ASTHMA

This study looks at how well a virtual program called Coach McLungs works when used in regular doctor visits for children with asthma. The program helps doctors and families make decisions together and provides asthma education. Researchers will track whether kids have fewer asth…

This study tests whether a new triple-combination inhaler (FF/UMEC/VI) works better than the usual two-medication inhaler (ICS/LABA) for adults whose asthma is not well controlled. About 1,366 participants will use one of the two treatments for 24 weeks, and researchers will meas…

This study tests a web-based program called CAMP Air designed to help urban teens with uncontrolled asthma. About 374 Black and Hispanic adolescents will use the program to improve symptom control and reduce emergency visits. The goal is to see if an online approach can make asth…

This study tests a wearable device called AeviceMD that monitors breathing in children with poorly controlled asthma. Twenty kids aged 3 to 18 will use the device at home to track their respiratory health. The goal is to help families manage asthma better and allow doctors to adj…

This study tests a new antibody drug (610) for adults with severe eosinophilic asthma, a type of asthma linked to high levels of certain white blood cells. The goal is to see if adding this drug to standard treatment improves lung function and reduces asthma attacks over 52 weeks…

This study tests a new medicine, GSK5784283, for adults aged 18 to 75 whose asthma is not well controlled despite regular treatments. The drug blocks a protein called TSLP that may cause inflammation. The trial has two parts: first to find the best dose by checking lung function …

This study looks at 120 adults with asthma that is not well controlled by their current medium-dose inhaler. Researchers want to see if adding the injectable drug dupilumab to the usual inhaler works better than simply increasing the inhaler dose. The goal is to reduce severe ast…

This study tests whether adding dupilumab to standard asthma care can prevent asthma attacks in 240 children and teens (ages 6-17) living in urban areas who have frequent asthma attacks. Participants receive either dupilumab or a placebo for 12 months, and researchers count how m…

This study tests whether dupilumab, an injectable drug, can slow the long-term decline in lung function for adults with moderate to severe asthma that is not well controlled by current treatments. About 1,300 participants will receive either dupilumab or a placebo for 3 years, al…

This study looks at whether people aged 12 and older with a specific gene change (IL-4RαR576) get more help from the drug dupilumab to control their asthma. Over 48 weeks, researchers will count how many severe asthma attacks happen and check lung function. The goal is to see if …

This study tests an experimental drug called rocatinlimab in 317 adults with moderate-to-severe asthma. The goal is to see if it can reduce the number of asthma attacks when added to standard inhaler therapy. Participants receive either the drug or a placebo, and researchers trac…

This study looks at whether a smart spacer device can help children and young people (ages 6-18) with asthma use their inhalers correctly. Many kids don't use their inhalers the right way, leading to poor asthma control. The study will randomly assign participants to receive eith…

This study looks at whether a structured follow-up clinic for adults after an asthma attack improves disease management and reduces future severe attacks. 230 participants will either attend in-person clinic visits or receive phone follow-ups. The goal is to see if the clinic hel…

This study looks at the long-term safety and effectiveness of a drug called amlitelimab for adults with moderate-to-severe asthma. Participants had already completed a previous amlitelimab study. The goal is to see if the drug remains safe and helps control asthma over up to 144 …

This study tests an experimental drug, solrikitug, in 145 adults with asthma who still have symptoms despite using standard inhalers. The main goal is to see if the drug can lower certain immune cells (eosinophils) in the blood, which are linked to asthma attacks. Participants re…

This study looks at a different way to use asthma inhalers for people who often forget to take their daily maintenance inhaler. Instead of using a daily inhaler, participants will use a combination inhaler only when they have symptoms. The goal is to see if this approach helps pe…

This study tests a drug called benralizumab in 75 adults with severe asthma that is not well controlled by standard inhalers. The goal is to see if the drug can reduce airway inflammation and improve lung structure and function over 48 weeks. Participants continue their usual ast…

This study follows 155 people with severe asthma who are starting a new medicine called tezepelumab. Researchers want to see how well it controls asthma symptoms and improves quality of life over two years in real-world clinics across Greece. The goal is to understand if this tre…

This study aimed to compare two treatment options for adults with T2-high asthma that remains uncontrolled despite using a medium-dose inhaler combination. The two options were increasing the dose of the inhaled corticosteroid or adding a third medication (triple therapy). The go…

This study looks at whether changing the rescue inhaler from albuterol alone to albuterol plus budesonide can lower the number of severe asthma attacks. About 1,500 adults with asthma who have had at least one severe attack in the past year will switch to the new inhaler. Researc…

This study checks if a new version of a common asthma inhaler works just as well as the current one. About 422 adults with asthma will use both inhalers and a placebo to compare lung function. The goal is to make sure the new propellant is safe and effective.

This study looks at whether giving C-section babies a dose of their mother's vaginal bacteria can lower their risk of developing allergies and asthma. Researchers believe that babies born by C-section miss out on beneficial bacteria that help train the immune system. The study in…

This study tests whether a drug called omalizumab can prevent asthma from developing in young children at high risk. The trial involves 200 children aged 2-3 years old who have had wheezing episodes and allergies. They receive the drug or a placebo for two years, then are monitor…

This study looks at whether giving pregnant mothers extra vitamin D can prevent asthma symptoms like wheezing in their children. About 600 mothers from a Danish asthma study took either a high dose (2400 IU) of vitamin D or a placebo daily from week 24 of pregnancy until one week…

This small pilot study tests whether taking oral probiotics for 12 weeks can improve asthma control and insulin resistance in obese adults with asthma. Researchers will measure changes in gut and airway bacteria, inflammation, and breathing tests. Only 7 participants are enrolled…

This early-stage study tests a new medicine called GB-0895 in adults with mild-to-moderate asthma or COPD. The main goal is to check if the drug is safe and how the body handles it. About 156 participants will receive either the drug or a placebo. This research is a first step to…

This study tests a digital platform called aflo™ that attaches to asthma inhalers to give real-time feedback on technique and medication reminders. About 26 children and adults with uncontrolled asthma will use the device for 3 months. The goal is to see if it improves how well t…

This study planned to test whether osteopathic manipulative treatment (OMT) — a hands-on technique to improve chest movement — could reduce lung inflammation and improve breathing in adults with asthma. About 100 participants would have been enrolled, but the study was withdrawn …

This study looks at whether mepolizumab, a drug already used to reduce asthma attacks, can also help people with severe asthma become more physically active. Researchers will track daily steps and exercise tolerance in 62 adults over six months. The goal is to see if the treatmen…

This study looks at whether using HEPA air purifiers at home can improve asthma symptoms in children, and if overweight kids benefit more. About 200 children with asthma from Baltimore, half overweight and half normal weight, will receive either real or fake air purifiers. The go…

This study tests a program called SaMBA-WTC to help World Trade Center responders with asthma better manage their condition. About 56 adults with uncontrolled asthma will receive either the program or general health information. The goal is to see if the program improves asthma c…

This study tests a new drug called APG777 in 31 adults with mild-to-moderate asthma. The main goal is to check if the drug is safe and how the body processes it. Participants receive either the drug or a placebo, and researchers monitor for side effects and measure drug levels in…

This study aimed to see if giving children with asthma a nebulized steroid (budesonide) after an emergency room visit, on top of standard oral steroids, could reduce the chance of another attack within a month. It planned to enroll children aged 2 to 8 who had an asthma flare-up …

This study tests a 24-week physical activity program designed specifically for Black women with asthma. The goal is to see if the program improves asthma control and quality of life compared to standard asthma education. About 224 women will take part, and researchers will also c…

This study works to create a simple questionnaire that helps doctors find small airway problems in people with COPD. Researchers will test the questionnaire on 108 adults and compare it with standard breathing tests. The goal is to make diagnosis easier and more accurate in every…

This study tests a new digital platform that helps hospitals share patient information more reliably when a patient is transferred from one hospital to another. About 1,000 adults being moved to Brigham and Women's Hospital from three other hospitals will take part. The goal is t…

This observational study looks at over 1,000 adults with asthma to better understand different disease types and how well treatments work. Researchers will use real-world data and genetic information to describe asthma subtypes and track who responds to therapy. The goal is to im…

This study aimed to see if removing mucus plugs from the airways using a scope (bronchoscopy) is safe and improves lung function in people with asthma. It planned to enroll adults aged 18-70 with asthma and low lung function. However, the study was withdrawn before any participan…

This study looks at whether the respiratory syncytial virus (RSV) can pass from a pregnant woman to her unborn baby. Researchers will test blood from mothers and umbilical cords to check for RSV and other viruses. They will also follow the babies for up to 4 years to see if they …

This study was designed to see if COVID-19 makes asthma worse or changes how well patients can control their asthma. Researchers planned to compare asthma patients who had a severe COVID-19 infection with those who did not, tracking their lung function and symptoms for a year. Th…

This study examines 150 preschool children (ages 1 to under 5) hospitalized for a severe asthma attack. Researchers measure immune and inflammatory markers in blood and sputum to see if different wheezing patterns have different underlying causes. Children are followed until age …

This study follows 180 infants from birth to age 1-2 years to see how bacteria in their upper airways change over time. Researchers want to learn if certain bacteria cause inflammation and lower lung function, which could lead to asthma. The study does not test any treatment, but…

This study tracks 718 asthma patients who are starting the medication DUPIXENT in real-world settings, not in a controlled lab. Researchers want to learn about the patients' backgrounds, how they use the drug, and how well it works over time. The goal is to gather long-term safet…

This study follows 376 asthma patients aged 12 and older who are starting Dupixent in everyday medical practice. Researchers will collect information on patients' medical history, how they use the drug, and how well it controls their asthma. The goal is to understand real-world e…

This study aimed to see if a computer program could predict how long patients would stay in a home hospital program. Researchers used data from past patients to train the program. The study was withdrawn before enrolling any participants, so no results are available.

This study looks at adults with asthma to learn more about their condition, including how severe it is and what factors affect it. Researchers will collect medical history and do lung function tests. The goal is to build a database that helps with future asthma research. About 25…

This study watches 315 people with severe asthma in Italy who are starting a new drug called tezepelumab. Researchers will track their health, asthma attacks, and other conditions for up to two years. The goal is to see how well the drug works in real life, not just in a lab.

This study uses special MRI scans with inhaled gases to see how lungs work in people with asthma, COPD, or COVID-19 (including Long COVID). Researchers will track up to 160 participants over several years to understand how these diseases change the lungs over time. The goal is to…

This study was designed to find the best way to give the asthma drug terbutaline sulfate, comparing injection under the skin versus into a vein. It planned to enroll adults with asthma to measure how the drug moves through the body and affects breathing. However, the study was wi…

This study looks at how air pollution and the body's internal clock (circadian rhythm) interact in people with asthma. Researchers will measure tiny molecules called microRNAs in sputum samples from 20 adults with and without asthma, collected at different times over 48 hours. Th…

This study observes 100 people with severe asthma who are taking biologic drugs. Researchers measure how the body's immune system reacts to the drug and whether that affects how well the treatment works. The goal is to better understand drug effectiveness and safety over time.

This study watches how Chinese asthma patients use biologic medicines and how well they work. About 202 people will be followed for a year while getting their usual care. The goal is to learn about treatment patterns, not to test a new drug.

This study aimed to see if a computer program could predict potassium levels in the blood using a simple heart monitor. Researchers planned to use data from patients treated at home. The study was withdrawn before any participants were enrolled, so no results are available.

This study looks at 1,600 adults in Hong Kong who have been diagnosed with asthma or COPD to find out how many actually have both conditions (called Asthma-COPD Overlap). Researchers will track their health for 3 years to see how they do and whether their treatments match current…

This study aimed to understand why some people with asthma develop mucus plugs in their airways. Researchers planned to use a thin, camera-guided tube to collect samples from the lungs of 60 adults—some with asthma and mucus plugs, some with asthma but no plugs, and healthy volun…