E-Cigarettes tested as a safer alternative for asthmatic smokers
NCT ID NCT05278065
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study gave free e-cigarettes to 17 adult smokers with asthma for 8 weeks to see if they would smoke fewer regular cigarettes and have better lung function. Researchers measured changes in smoking habits, dependence, and asthma symptoms. The goal was to gather early information on whether e-cigarettes could reduce harm in this group.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- electronic cigarette with 5% nicotine e-liquid
- What this could lead to
- If it works, this could point toward a way to help smokers with asthma cut down on cigarettes and possibly improve their lung function.
- What could go wrong
- This was a very small study (17 people) with no control group, so results may not apply widely. The long-term safety of e-cigarettes is still unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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17 people
The number who actually took part.
- Started
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May 2022
- Finished
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Sep 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
21 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male or female (50%), 21 to 65 (inclusive) years of age; * Persistent asthma symptoms (i.e., episodic symptoms of airflow obstruction / airway hyperresponsiveness (AHR) as documented in review of medical history); * Currently prescribed SABA medication; * Past-year smoking of ≥5 cigarettes/day; * Exhaled CO ≥ 6 ppm at baseline; * Zero breath alcohol during informed consent for participation; * English-speaking at an 8th grade level. Exclusion Criteria: * Intention to quit smoking during the next 30 days; * Current engagement in any smoking cessation treatment; * Current self-identification as regular ENDS user or using ENDS \> 2 days / week; * Medical contraindication to nicotine; * Pregnancy (due to toxicity of nicotine and tobacco products); * Current alcohol dependence (AUDIT \> 15) * Urine-screened or past-month self-reported use of illicit substances (amphetamine, cocaine, methamphetamine, opioids, benzodiazepines); * Current psychosis, mania, or suicidal ideation;
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Center for Alcohol and Addiction Studies
Providence, Rhode Island, 02903, United States
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