to better understand asthma and improve future treatments.

This study looks at 60 adults aged 35-75 with either allergic or eosinophilic asthma to see if their symptoms, breathing problems, and frailty levels differ. Researchers will measure lung function, breathlessness, fatigue, and quality of life. The goal is to help doctors design b…

This study examines lung tissue from 120 adults (ages 18-70) with and without asthma to measure levels of two proteins, ezrin and Pip5k1α, in airway smooth muscle. The goal is to understand how these proteins change in asthma, which could lead to new treatment approaches. Partici…

This study is observing 355 adults with asthma in China to learn about their symptoms, treatments, and biological markers. The goal is to identify different types of asthma to help develop more personalized treatment strategies in the future. Participants will undergo lung functi…

This study looks at the bacteria living in the airways of infants under 2 years old with severe asthma. Researchers want to understand how these bacteria differ from normal and how they relate to the immune system. The goal is to find new ways to treat severe asthma in babies. Th…

This study looks at how two different inhalers deliver asthma medicine into the bodies of children aged 4 to 12. The goal is to compare the amount of drug absorbed and check for safety. About 12 children with stable asthma will take part. The results will help doctors understand …

This study looks at how a person's genes and their environment (like pollution, diet, and lifestyle) work together to cause common diseases such as diabetes, heart disease, and asthma. Researchers are collecting health questionnaires and genetic data from 25,000 adults to build a…

This study looks at whether a simple breathing test called impulse oscillometry (IOS) can better track asthma control than standard tests. Fifty adults with asthma who are changing their maintenance medication will take lung function tests and questionnaires at the start and agai…

This study looks at how the immune system's first response (innate immunity) reacts to certain environmental triggers. Researchers want to understand if these reactions are linked to long-term illnesses like asthma, heart disease, and cancer. Healthy volunteers aged 18 to 45 will…