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Can a nasal air device calm Asthma's hidden nerve stress?

NCT ID NCT05704101

Knowledge-focused Sponsor: RWTH Aachen University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This completed study looked at how nasal high-flow therapy (NHFT) affects breathing and the nervous system in 30 adults with asthma. Researchers measured nerve activity and heart rate to see if NHFT could reduce overactive stress signals. The goal was to gather knowledge, not to test a treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nasal high-flow therapy
What this could lead to
If successful, this could help researchers understand whether nasal high-flow therapy might improve breathing and reduce stress on the nervous system in people with asthma.
What could go wrong
This is a small, early-stage study focused on measuring body signals, not on treating asthma. The results may not lead to any new treatment or apply to all asthma patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

30 people

The number who actually took part.

Started

Jul 2023

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Asthma patients (n=20) and Controls (n=10) patients without an established cardiovascular disease will be enrolled and the extent, nature and mechanism of SNA increase compared with healthy controls matched in a 2:1 ratio for age, sex and body mass index (BMI).

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Clinically diagnosed Asthma * Age ≥ 18 * Ability and willingness to give informed consent to participate in the study Exclusion Criteria: * Atrial fibrillation * Active pacing of the heart by a cardiac pacemaker (i.e. no intrinsic heart rate) * Clinically pre-established cardiovascular disease or other pulmonary diseases (e.g. arterial hypertension, systolic heart failure, COPD) * In-patient stay in the hospital within the last 4 weeks prior to the study examination date * Severe polyneuropathy

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Conditions

The condition(s) this trial relates to.

asthma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Asthma

Contacts and locations

Locations

  • University Hospital RWTH Aachen-Department of Pneumology and Intensive Care

    Aachen, North Rhine-Westphalia, 52074, Germany

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Other studies related to the condition(s) this trial covers.