ASTHMA

This study tests a new inhaler containing three medicines (QVM149) against a standard two-medicine inhaler in 304 teenagers aged 12 to 17 with asthma. The goal is to see if the triple combination improves lung function and symptom control over 52 weeks. Participants will be rando…

This study looks at adults with asthma that is not well controlled by their current medium-dose inhaler. Researchers want to see if switching to a higher dose or a different combination inhaler can improve the function of the small airways in the lungs. Participants will take one…

This study compares two proven asthma treatment plans—MART and PARTICS—to see which works better at preventing severe asthma attacks. About 4,100 adults with moderate-to-severe asthma who are at risk for flare-ups will take part. Participants will be randomly assigned to one of t…

This study tests whether a slow-release form of the hormone DHEA can improve asthma control in adults aged 18 to 50. Asthma treatments like glucocorticoids can lower DHEA levels, so researchers want to see if adding DHEA helps. The study will measure asthma control scores and lun…

This study aims to create and test a digital tool to screen and manage asthma and allergic diseases in nearly 10,000 Chinese adults. Participants will use a platform to track symptoms and behaviors for at least a year, and some will try non-drug approaches like allergen-proof bed…

This study offers continued access to benralizumab (Fasenra) for people with asthma, eosinophilic granulomatosis with polyangiitis (EGPA), or hypereosinophilic syndrome (HES) who completed a previous benralizumab study and are still benefiting. About 230 participants will receive…

This study tests whether a new inhaler with three medicines (CHF 5993) works better than a standard two-medicine inhaler for people whose asthma is not well controlled. About 554 Chinese adults with asthma will use either the triple or dual inhaler for 24 weeks. The main goal is …

This study tests a simple idea: scheduling a telehealth appointment with an asthma specialist before patients leave the ER after an asthma attack. Many people never see a specialist afterward, missing out on treatments that could prevent future attacks. The study will compare thi…

This study tests if a new drug called QL2302 works as well and is as safe as the current drug Tezspire for adults with severe asthma that is not controlled by standard treatments. About 636 adults aged 18-80 will get either QL2302 or Tezspire as an injection every 4 weeks for 48 …

This study tests a new medicine called depemokimab for people with Type 2 asthma who are at risk of asthma attacks. The goal is to see if adding this drug to standard care can reduce attacks, help patients achieve remission (no attacks and no need for steroid pills), and slow lun…

This study tests whether reducing radon gas in homes can improve asthma control. About 180 adults with uncontrolled asthma will have their homes tested and some will get radon mitigation. Researchers will track how many days participants have asthma symptoms to see if the interve…

This study tests a new drug called AK139 in 160 adults with moderate to severe asthma. The goal is to see if it improves lung function and reduces airway inflammation safely. Participants will receive either AK139 or a placebo, and researchers will monitor side effects and immune…

This study aims to see how accurate two scoring methods (GINA-P and ACT-P) are at measuring asthma control in adults. Researchers will ask 144 adults with asthma to fill out questionnaires and take a lung function test. The results could help doctors use simple tools to better as…

This study tests whether a program called Body Awareness Therapy can improve physical and emotional health in adults with asthma. Participants will be randomly assigned to either the therapy or standard care. The therapy includes gentle exercises focused on posture, breathing, an…

This study looks at whether a CPAP machine, often used for sleep apnea, can help people with large airway collapse (LAC), a condition where the windpipe collapses during breathing, causing shortness of breath and cough. About 60 adults with LAC will either use CPAP or continue us…

This study looks at whether adding a traditional Chinese herbal formula (Liqin Zhike) to standard asthma inhalers can improve outcomes for people with cough variant asthma. About 236 adults aged 18-70 with a new diagnosis will be followed to see if the combination lowers the chan…

This study compares a single steroid injection to a 5-day course of steroid pills for adults who come to the ER with an asthma attack. The goal is to see if the shot works just as well at preventing another ER visit or hospitalization within 30 days. About 182 English- or Spanish…

This study tests whether L-menthol, a minty compound, can reduce breathlessness and improve exercise ability in adults with asthma. Twenty participants will try L-menthol and a placebo in random order, comparing their breathing and exercise performance. The goal is to see if this…

This study compares a joint consultation with a lung doctor and an ear-nose-throat specialist against standard separate visits for adults with asthma and chronic sinusitis with nasal polyps. The goal is to see if the combined approach reduces the need for oral steroids over one y…

This study will test a program called CALM that helps Black adults with asthma learn to cope with stress. The goal is to see if the program is practical and helpful for this group. About 50 people will take part, and the study will measure how well they accept the program and if …

This study tests a new nebulizer treatment made from tiny particles from stem cells (hUC-MSC-sEV-002) for people with both allergic rhinitis and asthma. The goal is to see if it is safe and can improve symptoms and quality of life. About 18 adults aged 18-60 will inhale the treat…

This study tests whether watching a medical TV drama can improve asthma knowledge in young adults (18-35) without medical backgrounds. Participants will be randomly assigned to watch the drama or not, and their asthma understanding will be measured. The goal is to see if entertai…

This study looks at whether a 12-week vegan diet can lower inflammation and improve immune markers in adults with mild to moderate asthma, compared to a regular diet. Researchers will also include healthy participants to see how diet affects everyone. The goal is to understand if…

This study looks at how breathing in wildfire smoke can harm your lungs and brain over time. Researchers will expose 24 healthy adults to different amounts of smoke in a safe setting to measure changes in breathing and thinking. The goal is to find out who is most at risk and how…

This study looks at whether giving people with heart disease, asthma, or COPD real-time air quality information on their phone helps them avoid pollution while exercising outdoors. About 80 adults will use a special app that tracks their activity and local pollution levels. The g…

This study looks at how the immune system works in people with lung diseases like asthma, COPD, pneumonia, and tuberculosis. Researchers will analyze a single blood sample from 100 adults to see how certain immune cells respond to inflammation and infection. Participants won't re…

This study will observe 42,000 children with asthma in China to understand how well their asthma is controlled and what type of airway inflammation they have. Researchers will use tests and questionnaires to gather information. The goal is to improve treatment and help doctors us…

This study uses artificial intelligence to understand how air pollution and climate change affect respiratory diseases like asthma and allergic rhinitis. Researchers will gather health data from about 1,900 patients across nine European countries and combine it with environmental…