Pregnancy disorder

This study tested a program that combines community-based fetal ultrasound with care navigation to help pregnant women with substance use disorder engage in prenatal care and substance use treatment. The program used motivational interviewing and strength-based education to suppo…

This trial tests whether a 10-week therapeutic exercise program, including relaxation and stretching, can influence the mode of delivery in first-time mothers aged 35-40 who have a rigid perineum. Participants are randomly assigned to either the exercise program plus routine advi…

This trial compares two surgical strategies for managing placenta accreta, a condition where the placenta grows too deeply into the uterine wall and can cause severe bleeding during delivery. One approach is a caesarean hysterectomy, which removes the uterus after the baby is bor…

This study tests whether a wireless monitor worn for 24 hours after an emergency C-section can alert doctors when a new mother's vital signs become dangerous. Over 3,000 women in Uganda will wear the device, which sends alerts if heart rate, blood pressure, or other readings fall…

This study tested whether giving pregnant women a balanced energy and protein supplement (BEP) can improve birth weight and reduce complications like low birth weight and preterm birth. Over 3,300 women in Bangladesh were randomly assigned to receive either BEP or standard prenat…

This study tests whether a single intravenous dose of ferumoxytol raises hemoglobin more effectively than daily oral ferrous sulfate in pregnant women with iron deficiency anemia. Participants are between 24 and 34 weeks pregnant with a single baby. The trial measures hemoglobin …

This study tested whether adding a smartphone app with short videos on mental health, diet, exercise, and insulin adjustment to standard care could improve blood sugar control and birth weight in pregnant women with diabetes. Over 600 women participated. The goal was to see if th…

This study tested whether a once-monthly injection of buprenorphine works as well as daily pills to treat opioid use disorder in 140 pregnant women. The goal was to see if the monthly shot could reduce illicit opioid use during pregnancy and after birth. Results help doctors choo…

This study tested whether a stricter blood pressure goal (below 135/85) after a pregnancy complicated by high blood pressure is better than the usual care (below 150/100). About 60 new mothers were enrolled and followed for six months. The goal is to see if tighter control is pos…

This study tested a counseling program for couples in Zambia to help pregnant women living with HIV stay healthy. Nearly 500 couples took part. The program aimed to improve HIV medication adherence and viral suppression through relationship strengthening.

This study tested two doses of tranexamic acid (a drug that helps blood clot) to see if it could reduce blood loss during cesarean deliveries when heavy bleeding occurs. 225 women who experienced significant bleeding during a planned or non-emergency C-section were randomly given…

This early-stage study tested whether a brief therapy program plus a mobile app could help pregnant and postpartum women stay on their buprenorphine medication for opioid use disorder. Fifteen pregnant women took part, attending therapy sessions and using the app for up to 9 mont…

This study looked at 170 women with severe pre-eclampsia in the ICU to see which blood pressure drug—phentolamine or glyceryl trinitrate (GTN)—better protects kidney function. Pre-eclampsia can harm the kidneys, and GTN has been linked to kidney injury in some cases. The research…

This study tested an online personalized program for pregnant women with obesity to help them gain the right amount of weight and reduce the need for delivery interventions like C-sections or forceps. Over 800 women participated, using a secure website to communicate with dietiti…

This study looked at 88 pregnant women whose water broke before labor started, comparing those who got labor-inducing gel right away versus those who waited 24 hours. The goal was to see which approach led to shorter labor and more vaginal deliveries. The findings could help guid…

This study tested three football-based programs for teen girls in Zambia to improve HIV testing, birth control use, and mental health. Over 2,100 girls from 32 schools took part. The programs aimed to make it easier for girls to get sexual health services and stick with HIV treat…

This study tested whether placing two stitches instead of one around the cervix during an emergency can help women with a weak cervix carry their pregnancy longer. The trial included 81 women between 16 and 25 weeks of pregnancy whose membranes were bulging out. The goal was to s…

This study tested a new wearable patch called TOCONAUTE that sticks to a mother's belly during labor. The patch measures the baby's heart rate and the mother's contractions, just like the standard monitors but without wires. Researchers compared the patch's readings to the usual …

This study tested a small, portable ultrasound device (echOpen O1) for pregnancy follow-ups in Senegal, where access to standard machines is limited. 224 pregnant women were scanned with both the portable device and a regular ultrasound machine to see if the portable one could re…

This trial tests whether a group prenatal care model that includes social services can improve maternal mental health and reduce preterm birth compared to standard individual care with added services. Pregnant women eligible for Medi-Cal in central California are randomly assigne…

This trial tests whether a structured antenatal education program can reduce cesarean section rates among first-time mothers in Turkey. Researchers will enroll 120 pregnant women at 28 weeks or more, with 40 receiving a 4-hour childbirth preparation class and 80 serving as contro…

This study is testing whether following a Mediterranean diet during pregnancy can reduce the chance of children developing allergies by age 2. Researchers are enrolling 276 healthy pregnant women (ages 20-35) who are at risk of having a baby with allergies. Participants receive p…

This pilot study tests whether offering multiple micronutrient supplements (MMS) directly at antenatal clinics in Botswana increases their use among pregnant women. The study will measure how well clinics adopt the program and whether it improves outcomes like weight gain, anemia…

This large study tested whether giving tranexamic acid (TXA) during C-sections can prevent severe bleeding. Over 11,000 women received either TXA or a placebo right after delivery. The goal was to see if TXA reduces the need for blood transfusions or death. Results could change h…

This study looked at two approaches to giving iodine supplements to pregnant women. One group received a daily iodine pill from 14 weeks until delivery. The other group had their urine iodine tested first; only those with low levels got iodine, while others got an iron pill. The …

This study tested a program to help pregnant women with overweight or obesity avoid gaining too much weight. The program included setting goals, tracking weight, learning skills, and getting support from WIC counselors. 416 women from Philadelphia WIC took part, and researchers m…

This study tested whether giving intravenous iron to pregnant women who have low iron stores but not yet anemia can prevent them from becoming anemic and help their babies grow normally. 600 women took part. The goal is to see if a single IV dose works better than usual care.

This completed trial tested a program to increase COVID-19 vaccination among pregnant women. Over 6,900 participants were involved across OB/GYN practices. The program included training for healthcare providers, reminders, and feedback on vaccination rates. The goal was to see if…

This study tests whether a buprenorphine patch can reduce withdrawal symptoms when pregnant women with opioid use disorder start sublingual buprenorphine treatment. Forty participants will receive either a real patch or a sham bandage during the initial withdrawal period. Researc…

This trial explores whether two different internet-delivered programs can help pregnant women reduce stress, anxiety, and depression. One program teaches cognitive-behavioral stress management skills, while the other is a supportive group discussion. Researchers will measure chan…

This trial tests whether an 8-week mindfulness-based stress reduction program can help first-time pregnant women feel less depressed, improve their psychological well-being, and strengthen their attachment to their unborn baby. About 108 women in their first pregnancy, between 13…

This trial investigates whether combining electroacupuncture with stabilizing exercises can reduce pain and limit pelvic joint separation in pregnant women with symphysis pubis dysfunction. Sixty women between 25 and 28 weeks of pregnancy will either receive six weeks of electroa…

This study tests whether a gentle hands-on technique called myofascial release, combined with specific exercises, can reduce round ligament pain in pregnant women. The trial includes 70 women at 24 weeks of pregnancy who have this type of pain. One group receives the manual thera…

This study tests whether giving first-time mothers a written labor guide when they are admitted for labor induction helps them feel more in control during childbirth. Half the participants receive the guide, while the other half get standard counseling. Researchers measure percei…

This study tested a device called the Hypotension Prediction Index (HPI) to see if it can reduce low blood pressure during planned C-sections. Low blood pressure after spinal anesthesia can harm both mother and baby. The device alerts doctors before blood pressure drops, so they …

This study investigates whether laughter yoga can lower stress and improve quality of life for pregnant women diagnosed with gestational diabetes. Participants will practice laughter yoga sessions that combine breathing exercises, clapping, and playful activities. The trial measu…

This study looked at whether adding supervised Pilates exercises and structured prenatal education to standard care could reduce depressive symptoms, low back pain, and labor pain in first-time mothers. 85 pregnant women participated, with some attending the program and others re…

This study tested a new monitoring system that predicts when a mother's blood pressure might drop dangerously during a planned C-section. The device uses a finger cuff to continuously measure blood pressure and an algorithm to warn doctors before a drop occurs. Researchers compar…

This study tested whether a four-week program of obstetric exercises could reduce depression, pregnancy complaints, and improve quality of life in 100 pregnant women in their third trimester. Half did the exercises with a physiotherapist, while the other half received standard pr…

This study looked at whether a simple intervention to relieve breast tenderness in late pregnancy could improve breastfeeding, reduce breast engorgement, and lower stress for new mothers. Researchers followed 160 healthy pregnant women from 36 weeks onward. The goal was to see if…

This study looked at whether giving birth in water (waterbirth) is better than a traditional land birth for low-risk, healthy women. Researchers compared pain medication use, labor length, breastfeeding rates, and satisfaction between the two groups. The goal was to see if waterb…

This study tested whether wearing virtual reality glasses during a routine postpartum uterine tone assessment could lower anxiety and pain while increasing comfort. 146 women within 24 hours of giving birth participated. Researchers measured pain with a visual scale and anxiety w…

This study tested two ways of giving epidurals to 102 pregnant women in labor: a standard method and a newer one called dural puncture epidural (DPE). The goal was to see which provides faster pain relief and better satisfaction. Results help doctors choose the best option for ma…

This pilot study tested whether giving two medications (mifepristone and misoprostol) at the same time helps women deliver faster after a nonviable second-trimester pregnancy, compared to misoprostol alone. Thirty women between 14 and 28 weeks pregnant who needed labor induction …

This study tested whether an 8-week mindfulness-based cognitive therapy (MBCT) program can reduce stress, anxiety, and depression in pregnant women at risk for psychological distress. 84 women participated, with some receiving MBCT and others getting usual care. The goal was to u…

This study looked at whether mind-body exercises (like gentle movement and breathing) can lower stress, anxiety, and fatigue in pregnant women. 34 women in their second trimester were split into two groups: one did mind-body exercises, the other did relaxation exercises. The goal…

This study tested whether having a doula—a trained support person—before, during, and after delivery improves how Black birthing people feel about their care. 30 participants completed surveys about communication with their provider and overall care. The goal was to see if doula …

This study tested whether giving pregnant trainee doctors extra support—like a smart bassinet, wearable breast pump, 24/7 online perinatal care, and a faculty mentor—could reduce burnout and improve wellbeing. 156 pregnant residents and fellows from four hospitals were randomly a…

This study tested whether a hand massage technique called Su-Jok can reduce low back pain and improve comfort in pregnant women. 74 women with back pain at 32 weeks or more of pregnancy received the massage. Researchers measured pain and comfort using standard scales. The goal is…

This study tested whether a specific hand massage technique (seed therapy or su jok) can reduce nausea and vomiting and improve quality of life in pregnant women hospitalized with hyperemesis gravidarum, a severe form of morning sickness. Researchers enrolled 70 pregnant women an…

This study tested a mobile app called JUN that uses artificial intelligence to track symptoms and give timely advice to pregnant women. The goal was to see if the app helps women feel more confident in managing their health, especially those under criminal justice supervision lik…

This study looked at whether two sessions of hypnosis could lower anxiety in pregnant women with preterm premature rupture of membranes (PPROM). 60 women took part, with some receiving hypnosis and others standard care. The goal was to see if hypnosis helps reduce anxiety and imp…

This study tested whether kinesiotaping, a drug-free elastic tape, can relieve pelvic girdle pain in pregnant women. 72 participants wore the tape for five days, and researchers measured pain levels before and after. The goal was to see if this simple, no-side-effect approach cou…

This study compared using a cervical balloon catheter (a soft tube with a balloon) to prostaglandin drugs for inducing labor in 44 women who had a previous C-section. The goal was to see if the balloon method is safer and just as effective. The trial is now complete, and results …

This study tested a non-drug treatment called Personalized Integrated Chronotherapy (PIC) for depression during pregnancy and after childbirth. 120 pregnant women with major depression were randomly assigned to receive either usual care (medication or therapy) or PIC plus usual c…

This study looked at whether diaphragmatic breathing exercises could help pregnant women with low back pain. Fifty-eight women between 19 and 29 weeks pregnant did breathing exercises twice a day for six weeks. Researchers measured pain, disability, balance, and quality of life t…

This study looked at whether a regular stretching routine could improve heart health in pregnant women with obesity. 224 women were assigned to either a stretching program or usual care (moderate exercise). The researchers measured blood pressure and other heart-related markers f…

This study compared two medications, norepinephrine and phenylephrine, for treating low blood pressure during spinal anesthesia in C-sections. 46 women were randomly given one of the two drugs when their blood pressure dropped. Both drugs worked well, but norepinephrine kept the …

This study aims to adapt a program called Staying Healthy After Childbirth (STAC) for Black women and birthing persons. Researchers will work with community organizations and advisory boards to identify barriers and facilitators to implementation. The goal is to make the program …

This pilot study tests whether providing food boxes and extra money for healthy groceries can reduce food insecurity and improve birth outcomes for pregnant people on Medicaid. About 124 participants will receive either food delivery or financial support, along with recipes and h…

This study tested whether a very low energy diet (800 calories a day using meal replacements) before pregnancy could improve the health of obese women and their babies. 147 women participated, including those with obesity and healthy-weight women for comparison. Researchers measu…

This observational study looks at health data from about 10 million U.S. birth records to find the safest amount of weight gain during pregnancy for women with obesity. Current guidelines recommend the same 5 to 9 kg gain for all, but obesity has different levels of severity. Res…

This large observational study across multiple African sites tracks pregnant women who use antimalarial drugs, especially in the first trimester. The goal is to assess whether these medications are linked to miscarriage, stillbirth, or major birth defects. By following thousands …

This study investigates whether women who had high blood pressure during pregnancy (hypertensive disorders) show differences in brain health in midlife compared to those with normal pregnancies. Participants undergo MRI scans, blood tests, cognitive assessments, and sleep monitor…

This study looks at how lung ultrasound can help find lung issues early in women who are critically ill due to pregnancy complications or gynecologic cancer. Researchers will check for different lung ultrasound patterns and see if they relate to patient outcomes like death or nee…

This study tests a smartphone app designed to help African American and Spanish-speaking patients recognize warning signs of pregnancy-related death. Participants choose symptoms they are having and get advice on when to call a doctor or go to the emergency room. The goal is to s…

This study follows thousands of pregnant women in France who had or likely had COVID-19 during pregnancy or shortly after giving birth. Researchers track health problems in both mothers and newborns up to 12 weeks after delivery, using medical records and questionnaires about men…

This study looked at 50 women aged 30–50 who had a cervical conization (a cone-shaped biopsy) to treat abnormal cervical cells. Researchers measured blood flow in the uterine artery before and one month after surgery using Doppler ultrasound. The goal was to see if the surgery ch…

This study looked at the health and lifestyle habits of 143 pregnant women in Baton Rouge during their third trimester. Participants filled out questionnaires about their eating, physical activity, sleep, and overall well-being. The goal was to gather information, not to test a t…

This study looks at whether women who had a cervical procedure called LEEP (loop electrosurgical excision procedure) before age 25 face higher risks in future pregnancies, such as preterm labor or early rupture of membranes. Researchers reviewed records of 115 women who had LEEP …

This study compared two artificial intelligence (AI) models to the standard Hadlock formula for estimating fetal weight from ultrasound scans. Researchers analyzed scans from 283 pregnant women between 24 and 42 weeks of pregnancy. The goal was to see if AI could be more accurate…

This study looked at how often a harmless condition called deciduosis appears during C-sections. Researchers examined 31 women and found that about 10% had this benign lesion, which was linked to abdominal pain during pregnancy. The goal was to better understand how common it is …

This study tested a training program for prenatal healthcare providers to help them use medication-assisted treatment (MAT) for opioid use disorder during pregnancy. Researchers looked at data from over 1,000 patients to see if the program increased use of MAT and improved health…

This study tested a new care plan for 100 low-risk mothers and their newborns, allowing them to go home within 24 hours after a normal vaginal delivery. Participants received daily visits from a midwife for the first three days and used a special mobile app to stay in touch with …

This study looked at brain activity in pregnant women with opioid use disorder who were taking medication therapy. Researchers compared their brain scans to those of healthy pregnant women to see if there were differences. The goal was to learn more about how the body processes t…

This study tested whether a specific brand of prenatal multivitamin (Ritual) improves nutrient levels in pregnant women and their babies compared to another over-the-counter brand. About 80 pregnant women took one of the two vitamins throughout pregnancy, and researchers measured…

This study looked at whether pregnant women would accept using a vibrating relaxation tool to help with pain. 32 pregnant women were asked to use the tool at least twice. The goal was to see if this approach is worth studying further, not to prove it works.

This completed study looked at two new ways to understand why some labors slow down or stall (called labor dystocia). Researchers measured lactate levels in amniotic fluid and electrical signals from the uterus in 42 healthy women giving birth at term. The goal was to gather info…

This study tested a special nursing program that teaches pregnant women with preeclampsia about climate-related health risks, like heat and pollution. 104 women took part, with half receiving the program plus usual care and half receiving usual care alone. The goal was to see if …

This study looked at how babies suck on bottle nipples with different hole sizes. Researchers wanted to see if mothers who lost weight before pregnancy had babies with different sucking patterns. Ten mothers and their infants took part. The goal was to learn more about infant fee…

This study looked at how two hormones that rise during pregnancy—estradiol and cortisol—affect the way the body breaks down THC, the main active ingredient in cannabis. Fourteen healthy women of childbearing age took part. Researchers measured THC levels in the blood after taking…

This study tested whether playing recordings of a mother's voice to preterm babies in the NICU helps their brain and language development. Researchers enrolled 57 preterm infants born between 24 and 31 weeks. The goal was to see if this simple, non-invasive intervention could imp…

This study looked at 89 obese pregnant women to find out how common sleep apnea is and whether it is linked to high blood pressure, preeclampsia, or poor fetal outcomes. Participants had a sleep test (polysomnography) to detect apnea. The goal was to understand the connection and…

This study looked at how pregnancy changes the levels of the HIV drug doravirine in the blood. Seven pregnant women living with HIV took a single dose of doravirine during their second and third trimesters, and again after giving birth. The goal was to find the right dose for pre…

This study followed over 2,000 pregnant women to measure their blood sugar levels throughout pregnancy. The goal was to see how glucose patterns relate to gestational diabetes and whether the baby is born larger than normal. Researchers used continuous glucose monitors and standa…

This study tested a program called OPTIMIZE that uses a checklist and patient navigators to help Black pregnant women get better care during and after pregnancy. About 548 women took part across several clinics. Half the clinics used the program, and half provided standard care. …

This study looked at whether home visits by healthcare providers during pregnancy can improve mothers' knowledge, increase vaginal births, boost breastfeeding confidence, and reduce postpartum depression. Sixty-four first-time mothers with low-risk pregnancies took part. The appr…

This completed study looked at why some pregnant women in France choose not to join randomized clinical trials about pregnancy and childbirth. Researchers surveyed 526 women to find out what factors — like age, education, or how the study was explained — might influence their dec…

This study looked at how emergency general surgery affects pregnant women and their unborn babies. Researchers planned to follow pregnant women who needed surgery for problems like appendicitis or gallbladder disease. The goal was to learn more about the safety of these surgeries…

This study looked at over 2,100 people with listeriosis, a serious foodborne infection that can cause blood infections, brain infections, and pregnancy complications. Researchers collected data to find out which clinical, biological, and genetic factors make someone more likely t…

This study looked at whether iron supplements improve how well vaccines work in pregnant women with anemia (low iron). Researchers compared their immune responses to tetanus, diphtheria, and COVID-19 vaccines against women without anemia. The goal was to see if correcting iron de…

This study looked at pregnant women being treated for opioid use disorder with two different forms of buprenorphine: a monthly shot and a daily tablet. Researchers measured drug levels in the mother's blood and checked the baby's heart rate to see how each treatment affected both…

This study looked at 71 babies born to mothers who took either a monthly injection or a daily tablet of buprenorphine for opioid use disorder during pregnancy. Researchers measured the babies' thinking, language, and motor skills using a standard child development test. The goal …

This study looked at how much vitamin D pregnant women need to reach healthy levels. 105 women at risk of deficiency took either 20 or 40 micrograms of vitamin D daily throughout pregnancy. Researchers measured their vitamin D levels and other health markers to see which dose wor…

This study tested whether pregnant women can have their pre-birth anesthesia consultation through a video call instead of coming to the hospital. 60 women participated, using a telemedicine cabin or cart near their home. The goal was to see if the video assessment of the airway i…

This study tested a shared decision-making tool called NEST to help pregnant women understand and choose noninvasive prenatal testing (NIPT). Over 600 pregnant women participated, comparing those who used the tool with those who received usual care. The goal was to see if the too…

This study looked at how much methionine, a building block of protein, pregnant women need during early and late pregnancy. Researchers tested 69 healthy pregnant women using special diets and breath tests. The goal is to improve current dietary recommendations, which are based o…

This completed study compared the heart effects of two drugs, oxytocin and carbetocin, given to prevent bleeding after childbirth. Researchers measured a heart injury marker (troponin I) in 240 healthy pregnant women after delivery. The goal was to see if carbetocin might be less…

This study looked at how obesity might affect the cells in the uterus that help with labor. Researchers took blood and uterine tissue samples from 38 women having C-sections, some with normal weight and some obese. They wanted to see if certain cells and chemicals in the blood co…

This study looked at 1,000 women who gave birth at age 45 or older to understand the risks and complications they face. Researchers examined issues like preterm birth, delivery complications, and how long mothers stayed in the hospital. The goal was to gather information to help …

This completed observational study looked at 150 women to see how different types of fibroid removal surgery (hysteroscopic, laparoscopic, or laparotomic) affect pregnancy outcomes. It compared women who had surgery with those who did not, and also looked at whether surgery durin…

This study looked at two natural cell processes—autophagy (cell cleaning) and apoptosis (cell death)—in 97 pregnant women. Researchers wanted to see how these processes vary in normal pregnancies and in women at risk for complications. The goal was to understand the balance betwe…

This study looked at whether viral infections and diabetes in pregnant women are linked to congenital heart defects in their babies. Researchers analyzed blood and stool samples from 114 women to detect viruses and immune responses. The goal was to gather knowledge for future lar…

This study looked at why pregnant women tend to get more severe flu but not worse COVID-19. Researchers collected nasal brush samples and blood from 48 pregnant and non-pregnant women to compare how their immune systems respond to these viruses. The goal is to understand the prot…

This study looked at how the antibiotic amoxicillin works in pregnant women to help prevent passing syphilis to their babies. Researchers measured drug levels in the blood of 13 pregnant women during the second and third trimesters and after birth. The goal was to find the right …

This study measured certain proteins (histones and HMGB1) in the blood of 115 pregnant women to see if they could help detect placenta-related complications like pre-eclampsia. Researchers compared women with normal pregnancies, those with complications, and healthy non-pregnant …

This study followed over 1,500 women who had pregnancy losses and were tested for antiphospholipid syndrome (APS) and other clotting disorders. Researchers compared cancer rates among women with APS, those with other clotting gene changes, and those with no clotting issues. The g…

This study followed 168 women with Multiple Sclerosis who were pregnant or planning pregnancy. Researchers collected information through phone interviews every three months during pregnancy and tracked the baby's growth for up to three years after birth. The goal was to understan…

This study tested a new prenatal care model that includes fathers. 216 young couples participated in co-parenting education, parenting classes, and job skills training. The goal was to see if this approach could improve relationships and prepare parents for their baby's arrival.

This study tested a new, non-invasive device that uses light to measure a baby's oxygen levels through the mother's belly during labor. 35 women in labor participated. The device was used only for research and did not guide any medical decisions. The goal was to see if the device…

This study tested a training program for labor and delivery providers in Tanzania to reduce HIV stigma during childbirth. The training used simulations and hands-on learning to help providers offer more respectful care. Researchers compared how women rated their care before and a…

This study surveyed 145 women with migraines who were pregnant between 2019 and 2021. It compared pregnancy and baby health between those who used the Nerivio device for migraine attacks and those who didn't. The goal was to see if using Nerivio during pregnancy is safe for both …

This completed study looked at why some pregnant women chose not to take part in a larger trial on early screening for pre-eclampsia, a serious pregnancy condition. Researchers surveyed 472 women to find factors linked to refusal and to understand their reasons for saying yes or …

This completed trial compared two training programs for first-time pregnant women: one focused on preparing for the maternal role, and the other on mindfulness-centered occupational therapy. The study included 74 women between 14-27 weeks of pregnancy and followed them after birt…

This completed study interviewed 28 women with a history of bulimia or binge-eating disorder about their pregnancy and postpartum experiences. Researchers aimed to understand how these women cope with body changes and interact with healthcare services. The goal is to improve care…