ASTHMA

This early-stage study tested an inhaled drug called ARO-MUC5AC, designed to reduce thick mucus in the lungs of people with asthma or COPD. It involved 78 healthy volunteers and patients to check if the drug was safe and how it behaved in the body. The main goal was to see if it …

This study tested an oral medication called dexpramipexole for people with severe asthma that is not well-controlled by standard inhalers. Over 1,000 participants took either the drug or a placebo pill for one year to see if it reduced the number of serious asthma flare-ups. The …

This study tested an oral medication called dexpramipexole for people with severe asthma driven by high levels of a specific white blood cell (eosinophils). Over 650 participants took either the drug or a placebo pill for one year to see if it safely reduced the number of serious…

This study tested whether adding the experimental drug RPT193 to standard asthma inhalers could help adults whose asthma isn't fully controlled. Participants had moderate-to-severe asthma and continued using their regular inhalers while receiving either RPT193 or a placebo for 14…

This study aimed to test how a chewable asthma drug called fevipiprant is processed by the body in children aged 6 to 12. It was a short, 8-day trial to find the right dose for kids for future studies. However, the drug's development program was discontinued, so this study was te…

This study tested whether a drug called n-acetylcysteine (NAC), which breaks down mucus, could improve lung function in adults with moderate-to-severe asthma. Participants had evidence of mucus plugs in their lungs seen on CT scans. In this small, terminated trial, adults receive…

This study aimed to discover new causes of severe asthma attacks and better understand how common steroid inhalers work. Researchers analyzed mucus and saliva from 67 adults during a serious asthma episode. The goal was to find clues that could lead to new treatments by studying …