Brown University

This study tests whether a smartphone app that connects people recovering from opioid use disorder with peer support can help them stay in treatment and feel more supported. About 1,300 adults who own a smartphone and are in recovery or treatment for opioid use disorder will use …

This study tested whether a combination of two immunotherapy drugs, nivolumab and low-dose ipilimumab, can help prevent melanoma from returning after surgical removal. The trial enrolled 22 adults with high-risk stage III or resected stage IV melanoma. Participants received the d…

This study is for people with HER2-positive esophageal or stomach cancer who have finished chemoradiation and surgery but still had some cancer cells left. It tests whether a year-long combination of two drugs, trastuzumab deruxtecan (Enhertu) and nivolumab, can safely prevent th…

This study tests whether the immunotherapy drug nivolumab, alone or combined with ipilimumab, can shrink tumors in people with advanced clear cell carcinoma of the ovary, fallopian tube, peritoneum, or other organs. About 46 participants with recurrent or metastatic disease will …

This study tests a program called CLASP for veterans at high risk of suicide after leaving the hospital. About 850 veterans will either get usual care or usual care plus extra support through CLASP for 6 months. Researchers will track suicide attempts, deaths, and related behavio…

This study was designed to test a device called NovoTTF-200A combined with the immunotherapy drug pembrolizumab in people with melanoma that had spread to the brain. The goal was to see if the combination was safe and effective. However, the study was withdrawn before any partici…

This study tests a program called Safe South Africa, designed to help teenage boys avoid HIV and stop violence against partners. The program teaches healthy behaviors and attitudes. Researchers are studying 836 boys aged 15-17 in South African high schools to see if the program r…

This study tests whether a short, acceptance-based behavioral therapy can help LGBTQ+ adults who have mild or worse anxiety or depression. About 240 participants will either receive this therapy or their usual care. The goal is to see if the therapy reduces symptoms and improves …

This study looks at whether creating a personalized music playlist can help people cope with the loss of a spouse or life partner. About 30 adults from a grief support group will take part. They will talk about their loved one and their grief, then build a playlist with guidance …

This study tests a mindfulness program (called GEM) delivered through an app and weekly group video calls. It aims to see if young adults aged 18-24 who faced early life hardships find it helpful and easy to use. The main goal is to reduce symptoms of anxiety and depression. 44 p…

This study aims to see if machine learning can predict which HIV patients are likely to miss clinic visits or have treatment failure. Researchers will develop risk prediction tools and test them in large HIV care programs in Kenya. The goal is to help healthcare workers intervene…