Brown University

This study tests whether a drug that blocks alpha-1 receptors can help people with alcohol use disorder drink less and feel less craving. About 184 adults who want to cut back or quit drinking will take the drug or a placebo and report their drinking and cravings. The goal is to …

This study tests whether a combination of two immune-boosting drugs (nivolumab and ipilimumab) works better than nivolumab alone for people with advanced clear cell cancers of the ovary, fallopian tube, peritoneum, or other areas. About 46 participants will receive one of the two…

This study compares two ways of delivering meals to homebound adults aged 66 and older who are on Meals on Wheels waiting lists. One group gets a hot meal delivered daily, five days a week; the other receives a box of 10 frozen meals every two weeks. Researchers track how many da…

This study is for people with HER2-positive esophageal or gastroesophageal junction cancer who have already completed chemoradiation and surgery. The goal is to see if adding a year of treatment with trastuzumab deruxtecan (Enhertu) plus nivolumab is safe and helps prevent the ca…

This phase II trial tests a combination of two immunotherapy drugs, nivolumab and low-dose ipilimumab, given after surgery to patients with stage III or resected stage IV melanoma. The goal is to see if this regimen is safer and more effective than standard high-dose interferon, …

This study tests whether a smartphone app that connects people in recovery from opioid use disorder with peer supporters can help them stay on track. About 1,300 adults who own a smartphone and are in recovery or treatment will use the app or receive usual care. Researchers will …

This study planned to test a device called NovoTTF-200A (which uses electric fields to disrupt cancer cells) together with the drug pembrolizumab in people with melanoma that had spread to the brain. The goal was to see if the combination was safe and effective. However, the stud…

Researchers at Brown University are testing whether cash incentives encourage adults to exercise more. Participants with a YMCA membership can earn up to $100 or $200 for attending at least 50 gym sessions over 6 months. The study compares two incentive levels against a control g…

This trial tests a stepped-care intervention for mothers of young children enrolled in Head Start. The program aims to prevent depression in those with mild symptoms and help those with more severe symptoms connect to mental health services. Researchers will measure changes in de…

This pilot study tests a family-based program called Modified Family Talk, designed to help prevent substance use in teenagers aged 12-18 whose parents are in recovery from substance use disorder. The program consists of six sessions over 12 weeks, aiming to strengthen family res…

This study tests whether creating a personal music playlist can help people process grief after losing a spouse or life partner. Thirty participants from a grief support group will work with a researcher to build a playlist and reflect on their experience. The goal is to see if m…

This study tests a short, acceptance-based therapy (ABBT) to help LGBTQ+ adults with mild anxiety or depression worsened by the COVID-19 pandemic. 240 participants will either receive the therapy or standard care. The goal is to see if ABBT can reduce symptoms and improve social …

Researchers at Brown University are studying perceptual learning: how practice with visual tasks changes what people can detect or tell apart. Healthy adults aged 18 to 60 with normal or corrected-to-normal vision complete behavioral visual exercises while the team records brain …

This study in Sierra Leone tests whether using mobile phones to supervise teachers can improve how they deliver a mental health program called the Youth Readiness Intervention (YRI) to students. About 1,454 youth and their teachers from secondary schools will take part. The YRI i…

This study tests whether machine learning can predict which HIV patients are likely to miss clinic visits or have treatment failure. Researchers will give clinic workers risk alerts to help them reach out to high-risk patients. The goal is to improve retention in care and viral s…