ASTHMA

This study is testing an injectable medication called tezepelumab in children aged 5 to 12 with severe asthma that is not well-controlled by their current inhalers and medications. Over 200 children will receive either the real drug or a placebo injection every few weeks for a ye…

This study is testing a new combination asthma inhaler called QMF149 against a commonly used inhaler, budesonide, in children aged 6 to 12. About 200 children with asthma will try each inhaler for 12 weeks to see which one works better at improving lung function and controlling a…

This study is testing whether a new digital inhaler with lights and reminders helps children with asthma take their daily steroid medication more consistently than a standard inhaler. Researchers will follow about 200 children aged 5-16 for 12 weeks to see if better medication us…

This study is testing whether escitalopram, a common antidepressant, can help reduce the number of severe asthma attacks in adults who continue to have frequent flare-ups despite using standard high-dose inhalers. Researchers will compare the drug to a placebo (inactive pill) ove…

This study is investigating whether the medication dupilumab can improve how well the lungs clear mucus in people with moderate-to-severe asthma. Over 12 weeks, 30 participants will receive either dupilumab or a placebo (inactive substance) to compare the effects. Researchers wil…

This study aims to learn about the long-term safety and effectiveness of an investigational drug called lunsekimig for adults with asthma. It is an extension study for up to 100 weeks, open to 900 people who have already completed a previous related study. The main goal is to see…

This study is testing whether adding a third medication (umeclidinium) to a standard two-drug inhaler helps teens with asthma breathe better. About 290 participants aged 12-17, whose asthma is not well-controlled on their current inhaler, will use either the triple or dual inhale…

This study looks at how two different rescue inhalers work for adults with asthma in their everyday lives. Researchers will compare Airsupra and the commonly used albuterol in 4,000 people across the United States. The main goal is to see which medication better reduces the risk …

This study is testing an investigational injection called SHR-1905 for adults whose severe asthma is not well controlled by their current medications. The main goal is to see if SHR-1905 can safely reduce the yearly rate of serious asthma flare-ups (exacerbations) that require ex…

This study is testing a brief, one-time conversation tool called BREATHE, designed to be used during regular doctor visits. It aims to help Black adults with uncontrolled asthma work better with their doctors to manage their condition. The research will see if this 9-minute share…

This study is testing whether a combination inhaler (budesonide/albuterol) works better than a standard albuterol inhaler when used as needed to prevent severe asthma attacks. It involves 440 teenagers aged 12-18 who have asthma and have had at least one serious attack in the pas…

This study is testing whether weekly phone coaching can help adults with asthma who avoid using their inhaled steroid medication due to anxiety. The coaching includes education, relaxation techniques, and motivational support. Researchers aim to see if this approach helps people …

This study is testing if semaglutide, a medication already approved for diabetes and weight loss, can help control asthma in adults who are overweight and still have symptoms despite using standard inhalers. One hundred participants will be randomly assigned to receive either the…

This study aims to see if using one combined inhaler for both daily control and quick relief works better than the standard approach of using two separate inhalers for children with asthma. Over 1,000 children and teens in South Africa will use either the single inhaler or standa…

This study is testing a smartphone app designed to help adults with asthma manage their condition. The app analyzes short voice samples to detect early signs of worsening symptoms and connects users with educational resources and community support. Researchers will compare the ap…

This is the first study in humans to test the safety of a new experimental drug called AMG 691 for asthma. Researchers will give single and multiple doses to 124 healthy adults and adults with mild-to-moderate asthma to see how their bodies handle the drug and check for side effe…

This study is testing whether an injectable medication called depemokimab can improve the physical structure of the lungs in adults with a specific, severe type of asthma. Researchers will use detailed CT scans and optional lung sampling to see if the drug reduces mucus plugs and…

This study is testing an inhaled drug called glycopyrronium to see if it helps children aged 6 to 12 with moderate to severe asthma breathe better. About 42 children will try two different doses of the drug and a placebo (an inactive substance) in a random order to compare their …

This study aims to see how well the drug tezepelumab works for adults with chronic nasal polyps, with or without asthma, in real-world medical settings. It will follow 110 participants in Russia for about a year to measure changes in their nasal symptoms, asthma control, and over…

This study is testing a new oral drug called ENV-294 to see if it can help adults whose moderate-to-severe asthma is not fully controlled by their current inhalers. About 50 participants will take either the new drug or a placebo pill daily for 12 weeks. Researchers will check if…

This study aims to see how well a specific 3-in-1 inhaler (Trimbow) works for controlling asthma symptoms in everyday life. It will follow 200 adults with severe, uncontrolled asthma for 6 months after they switch to this inhaler. The main goal is to measure changes in symptom sc…

This study is testing a new combination inhaler (containing fluticasone and albuterol) to see if it works better than a standard albuterol inhaler at preventing severe asthma attacks that require emergency care or steroids. It will involve about 2700 adults and children with asth…

This study is testing whether a new injectable medication called lunsekimig can help control asthma and reduce the number of serious flare-ups in adults. It is for people with high-risk asthma who have had at least one bad attack in the past year but are not currently eligible fo…

This study is testing if using a CPAP machine at night can help people who have both severe, uncontrolled asthma and sleep apnea. Researchers will compare asthma control over 12 months in adults who receive standard care versus those who also use a CPAP machine. The goal is to se…

This large study aims to find the best way to prevent serious asthma flare-ups in everyday primary care. It will compare two existing treatments: a special rescue inhaler containing steroids (called R-ICS) and a preventive antibiotic pill (azithromycin), both alone and combined. …

This study is testing whether suddenly ill adults with conditions like infections, heart failure, or breathing problems can be safely treated at home instead of in a hospital. About 3,000 participants will receive hospital-level care at home with doctors, nurses, tests, and treat…

This study is testing whether a new injection medicine called PF-07275315 can help adults with moderate-to-severe asthma that isn't well controlled by their current treatments. Over 12 weeks, 252 participants will receive either the actual medicine or placebo shots to compare saf…

This study is testing a new combination asthma inhaler that contains both a steroid (fluticasone) and a fast-acting reliever (albuterol). It will compare this new inhaler against the individual medicines and a placebo over 4 weeks in 724 people aged 12 and older with asthma. The …

This study is testing a digital sensor that attaches to a standard asthma inhaler. The sensor and app provide real-time feedback on a person's inhaler technique and send medication reminders. Researchers want to see if this 'digital coach' helps people use their inhalers correctl…

This study is testing whether a new drug called brenipatide can help adults whose moderate-to-severe asthma is not well controlled by current medications. Over 500 participants will receive either the drug or a placebo for a year to see if it safely reduces the number of serious …

This study aims to see if a new asthma inhaler, which uses a more climate-friendly gas, works just as well as current inhalers. About 780 adults with mild to moderate asthma will try both inhalers to compare their safety and effectiveness. The main goal is to ensure the new, envi…

This study is testing if a medication called dupilumab can help control severe asthma in very young children. It will involve about 90 kids, aged 2 to under 6, whose asthma is not well-managed with standard inhalers. For one year, children will receive either dupilumab or a place…

This study is testing if adding regular treadmill walking to a low-calorie diet helps women who have both Polycystic Ovary Syndrome (PCOS) and asthma. Forty women will be split into two groups: one group will do the diet plus exercise, while the other will follow the diet plan al…

This is an early-stage study to check the safety and body's response to a new drug called IBI3002 for people with asthma. It will involve a small group of adults whose asthma is not fully controlled despite using standard inhalers. Participants will receive injections of either t…

This study aims to find out if the drug dupilumab can prevent or slow the long-term decline in lung function for adults with uncontrolled moderate-to-severe asthma. Over 1,300 participants will receive either dupilumab or a placebo (inactive substance) alongside their standard as…

This study is testing if placing a temporary balloon in the stomach, combined with diet and exercise, helps obese adults with uncontrolled asthma breathe better. Researchers will compare this approach to diet and exercise alone. The main goal is to see if more people using the ba…

This study is for adults whose asthma remains poorly controlled despite using a standard medium-strength inhaler. It aims to find out which next step works better: adding a new injectable drug (dupilumab) to the current inhaler, or simply switching to a higher-dose inhaler. The m…

This study aims to find out if giving an intravenous (IV) magnesium drip early helps children who are still struggling to breathe after initial emergency asthma treatment. It will compare magnesium to a placebo (saltwater) in about 192 children aged 2-17. The main goal is to see …

This study is testing an investigational medicine called tozorakimab, given as an injection under the skin, for adults whose asthma is not well-controlled even with standard high-dose inhalers. The main goal is to see if different doses of tozorakimab can safely reduce the number…

This study is testing whether a combination inhaler (budesonide-albuterol) works better than a standard albuterol inhaler at preventing severe asthma attacks when used as needed. About 790 Chinese adults with symptomatic asthma who've had at least one severe attack in the past ye…

This study is testing whether a new drug called 610 can reduce serious asthma attacks in Chinese adults with severe asthma. About 480 participants will receive either the drug or a placebo for one year to see if it lowers the number of attacks requiring emergency care. The main g…

This study is testing an injectable medication called benralizumab in children and teenagers with a severe type of asthma. The goal is to see if it can safely reduce the number of serious asthma attacks (exacerbations) and improve daily symptoms. About 200 participants, aged 6 to…

This study tests whether computer alerts in hospital systems can help doctors prescribe fewer unnecessary antibiotics to children with common lung infections like pneumonia, bronchiolitis, and asthma flare-ups. It involves 2,800 children at three U.S. hospitals. The goal is to sa…

This study is testing a mobile health program designed to help young African American adults (ages 18-30) with uncontrolled asthma. The program uses a combination of a smartphone app, video meetings with a nurse, text messages, and activity tracking. Researchers want to see if th…

This study is testing a smart inhaler system to see if it helps adults with poorly controlled asthma use their medication correctly and consistently. Over one year, 60 participants will use a special cap on their regular inhaler that connects to a phone app, which provides feedba…

This study is testing whether metformin, a common diabetes medication, can help control asthma in overweight or obese adults whose asthma isn't well-managed with standard inhalers. 100 participants will take either metformin or a placebo pill daily for six months while researcher…

This study is testing a new injectable medicine called solrikitug to see if it can help control asthma. About 140 adults with asthma will receive either the study drug or a placebo injection for 12 weeks, while continuing their usual asthma medications. Researchers will check if …

This study is testing a self-management program designed to help World Trade Center responders better control their asthma. The program teaches participants how to properly use their inhalers and manage their symptoms. Researchers will measure whether the program improves asthma …

This study is testing a new handheld device called fenoTRACK that measures a marker of lung inflammation in a person's breath. It aims to see if the device works reliably both in a clinic and when used at home by adults and children with asthma. The research will check if the dev…

This study is testing a new smartphone app called AWARE that uses your phone's microphone and speakers to listen to your breathing. The goal is to see if it can accurately help doctors diagnose lung diseases like asthma and COPD, and spot when symptoms are getting worse. Research…

This study is testing a new wearable device called the C-mo System to see how well it can automatically detect and analyze coughs. About 245 adults and children (age 2+) with a troublesome cough from conditions like asthma or COPD will wear the device for one day and fill out que…

This study is testing a wearable device called AeviceMD that listens to lung sounds to detect wheezing. Researchers want to see if the device is as accurate as a doctor listening with a stethoscope. The study will enroll 160 children (age 3+) and adults having an asthma flare-up.…

This study aims to see if two new, easier-to-perform breathing tests can help primary care doctors accurately diagnose asthma and COPD. It will involve 600 adults with symptoms but no prior diagnosis. The goal is to compare the accuracy of these new tests performed in a regular d…

This study is testing two new types of MRI scans that use safe, inhaled gases instead of radiation to create detailed pictures of the lungs. Researchers want to see if these scans can detect changes in lung structure and function in people with cystic fibrosis or asthma more clea…

This study aims to see if finding and treating people with undiagnosed asthma or COPD early can make them feel better. Researchers will use an online questionnaire to find adults with breathing symptoms but no diagnosis. Those likely to have asthma or COPD will join a trial where…

This study is testing if taking a high dose of fish oil during pregnancy can prevent asthma and wheezing in young children. It will enroll 2,000 pregnant women with low omega-3 levels and give them either fish oil or a placebo pill from mid-pregnancy until after birth. Researcher…

This study is testing if giving pregnant women a higher dose of vitamin D can help prevent their children from developing asthma, persistent wheezing, and other related conditions like allergies and infections during early childhood. It will involve 2,000 pregnant women who will …

This study is testing whether a device called the Lung Master can help people breathe better by improving lung capacity. Healthy adults in two age groups (19-35 and 65+) will use the device at home daily for one month while tracking their use. Researchers will measure lung functi…

This study is testing whether a specific yoga-style breathing exercise (alternate nostril breathing) works as well as a standard medical device (an incentive spirometer) to help people with asthma breathe better. Researchers will measure lung function and quality of life in 54 ad…

This study is testing whether combining neck posture exercises with specific breathing techniques can help adults with asthma breathe better. Researchers want to see if these non-drug approaches can improve lung function and chest expansion. Participants will do a 4-week program …

This study is testing a new interactive training device that gives people feedback on how to use their inhaler correctly. It will enroll 140 adults with COPD or asthma to see if using the training device for 6 weeks improves their technique and breathing compared to standard educ…

This study is testing a new way to help teenagers with asthma feel more confident managing their condition. Teens will either get a standard doctor's visit or a visit focused on building their self-management skills based on a special questionnaire. The main goal is to see if thi…

This study aims to understand how genetic factors contribute to the development of various lung diseases, including cystic fibrosis, asthma, and pulmonary fibrosis. Researchers will enroll 3,500 participants, both with and without lung conditions, to examine their genes and compa…

This study aims to find out how common asthma and COPD are among workers in an industrial area of Thailand. Researchers will survey 310 adult workers about their breathing symptoms and test their lung function. The goal is to gather information to better understand the health ris…

This study aims to better understand asthma by observing 355 Chinese adults with the condition. Researchers will collect detailed information about patients' symptoms, treatments, and biological markers to identify different types of asthma. The findings may help develop more per…

This study aims to better understand different patterns in chronic lung diseases like asthma, COPD, and cystic fibrosis. Researchers will observe 470 adult patients over 10 years, collecting health data during their regular doctor visits. The goal is to identify shared disease fe…

This project collects additional medical record data from people who previously participated in the Salford Lung Study for asthma. Researchers will gather up to 10 years of past and future electronic health information and a one-time questionnaire from 3,500 participants. The goa…

This study aims to find out if a newer, simpler breathing test called impulse oscillometry (IOS) provides useful information for monitoring asthma in adults. Researchers will follow 50 adult asthma patients who are changing their regular asthma medication. Participants will do br…

This study aims to understand what causes immune cells to gather in the lungs of people with asthma. Researchers will compare people with allergic asthma, healthy individuals, and people with allergies but no asthma. The goal is to identify the specific signals that recruit these…

This study aims to collect real-world information on patients with severe, hard-to-control asthma who are prescribed the biologic drug tezepelumab in Italy. It will follow 300 patients for up to two years to understand their characteristics, track their symptoms, and see how well…

This study aims to understand how two different inhaler versions of the same asthma medication are absorbed into the body of children. It will enroll 12 children with asthma, aged 4 to under 12. Each child will try both inhalers in a single dose to compare how the drugs move thro…

This study aims to understand how the community of bacteria and viruses in the nose and throat is connected to different types and severities of adult asthma. Researchers will collect swab samples from 140 adults with asthma and track their health over two years. The goal is to g…

This study aims to observe and collect information on how 500 adults with severe, difficult-to-control asthma in Hong Kong are managed by their doctors over two years. It will track their symptoms, asthma flare-ups, hospital visits, and their experience with newer, expensive biol…

This study aims to understand how the body processes and breaks down a common anti-inflammatory steroid medication called prednisolone when given at high doses. Researchers will measure drug levels in the blood and urine of 120 patients who are taking high doses of prednisolone f…

This study aims to understand why some people with eczema and related allergies like asthma and food allergies go into remission while others do not. Researchers will follow 1,000 participants, including healthy people, over time to collect health and lifestyle data. The goal is …

This study aims to understand why some people with asthma don't get better with standard inhaler medicines. Researchers will use special MRI and CT scans to look at the shape of participants' airways. They want to see if blocked or narrow airways stop inhaled medicine from reachi…

This study aims to understand how the community of bacteria in the airways might be linked to severe asthma in infants. Researchers will collect and analyze fluid samples from the nose, throat, and lungs of 100 babies under 2 years old who have severe asthma. The goal is to gathe…

This study aims to test whether new types of CT scans can effectively measure changes in bone density and bone marrow fat in people with severe asthma who take oral steroids. Researchers will compare scans from a small group of patients who take steroids to those who do not, look…

This study aims to understand if weakness in the main breathing muscle (the diaphragm) is common in people with lung diseases like asthma, COPD, fibrosis, or pulmonary hypertension, and if it can predict future health problems. Researchers will measure muscle strength, lung funct…

This study aims to understand how a person's genes affect how their immune cells respond to potential threats. Researchers will collect blood from healthy volunteers to grow immune cells in a lab and test their reactions. The goal is to learn if certain genetic patterns make peop…

This study is testing whether a new, more environmentally friendly propellant (HFA-152a) works as well as the current standard (HFA-134a) in asthma rescue inhalers. It will involve 84 adults with mild asthma, who will use inhalers with each propellant. Researchers will measure ho…

This study aims to understand if a common asthma medication (salbutamol) can improve exercise performance in non-asthmatic endurance athletes. Researchers are recruiting 64 healthy male and female runners and cyclists to test if the drug helps a specific group who experience brea…

This study aims to understand how exposure to environmental fungi affects people with asthma, allergic bronchopulmonary aspergillosis (ABPA), and bronchiectasis. Researchers will observe 125 participants, including healthy people, for 6 months. They will collect dust samples from…

This study aims to learn about the unique chemical patterns in the blood and urine of children aged 12-17 with asthma. Researchers will observe 100 children who are already receiving their standard asthma care to see if certain chemicals are linked to asthma flare-ups and treatme…

This study looks back at medical records to understand how biologic drugs are used to treat severe asthma in Hong Kong. Researchers will review the health data of 360 adults who received these treatments to see how well they worked and how safe they were. The goal is to learn abo…

This study aims to check if a Turkish translation of a breathing pattern assessment tool works well for people with asthma. Researchers will give the tool to 100 Turkish-speaking adults with severe asthma to see if it produces consistent and accurate results. The goal is to provi…

This study aims to understand if people with allergic asthma experience symptoms, breathing difficulties, and frailty differently than those with eosinophilic asthma. Researchers will compare 60 adults with either type of asthma using questionnaires and breathing tests. The goal …

This study aims to understand how environmental factors like bacteria and household dust affect asthma over time. Researchers will follow 400 adults with moderate-to-severe asthma for five years, collecting samples like blood, saliva, stool, and dust. The goal is to gather inform…

This study aims to understand how our environment and our genes work together to influence our risk for common diseases like diabetes, heart disease, and asthma. It will enroll 25,000 adults to collect detailed health, lifestyle, and genetic information to build a research resour…

This study aims to understand asthma better by measuring two specific proteins, Ezrin and Pip5k1α, in the airway muscle tissue of people with and without asthma. Researchers will analyze 120 preserved lung tissue samples from previous surgeries. The goal is to see if these protei…

This study aims to understand how genetics influence asthma severity and types in Chinese people. Researchers will collect blood samples and health information from 1000 asthma patients and 1000 healthy volunteers. The goal is to identify specific genetic patterns that make some …

This study aims to understand if and how severe asthma affects the brain. Researchers will compare brain scans, blood tests, and questionnaires from 100 adults with severe asthma to those from healthy adults. The goal is to see if lung inflammation is linked to brain inflammation…

This study aims to see if pictures of a child's tongue and measurements of their pulse can help doctors better understand and monitor their asthma. It will enroll 1,000 children with asthma, collecting this information during their regular check-ups. The goal is to find non-invas…

This Canadian study aims to understand how mucus buildup affects people with asthma, COPD, and chronic cough. Researchers will use CT scans and other tests to measure mucus in 240 adults and 50 children over two years. The goal is to find better ways to identify and treat mucus p…