Brown University

This study tests a reduced-intensity treatment plan for adults aged 65 and older with head and neck cancer who are considered frail. Participants receive a personalized combination of chemotherapy and immunotherapy based on their tumor markers, followed by radiation. The goal is …

This study is for people with early to mid-stage non-small cell lung cancer that can be removed with surgery. Before surgery, participants will receive a combination of low-dose radiation and two immunotherapy drugs (ipilimumab and nivolumab). The goal is to see if this treatment…

This study is for sexual and gender minority young people (ages 18-24) living with HIV in Rio de Janeiro, Brazil. It tests a program that combines counseling and technology to help them take their antiretroviral therapy (ART) regularly. The goal is to improve social support, conf…

This study tests a two-drug combination (mosunetuzumab and lenalidomide) as the first treatment for adults with follicular or marginal zone lymphoma. Participants start with mosunetuzumab alone, then add lenalidomide if the cancer only partially responds. The goal is to see how m…

This study tests whether a drug that blocks alpha-1 receptors can help people with alcohol use disorder drink less and feel fewer cravings. Researchers want to understand how stress plays a role in drinking. About 184 adults who want to cut back or quit drinking will take the med…

This study tests whether probenecid, a medication currently used for gout, can help people with alcohol use disorder drink less and feel less craving. About 120 adults who drink heavily will take probenecid or a placebo daily for 16 weeks. Researchers will measure cravings in the…

This study tests whether e-cigarettes or nicotine replacement therapy can help people quit smoking and manage weight gain. Researchers will track daily cigarette use, carbon monoxide levels, and weight changes in 60 adults with obesity who smoke at least 5 cigarettes per day. Par…

This study tests a program called STEP that teaches teens skills like mindfulness, gratitude, and savoring positive moments to reduce suicidal thoughts and attempts. About 216 teens hospitalized for suicide risk will be randomly assigned to STEP or standard care. The goal is to s…

This study tests whether a single dose of insulin given as a nasal spray can reduce cravings and the effects of alcohol in people with alcohol use disorder. Forty non-treatment-seeking adults will receive either insulin or a placebo spray, then be exposed to alcohol-related cues …

This study tests whether a dexamethasone mouthwash can reduce mouth sores caused by the cancer drug datopotamab deruxtecan (Dato-DXd). About 60 adults with advanced HER2-negative breast cancer or non-small cell lung cancer will use the mouthwash four times a day for the first fiv…

This study is testing a digital platform and teacher training program to reduce suicidal thoughts and behaviors in Colombian youth aged 14-19. The platform offers self-help tools, safety planning, and counseling links, while teachers get training to spot warning signs. Researcher…

This study looks at how practicing certain visual tasks can improve our ability to see or detect things—a process called perceptual learning. Researchers will also scan participants' brains to see how brain activity changes with training. Healthy adults aged 18 to 60 with normal …

This study looks at how recalling a memory over and over changes the way the brain represents what we see. Healthy adults aged 18-40 will have their brains scanned with fMRI while they remember simple patterns or natural images. The goal is to understand if repeated recall streng…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to see if daily changes in these factors can predict whether pain becomes long-term or flares up. A smaller group will also …

This study looks at how young adults (ages 18-25) who smoke both marijuana and tobacco decide to use each substance when prices change. Researchers will measure cravings after showing pictures of marijuana or tobacco. The goal is to understand patterns of dual use, not to test a …

This study looks at how sleep improves visual learning. Ten healthy volunteers aged 18-30 will have their brains scanned with MRI while sleeping to see how the brain processes visual information. The goal is to understand the brain activity behind learning during sleep.