ASTHMA

This study tested two ways of using the Foster inhaler in 1714 adults with asthma that was not fully controlled. One group used Foster both as a daily maintenance treatment and as needed for relief, while the other group used Foster daily plus a separate salbutamol inhaler for re…

This study looked at the long-term safety of a drug called depemokimab in 641 adults and teenagers with severe asthma that involves high levels of certain white blood cells (eosinophils). Participants had already completed earlier studies of the drug and continued treatment for 1…

This study looked at whether giving electronic cigarettes (e-cigarettes) to adults with asthma who smoke regular cigarettes could help them cut down on smoking and improve their lung health. Seventeen people took part, and researchers measured changes in how many cigarettes they …

This study tested the drug dupilumab in 109 adults with moderate to severe asthma that was not well controlled. The goal was to see if the drug could reduce lung inflammation and improve breathing, as measured by lung scans and breathing tests. Participants received either dupilu…

This study tested whether adding an extra medication (glycopyrrolate) to a standard asthma inhaler (QVAR) helps people whose asthma is not well controlled. 98 adults with asthma took either the combination or a placebo for 6 weeks. Results showed that the combination improved lun…

This study tested an experimental daily pill called atuliflapon in 670 adults with moderate to severe asthma that is not well controlled by current treatments. The goal was to see if the drug could reduce asthma worsening episodes compared to a placebo over 12 weeks. Participants…

This study tested a telemedicine program for children with asthma who visited the emergency room. The program connected them with their primary care doctor via video within a week of discharge, plus two follow-ups, to ensure they got proper preventive medications and education. T…

This study looked at how well the drug tezepelumab works for people with severe uncontrolled asthma in real-world settings, outside of a controlled trial. Over 500 participants aged 12 and older were followed after starting tezepelumab. The main goal was to measure changes in ast…

This study looked at the long-term safety of dupilumab in 378 children with asthma who had already taken the drug in a previous study. The main goal was to track side effects over one year. A smaller part of the study in Japan also checked how well the drug improved lung function…

This study looked at how well a triple-combination inhaler (BDP/FF/G) works in everyday life for adults with asthma. It included 281 people whose asthma was not well controlled despite using other treatments. The main goal was to see if their symptom scores improved after 6 month…

This study looked at 28 adults with both moderate-to-severe asthma and chronic sinusitis with nasal polyps who were treated with dupilumab for 24 months. After two years, 88% had both conditions under control (called dual remission), meaning fewer symptoms, no flare-ups, and no n…

This study tested a type of allergy immunotherapy (Clustoid®) for people with dust mite allergies. It included 140 patients aged 5 to 65 who received the treatment for at least one year. The goal was to see if it reduces allergy symptoms and the need for medication, while also ch…

This study looked at whether adults with acute illnesses like infections, heart failure, or COPD can be safely treated at home instead of in a hospital. 160 rural patients were randomly assigned to receive hospital-level care at home or usual hospital care. The goal was to see if…

This study compared a new drug called depemokimab (GSK3511294) to two existing treatments (mepolizumab and benralizumab) in over 1,700 people aged 12 and older with severe eosinophilic asthma. The goal was to see if switching to depemokimab is as effective at preventing asthma at…

This study tested a new way to help children with asthma take their daily medicine. Instead of just giving a prescription at the ER, the medicine was given right there and then supervised at school. The goal was to see if this approach would reduce the number of kids who end up b…

This study tested whether a combination inhaler (containing both an anti-inflammatory steroid and a fast-acting bronchodilator) works better than a steroid-only inhaler for adults with asthma. Over 1,300 participants on medium or high doses of inhaled steroids took part. The goal…

This study looked at 620 adults with asthma whose symptoms were not well controlled by their current treatments. They started using a combination inhaler (beclometasone/formoterol) through a device called NEXThaler. After 6 months, researchers measured how many people improved th…

This study tested a program where school health centers help children with asthma take their daily preventive medicine. The goal was to reduce asthma symptoms, emergency visits, and missed school days. The study included 29 children with persistent asthma from communities with he…

This study tested a new drug, lunsekimig, in 685 adults with moderate-to-severe asthma. Participants received either the drug or a placebo as an add-on to their usual asthma medications. The main goal was to see if lunsekimig could reduce the number of asthma attacks and improve …

This study followed 147 adults with moderate-to-severe asthma whose doctors prescribed the triple-inhaler Trimbow. Researchers observed how patients used the inhaler in real life and measured changes in asthma control, quality of life, and lung function over time. The goal was to…

This study compared two medications, dupilumab and omalizumab, in 360 adults with severe nasal polyps and asthma. The goal was to see which drug better shrinks polyps and improves sense of smell. Both are injected treatments that help control symptoms but do not cure the conditio…

This study tested a mobile health tool called AIM2ACT designed to help adolescents ages 12-15 with poorly controlled asthma better manage their condition. The tool was used alongside standard care to improve asthma control, measured by a questionnaire. The study involved 320 teen…

This study looked at 653 people with severe asthma that was not controlled by other treatments. They received FASENRA injections over a long period to see if it was safe and helped control their asthma. The main goal was to track side effects and check if symptoms improved.

This study tested a new inhaler (CHF 1535) that combines two medicines—a steroid and a long-acting bronchodilator—against a standard steroid-only inhaler in 542 adults with asthma that wasn't well controlled. The goal was to see if the combination improved morning lung function m…

This study tested whether adding the drug QAW039 to standard asthma treatments helps people whose asthma is still not under control. Over 700 adults and teens took either QAW039 or a placebo for 12 weeks. The main goal was to see if their lung function improved, measured by how m…

This study tested a new way to help people with two or more long-term health problems like HIV, high blood pressure, diabetes, asthma, or depression. Over 1,800 adults aged 40 and older in South Africa took part. Some clinics used a special decision-support tool and home visits f…

This study tested a new propellant (HFA-152a) that is better for the environment in a common asthma inhaler. 827 adults with moderate to severe asthma used either the new or the current inhaler for 12 weeks. The goal was to see if the new version is as safe and works just as well…

This study tested how well tezepelumab works for adults with severe asthma that is not controlled by other treatments. Researchers measured asthma control and cough-related quality of life over 52 weeks. The goal was to see if the drug improves daily symptoms in real-world settin…

This study tested whether a technology-based education program delivered by peer mentors or adult educators helps teenagers aged 14-17 with asthma. 48 teens were split into two intervention groups and a control group. Researchers measured changes in asthma control, quality of lif…

This study tested whether a combination inhaler (budesonide and formoterol) works better than a steroid-only inhaler (budesonide) for people whose asthma is not well controlled. Over 12 weeks, 374 adults and teens aged 12 to 80 took part. The main goal was to see if the combinati…

This study tested a program that uses technology to help teenagers with moderate to severe asthma remember to take their daily inhaler medication. 72 teens participated, and the program tracked their inhaler use electronically. The goal was to see if the program improved how ofte…

This study tested whether adding a drug called glycopyrrolate to a standard asthma inhaler (Foster) helps people whose asthma is not well controlled with their current medications. 211 adults with uncontrolled asthma took part. The main goal was to see if the combination improved…

This study looked at how well and how safely the drug tezepelumab works for people aged 12 and older with severe asthma, including groups often left out of research. Over 52 weeks, researchers tracked asthma attacks, hospital visits, and medication use. The goal was to see if tez…

This study tested whether a digital inhaler system (a smart inhaler with an app) helps people with asthma gain better control of their condition. About 333 people aged 13 and older with asthma took part. Half used the smart inhaler system, and the other half used their usual resc…

This study looked at whether giving children with asthma and mild acid reflux a dose of the medicine lansoprazole based on their genes could improve both conditions. 41 children aged 6 to 17 with poorly controlled asthma took part. The goal was to see if personalized dosing leads…

This pilot study tested whether weekly reminder messages help adults with severe asthma stay on track with home breathing tests. Thirty participants used a digital device to monitor their lung function for three months. Those who received reminders completed more weekly tests tha…

This study tested an experimental drug called QAW039 in 675 adults and teens with asthma that wasn't well controlled by their current medications. Participants took either QAW039 or a placebo pill alongside their usual asthma treatments for 12 weeks. The main goal was to see if Q…

This study tested a new drug called AZD4604 in 36 adults with moderate-to-severe asthma. The goal was to see if it reduces airway inflammation better than a placebo over 4 weeks. Participants took the drug or a placebo and had their airway cells checked for signs of inflammation.…

This study tested a new inhaler that combines two medicines (budesonide and formoterol) for people whose asthma is not well controlled. Over 600 adults and teens took part for 24 weeks. The main goal was to see if the new inhaler improved lung function better than using one medic…

This study tested several treatments for people with severe asthma that is hard to control. About 950 participants tried different therapies in a crossover design, with each treatment lasting 16 weeks. The goal was to see if these precision treatments could improve lung function …

This study tested how well benralizumab, an asthma medication, works for people with severe uncontrolled asthma in everyday settings in Taiwan. 43 adults took the drug and reported their symptoms using questionnaires. The goal was to see if asthma control improved after starting …

This study tested an experimental inhaled drug called AZD8630 in 537 adults whose asthma is not well controlled despite using standard inhalers. Participants took the drug once daily for 12 weeks. The goal was to see if it could prevent asthma flare-ups and improve lung function …

This study looked at whether taking vitamin D every day can lower the risk of serious lung problems in children and teens with sickle cell disease. Lung issues like infections and acute chest syndrome are major causes of illness in this group. The study involved 58 participants a…

This study tested the drug tezepelumab in 27 adults with moderate-to-severe asthma that was not well controlled by current treatments. The goal was to see if the drug could improve how air moves through the lungs and reduce airway inflammation and mucus plugs. Participants receiv…

This study tested a new drug called amlitelimab in 437 adults with moderate-to-severe asthma. Participants received either the drug or a placebo as an add-on to their usual asthma medications. The main goal was to see if amlitelimab could reduce the number of severe asthma attack…

This study tested a monthly injection called tezepelumab in 305 adults with severe asthma who needed daily steroid pills. The goal was to see if the drug could help them safely reduce or stop their steroid use. Results showed many participants could lower their steroid dose witho…

This study tested a new inhaler medicine called AZD4604 in 339 adults with moderate-to-severe asthma that is not well controlled by their current treatments. Participants took the medicine or a placebo twice a day for 12 weeks. The goal was to see if the new medicine could reduce…

This study looked at whether two simple tests—a breath test (FeNO) and a blood test (eosinophil count)—can help diagnose asthma more easily than current hospital-based breathing tests. Researchers studied 123 people with suspected asthma to see if these portable tests could accur…

This study tested whether a daily oral bacterial extract, Broncho-Vaxom, could prevent wheezing lower respiratory tract infections in infants at high risk for asthma. Over 800 infants aged 6-18 months received either the extract or a placebo for 10 days each month over two years.…

This study looked at whether giving pregnant women extra vitamin D could stop their children from developing asthma or wheezing in early childhood. About 876 pregnant women with a personal or family history of allergies or asthma took part. The main goal was to see if the childre…

This study tested an inhaled drug called ARO-RAGE in 127 healthy volunteers and people with asthma. The goal was to see if it is safe and how it affects lung function. Participants received one or two doses of the drug or a placebo. The results will help decide if further testing…

This study tested whether a new propellant (HFO) in asthma inhalers causes breathing problems compared to the standard propellant (HFA). 52 adults with well-controlled asthma took part. The main goal was to measure lung function right after using each inhaler to see if the new on…

This study tested whether mepolizumab, a drug that reduces certain immune cells, can lessen chronic cough in people with asthma or a related airway condition. 46 adults with a cough lasting over 8 weeks received the drug, and researchers measured their cough frequency over 14 wee…

This study looked at whether acupuncture can help people with mild-to-moderate persistent asthma. Researchers measured asthma control, symptom-free days, and lung function in 200 adults. The goal was to see if adding acupuncture to standard care improves symptoms and quality of l…

This early-stage study tested a new drug, TR4, in 12 adults with mild-to-moderate asthma. The goal was to check if the drug is safe and how it affects the airways. Participants received either TR4 or a placebo, and researchers measured lung function and other health markers.

This early-stage study tested a single dose of IBI3002 in 52 healthy adults and people with mild to moderate asthma to see if it is safe and how the body processes it. Participants were randomly assigned to receive either the drug or a placebo, and were monitored for about 5 week…

This study tested a new inhaler (PT027) that combines a fast-acting bronchodilator with a steroid against a standard bronchodilator inhaler (PT007) in 190 adults with asthma. Researchers measured how well each drug improved lung function after triggering airway narrowing with a m…

This study tested whether a mobile app that lets people with asthma report their symptoms between doctor visits can improve their quality of life. Over 400 adults with asthma used either the app or received usual care. Researchers measured changes in asthma-related quality of lif…

This study looked at 101 children aged 6 to 17 with moderate to severe asthma attacks in the emergency room. It compared two medications: standard racemic albuterol and a purified version called levalbuterol. The goal was to see which one improved breathing better and reduced the…

This study tested a single dose of an inhaled drug called AZD8630 in 10 teenagers with asthma. The goal was to see how the drug moves through the body and whether it is safe. Participants used a dry powder inhaler and were monitored for side effects and immune responses.

This early-stage study tested a new daily inhaler called AZD8630 in 24 adults with asthma who already use medium-to-high dose steroid inhalers and long-acting bronchodilators. The main goals were to check safety and how the drug moves through the body. Participants took the inhal…

This study followed 112 adults with severe asthma who started taking dupilumab (Dupixent®) to see how their quality of life changed over a year. Researchers measured breathing, activity, and emotional well-being using a standard questionnaire. The goal was to understand the drug'…

This study tested a new inhaler called PT007 in 118 adults with asthma. Participants received a single dose of PT007, a placebo, or the standard inhaler Ventolin on separate days. The main goal was to see how well PT007 improved lung function over 6 hours compared to the other tr…

This study tested whether a 12-week remote exercise program using a mobile app is practical and helpful for 20 adults with obesity and poorly controlled asthma. Participants received a personalized exercise plan and were monitored remotely. The main goal was to see if people woul…

This study tested two different devices that deliver the asthma rescue drug salbutamol: a standard inhaler with a spacer and a newer vibrating mesh nebulizer. 16 adults with mild-to-moderate asthma took part. Researchers measured how quickly and completely their lungs recovered a…

This study tested an inhaled solution of Ectoin, a natural substance, in 18 adults with mild asthma. The goal was to find a safe and effective dose that might reduce airway sensitivity. Researchers measured how much methacholine (a trigger) was needed to cause a 20% drop in lung …

This study tested whether MitoQ, a dietary supplement, can improve airway function in 47 obese adults with poorly controlled asthma. Participants took MitoQ or a placebo for 14 weeks. The main goal was to see if MitoQ reduces airway reactivity, a key asthma symptom.

This study looked at whether the color of an asthma inhaler (pink vs. white) affects how people perceive their asthma symptoms. 78 adults with moderate to severe asthma used both colored inhalers and rated their symptoms. The goal was to see if the device color influences symptom…

This study tested whether a simple, home-based pulmonary rehabilitation program could improve breathing, exercise ability, and quality of life in adults with asthma. Thirty adults with asthma followed an 8-week home exercise plan using basic equipment. The results showed improvem…

This study tested the safety of two drugs, mirabegron and montelukast, in 78 people with liver cirrhosis who also had overactive bladder and asthma. Researchers wanted to see if these drugs could be used safely in this group. The study focused on side effects and changes in bladd…

This study tested the Buteyko breathing technique in 90 adults with asthma. Participants were split into two groups: one learned the breathing method, the other did not. Researchers measured changes in fatigue, exercise ability, and asthma control. The goal was to see if this bre…

This early-stage study tested a new drug called SAR443765 in 36 people to see if it is safe and how the body processes it. Healthy adults received single or multiple doses, while people with mild-to-moderate asthma received a single dose. The goal was to check for side effects an…

This study looked at whether adding special breathing exercises (inspiratory muscle training) to a swimming program helps children with mild asthma breathe better and control their symptoms. Thirty children aged 8-11 took part in a 4-week swimming program, with half also doing br…

This study tested whether a salmon oil supplement called CARDIO® could reduce asthma attacks in adults. 70 participants took either the supplement or a placebo alongside their usual asthma medications for 20 weeks. The goal was to see if the supplement's anti-inflammatory propert…

This study looked at whether adding Bridge Pose yoga to Papworth breathing exercises helps teens and young adults with mild-to-moderate asthma. Fifty-eight participants practiced either breathing alone or breathing plus yoga five times a week for eight weeks. Researchers measured…

This study looked at whether breathing and posture exercises, done remotely via video calls, could improve breathing, posture, and quality of life in young adults with asthma. Twelve participants aged 18-26 with stable asthma took part. The goal was to see if these exercises coul…

This study tested whether inhaling thyme oil can improve asthma control and breathing in 156 adults with asthma. Participants used a thyme oil inhaler stick or a placebo (empty stick) three times daily for four days. The goal was to see if thyme oil reduces symptoms like wheezing…

This study looked at the long-term safety of a new propellant (HFA-152a) used in salbutamol rescue inhalers for adults with asthma. It compared the new propellant to the current standard (HFA-134a) in 477 participants. The main goal was to see if the new propellant caused any sid…

This study compared two types of stretching exercises—intercostal and thoracic cage—in 56 adults with asthma. The goal was to see if these stretches could improve chest expansion, reduce shortness of breath, and increase oxygen levels. Participants were clinically stable and did …

This study looked at whether the 6-minute stepper test (stepping up and down for six minutes) is a good way to measure exercise capacity in adults with asthma. 41 people with well-controlled asthma took part. Researchers compared the stepper test results with a standard treadmill…

This study observed over 1,800 children hospitalized for serious breathing issues like bronchiolitis, pneumonia, or asthma. It aimed to track how many children under 12 months were hospitalized for bronchiolitis after a new immunization became available. The study did not test an…

This study tested a smartphone app called Hyfe Cough Tracker to see if it can help doctors screen, diagnose, and manage patients with respiratory diseases like COPD, asthma, and COVID-19. Over 600 participants used the app to track their coughs, and researchers compared the app's…

This study checked if a Turkish version of the Brompton Breathing Pattern Assessment Tool (BPAT) works well for people with asthma. Researchers tested 101 Turkish-speaking adults with severe asthma to see if the tool gives consistent and accurate results. The goal was to provide …

This study tested a new home device that monitors breathing patterns in 120 adults with severe asthma. The goal was to see if changes in resting breathing could predict when an asthma attack might occur. No treatment was given; the study only observed breathing signals to see if …

This study collected fluid and cells from the lungs of 574 people with and without asthma using a thin tube called a bronchoscope. The goal was to learn more about what causes airway inflammation in asthma. Findings may help identify new targets for future treatments.

This early-stage study tested a single injection of an experimental drug called HBM9378 in 50 healthy Chinese adults to see if it is safe and how the body processes it. The goal was not to treat asthma but to gather important safety and drug-level information for future studies. …

This study tested a program to train doctors on the latest asthma guidelines and help them put that knowledge into practice. About 1500 people with asthma from 30 hospitals in China took part. The goal was to see if the program led to better use of inhaled steroids and improved a…

This study looked at how 120 children with asthma and their families use emergency inhalers at home during asthma attacks. Using smart inhalers and a mobile app, researchers tracked symptoms and medication use to understand real-world patterns. The goal was to create better, more…

This study looked at nearly 20,000 adults with asthma to see if long-term use of inhaled or oral steroids increases the risk of bone thinning (osteoporosis) and other health problems like diabetes and high blood pressure. Researchers compared people who took higher doses of stero…

This study looked at whether a family of proteins called GPCRs, found on the surface of cells, could be used as biomarkers to help diagnose or track chronic lung diseases like asthma and COPD. Researchers analyzed blood samples from 205 people (healthy volunteers and patients wit…

This study looked at CT scans from 233 people with severe asthma to see if body composition (like muscle size and quality) could predict how well they respond to biologic therapies. Researchers used advanced image analysis to find markers that might help doctors choose the right …

This study followed 2,660 children aged 5–16 with asthma to learn what causes asthma attacks and loss of control. Researchers collected saliva, nasal, and urine samples to find patterns. The goal was to improve how asthma is managed in real life, not to test a new treatment.

This study looked at how mepolizumab, a biologic drug, changes inflammation in people with severe eosinophilic asthma. Researchers measured immune and metabolic markers in the nose, lungs, and blood of 15 adults. The goal was to better understand the drug's full impact beyond jus…

This study looked at 39 children with asthma to see if those with depression have different lung inflammation and respond better to a type of inhaler called ipratropium. Researchers measured lung function before and after the inhaler. The goal was to understand if depression chan…

This study looked at how much of the asthma drug CHF 6001 gets into the blood of teenagers compared to adults after a single dose. It involved 50 people with asthma. The goal was to understand the drug's behavior, not to test if it works or helps symptoms.

This early-stage study tested a new drug called XKH001 in 24 healthy adults to see if it is safe and how the body processes it. Participants received multiple doses of the drug or a placebo. The goal was to check for side effects and measure drug levels in the blood, not to treat…

This study tested whether a mobile app paired with a Bluetooth peak flow meter could help people with asthma track their breathing better. 83 patients, including some who were pregnant, used the app to send daily readings. The goal was to see if this approach was practical and us…

This study looked at past patient records to see if a computer program could predict who would need to be readmitted to the hospital within 30 days of leaving. Researchers used data from 372 patients treated at home through a hospital program. The goal was to improve care, not to…

This study looked at blood and airway samples from 23 adults during a sudden asthma attack and again after recovery. The goal was to understand what causes these attacks at a molecular level. The findings may help researchers develop better treatments in the future.

This early-stage study tested a single dose of the experimental antibody SM17 in 30 healthy Chinese adults to see if it is safe and how the body processes it. The goal was not to treat any disease, but to gather important safety and drug-level information for future studies in co…

This study looked at 50 adults with severe asthma who were already taking the drug mepolizumab. Researchers measured the amount of drug in their blood to see if levels differ between people who respond well and those who don't. The goal is to understand why some patients don't ge…

This study looked at whether treating depression in caregivers (parents or guardians) of children with asthma could improve the child's asthma control and quality of life. Over one year, 205 caregivers with major depression and their children (ages 7-17) with persistent asthma we…

This study looked at whether teaching children with asthma (ages 7-11) about their condition improves their asthma knowledge, control, and quality of life. 70 children and their families took part. The goal was to see if education, delivered via smartphone or computer, could help…

This study followed 171 adults with severe asthma, milder asthma, or no asthma over several years. Researchers collected medical history, lung function tests, and samples to understand how severe asthma progresses and what complications arise. The goal is to find new ways to trea…

This study looked at whether sending paper letters along with emails to doctors helps them switch asthma patients to inhalers that are better for the environment. 273 primary care practices in West Yorkshire took part. The goal was to see if the extra paper reminder led to more p…

This study looked at 123 adults with COPD or asthma to see if doctors can estimate breathing muscle strength using easy-to-get measurements like peak airflow and body composition. Participants did breathing tests and a fixed-pressure exercise until they got tired. The goal was to…

This study followed nearly 90,000 farmers and their spouses to confirm health changes they reported, such as asthma and Parkinson's disease. Researchers checked medical records and collected cheek swabs to verify diagnoses. The goal was to better understand how pesticides and oth…

This study looked at over 400 workers with asthma to see if those exposed to flour (like bakers) are more likely to be allergic to grass pollen. Researchers analyzed medical records from a French hospital to understand how job-related allergens might trigger or worsen asthma. The…

This study looked at whether a set of care guidelines could help community hospitals use proven treatments for children with asthma, pneumonia, or bronchiolitis. Over 11,000 children participated across multiple hospitals. The goal was to see if these guidelines increased the use…

This study tracked 581 pregnant women to see if the drug dupilumab (used for eczema or asthma) affects pregnancy or baby health. It compared women who took dupilumab to those with the same diseases who did not, and to healthy pregnant women. The goal was to check for birth defect…

This study followed 18 adults with severe asthma for at least 3 years to understand their symptoms, treatments, and daily life. Researchers collected data from medical records and monthly patient surveys. No new treatments were tested; the goal was to learn more about how severe …

This study looked at whether a diet low in salt and sugar can reduce common side effects of corticosteroid treatment, such as weight gain, high blood pressure, and diabetes. Fifty adults with autoimmune diseases or asthma who were starting high-dose corticosteroids took part. Res…

This study aimed to learn more about what causes asthma by collecting genetic and health information from 83 adults of African, African American, or African Caribbean descent. Participants provided blood, skin, and breathing test samples, and answered questions about their health…

This study looked at how different breathing exercises affect genes in 84 adults with severe asthma. Researchers compared standard respiratory rehab with a program that also included muscle-strengthening breathing exercises. They measured changes in exercise ability, shortness of…

This study looked at 49 obese adults with asthma to understand why they often have more severe symptoms and don't respond well to standard treatments. Researchers used special MRI scans and genetic analysis of lung cells to examine airway damage and scarring. The goal was to unco…

This study looked back at medical records of 420 people with severe asthma in Spain who were given the drug tezepelumab after it was approved. The goal was to describe their characteristics, like age and smoking history, and track how well their asthma was controlled over time. I…

This early-stage study tested a new medicine called 9MW1911 in 48 healthy adults to see if it is safe and how the body processes it. The goal was to find the right dose and check for side effects, not to treat any disease. Results will help guide future studies in people with ast…

This study looked at data from 526 patients treated at home through a hospital-at-home program. Researchers used a computer algorithm to try to predict if a patient would get worse during their stay. The goal was to see if machine learning could help doctors spot problems earlier…

This study tested how easy and acceptable the P-STEP mobile app is for people with chronic conditions like asthma, COPD, heart disease, or type 2 diabetes. 178 adults in Leicester, UK, used the app for 12 weeks and gave feedback on its usability. The goal was to see if the app is…

This study looked at 174 adults with severe asthma who were starting a new biologic treatment (biotherapy). The goal was to see if their ability to work and be productive at their jobs improved after 6 months of treatment. Researchers measured presenteeism, which means being at w…

This study looked at inflammation in the small airways of the lungs in people with mild to moderate asthma. Researchers tested whether an inhaled steroid with small particles could reduce that inflammation better than one with large particles. 57 adults took part, using lung func…

This study looked at whether a natural chemical called TGF-Beta, found in higher levels in asthmatic lungs, makes people with asthma more vulnerable to RSV, a common respiratory virus. Researchers collected lung cells from 113 healthy adults and mild asthmatics using a thin tube …

This study looked at whether children who grow up on farms, and are exposed to more microbes, have fewer severe colds, breathing problems, and allergies. Researchers tracked 290 children aged 4 to 12, including farm kids and city kids with or without asthma. The goal was to under…

This study measured breathing patterns in 163 people with asthma or COPD to help computers predict how aerosol drugs deposit in the lungs. Researchers aimed to find links between breathing, disease severity, and drug dose. The goal is to make inhaler therapy more personalized and…

This study tested whether a new propellant (HFA-152a) used in inhalers affects the lungs' ability to clear mucus, compared to a standard propellant (HFA-134a). Twenty-four healthy adults inhaled each propellant and then breathed in a harmless radioactive tracer to measure lung cl…

This study looked at how the drug dupilumab changes genes and proteins in airway cells from adults with allergic asthma and obesity (BMI 30 or higher). Researchers collected nasal cells from 28 participants and tested them in the lab to understand how dupilumab affects inflammati…

This study looked at how a treatment called nasal high-flow therapy (NHFT) affects breathing and the body's 'fight-or-flight' nerve signals in 30 adults with asthma. Researchers measured heart rate, blood pressure, and nerve activity to see if NHFT changes these patterns. The goa…

This study looked at whether a person's blood group antigens are connected to asthma attacks. Researchers followed 126 people with asthma to see if certain blood types had more flare-ups needing steroids. The goal was to understand, not to test a new treatment.

This study tested a new propellant (HFA-152a) in salbutamol inhalers to see if it delivers the drug similarly to the current propellant (HFA-134a). Sixty healthy adults aged 18-55 received single doses of 200 or 800 micrograms in a crossover design. The goal was to compare how mu…

This study looked at how small changes in the COX-2 gene affect the balance of immune cells that can lead to allergies or asthma. Researchers collected blood and urine samples from 117 adults to analyze these gene variations. No treatments were given; the goal was simply to under…

Asthma is caused by or worsened by different things in different people. It is because of these differences that not all people with asthma respond the same to all treatments and medicines. If the investigators can better identify the changes in the airways or breathing pipes in …